-
1
-
-
40949155240
-
Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
-
Arakawa R., Ito H., Takano A., Takahashi H., Morimoto T., Sassa T., Ohta K., Kato M., Okubo Y., Suhara T. Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia. Psychopharmacology 2008, 197:229-235.
-
(2008)
Psychopharmacology
, vol.197
, pp. 229-235
-
-
Arakawa, R.1
Ito, H.2
Takano, A.3
Takahashi, H.4
Morimoto, T.5
Sassa, T.6
Ohta, K.7
Kato, M.8
Okubo, Y.9
Suhara, T.10
-
2
-
-
0031717385
-
Distribution after repeated oral administration of different dose levels of risperidone and 9-hydroxy-risperidone in the brain and other tissues of rat
-
Aravagiri M., Yuwiler A., Marder S.R. Distribution after repeated oral administration of different dose levels of risperidone and 9-hydroxy-risperidone in the brain and other tissues of rat. Psychopharmacology 1998, 139:356-363.
-
(1998)
Psychopharmacology
, vol.139
, pp. 356-363
-
-
Aravagiri, M.1
Yuwiler, A.2
Marder, S.R.3
-
3
-
-
9744251578
-
The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry
-
Baumann P., Hiemke C., Ulrich S., Eckermann G., Gaertner I., Gerlach M., Kuss H.J., Laux G., Muller-Oerlinghausen B., Rao M.L., Riederer P., Zernig G. The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry. Pharmacopsychiatry 2004, 37:243-265.
-
(2004)
Pharmacopsychiatry
, vol.37
, pp. 243-265
-
-
Baumann, P.1
Hiemke, C.2
Ulrich, S.3
Eckermann, G.4
Gaertner, I.5
Gerlach, M.6
Kuss, H.J.7
Laux, G.8
Muller-Oerlinghausen, B.9
Rao, M.L.10
Riederer, P.11
Zernig, G.12
-
4
-
-
15244339914
-
In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption
-
Bergstrom C.A. In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption. Basic Clin. Pharmacol. Toxicol. 2005, 96:156-161.
-
(2005)
Basic Clin. Pharmacol. Toxicol.
, vol.96
, pp. 156-161
-
-
Bergstrom, C.A.1
-
5
-
-
34547932450
-
Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains
-
Bodor N., Tóth-Sarudy E., Holm T., Pallagi I., Vass E., Buchwald P., Langel U. Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains. J. Pharm. Pharmacol. 2007, 59:1065-1076.
-
(2007)
J. Pharm. Pharmacol.
, vol.59
, pp. 1065-1076
-
-
Bodor, N.1
Tóth-Sarudy, E.2
Holm, T.3
Pallagi, I.4
Vass, E.5
Buchwald, P.6
Langel, U.7
-
6
-
-
0037205138
-
In vitro P-glycoprotein affinity for atypical and conventional antipsychotics
-
Boulton D.W., DeVane C.L., Liston H.L., Markowitz J.S. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002, 71:163-169.
-
(2002)
Life Sci.
, vol.71
, pp. 163-169
-
-
Boulton, D.W.1
DeVane, C.L.2
Liston, H.L.3
Markowitz, J.S.4
-
8
-
-
27744476275
-
Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist
-
Burstein E.S., Ma J., Wong S., Gao Y., Pham E., Knapp A.E., Nash N.R., Olsson R., Davis R.E., Hacksell U., Weiner D.M., Brann M.R. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J. Pharmacol. Exp. Ther. 2005, 315:1278-1287.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 1278-1287
-
-
Burstein, E.S.1
Ma, J.2
Wong, S.3
Gao, Y.4
Pham, E.5
Knapp, A.E.6
Nash, N.R.7
Olsson, R.8
Davis, R.E.9
Hacksell, U.10
Weiner, D.M.11
Brann, M.R.12
-
9
-
-
0025826820
-
Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity
-
Carrupt P.A., Testa B., Bechalany A., el Tayar N., Descas P., Perrissoud D. Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity. J. Med. Chem. 1991, 34:1272-1275.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1272-1275
-
-
Carrupt, P.A.1
Testa, B.2
Bechalany, A.3
el Tayar, N.4
Descas, P.5
Perrissoud, D.6
-
10
-
-
0037198965
-
Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain
-
Chinta S.J., Pai H.V., Upadhya S.C., Boyd M.R., Ravindranath V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res. Mol. Brain Res. 2002, 103:49-61.
