Vitamin E in aging, dementia, and Alzheimer's disease

BioFactors

Volumn 38, Issue 2, 2012, Pages 90-97

  Joshi, Yash B ^a   Praticò, Domenico ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Brain aging; Dementia; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; BETA TOCOPHEROL; BETA TOCOTRIENOL; DELTA TOCOPHEROL; GAMMA TOCOPHEROL; GAMMA TOCOTRIENOL; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; COGNITION; DEMENTIA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

AGING; ALZHEIMER DISEASE; ANIMALS; BRAIN; DEMENTIA; HUMANS; OXIDATION-REDUCTION; VITAMIN E;

EID: 84859428415     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.195     Document Type: Review

References (88)

1. Evans, H. M., and Bishop, K. S. ( 1922) On the existence of a hitherto unrecognized dietary factor essential for reproduction, Science, 56, 650-651.
2. Sondergaad, E., and Dam, H. ( 1966) Influence of the level of dietary linoleic acid on the amount of d-alpha-tocopherol acetate required for protection against encephalomalcia. Z. Ernahrungswiss 6, 253-258.
3. Granados, H., and Dam, H. ( 1950) On the histochemical relationship between peroxidation and the yellow-brown pigment in the adipose tissue of vitamin E-deficient rats. Acta Pathol. Microbiol. Scand. 27, 591-598.
4. Harris, P. L., and Embree, N. D. ( 1963) Quantitative consideration of the effect of polyunsaturated fatty acid content of the diet upon the requirements for vitamin E. Am. J. Clin. Nutr. 13, 385-392.
5. Wolf, G. ( 2005) The discovery of the antioxidant function of vitamin E: the contribution of Henry A. Matill. J. Nutr. 135, 363-366.
6. Traber, M. G., and Atkinson, J. ( 2007) Vitamin E, antioxidant and nothing more. Free Radic. Biol. Med. 43, 3-15.
7. Zingg, J. M. ( 2007) Modulation of signal transduction by vitamin E. Mol. Aspects Med. 28, 481-506.
8. Zingg, J. M., and Azzi, A. ( 2004) Non antioxidant activities of vitamin E. Curr. Med. Chem. 11, 1113-1133.
9. Roy, S., Lado, B. H., Khanna, S., and Sen, C. K. ( 2002) Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Lett. 530, 17-23.
10. Rimbach, G., Minihane, A. M., Majewicz, J., Fisher, A., Pallauf, J., Virgili, F., and Weinberg, P. D. ( 2002) Regulation of cell signaling by vitamin E. Proc. Nutr. Soc. 61, 415-425.
11. Kolosova, N. G., Shcheglova, T. V., Sergeeva, S. V., and Loskutova, L.V. ( 2006) Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol. Aging 27, 1289-1297.
12. Sheppard, A. J., Pennington, J. A. T., and Weihrauch, J. L. ( 1993) Analysis and distribution of vitamin E in vegetable oils and foods. In Vitamin E in Health and Disease ( Packer, L., Fuchs, J., eds.). pp. 9-31, Marcel Dekker, Inc., New York.
13. IUPAC-IUB Joint Commission on Biochemical Nomenclature.( 1982) Nomenclature of tocopherols and related compounds. Recommendations 1982. Eur. J. Biochem. 123, 473-475.
14. Sies, H., and Murphy, M. E. ( 1991) Role of tocopherols in the protection of biological systems against oxidative damage. J. Photochem. Photobiol. 8, 211-218.
15. Brigelius-Flohe, R., and Traber, M. G. ( 1999) Vitamin E: function and metabolism. FASEB J. 13, 1145-1155.
16. Yap, S. P., Yuen, K. H., and Wong, J. W. ( 2001) Pharmacokinetics and bioavailability of alpha-, gamma-, and delta-tocotrienols under different food status. J. Pharm. Pharmacol. 53, 67-71.
