Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Cho, In Su ^a   Jung, Miyoung ^a   Kwon, Ki Sun ^b   Moon, Eunpyo ^a   Cho, Jang Hyeon ^c   Yoon, Kun Ho ^d   Kim, Ji Won ^d   Lee, Young Don ^a   Kim, Sung Soo ^a   Suh Kim, Haeyoung ^a  

^a Ajou University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; GLUCOSE; INDUCIBLE CYCLIC AMP EARLY REPRESSOR PROTEIN; INSULIN; MESSENGER RNA; NEUROGENIC DIFFERENTIATION FACTOR; PHOSPHOPROTEIN PHOSPHATASE 2A; SMALL INTERFERING RNA; SULFONYLUREA RECEPTOR 1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NEUROD1 PROTEIN, RAT; PHOSPHOPROTEIN PHOSPHATASE 2;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE TARGETING; HYPERGLYCEMIA; INSULIN GENE; NEGATIVE FEEDBACK; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET DISEASE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SULFONYLUREA RECEPTOR 1 GENE; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; HUMAN; METABOLISM; PANCREAS ISLET BETA CELL; SECRETION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; CRICETINAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; PROTEIN PHOSPHATASE 2; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84859233772     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034860     Document Type: Article

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