-
(2002)
Brain Res. Mol. Brain Res.
, vol.103
, pp. 49-61
-
-
Chinta, S.J.1
Pai, H.V.2
Upadhya, S.C.3
Boyd, M.R.4
Ravindranath, V.5
-
11
-
-
0027461574
-
Treatment with clozapine and its effect on plasma homovanillic acid and norepinephrine concentrations in schizophrenia
-
Davidson M., Kahn R.S., Stern R.G., Hirschowitz J., Apter S., Knott P., Davis K.L. Treatment with clozapine and its effect on plasma homovanillic acid and norepinephrine concentrations in schizophrenia. Psychiatry Res. 1993, 46:151-163.
-
(1993)
Psychiatry Res.
, vol.46
, pp. 151-163
-
-
Davidson, M.1
Kahn, R.S.2
Stern, R.G.3
Hirschowitz, J.4
Apter, S.5
Knott, P.6
Davis, K.L.7
-
12
-
-
34249275309
-
Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study
-
Davidson M., Emsley R., Kramer M., Ford L., Pan G., Lim P., Eerdekens M. Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study. Schizophr. Res. 2007, 93:117-130.
-
(2007)
Schizophr. Res.
, vol.93
, pp. 117-130
-
-
Davidson, M.1
Emsley, R.2
Kramer, M.3
Ford, L.4
Pan, G.5
Lim, P.6
Eerdekens, M.7
-
13
-
-
42249096010
-
Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports
-
de Leon J., Nikoloff M. Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. CNS Spectr. 2008, 13:133-135.
-
(2008)
CNS Spectr.
, vol.13
, pp. 133-135
-
-
de Leon, J.1
Nikoloff, M.2
-
14
-
-
13844320650
-
The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation
-
de Leon J., Susce M.T., Pan R.M., Fairchild M., Koch W.H., Wedlund P.J. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J. Clin. Psychiatry 2005, 66:15-27.
-
(2005)
J. Clin. Psychiatry
, vol.66
, pp. 15-27
-
-
de Leon, J.1
Susce, M.T.2
Pan, R.M.3
Fairchild, M.4
Koch, W.H.5
Wedlund, P.J.6
-
15
-
-
75849125839
-
The pharmacokinetics of paliperidone versus risperidone
-
de Leon J., Wynn G., Sandson N.B. The pharmacokinetics of paliperidone versus risperidone. Psychosomatics 2010, 51:80-88.
-
(2010)
Psychosomatics
, vol.51
, pp. 80-88
-
-
de Leon, J.1
Wynn, G.2
Sandson, N.B.3
-
16
-
-
1842535990
-
Classification analysis of P-glycoprotein substrate specificity
-
Didziapetris R., Japertas P., Avdeef A., Petrauskas A. Classification analysis of P-glycoprotein substrate specificity. J. Drug Target. 2003, 11:391-406.
