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Volumn 39, Issue 4, 2006, Pages 121-127

The complexity of active metabolites in therapeutic drug monitoring of psychotropic drugs

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; CLOMIPRAMINE; CLOZAPINE; CYTOCHROME P450 2D6; DESVENLAFAXINE; DOXEPIN; DRUG METABOLITE; FLUOXETINE; FLUVOXAMINE; GLYCOPROTEIN P; IMIPRAMINE; NORCLOZAPINE; NORDOXEPIN; NORFLUOXETINE; PALIPERIDONE; PAROXETINE; PSYCHOTROPIC AGENT; QUINIDINE; RISPERIDONE; TERBINAFINE; THIORIDAZINE; VENLAFAXINE; VERAPAMIL;

EID: 33746917486     PISSN: 01763679     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-946701     Document Type: Review
Times cited : (56)

References (59)
  • 1
    • 0033710657 scopus 로고    scopus 로고
    • CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: Intraindividual variability and plasma concentration correlations
    • Alfaro CL, Lam YW, Simpson J, Ereshefsky L. CYP2D6 inhibition by fluoxetine, paroxetine, sertraline, and venlafaxine in a crossover study: intraindividual variability and plasma concentration correlations. J Clin Pharmacol 2000; 40: 58-66
    • (2000) J Clin Pharmacol , vol.40 , pp. 58-66
    • Alfaro, C.L.1    Lam, Y.W.2    Simpson, J.3    Ereshefsky, L.4
  • 2
    • 0036166661 scopus 로고    scopus 로고
    • Brain, plasma and tissue pharmacokinetics of risperidone and 9-hydroxyrisperidone after separate oral administration to rats
    • Aravagiri M, Marder SR. Brain, plasma and tissue pharmacokinetics of risperidone and 9-hydroxyrisperidone after separate oral administration to rats. Psychopharmacology (Berl) 2002; 159: 424-431
    • (2002) Psychopharmacology (Berl) , vol.159 , pp. 424-431
    • Aravagiri, M.1    Marder, S.R.2
  • 4
    • 0022692071 scopus 로고
    • Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin
    • Baumann P, Jonzier-Perey M, Koeb L, Kupfer A, Tinguely D, Schopf J. Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. Int Clin Psychopharmacol 1986; 1: 102-112
    • (1986) Int Clin Psychopharmacol , vol.1 , pp. 102-112
    • Baumann, P.1    Jonzier-Perey, M.2    Koeb, L.3    Kupfer, A.4    Tinguely, D.5    Schopf, J.6
  • 5
    • 0026505577 scopus 로고
    • Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline
    • Baumann P, Meyer JW, Amey M, Baettig D, Bryois C, Jonzier-Perey M et al. Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline. Ther Drug Monit 1992; 14: 1-8
    • (1992) Ther Drug Monit , vol.14 , pp. 1-8
    • Baumann, P.1    Meyer, J.W.2    Amey, M.3    Baettig, D.4    Bryois, C.5    Jonzier-Perey, M.6
  • 7
    • 0018819829 scopus 로고
    • Some pharmacological aspects of desmethylclomipramine
    • Benfield DP, Harries CM, Luscombe DK. Some pharmacological aspects of desmethylclomipramine. Postgrad Med J 1980; 56 (Suppl 1): 13-18
    • (1980) Postgrad Med J , vol.56 , Issue.SUPPL. 1 , pp. 13-18
    • Benfield, D.P.1    Harries, C.M.2    Luscombe, D.K.3
  • 8
    • 0022510805 scopus 로고
    • Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism
    • Brosen K, Klysner R, Gram LF, Otton SV, Been P, Bertilsson L. Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. Eur J Clin Pharmacol 1986; 30: 679-684
    • (1986) Eur J Clin Pharmacol , vol.30 , pp. 679-684
    • Brosen, K.1    Klysner, R.2    Gram, L.F.3    Otton, S.V.4    Been, P.5    Bertilsson, L.6
  • 10
    • 13844320650 scopus 로고    scopus 로고
    • The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation
    • de LJ, Susce MT, Pan RM, Fairchild M, Koch WH, Wedlund PJ. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry 2005; 66: 15-27
    • (2005) J Clin Psychiatry , vol.66 , pp. 15-27
    • De, L.J.1    Susce, M.T.2    Pan, R.M.3    Fairchild, M.4    Koch, W.H.5    Wedlund, P.J.6