17. Traber, M. G., Elsner, A., and Brigelius-Flohe, R. ( 1998) Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopheryl acetates. FEBS Lett. 437, 145-148.
18. Hacquebard, M., and Carpentier, Y. A. ( 2005) Vitamin E: absorption, plasma transport and cell uptake. Curr. Opin. Clin. Nutr. Metab. Care 8, 133-138.
19. O'Byrne, D., Grundy, S., Packer, L., Devaraj, S., Baldenius, K., Hoppe, P. P., Kraemer, K., Jialal, I., and Traber, M. G. ( 2000) Studies of LDL oxidation following alpha-, gamma-, or delta-tocotrienyl acetate supplementation of hypercholesterolemic humans. Free Radic. Biol. Med. 29, 834-845.
20. Horiguchi, M., Arita, M., Kaempf-Rotzoll, D. E., Tsujimoto, M., Inoue, K., and Arai, H. ( 2003) pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes. Genes Cells 8, 789-800.
21. Traber, M. G., Burton, G. W., and Hamilton, R. L. ( 2005) Vitamin E trafficking. Ann. N. Y. Acad. Sci. 1031, 1-12.
22. Burton, G. W., and Traber, M. G. ( 1990) Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annu. Rev. Nutr. 10, 357-382.
23. Azzi, A., Aratri, E., Boscoboinik, D., Clement, S., Ozer, N. K., Ricciarelli, R., and Spycher, S. ( 1998) Molecular basis of a-tocopherol control of smooth muscle cell proliferation. Biofactors 7, 3-14.
24. Brigelius-Flohe, R. ( 2009) Vitamin E: the shrew waiting to be tamed. Free Radic. Biol. Med. 46, 543-554.
25. Sen, C. K., Khanna, S., Rink, C., and Roy, S. ( 2007) Tocotrienols: the emerging face of natural vitamin E. Vitam. Horm. 76, 203-261.
26. Khanna, S., Parinandi, N. L., Kotha, S. R., Roy, S., Rink, C., Bibus, D., and Sen, C. K. ( 2010) Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J. Neurochem. 112, 1249-1260.
27. Reiter, E., Jiang, Q., and Christen, S. ( 2007) Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol. Aspects Med. 28, 668-691.
28. Naito, Y., Shimozawa, M., Kuroda, M., Nakabe, N., Manabe, H., Katada, K., Kokura, S., Ichikawa, H., Yoshida, N., Noguchi, N., Yoshikawa, T. ( 2005) Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules. Atherosclerosis 180, 19-25.
29. Gavrilov, L. A., and Heuveline, P. ( 2003) Aging of Population. In The Encyclopedia of Population ( Demeny, P., McNicoll, G., eds.). pp. 32-37, Macmillan, New York.
30. Essink-Bot, M. L., Periera, J., Packer, C., Schwarzinger, M., and Burstrom, K. ( 2002) Cross-national comparability of burden of disease estimates: the European Disability Weights Project. Bull. World Health Organ. 80, 644-652.
31. Zhu, X., Lee, H. G., Perry, G., and Smith, M. A. ( 2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim. Biophys. Acta 177, 494-502.
32. Yeo, L. H., Horan, M. A., Jones, M., and Pendleton, N. ( 2007) Perceptions of risk and prevention of dementia in the healthy elderly. Dement Geriatr. Cogn. Disord. 23, 368-371.
33. Berr, C., Wancata, J., and Ritchie, K. ( 2005) Prevalence of dementia in the elderly in Europe. Eur. Neuropsychopharmacol. 15, 463-471.
34. Corrada, M. M., Brookmeyer, R., Berlau, D., Paganini-Hill, A., and Kawas, C. H. ( 2008) Prevalence of dementia after age 90: results from The 90+ Study. Neurology 71, 337-343.