-
(2003)
J. Drug Target.
, vol.11
, pp. 391-406
-
-
Didziapetris, R.1
Japertas, P.2
Avdeef, A.3
Petrauskas, A.4
-
17
-
-
0345275779
-
A passion for P450s (rememberances of the early history of research on cytochrome P450)
-
Estabrook R.W. A passion for P450s (rememberances of the early history of research on cytochrome P450). Drug Metab. Dispos. 2003, 31:1461-1473.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1461-1473
-
-
Estabrook, R.W.1
-
18
-
-
38749087222
-
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system
-
Feng B., Mills J.B., Davidson R.E., Mireles R.J., Janiszewski J.S., Troutman M.D., de Morais S.M. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab. Dispos. 2008, 36:268-275.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 268-275
-
-
Feng, B.1
Mills, J.B.2
Davidson, R.E.3
Mireles, R.J.4
Janiszewski, J.S.5
Troutman, M.D.6
de Morais, S.M.7
-
19
-
-
0031695039
-
Blood-brain barrier permeation: molecular parameters governing passive diffusion
-
Fischer H., Gottschlich R., Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membr. Biol. 1998, 165:201-211.
-
(1998)
J. Membr. Biol.
, vol.165
, pp. 201-211
-
-
Fischer, H.1
Gottschlich, R.2
Seelig, A.3
-
20
-
-
0026724017
-
Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine
-
Frances B., Gout R., Monsarrat B., Cros J., Zajac J.M. Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine. J. Pharmacol. Exp. Ther. 1992, 262:25-31.
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.262
, pp. 25-31
-
-
Frances, B.1
Gout, R.2
Monsarrat, B.3
Cros, J.4
Zajac, J.M.5
-
21
-
-
33846598505
-
Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype
-
Garcia-Quetglas E., Azanza J.R., Sadaba B., Munoz M.J., Gil I., Campanero M.A. Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol. Res. 2007, 55:122-130.
-
(2007)
Pharmacol. Res.
, vol.55
, pp. 122-130
-
-
Garcia-Quetglas, E.1
Azanza, J.R.2
Sadaba, B.3
Munoz, M.J.4
Gil, I.5
Campanero, M.A.6
-
22
-
-
0033901486
-
Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor
-
Gillen C., Haurand M., Kobelt D.J., Wnendt S. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn Schmiedebergs Arch. Pharmacol. 2000, 362:116-121.
-
(2000)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.362
, pp. 116-121
-
-
Gillen, C.1
Haurand, M.2
Kobelt, D.J.3
Wnendt, S.4
-
23
-
-
0035950120
-
Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume
-
Goodwin J.T., Conradi R.A., Ho N.F., Burton P.S. Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume. J. Med. Chem. 2001, 44:3721-3729.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3721-3729
-
-
Goodwin, J.T.1
Conradi, R.A.2
Ho, N.F.3
Burton, P.S.4
-
24
-
-
83455262686
-
In silico modeling for blood-brain barrier permeability protection
-
Springer, New York, C. Ehrhardt, K.J. Kim (Eds.)
-
Gorg P., Verma J., Roy N. In silico modeling for blood-brain barrier permeability protection. Drug Absorption Studies 2008, 510-556. Springer, New York. C. Ehrhardt, K.J. Kim (Eds.).
-
(2008)
Drug Absorption Studies
, pp. 510-556
-
-
Gorg, P.1
Verma, J.2
Roy, N.3
-
25
-
-
45949107902
-
On the rate and extent of drug delivery to the brain
-
Hammarlund-Udenaes M., Friden M., Syvanen S., Gupta A. On the rate and extent of drug delivery to the brain. Pharm. Res. 2008, 25:1737-1750.
-
(2008)
Pharm. Res.
, vol.25
, pp. 1737-1750
-
-
Hammarlund-Udenaes, M.1
Friden, M.2
Syvanen, S.3
Gupta, A.4
-
26
-
-
33746917486
-
The complexity of active metabolites in therapeutic drug monitoring of psychotropic drugs
-
Hendset M., Haslemo T., Rudberg I., Refsum H., Molden E. The complexity of active metabolites in therapeutic drug monitoring of psychotropic drugs. Pharmacopsychiatry 2006, 39:121-127.
-
(2006)
Pharmacopsychiatry
, vol.39
, pp. 121-127
-
-
Hendset, M.1
Haslemo, T.2
Rudberg, I.3
Refsum, H.4
Molden, E.5
-
27
-
-
39149104018
-
Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry
-
Hiemke C. Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry. Eur. J. Clin. Pharmacol. 2008, 64:159-166.
