Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

Biochemistry

Volumn 49, Issue 9, 2010, Pages 2058-2067

  Edwards, Achelle A ^a   Tipton, Jeremiah D ^b   Brenowitz, Michael D ^a   Emmett, Mark R ^b,c   Marshall, Alan G ^b,c   Evans, Gary B ^d   Tyler, Peter C ^d   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

^d CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SITES; CONFORMATIONAL STATE; DEUTERIUM EXCHANGE; DYNAMIC MOTIONS; FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY; HIGH RESOLUTION; HOMOTRIMERS; IMMUCILLIN-H; INOSINE; KINETIC ANALYSIS; MICHAELIS COMPLEX; PEPTIDE AMIDES; PROTEIN CONFORMATION; PROTEIN DYNAMICS; PURINE NUCLEOSIDE PHOSPHORYLASE; SEDIMENTATION RATES; STRONG BINDING; TRANSITION STATE; TRANSITION-STATE ANALOGUES;

AMIDES; BINDING ENERGY; BIOMOLECULES; COMPLEXATION; CONFORMATIONS; DEUTERIUM; ION EXCHANGE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; PHOSPHORYLATION; SEDIMENTATION;

BINDING SITES;

DEUTERIUM; FORODESINE; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CYCLOTRON; FOURIER TRANSFORMATION; HUMAN; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEDIMENTATION RATE;

AMIDES; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; DEUTERIUM EXCHANGE MEASUREMENT; ENTROPY; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; THERMODYNAMICS; WATER;

EID: 77749337724     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902041j     Document Type: Article

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