35. Drachman, D. A. ( 2004) If we live long enough, will we all be demented? Neurology 44, 1563-1565.
36. Hogan, D. B. ( 2008) If we live long enough, will we all be demented? Redux. Neurology 71, 310-311.
37. Haan, M. N., and Wallace, R. ( 2004) Can dementia be prevented? Brain aging in a population-based context. Annu. Rev. Public Health 25, 1-24.
38. Hogan, D. B., Bailey, P., Black, S., Carswell, A., Chertkow, H., Clarke, B., Cohen, C., Fisk, J. D., Forbes, D., Man-Son-Hing, M., Lanctot, K., Morgan, D., and Thorpe, L. ( 2008) Diagnosis and treatment of dementia. Part V: Nonpharmacologic and pharmacologic therapy for mild to moderate dementia. Can. Med. Ass. J. 179, 1019-1026.
39. Guide to Clinical Preventive Services, 3rd edn. Periodic Updates. Screen for Dementia. ( 2003). US Preventive Services Task Force. Recommendations and Rationale and Summary of the Evidence available at:
40. Burns, J. M., and Morris, J. C. ( 2008) Mild Cognitive Impairment and Early Alzheimer's Disease. Wiley, Chichester.
41. Patterson, C., Feightner, G. W., Garcia, A., Hsiung, G. Y. R., MacKnight, C., and Sadovnick, A. D. ( 2008) Diagnosis and treatment of dementia. Part I. Risk assessment and primary prevention of Alzheimer disease, Can. Med. Ass. J. 178, 548-556.
42. Mangialasche, F., Polidori, M. C., Monastero, R., Ercolani, S., Cecchetti, R., and Mecocci, P. ( 2009) Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive Impairment. Aging Res. Rev. 8, 285-305.
43. Sies, H., and Cadenas, E. ( 1985) Oxidative Stress: damage to intact cells and organs. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1152, 617-631.
44. Guérin, O., Andrieu, S., Schneider, S. M., Milano, M., Boulahssass, R., Brocker, P., and Vellas, B. ( 2005) Different modes of weight loss in Alzheimer disease: a prospective study of 395 participants. Am. J. Clin. Nutr. 82, 435-441.
45. Anlasik, T., Sies, H., Griffiths, H. R., Mecocci, P., Stahl, W., and Polidori, M. C. ( 2005) Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. Br. J. Nutr. 94, 639-642.
46. Polidori, M. C., Carrillo, J. C., Verde, P. E., Sies, H., Siegrist, J., and Stahl, W. ( 2009) Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels. Nutr. J. 8, 10.
47. Polidori, M. C., Praticò, D., Mariani, E., Aust, O., Anlasik, T., Mang, N., Pientka, L., Stahl, W., Sies, H., Mecocci, P., and Nelles, G. ( 2009) High fruit and vegetable intake, high antioxidant status and good cognitive performance are associated in healthy subjects. J. Alzheimers Dis. 17, 921-927.
48. Shatenstein, B., Kergoat, M. J., Reid, I., and Chicoine, M. E. ( 2008) Dietary intervention in older adults with early-stage Alzheimer dementia: early lessons learned. J. Nutr. Health Aging 12, 461-469.
49. Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., and Wilson, R. S. ( 2006) Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 67, 1370-1376.
50. Scarmeas, N., Stern, Y., Mayeaux, R., and Luchsinger, G. A. ( 2006) Mediterranean diet, Alzheimer disease, and vascular mediation. Arch. Neurol. 63, 1709-1717.
51. Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R., and Luchsinger, L. A. ( 2006) Mediterranean diet and the risk for Alzheimer's disease, Ann. Neurol. 59, 912-921.
52. Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C., Tzourio, C., Dartigues, J. F., and Alperovitch, A. ( 2007) Dietary patterns and risk of dementia: the Three-City Cohort Study. Neurology 69, 1921-1930.
53. Scarmeas, N., Luchsinger, J. A., Mayeux, R., and Stern, Y. ( 2007) Mediterranean diet and Alzheimer's disease mortality, Neurology 69, 1084-1093.
