-
3
-
-
61849124218
-
Defining balanced conditions for inhibitor screening assays that target bisubstrate enzymes
-
J. Yang Defining balanced conditions for inhibitor screening assays that target bisubstrate enzymes J. Biomol. Screen. 14 2009 111 120
-
(2009)
J. Biomol. Screen.
, vol.14
, pp. 111-120
-
-
Yang, J.1
-
4
-
-
84858117660
-
Factors influencing the inhibition of protein kinases
-
10.3109/14756366.2011.583922
-
M. Brockhoff Factors influencing the inhibition of protein kinases J. Enzyme Inhib. Med. Chem. 2011 10.3109/14756366.2011.583922
-
(2011)
J. Enzyme Inhib. Med. Chem.
-
-
Brockhoff, M.1
-
6
-
-
44649180430
-
The new challenges of biochemistry in identifying the next generation of protein kinase inhibitors
-
P. Chène The new challenges of biochemistry in identifying the next generation of protein kinase inhibitors Drug Discov. Today 13 2008 522 529
-
(2008)
Drug Discov. Today
, vol.13
, pp. 522-529
-
-
Chène, P.1
-
7
-
-
33746822258
-
Steady-state kinetic mechanism of PDK1
-
DOI 10.1074/jbc.M602448200
-
X. Gao, and T.K. Harris Steady-state kinetic mechanism of PDK1 J. Biol. Chem. 281 2006 21670 21681 (Pubitemid 44181870)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.31
, pp. 21670-21681
-
-
Gao, X.1
Harris, T.K.2
-
8
-
-
70350074904
-
Characterization of the CHK1 allosteric inhibitor binding site
-
D. Vanderpool Characterization of the CHK1 allosteric inhibitor binding site Biochemistry 48 2009 9823 9830
-
(2009)
Biochemistry
, vol.48
, pp. 9823-9830
-
-
Vanderpool, D.1
-
9
-
-
49449101644
-
Kinetic studies of Cdk5/p25 kinase: Phosphorylation of Tau and complex inhibition by two prototype inhibitors
-
M. Liu Kinetic studies of Cdk5/p25 kinase: phosphorylation of Tau and complex inhibition by two prototype inhibitors Biochemistry 47 2008 8367 8377
-
(2008)
Biochemistry
, vol.47
, pp. 8367-8377
-
-
Liu, M.1
-
10
-
-
0037449711
-
BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF-κB-dependent transcription in mice
-
DOI 10.1074/jbc.M209677200
-
J.R. Burke BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF-κB-dependent transcription in mice J. Biol. Chem. 278 2003 1450 1456 (Pubitemid 36801370)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.3
, pp. 1450-1456
-
-
Burke, J.R.1
Pattoli, M.A.2
Gregor, K.R.3
Brassil, P.J.4
MacMaster, J.F.5
McIntyre, K.W.6
Yang, X.7
Iotzova, V.S.8
Clarke, W.9
Strnad, J.10
Qiu, Y.11
Zusi, F.C.12
-
11
-
-
33748325882
-
Drug-target residence time and its implications for lead optimization
-
DOI 10.1038/nrd2082, PII NRD2082
-
R.A. Copeland Drug-target residence time and its implications for lead optimization Nat. Rev. Drug Discov. 5 2006 730 739 (Pubitemid 44323700)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 730-739
-
-
Copeland, R.A.1
Pompliano, D.L.2
Meek, T.D.3
-
12
-
-
33749623857
-
Can binding kinetics translate to a clinically differentiated drug? From theory to practice
-
DOI 10.2174/157018006778194754
-
D.C. Swinney Can binding kinetics translate to a clinically differentiated drug? From theory to practice Lett. Drug Des. Discov. 3 2006 569 574 (Pubitemid 44544011)
-
(2006)
Letters in Drug Design and Discovery
, vol.3
, Issue.8
, pp. 569-574
-
-
Swinney, D.C.1
-
13
-
-
44049103958
-
Residence time of receptor - Ligand complexes and its effect on biological function
-
DOI 10.1021/bi8002023
-
P.J. Tummino, and R.A. Copeland Residence time of receptor-ligand complexes and its effect on biological function Biochemistry 47 2008 5481 5492 (Pubitemid 351711169)
-
(2008)
Biochemistry
, vol.47
, Issue.20
, pp. 5481-5492
-
-
Tummino, P.J.1
Copeland, R.A.2
-
14
-
-
33745511768
-
Slow antagonist dissociation and long-lasting in vivo receptor protection
-
DOI 10.1016/j.tips.2006.05.001, PII S0165614706001283
-
G. Vauquelin, and I. Van Liefde Slow antagonist dissociation and long-lasting in vivo receptor protection Trends Pharmacol. Sci. 27 2006 355 359 (Pubitemid 43963183)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.7
, pp. 355-359
-
-
Vauquelin, G.1
Van Liefde, I.2
-
17
-
-
0023728105
-
The behavior and significance of slow-binding enzyme inhibitors
-
J.F. Morrison, and C.T. Walsh The behavior and significance of slow-binding enzyme inhibitors Adv. Enzymol. 61 1988 201 301
-
(1988)
Adv. Enzymol.