-
(2008)
Eur. J. Clin. Pharmacol.
, vol.64
, pp. 159-166
-
-
Hiemke, C.1
-
28
-
-
0036721406
-
The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats
-
Kapur S., Langlois X., Vinken P., Megens A.A., De Coster R., Andrews J.S. The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats. J. Pharmacol. Exp. Ther. 2002, 302:1129-1134.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 1129-1134
-
-
Kapur, S.1
Langlois, X.2
Vinken, P.3
Megens, A.A.4
De Coster, R.5
Andrews, J.S.6
-
29
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
-
Kelder J., Grootenhuis P.D., Bayada D.M., Delbressine L.P., Ploemen J.P. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs. Pharm. Res. 1999, 16:1514-1519.
-
(1999)
Pharm. Res.
, vol.16
, pp. 1514-1519
-
-
Kelder, J.1
Grootenhuis, P.D.2
Bayada, D.M.3
Delbressine, L.P.4
Ploemen, J.P.5
-
30
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46:3-26.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
31
-
-
33644911463
-
Detoxification and biotransformational imbalances
-
Liska D., Lyon M., Jones D.S. Detoxification and biotransformational imbalances. Explore (NY) 2006, 2:122-140.
-
(2006)
Explore (NY)
, vol.2
, pp. 122-140
-
-
Liska, D.1
Lyon, M.2
Jones, D.S.3
-
32
-
-
71549167580
-
Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents
-
Migliardi G., Spina E., D'Arrigo C., Gagliano A., Germano E., Siracusano R., Diaz F.J., de Leon J. Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33:1496-1501.
-
(2009)
Prog. Neuropsychopharmacol. Biol. Psychiatry
, vol.33
, pp. 1496-1501
-
-
Migliardi, G.1
Spina, E.2
D'Arrigo, C.3
Gagliano, A.4
Germano, E.5
Siracusano, R.6
Diaz, F.J.7
de Leon, J.8
-
33
-
-
3042519581
-
The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics
-
Miksys S., Tyndale R.F. The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. Drug Metab. Rev. 2004, 36:313-333.
-
(2004)
Drug Metab. Rev.
, vol.36
, pp. 313-333
-
-
Miksys, S.1
Tyndale, R.F.2
-
34
-
-
37549047119
-
The development of drug metabolism research as expressed in the publications of ASPET: Part 1, 1909-1958
-
Murphy P.J. The development of drug metabolism research as expressed in the publications of ASPET: Part 1, 1909-1958. Drug Metab. Dispos. 2008, 36:1-5.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 1-5
-
-
Murphy, P.J.1
-
35
-
-
44149113782
-
The development of drug metabolism research as expressed in the publications of ASPET: part 2, 1959-1983
-
Murphy P.J. The development of drug metabolism research as expressed in the publications of ASPET: part 2, 1959-1983. Drug Metab. Dispos. 2008, 36:981-985.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 981-985
-
-
Murphy, P.J.1
-
36
-
-
52949092351
-
The development of drug metabolism research as expressed in the publications of ASPET: part 3, 1984-2008
-
Murphy P.J. The development of drug metabolism research as expressed in the publications of ASPET: part 3, 1984-2008. Drug Metab. Dispos. 2008, 36:1977-1982.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 1977-1982
-
-
Murphy, P.J.1
-
37
-
-
41249090837
-
Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics
-
Olsen C.K., Brennum L.T., Kreilgaard M. Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics. Eur. J. Pharmacol. 2008, 584:318-327.
-
(2008)
Eur. J. Pharmacol.
, vol.584
, pp. 318-327
-
-
Olsen, C.K.1
Brennum, L.T.2
Kreilgaard, M.3
-
38
-
-
25844495011
-
Medicinal chemical properties of successful central nervous system drugs
-
Pajouhesh H., Lenz G.R. Medicinal chemical properties of successful central nervous system drugs. NeuroRx 2005, 2:541-553.