54. Burgener, S. C., Buettner, L., Coen Buckwalter, K., Beattie, E., Bossen, A. L., Fick, D. M., Fitzsimmons, S., Kolanowski, A., Richeson, N. E., Rose, K., Schreiner, A., Pringle Specht, J. K., Testad, I., Yu, F., and McKenzie, S. ( 2008) Evidence supporting nutritional interventions for persons in early stage Alzheimer's disease. J. Nutr. Health Aging 12, 18-21.
55. Serra-Majem, L., Bes-Rastrollo, M., Román-Viñas, B., Pfrimer, K., Sánchez-Villegas, A., and Martínez-González, M. A. ( 2009) Dietary patterns and nutritional adequacy in a Mediterranean country. Br. J. Nutr. 2( Suppl 101), S21-S28.
56. Galbusera, C., Facheris, M., Magni, F., Galimberti, G., Sala, G., Tremolada, L., Isella, V., Guerini, F. R., Apollonio, I., Galli-Kienle, M., and Ferrarese, C. ( 2004) Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients. Curr. Alzheimer Res. 1, 103-109.
57. Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., Wilson, R. S., Aggarwal, N. T., and Scherr, P. A. ( 2005) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am. J. Clin. Nutr. 81 508-514.
58. Hensley, K., Barnes, L. L., Christov, A., Tangney, C., Honer, W. G., Schneider, J. A., Bennet, D. A., and Morris, M. C. ( 2011) Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance. J. Alzheimers Dis. 24, 767-774.
59. Ravaglia, G., Forti, P., Lucicesare, A., Pisacane, N., Rietti, E., Mangialasche, F., Cecchetti, R., Patterson, C., and Mecocci, P. ( 2008) Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort. Am. J. Clin. Nutr. 87, 1306-1313.
60. Hill, A. ( 1971) Principles of Medical Statistics, 9th edn. Oxford University Press, New York.
61. McCann, J. C., and Ames, B. N. ( 2005) Is docosahexaenoic acid, an n-3 long chain polyunsaturated fatty acid, required for the development of normal brain function? An overview of evidence from cognitive and behavioural tests in humans and animals. Am. J. Clin. Nutr. 82, 281-295.
62. McCann, J. C., Hudes, M., and Ames, B. N. ( 2006) An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring. Neurosci. Biobehav. Rev. 30, 697-712.
63. McCann, J. C., Hudes, M., and Ames, B. N. ( 2008) Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 22, 982-1001.
64. Martin, A., Janigian, D., Shukitt-Hale, B., Prior, R. L., and Joseph, J. A. ( 1999) Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations. Brain Res. 845, 50-59.
65. Grundman, M. ( 2000) Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am. J. Clin. Nutr. 71, 630S-666S.
66. Martin, A., Youdim, K., Szprengiel, A., Shukitt-Hale, B., and Joseph, J. A. ( 2002) Roles of vitamins C and E on neurodegenerative diseases and cognitive performance. Nutr. Rev. 60, 308-334.
67. Helmer, C., Peuchant, E., Letenneur, L., Bourdel-Marchasson, I., Larrieu, S., Dartigues, J. F., Dubourg, L., Thomas, M. J., and Barberger-Gateau, P. ( 2003) Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study. Eur. J. Clin. Nutr. 57, 1555-1561.
68. Zandi, P. P., Anthony, J. C., Khachaturian, A. S., Stone, S. V., Gustafson, D., Tschanz, J. T., Norton, M. C., Welsch-Bohmer, K. A., Breitner, J. C. S.; and Cache County Study Group. ( 2004) Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements. Arch. Neurol. 61, 82-88.
69. Cherubini, A., Martin, A., Andres-Lacueva, C., Di Iorio, A., Lamponi, M., Mecocci, P., Bartali, B., Corsi, A., Senin, U., and Ferrucci, L. ( 2005) Vitamin E levels, cognitive impairment and dementia in older persons: the InChianti Study. Neurobiol. Aging 26, 987-994.