  • 11
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005; 33(1): 165-174
    • (2005) Drug Metab Dispos , vol.33 , Issue.1 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3    Hosea, N.A.4    Becker, S.5    Callegari, E.6
  • 12
    • 0035018421 scopus 로고    scopus 로고
    • Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers
    • Eap CB, Bondolfi G, Zullino D, Savary-Cosendai L, Powell-Golay K, Kosel M, Baumann P. Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers. J Clin Psychopharmacol 2001; 21: 330-334
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 330-334
    • Eap, C.B.1    Bondolfi, G.2    Zullino, D.3    Savary-Cosendai, L.4    Powell-Golay, K.5    Kosel, M.6    Baumann, P.7
  • 13
    • 0026439306 scopus 로고
    • Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo
    • Fuller RW, Snoddy HD, Krushinski JH, Robertson DW. Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo. Neuropharmacology 1992; 31: 997-1000
    • (1992) Neuropharmacology , vol.31 , pp. 997-1000
    • Fuller, R.W.1    Snoddy, H.D.2    Krushinski, J.H.3    Robertson, D.W.4
  • 14
    • 2442513407 scopus 로고    scopus 로고
    • P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline
    • Grauer MT, Uhr M. P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline. J Psychopharmacol 2004; 18: 66-74
    • (2004) J Psychopharmacol , vol.18 , pp. 66-74
    • Grauer, M.T.1    Uhr, M.2
  • 15
    • 0036001244 scopus 로고    scopus 로고
    • Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion
    • Guzey C, Norstrom A, Spigset O. Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion. Ther Drug Monit 2002; 24: 436-437
    • (2002) Ther Drug Monit , vol.24 , pp. 436-437
    • Guzey, C.1    Norstrom, A.2    Spigset, O.3
  • 16
    • 0027436269 scopus 로고
    • Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects
    • Huang ML, Van PA, Woestenborghs R, De CR, Heykants J, Jansen AA et al. Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects. Clin Pharmacol Ther 1993; 54: 257-268
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 257-268
    • Huang, M.L.1    Van, P.A.2    Woestenborghs, R.3    De, C.R.4    Heykants, J.5    Jansen, A.A.6
  • 17
    • 0029738965 scopus 로고    scopus 로고
    • Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
    • Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 1996; 51: 73-78
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 73-78
    • Jeppesen, U.1    Gram, L.F.2    Vistisen, K.3    Loft, S.4    Poulsen, H.E.5    Brosen, K.6
  • 18
    • 0036797601 scopus 로고    scopus 로고
    • Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E-and Z-doxepin in healthy volunteers
    • Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J. Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E-and Z-doxepin in healthy volunteers. Pharmacogenetics 2002; 12: 571-580
    • (2002) Pharmacogenetics , vol.12 , pp. 571-580
    • Kirchheiner, J.1    Meineke, I.2    Muller, G.3    Roots, I.4    Brockmoller, J.5
  • 19
    • 0036086164 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 deficiency and its clinical relevance in a patient treated with risperidone
    • Kohnke MD, Griese EU, Stosser D, Gaertner I, Barth G. Cytochrome P450 2D6 deficiency and its clinical relevance in a patient treated with risperidone. Pharmacopsychiatry 2002; 35: 116-118
    • (2002) Pharmacopsychiatry , vol.35 , pp. 116-118
    • Kohnke, M.D.1    Griese, E.U.2    Stosser, D.3    Gaertner, I.4    Barth, G.5
  • 20
    • 85047695626 scopus 로고    scopus 로고
    • In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations
    • Kosel M, Gnerre C, Voirol P, Amey M, Rochat B, Bouras C et al. In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations. Mol Psychiatry 2002; 7: 181-188