, vol.61
, pp. 201-301
-
-
Morrison, J.F.1
Walsh, C.T.2
-
18
-
-
0028924136
-
Kinetics of slow and tight-binding inhibitors
-
S.E. Szedlacsek, and R.G. Duggleby Kinetics of slow and tight-binding inhibitors Methods Enzymol. 249 1995 144 180
-
(1995)
Methods Enzymol.
, vol.249
, pp. 144-180
-
-
Szedlacsek, S.E.1
Duggleby, R.G.2
-
19
-
-
79952096135
-
Biochemical characterization of TAK-593, a novel vEGFR/PDGFR inhibitor with a two-step slow binding
-
H. Iwata Biochemical characterization of TAK-593, a novel vEGFR/PDGFR inhibitor with a two-step slow binding Biochemistry 50 2011 738 751
-
(2011)
Biochemistry
, vol.50
, pp. 738-751
-
-
Iwata, H.1
-
20
-
-
18344395134
-
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
-
DOI 10.1038/nsb770
-
C. Pargellis Inhibition of p38 MAP kinase by utilizing a novel allosteric site Nat. Struct. Biol. 9 2002 268 272 (Pubitemid 34289898)
-
(2002)
Nature Structural Biology
, vol.9
, Issue.4
, pp. 268-272
-
-
Pargellis, C.1
Tong, L.2
Churchill, L.3
Cirillo, P.F.4
Gilmore, T.5
Graham, A.G.6
Grob, P.M.7
Hickey, E.R.8
Moss, N.9
Pav, S.10
Regan, J.11
-
21
-
-
65249099497
-
Fundamental aspects of protein-protein association kinetics
-
G. Schreiber Fundamental aspects of protein-protein association kinetics Chem. Rev. 109 2009 839 860
-
(2009)
Chem. Rev.
, vol.109
, pp. 839-860
-
-
Schreiber, G.1
-
22
-
-
0025737863
-
Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: The influence of conformational restriction
-
M. Benveniste, and M.L. Mayer Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction Br. J. Pharmacol. 104 1991 207 221
-
(1991)
Br. J. Pharmacol.