70. Masaki, K. H., Losonczy, K. G., Izmirlian, G., Folcy, D. J., Ross, G. W., Petrovitch, H., Haulik, R., and White, L. R. ( 2000) Association of vitamin C and E supplement use with cognitive function and dementia in elderly men. Neurology 54, 1265-1272.
71. Morris, M. C., Evans, D. A., Biennas, J. L., Tangney, C. C., and Wilson, R. S. ( 2002) Vitamin E and cognitive decline in older persons. Arch. Neurol. 59, 1125-1132.
72. Grodstein, F., Chen, J., and Willet, W. C. ( 2003) High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am. J. Clin. Nutr. 77, 975-984.
73. Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S., and Thal, L. J. ( 1977) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N. Engl. J. Med. 336, 1216-1222.
74. Isaac, M. G., Quinn, R., and Tabet, N. ( 2008) Vitamin E for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst. Rev. 16, CD002854.
75. Mecocci, P., Mariani, E., Polidori, M. C., Hensley, K., and Butterfield, D. A. ( 2008) Antioxidant agents in Alzheimer's disease. Cent. Nerv. Syst. Agents Med. Chem. 8, 48-63.
76. Mangialasche, F., Kivipelto, M., Mecocci, P., Rizzuto, D., Palmer, K., Winblad, B., and Fratiglioni, L. ( 2010) High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J. Alzheimers Dis. 20, 1029-1037.
77. Gutierrez, A. D., de Serna, D. G., Robinson, I., and Schade, D. S. ( 2009) The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C. Metabolism 58, 469-478.
78. Khanna, S., Patel, V., Rink, C., Roy, S., and Sen, C. K. ( 2005) Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic. Biol. Med. 39, 1310-1319.
79. Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., and Gluud, C. ( 2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297, 842-857.
80. Querfurth, H. W., and LaFerla, F. M. ( 2010) Alzheimer's disease. N. Engl. J. Med. 362, 329-344.
81. Butterfield, D. A., and Boyd-Kimball, D. ( 2005) The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity. Biochim. Biophys. Acta. 1730, 149-156.
82. Yatin, S. M., Varadarajan, S., and Butterfield, D. A. ( 2000) Vitamin E prevents Alzheimer's amyloid-beta-peptide (1-42)-induced neuronal protein oxidation and reactive oxygen species production. J. Alzheimers Dis. 2, 123-131.
83. Kaneai, N., Arai, M., Takatsu, H., Fukui, K., and Urano, S. Vitamin E inhibits oxidative stress-induced denaturation of nerve terminal proteins involved in neurotransmission. J. Alzheimers Dis. [Epub ahead of print 2011 Oct 4].
84. Block, M. L. ( 2008) NADPH oxidase as a therapeutic target in Alzheimer's disease. BMC Neurosci. 9 ( Suppl 2), S8.
85. Chu, J., and Praticò, D. ( 2011) 5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann. Neurol. 69, 34-46.
86. McGreer, P. L. and McGreer, E. G. ( 2007) NSAIDs and Alzheimer disease: epidemiologic, animal model and clinical studies. Neurobiol. Aging 28, 639-647.
87. Voronkov, M., Braithwaite, S. P., and Stock, J. B. ( 2011) Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. Future Med. Chem. 3, 821-833.
88. Hensley, K., Benaksas, E. J., Bolli, R., Comp, P., Grammas, P., Hamdheydari, L., Mou, S., Pye, Q. N., Stoddard, M. F., Wallis, G., Williamson, K. S., West, M., Wechter, W. J., and Floyd, R. A. ( 2004) New perspectives on vitamin E: gamma-tocopherol and corboxyethylhydroxychroman metabolites in biology and medicine. Free Radic. Biol. Med. 36, 1-15.