-
(2005)
NeuroRx
, vol.2
, pp. 541-553
-
-
Pajouhesh, H.1
Lenz, G.R.2
-
39
-
-
34547633657
-
Brain drug development and brain drug targeting
-
Pardridge W.M. Brain drug development and brain drug targeting. Pharm. Res. 2007, 24:1729-1732.
-
(2007)
Pharm. Res.
, vol.24
, pp. 1729-1732
-
-
Pardridge, W.M.1
-
40
-
-
0024369341
-
Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite
-
Paul D., Standifer K.M., Inturrisi C.E., Pasternak G.W. Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite. J. Pharmacol. Exp. Ther. 1989, 251:477-483.
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.251
, pp. 477-483
-
-
Paul, D.1
Standifer, K.M.2
Inturrisi, C.E.3
Pasternak, G.W.4
-
41
-
-
0024315016
-
Xenobiotic metabolism in human brain-presence of cytochrome P-450 and associated mono-oxygenases
-
Ravindranath V., Anandatheerthavarada H.K., Shankar S.K. Xenobiotic metabolism in human brain-presence of cytochrome P-450 and associated mono-oxygenases. Brain Res. 1989, 496:331-335.
-
(1989)
Brain Res.
, vol.496
, pp. 331-335
-
-
Ravindranath, V.1
Anandatheerthavarada, H.K.2
Shankar, S.K.3
-
42
-
-
0031788790
-
Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance
-
Schaber G., Stevens I., Gaertner H.J., Dietz K., Breyer-Pfaff U. Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance. Br. J. Clin. Pharmacol. 1998, 46:453-459.
-
(1998)
Br. J. Clin. Pharmacol.
, vol.46
, pp. 453-459
-
-
Schaber, G.1
Stevens, I.2
Gaertner, H.J.3
Dietz, K.4
Breyer-Pfaff, U.5
-
43
-
-
0029930927
-
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
-
Schotte A., Janssen P.F., Gommeren W., Luyten W.H., Van Gompel P., Lesage A.S., De Loore K., Leysen J.E. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 1996, 124:57-73.
-
(1996)
Psychopharmacology
, vol.124
, pp. 57-73
-
-
Schotte, A.1
Janssen, P.F.2
Gommeren, W.3
Luyten, W.H.4
Van Gompel, P.5
Lesage, A.S.6
De Loore, K.7
Leysen, J.E.8
-
44
-
-
26444441486
-
An update of fast-off dopamine D2 atypical antipsychotics
-
Seeman P. An update of fast-off dopamine D2 atypical antipsychotics. Am J Psychiatry 2005, 162:1984-1985.
-
(2005)
Am J Psychiatry
, vol.162
, pp. 1984-1985
-
-
Seeman, P.1
-
45
-
-
0031902373
-
Intestinal absorption and stability of morphine 6-glucuronide in different physiological compartments of the rat
-
Stain-Texier F., Sandouk P., Scherrmann J.M. Intestinal absorption and stability of morphine 6-glucuronide in different physiological compartments of the rat. Drug Metab. Dispos. 1998, 26:383-387.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 383-387
-
-
Stain-Texier, F.1
Sandouk, P.2
Scherrmann, J.M.3
-
47
-
-
15244348590
-
Which in vitro screens guide the prediction of oral absorption and volume of distribution? Basic Clin
-
van De Waterbeemd H. Which in vitro screens guide the prediction of oral absorption and volume of distribution? Basic Clin. Pharmacol. Toxicol. 2005, 96:162-166.
-
(2005)
Pharmacol. Toxicol.
, vol.96
, pp. 162-166
-
-
van De Waterbeemd, H.1
-
48
-
-
0037955409
-
Relations of molecular properties with drug disposition: the case of gastrointestinal absorption and brain penetration
-
Verlag Helvetica Chemica Acta, Zurich, B. Testa, H. van De Waterbeemd, G. Folkers, R. Guy (Eds.)