, vol.104
, pp. 207-221
-
-
Benveniste, M.1
Mayer, M.L.2
-
24
-
-
79959492294
-
Design and structure of stapled peptides binding to estrogen receptors
-
C. Philipps Design and structure of stapled peptides binding to estrogen receptors J. Am. Chem. Soc. 133 2011 9696 9699
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 9696-9699
-
-
Philipps, C.1
-
25
-
-
0029873697
-
Rapid, electrostatically assisted association of proteins
-
DOI 10.1038/nsb0596-427
-
G. Schreiber, and A.R. Fersht Rapid, electrostatically assisted association of proteins Nat. Struct. Biol. 3 1996 427 431 (Pubitemid 26139441)
-
(1996)
Nature Structural Biology
, vol.3
, Issue.5
, pp. 427-431
-
-
Schreiber, G.1
Fersht, A.R.2
-
26
-
-
0033923367
-
Rational design of faster associating and tighter binding protein complexes
-
DOI 10.1038/76744
-
T. Selzer Rational design of faster associating and tighter binding protein complexes Nat. Struct. Biol. 7 2000 537 541 (Pubitemid 30445907)
-
(2000)
Nature Structural Biology
, vol.7
, Issue.7
, pp. 537-541
-
-
Selzer, T.1
Albeck, S.2
Schreiber, G.3
-
27
-
-
0000288714
-
Parameters for the description of transition states
-
J.E. Leffler Parameters for the description of transition states Science 117 1953 340 341
-
(1953)
Science
, vol.117
, pp. 340-341
-
-
Leffler, J.E.1
-
28
-
-
5144225084
-
Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates
-
DOI 10.1073/pnas.0406091101
-
A.R. Fersht Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates Proc. Natl. Acad. Sci. U. S. A. 101 2004 14338 14342 (Pubitemid 39346750)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.40
, pp. 14338-14342
-
-
Fersht, A.R.1
-
29
-
-
49449091883
-
Transition state for protein-DNA recognition
-
D.U. Ferreiro Transition state for protein-DNA recognition Proc. Natl. Acad. Sci. U. S. A. 105 2008 10797 10802
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 10797-10802
-
-
Ferreiro, D.U.1
-
30
-
-
79952741171
-
Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction
-
A. Bachmann Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction Proc. Natl. Acad. Sci. U. S. A. 108 2011 3952 3957
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 3952-3957
-
-
Bachmann, A.1
-
32
-
-
62449198130
-
Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions
-
J.R. Horn Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions Proc. Natl. Acad. Sci. U. S. A. 106 2009 2259 2264
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2259-2264
-
-
Horn, J.R.1
-
34
-
-
0031694146
-
Kinetic epitope mapping of the chicken lysozyme HyHEL-10 Fab complex: Delineation of docking trajectories
-
M.G. Taylor Kinetic epitope mapping of the chicken lysozyme HyHEL-10 Fab complex: delineation of docking trajectories Protein Sci. 7 1998 1857 1867
-
(1998)
Protein Sci.
, vol.7
, pp. 1857-1867
-
-
Taylor, M.G.1
-
35
-
-
42949161558
-
Binding-induced folding of a natively unstructured transcription factor
-
A.G. Turjanski Binding-induced folding of a natively unstructured transcription factor PLoS Comput. Biol. 4 2008 e1000060
-
(2008)
PLoS Comput. Biol.
, vol.4
, pp. 1000060
-
-
Turjanski, A.G.1
-
36
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
DOI 10.1158/0008-5472.CAN-04-1168
-
E.R. Wood A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells Cancer Res. 64 2004 6652 6659 (Pubitemid 39297926)
-
(2004)
Cancer Research
, vol.64
, Issue.18
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
Yuan, D.4
Hassell, A.5
Dickerson, S.H.6
Ellis, B.7
Pennisi, C.8
Horne, E.9
Lackey, K.10
Alligood, K.J.11
Rusnak, D.W.12
Gilmer, T.M.13
Shewchuk, L.14
-
37
-
-
79954505731
-
Study of the selectivity of insulin-like growth factor-1 receptor (IGF1R) inhibitors
-
P. Chène Study of the selectivity of insulin-like growth factor-1 receptor (IGF1R) inhibitors Open Enzyme Inhib. J. 3 2010 27 37
-
(2010)
Open Enzyme Inhib. J.
, vol.3
, pp. 27-37
-
-
Chène, P.1
-
38
-
-
34548058372
-
Pharmacological and functional comparison of the polo-like kinase family: Insight into inhibitor and substrate specificity
-
DOI 10.1021/bi7008745
-
E.F. Johnson Pharmacological and functional comparison of the Polo-like kinase family: insight into inhibitor and substrate specificity Biochemistry 46 2007 9551 9563 (Pubitemid 47291962)
-
(2007)
Biochemistry
, vol.46
, Issue.33
, pp. 9551-9563
-
-
Johnson, E.F.1
Stewart, K.D.2
Woods, K.W.3
Giranda, V.L.4
Luo, Y.5
-
39
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
D.D. Boehr The role of dynamic conformational ensembles in biomolecular recognition Nat. Chem. Biol. 5 2009 789 796
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 789-796
-
-
Boehr, D.D.1
-
40
-
-
69549120472
-
Conformational selection or induced fit: A flux description of reaction mechanism
-
G.G. Hammes Conformational selection or induced fit: a flux description of reaction mechanism Proc. Natl. Acad. Sci. U. S. A. 106 2009 13737 13741
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 13737-13741
-
-
Hammes, G.G.1
-
41
-
-
65249090946
-
Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis
-
T.R. Weikl, and V.C. Deuster Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis Proteins 75 2008 104 110
-
(2008)
Proteins
, vol.75
, pp. 104-110
-
-
Weikl, T.R.1
Deuster, V.C.2
-
42
-
-
77949587817
-
From induced fit to conformational selection: A continuum of binding mechanism controlled by the timescale of conformational transitions
-
H.X. Zhou From induced fit to conformational selection: a continuum of binding mechanism controlled by the timescale of conformational transitions Biophys. J. 98 2010 L15 L17
-
(2010)
Biophys. J.