    • (2002) Mol Psychiatry , vol.7 , pp. 181-188
    • Kosel, M.1    Gnerre, C.2    Voirol, P.3    Amey, M.4    Rochat, B.5    Bouras, C.6
  • 21
    • 0030055999 scopus 로고    scopus 로고
    • Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4-hydroxylation status in Japanese depressive patients
    • Koyama E, Tanaka T, Chiba K, Kawakatsu S, Morinobu S, Totsuka S, Ishizaki T. Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4-hydroxylation status in Japanese depressive patients. J Clin Psychopharmacol 1996; 16: 286-293
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 286-293
    • Koyama, E.1    Tanaka, T.2    Chiba, K.3    Kawakatsu, S.4    Morinobu, S.5    Totsuka, S.6    Ishizaki, T.7
  • 22
    • 0027405998 scopus 로고
    • Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists
    • Kuoppamaki M, Syvalahti E, Hietala J. Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists. Eur J Pharmacol 1993; 245: 179-182
    • (1993) Eur J Pharmacol , vol.245 , pp. 179-182
    • Kuoppamaki, M.1    Syvalahti, E.2    Hietala, J.3
  • 24
    • 3242732096 scopus 로고    scopus 로고
    • QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations
    • LLerena A, Berecz R, Dorado P, de la RA. QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. J Psychopharmacol 2004; 18: 189-193
    • (2004) J Psychopharmacol , vol.18 , pp. 189-193
    • Llerena, A.1    Berecz, R.2    Dorado, P.3    De La, R.A.4
  • 25
    • 1542620667 scopus 로고    scopus 로고
    • Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions
    • LLerena A, Dorado P, Berecz R, Gonzalez AP, Penas-LLedo EM. Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions. Eur J Clin Pharmacol 2004; 59: 869-873
    • (2004) Eur J Clin Pharmacol , vol.59 , pp. 869-873
    • Llerena, A.1    Dorado, P.2    Berecz, R.3    Gonzalez, A.P.4    Penas-Lledo, E.M.5
  • 27
    • 0030872484 scopus 로고    scopus 로고
    • Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy
    • Morinobu S, Tanaka T, Kawakatsu S, Totsuka S, Koyama E, Chiba K et al. Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy. Psychiatry Clin Neurosci 1997; 51: 253-257
    • (1997) Psychiatry Clin Neurosci , vol.51 , pp. 253-257
    • Morinobu, S.1    Tanaka, T.2    Kawakatsu, S.3    Totsuka, S.4    Koyama, E.5    Chiba, K.6
  • 28
    • 0022879288 scopus 로고
    • Anti-depressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative
    • Muth EA, Haskins JT, Moyer JA, Husbands GE, Nielsen ST, Sigg EB. Anti-depressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem Pharmacol 1986; 35: 4493-4497
    • (1986) Biochem Pharmacol , vol.35 , pp. 4493-4497
    • Muth, E.A.1    Haskins, J.T.2    Moyer, J.A.3    Husbands, G.E.4    Nielsen, S.T.5    Sigg, E.B.6
  • 30
    • 0027131435 scopus 로고
    • Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: Prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data
    • Noguchi T, Shimoda K, Takahashi S. Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data. J Affect Disord 1993; 29: 267-279
    • (1993) J Affect Disord , vol.29 , pp. 267-279
    • Noguchi, T.1    Shimoda, K.2    Takahashi, S.3
  • 31
    • 0028856537 scopus 로고
    • Comparative neurotransmitter reuptake and anticholinergic potencies of the 8-hydroxy metabolites of clomipramine
    • Nunez R, Perel JM. Comparative neurotransmitter reuptake and anticholinergic potencies of the 8-hydroxy metabolites of clomipramine. Psychopharmacol Bull 1995; 31: 217-221
    • (1995) Psychopharmacol Bull , vol.31 , pp. 217-221
    • Nunez, R.1    Perel, J.M.2
  • 32
    • 0020257675 scopus 로고
    • Plasma binding variations of amitriptyline and nortriptyline