-
van De Waterbeemd H., Smith D.A. Relations of molecular properties with drug disposition: the case of gastrointestinal absorption and brain penetration. Pharmacokinetic Optimization in Drug Research 2001, 51-64. Verlag Helvetica Chemica Acta, Zurich. B. Testa, H. van De Waterbeemd, G. Folkers, R. Guy (Eds.).
-
(2001)
Pharmacokinetic Optimization in Drug Research
, pp. 51-64
-
-
van De Waterbeemd, H.1
Smith, D.A.2
-
49
-
-
0032410164
-
Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors
-
van De Waterbeemd H., Camenisch G., Folkers G., Chretien J.R., Raevsky O.A. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J. Drug Target. 1998, 6:151-165.
-
(1998)
J. Drug Target.
, vol.6
, pp. 151-165
-
-
van De Waterbeemd, H.1
Camenisch, G.2
Folkers, G.3
Chretien, J.R.4
Raevsky, O.A.5
-
50
-
-
0035953319
-
Property-based design: optimization of drug absorption and pharmacokinetics
-
van De Waterbeemd H., Smith D.A., Beaumont K., Walker D.K. Property-based design: optimization of drug absorption and pharmacokinetics. J. Med. Chem. 2001, 44:1313-1333.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1313-1333
-
-
van De Waterbeemd, H.1
Smith, D.A.2
Beaumont, K.3
Walker, D.K.4
-
51
-
-
0035106611
-
Lipophilicity in PK design: methyl, ethyl, futile
-
van De Waterbeemd H., Smith D.A., Jones B.C. Lipophilicity in PK design: methyl, ethyl, futile. J. Comput. Aided Mol. Des. 2001, 15:273-286.
-
(2001)
J. Comput. Aided Mol. Des.
, vol.15
, pp. 273-286
-
-
van De Waterbeemd, H.1
Smith, D.A.2
Jones, B.C.3
-
52
-
-
68549122719
-
Physicochemical determinants of human renal clearance
-
Varma M.V., Feng B., Obach R.S., Troutman M.D., Chupka J., Miller H.R., El-Kattan A. Physicochemical determinants of human renal clearance. J. Med. Chem. 2009, 52:4844-4852.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4844-4852
-
-
Varma, M.V.1
Feng, B.2
Obach, R.S.3
Troutman, M.D.4
Chupka, J.5
Miller, H.R.6
El-Kattan, A.7
-
53
-
-
79960394539
-
CYP 2D6 polymorphism and interindividual variability of drug response. a risperidone study case
-
Voicu V.A., Radulescu F.S., Miron D.S., Mircioiu C. CYP 2D6 polymorphism and interindividual variability of drug response. a risperidone study case. Rev. Med. Farm. Targu-Mures 2007, 53:265-270.
-
(2007)
Rev. Med. Farm. Targu-Mures
, vol.53
, pp. 265-270
-
-
Voicu, V.A.1
Radulescu, F.S.2
Miron, D.S.3
Mircioiu, C.4
-
54
-
-
79960416887
-
A novel approach on pharmacokinetic/pharmacodynamic correlations of risperidone: understanding its safety and efficacy profiles
-
Voicu V.A., Medvedovici A.V., Miron D.S., Radulescu F.S. A novel approach on pharmacokinetic/pharmacodynamic correlations of risperidone: understanding its safety and efficacy profiles. Acta Endocrinol. (Buc) 2010, 6:265-285.