, vol.98
-
-
Zhou, H.X.1
-
43
-
-
0042020196
-
The kinetics of binding to p38 MAP kinase by analogues of BIRB 796
-
DOI 10.1016/S0960-894X(03)00656-5
-
J. Regan The kinetics of binding to p38 MAP kinase by analogues of BIRB 796 Bioorg. Med. Chem. Lett. 13 2003 3101 3104 (Pubitemid 36993646)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.18
, pp. 3101-3104
-
-
Regan, J.1
Pargellis, C.A.2
Cirillo, P.F.3
Gilmore, T.4
Hickey, E.R.5
Peet, G.W.6
Proto, A.7
Swinamer, A.8
Moss, N.9
-
44
-
-
0035226253
-
Isothermal titration calorimetry in drug discovery
-
W.H.J. Ward, and G.A. Holdgate Isothermal titration calorimetry in drug discovery Prog. Med. Chem. 38 2001 309 376
-
(2001)
Prog. Med. Chem.
, vol.38
, pp. 309-376
-
-
Ward, W.H.J.1
Holdgate, G.A.2
-
45
-
-
79953213695
-
Structural basis for selective small molecule kinase inhibition of activated c-Met
-
K.W. Rickert Structural basis for selective small molecule kinase inhibition of activated c-Met J. Biol. Chem. 286 2011 11218 11225
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 11218-11225
-
-
Rickert, K.W.1
-
46
-
-
68549123439
-
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds
-
A. Stroba 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds J. Med. Chem. 52 2009 4683 4693
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4683-4693
-
-
Stroba, A.1
-
48
-
-
19944426184
-
Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase a and Mutants
-
DOI 10.1021/jm049701n
-
C.B. Breitenlechner Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J. Med. Chem. 48 2005 163 170 (Pubitemid 40105257)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.1
, pp. 163-170
-
-
Breitenlechner, C.B.1
Friebe, W.-G.2
Brunet, E.3
Werner, G.4
Graul, K.5
Thomas, U.6
Kunkele, K.-P.7
Schafer, W.8
Gassel, M.9
Bossemeyer, D.10
Huber, R.11
Engh, R.A.12
Masjost, B.13
-
49
-
-
33847659183
-
C-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty
-
DOI 10.1016/j.str.2007.01.015, PII S0969212607000706
-
M.A. Seeliger c-src binds to the cancer drug Imatinib with an inactive abl/c-kit conformation and a distributed thermodynamic penalty Structure 15 2007 299 311 (Pubitemid 46366721)
-
(2007)
Structure
, vol.15
, Issue.3
, pp. 299-311
-
-
Seeliger, M.A.1
Nagar, B.2
Frank, F.3
Cao, X.4
Henderson, M.N.5
Kuriyan, J.6
-
50
-
-
77957229353
-
Thermodynamics guided lead drug discovery and optimization
-
G.G. Ferenczy, and G.M. Keseru Thermodynamics guided lead drug discovery and optimization Drug Discov. Today 15 2010 919 932
-
(2010)
Drug Discov. Today
, vol.15
, pp. 919-932
-
-
Ferenczy, G.G.1
Keseru, G.M.2
-
51
-
-
52049123291
-
Do enthalpy and entropy distinguish first in class from best in class?
