Effects of supraphysiologic concentration glucose on pancreatic duodenal homeobox-1 expression and insulin secretion in rats

Chinese Medical Journal

Volumn 120, Issue 11, 2007, Pages 1020-1023

  Xiao, Chang Qing ^a   Deng, Hong Ming ^a   Huang, Yun ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Glucose; Insulin secretion; Islet cells; Pancreatic duodenal homeobox 1

Indexed keywords

GLUCOSE; INSULIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; EXPERIMENTAL STUDY; HORMONE DETERMINATION; IMMUNOHISTOCHEMISTRY; INCUBATION TEMPERATURE; INCUBATION TIME; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET CELL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; TISSUE SECTION;

EID: 34250209165     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200706010-00016     Document Type: Article

References (11)

1. Hui H, Perfetti R. Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. Eur J Endocrinol 2002; 146: 129-141.
2. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997; 15: 106-110.
3. Ahlgren U, Jonsson J, Jonsson L, Simu Y, Edlund H. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 1763-1768.
4. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston PW, et al. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 2002; 277: 11225-11232.
5. Thomas MK, Devon ON, Lee JH, Peter A, Schlosser DA, Tenser MS, et al. Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 2001; 108: 319-329.
6. Stoffers DA, Stanojevic V, Habener JF. Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 1998; 102: 232-241.
7. Shen SX, Dong YH, Feng LN, Bi YJ. Research of islet cell culture technology of SD rats. Chin J Organ Transplant (Chin) 1995; 16: 158-160.
8. Boden G, Ruiz J, Kim CJ, Chen X. Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects. Am J Physiol 1996; 270: E251-E258.
9. Hosokawa YA, Leahy JL. Parallel reduction of pancreas insulin content and insulin secretion in 48-h tolbutamide-infused normoglycemic rats. Diabetes 1997; 46: 808-813.
10. Robertson RP, Olson LK, Zhang HJ. Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes 1994; 43: 1085-1089.
11. Moran A, Zhang HJ, Olson LK, Harmon JS, Poitout V, Robertson RP. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15. J Clin Invest 1997; 99: 534-539.