-
(2010)
Acta Endocrinol. (Buc)
, vol.6
, pp. 265-285
-
-
Voicu, V.A.1
Medvedovici, A.V.2
Miron, D.S.3
Radulescu, F.S.4
-
55
-
-
74549193402
-
The toxicokinetics and toxicodynamics of organophosphonates versus the pharmacokinetics and pharmacodynamics of oxime antidotes: biological consequences
-
Voicu V.A., Thiermann H., Radulescu F.S., Mircioiu C., Miron D.S. The toxicokinetics and toxicodynamics of organophosphonates versus the pharmacokinetics and pharmacodynamics of oxime antidotes: biological consequences. Basic Clin. Pharmacol. Toxicol. 2010, 106:73-85.
-
(2010)
Basic Clin. Pharmacol. Toxicol.
, vol.106
, pp. 73-85
-
-
Voicu, V.A.1
Thiermann, H.2
Radulescu, F.S.3
Mircioiu, C.4
Miron, D.S.5
-
56
-
-
10644268555
-
The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein
-
Wang J.S., Ruan Y., Taylor R.M., Donovan J.L., Markowitz J.S., DeVane C.L. The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein. Int. J. Neuropsychopharmacol. 2004, 7:415-419.
-
(2004)
Int. J. Neuropsychopharmacol.
, vol.7
, pp. 415-419
-
-
Wang, J.S.1
Ruan, Y.2
Taylor, R.M.3
Donovan, J.L.4
Markowitz, J.S.5
DeVane, C.L.6
-
57
-
-
0344141457
-
Distribution of clozapine and desmethylclozapine between blood and brain in rats
-
Weigmann H., Hartter S., Fischer V., Dahmen N., Hiemke C. Distribution of clozapine and desmethylclozapine between blood and brain in rats. Eur. Neuropsychopharmacol. 1999, 9:253-256.
-
(1999)
Eur. Neuropsychopharmacol.
, vol.9
, pp. 253-256
-
-
Weigmann, H.1
Hartter, S.2
Fischer, V.3
Dahmen, N.4
Hiemke, C.5
-
58
-
-
19944426901
-
The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine
-
Weiner D.M., Meltzer H.Y., Veinbergs I., Donohue E.M., Spalding T.A., Smith T.T., Mohell N., Harvey S.C., Lameh J., Nash N., Vanover K.E., Olsson R., Jayathilake K., Lee M., Levey A.I., Hacksell U., Burstein E.S., Davis R.E., Brann M.R. The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine. Psychopharmacology 2004, 177:207-216.
-
(2004)
Psychopharmacology
, vol.177
, pp. 207-216
-
-
Weiner, D.M.1
Meltzer, H.Y.2
Veinbergs, I.3
Donohue, E.M.4
Spalding, T.A.5
Smith, T.T.6
Mohell, N.7
Harvey, S.C.8
Lameh, J.9
Nash, N.10
Vanover, K.E.11
Olsson, R.12
Jayathilake, K.13
Lee, M.14
Levey, A.I.15
Hacksell, U.16
Burstein, E.S.17
Davis, R.E.18
Brann, M.R.19
-
60
-
-
0004844581
-
Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine
-
Wu D., Kang Y.S., Bickel U., Pardridge W.M. Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine. Drug Metab. Dispos. 1997, 25:768-771.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 768-771
-
-
Wu, D.1
Kang, Y.S.2
Bickel, U.3
Pardridge, W.M.4
-
61
-
-
0034829228
-
Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes
-
Yasui-Furukori N., Hidestrand M., Spina E., Facciola G., Scordo M.G., Tybring G. Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab. Dispos. 2001, 29:1263-1268.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1263-1268
-
-
Yasui-Furukori, N.1
Hidestrand, M.2
Spina, E.3
Facciola, G.4
Scordo, M.G.5
Tybring, G.6
-
62
-
-
46749152924
-
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds
-
Zhang L., Zhu H., Oprea T.I., Golbraikh A., Tropsha A. QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm. Res. 2008, 25:1902-1914.
-
(2008)
Pharm. Res.
, vol.25
, pp. 1902-1914
-
-
Zhang, L.1
Zhu, H.2
Oprea, T.I.3
Golbraikh, A.4
Tropsha, A.5
|