-
E. Freire Do enthalpy and entropy distinguish first in class from best in class? Drug Discov. Today 13 2008 869 874
-
(2008)
Drug Discov. Today
, vol.13
, pp. 869-874
-
-
Freire, E.1
-
52
-
-
33645319676
-
Overcoming roadblocks in lead optimization: A thermodynamic perspective
-
DOI 10.1111/j.1747-0285.2005.00314.x
-
A.J. Ruben Overcoming roadblocks in lead optimization: a thermodynamic perspective Chem. Biol. Drug Des. 67 2006 2 4 (Pubitemid 43881382)
-
(2006)
Chemical Biology and Drug Design
, vol.67
, Issue.1
, pp. 2-4
-
-
Ruben, A.J.1
Kiso, Y.2
Freire, E.3
-
53
-
-
0035861396
-
The application of thermodynamic methods in drug design
-
DOI 10.1016/S0040-6031(01)00671-2, PII S0040603101006712
-
A. Velazquez-Campoy The application of thermodynamic methods in drug design Thermochim. Acta 380 2001 217 227 (Pubitemid 33096436)
-
(2001)
Thermochimica Acta
, vol.380
, Issue.2
, pp. 217-227
-
-
Velazquez-Campoy, A.1
Luque, I.2
Freire, E.3
-
55
-
-
0031872177
-
Electrostatic contributions to heat capacity changes of DNA-ligand binding
-
K. Gallagher, and K. Sharp Electrostatic contributions to heat capacity changes of DNA-ligand binding Biophys. J. 75 1998 769 776 (Pubitemid 28357518)
-
(1998)
Biophysical Journal
, vol.75
, Issue.2
, pp. 769-776
-
-
Gallagher, K.1
Sharp, K.2
-
56
-
-
0026684671
-
Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from water
-
R.S. Spolar Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from water Biochemistry 31 1992 3947 3955
-
(1992)
Biochemistry
, vol.31
, pp. 3947-3955
-
-
Spolar, R.S.1
-
57
-
-
0041854716
-
Understanding binding affinity: A combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin
-
DOI 10.1021/ja034676g
-
R. Talhout Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin J. Am. Chem. Soc. 125 2003 10570 10579 (Pubitemid 37055908)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.35
, pp. 10570-10579
-
-
Talhout, R.1
Villa, A.2
Mark, A.E.3
Engberts, J.B.F.N.4
-
58
-
-
48249120348
-
Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodopicolinate synthase by (S)-lysine
-
C.P. Phenix, and D.R.J. Palmer Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodopicolinate synthase by (S)-lysine Biochemistry 47 2008 7779 7781
-
(2008)
Biochemistry
, vol.47
, pp. 7779-7781
-
-
Phenix, C.P.1
Palmer, D.R.J.2
-
59
-
-
42349106956
-
Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors
-
DOI 10.1021/bi702397d
-
O. Anderka Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors Biochemistry 47 2008 4683 4691 (Pubitemid 351555489)
-
(2008)
Biochemistry
, vol.47
, Issue.16
, pp. 4683-4691
-
-
Anderka, O.1
Loenze, P.2
Klabunde, T.3
Dreyer, M.K.4
Defossa, E.5
Wendt, K.U.6
Schmoll, D.7
-
60
-
-
0029395478
-
Win some, lose some: Enthalpy-entropy compensation in weak intermolecular interactions
-
J.D. Dunitz Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions Chem. Biol. 2 1995 709 712
-
(1995)
Chem. Biol.
, vol.2
, pp. 709-712
-
-
Dunitz, J.D.1
-
61
-
-
9644258919
-
The cost of conformational order: Entropy changes in molecular associations
-
M.S. Searle, and D.H. Williams The cost of conformational order: entropy changes in molecular associations J. Am. Chem. Soc. 114 1992 10690 10697
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10690-10697
-
-
Searle, M.S.1
Williams, D.H.2
-
62
-
-
0036120608
-
Enthalpy-entropy compensation: A phantom phenomenon
-
A. Cornish-Bowden Enthalpy-entropy compensation: a phantom phenomenon J. Biosci. 27 2002 121 126 (Pubitemid 34218614)
-
(2002)
Journal of Biosciences
, vol.27
, Issue.2
, pp. 121-126
-
-
Cornish-Bowden, A.1
-
63
-
-
28044466911
-
Enthalpy-entropy compensation is not a general feature of weak association
-
DOI 10.1021/ja054519c
-
D.M. Ford Enthalpy-entropy compensation is not a general feature of weak association J. Am. Chem. Soc. 127 2005 16167 16170 (Pubitemid 41689244)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.46
, pp. 16167-16170
-
-
Ford, D.M.1
-
64
-
-
0020674436
-
Errors in the evaluation of Arrhenius and van't Hoff plots
-
T. Keleti Errors in the evaluation of Arrhenius and van't Hoff plots Biochem. J. 209 1983 277 280
-
(1983)
Biochem. J.
, vol.209
, pp. 277-280
-
-
Keleti, T.1
-
66
-
-
77950022453
-
Non additivity of functional group contributions in protein-ligand binding: A comprehensive study by crystallography and isothermal titration calorimetry
-
B. Baum Non additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry J. Mol. Biol. 397 2010 1042 1054
-
(2010)
J. Mol. Biol.
, vol.397
, pp. 1042-1054
-
-
Baum, B.1
-
67
-
-
33646559968
-
The paradoxical thermodynamic basis for the interaction of ethylene glycol, glycine, and sarcosine chains with bovine carbonic anhydrase II: An unexpected manifestation of enthalpy/entropy compensation
-
DOI 10.1021/ja060070r
-
V.M. Krishnamurthy The paradoxical thermodynamic basis for the interaction of ethylene glycol, glycine, and sarcosine chains with bovine carbonic anhydrase II: an unexpected manifestation of enthalpy/entropy compensation J. Am. Chem. Soc. 128 2006 5802 5812 (Pubitemid 43724384)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.17
, pp. 5802-5812
-
-
Krishnamurthy, V.M.1
Bohall, B.R.2
Semetey, V.3
Whitesides, G.M.4
-
69
-
-
79960886778
-
A multidisciplinary approach to probing enthalpy-entropy compensation and interfacial mobility model
-
E.M. Wilfong A multidisciplinary approach to probing enthalpy-entropy compensation and interfacial mobility model J. Am. Chem. Soc. 133 2011 11515 11523
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 11515-11523
-
-
Wilfong, E.M.1
-
70
-
-
77749337724
-
Conformational states of human purine nucleoside phosphorylase at rest, at work and with transition state analogues
-
A.A. Edwards Conformational states of human purine nucleoside phosphorylase at rest, at work and with transition state analogues Biochemistry 49 2010 2058 2067
-
(2010)
Biochemistry
, vol.49
, pp. 2058-2067
-
-
Edwards, A.A.1
-
71
-
-
77958035712
-
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3
-
C. Diehl Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3 J. Am. Chem. Soc. 132 2010 14577 14589
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 14577-14589
-
-
Diehl, C.1
-
72
-
-
47649098600
-
Cooperativity and biological complexity
-
DOI 10.1038/nchembio0808-435, PII NCHEMBIO0808435
-
A. Whitty Cooperativity and biological complexity Nat. Chem. Biol. 4 2008 435 439 (Pubitemid 352019765)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.8
, pp. 435-439
-
-
Whitty, A.1
-
73
-
-
10944261243
-
Understanding noncovalent interactions: Ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes
-
DOI 10.1002/anie.200300644
-
D.H. Williams Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes Angew. Chem. Int. Ed. 43 2004 6596 6616 (Pubitemid 40018986)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.48
, pp. 6596-6616
-
-
Williams, D.H.1
Stephens, E.2
O'Brien, D.P.3
Zhou, M.4
-
74
-
-
0345099650
-
Cooperativity, partially bound states, and enthalpy-entropy compensation
-
DOI 10.1016/j.chembiol.2003.10.009
-
C.A. Hunter, and S. Tomas Cooperativity, partially bound states, and enthalpy-entropy compensation Chem. Biol. 10 2003 1023 1032 (Pubitemid 37496432)
-
(2003)
Chemistry and Biology
, vol.10
, Issue.11
, pp. 1023-1032
-
-
Hunter, C.A.1
Tomas, S.2
-
75
-
-
77949359890
-
Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: Synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors
-
L. Muley Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors J. Med. Chem. 53 2010 2126 2135
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2126-2135
-
-
Muley, L.1
|