    • Pike E, Skuterud B. Plasma binding variations of amitriptyline and nortriptyline. Clin Pharmacol Ther 1982; 32: 228-234
    • (1982) Clin Pharmacol Ther , vol.32 , pp. 228-234
    • Pike, E.1    Skuterud, B.2
  • 33
    • 0017336951 scopus 로고
    • Doxepin up-to-date: A review of its pharmacological properties and therapeutic efficacy with particular reference to depression
    • Pinder RM, Brogden RN, Speight TM, Avery GS. Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression. Drugs 1977; 13: 161-218
    • (1977) Drugs , vol.13 , pp. 161-218
    • Pinder, R.M.1    Brogden, R.N.2    Speight, T.M.3    Avery, G.S.4
  • 34
    • 0026471667 scopus 로고
    • Imipramine and 2-hydroxyimipramine: Comparative cardiotoxicity and pharmacokinetics in swine
    • Pollock BG, Perel JM. Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine. Psychopharmacology (Berl) 1992; 109: 57-62
    • (1992) Psychopharmacology (Berl) , vol.109 , pp. 57-62
    • Pollock, B.G.1    Perel, J.M.2
  • 38
    • 0031671444 scopus 로고    scopus 로고
    • Metabolism of xenobiotics in the central nervous system: Implications and challenges
    • Ravindranath V. Metabolism of xenobiotics in the central nervous system: implications and challenges. Biochem Pharmacol 1998; 56: 547-551
    • (1998) Biochem Pharmacol , vol.56 , pp. 547-551
    • Ravindranath, V.1
  • 39
    • 0030949753 scopus 로고    scopus 로고
    • The role of metabolites of antidepressants in the treatment of depression
    • Rudorfer MV, Potter WZ. The role of metabolites of antidepressants in the treatment of depression. Cns Drugs 1997; 7: 273-312
    • (1997) Cns Drugs , vol.7 , pp. 273-312
    • Rudorfer, M.V.1    Potter, W.Z.2
  • 40
    • 0032981063 scopus 로고    scopus 로고
    • Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding
    • Sanchez C, Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol 1999; 19: 467-489
    • (1999) Cell Mol Neurobiol , vol.19 , pp. 467-489
    • Sanchez, C.1    Hyttel, J.2
  • 41
    • 20444480695 scopus 로고    scopus 로고
    • Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
    • Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC et al. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther 2005; 77: 503-514
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 503-514
    • Sasongko, L.1    Link, J.M.2    Muzi, M.3    Mankoff, D.A.4    Yang, X.5    Collier, A.C.6
  • 42
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • Schinkel AH, Wagenaar E, Mol CA, van DL. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996; 97: 2517-2524
    • (1996) J Clin Invest , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.3    Van, D.L.4
  • 45
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • Sim SC, Risinger C, Dahl ML, Aklillu E, Christensen M, Bertilsson L, Ingelman-Sundberg M. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 2006; 79: 103-113
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3    Aklillu, E.4    Christensen, M.5    Bertilsson, L.6    Ingelman-Sundberg, M.7
  • 46
    • 10744223983 scopus 로고    scopus 로고
    • N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity
    • Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB et al. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 2003; 100: 13674-13679
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13674-13679
    • Sur, C.1    Mallorga, P.J.2    Wittmann, M.3    Jacobson, M.A.4    Pascarella, D.5    Williams, J.B.6
  • 47
    • 0035118696 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression
    • Szymura-Oleksiak J, Wyska E, Wasieczko A. Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression. Psychopharmacology (Berl) 2001; 154: 38-42
    • (2001) Psychopharmacology (Berl) , vol.154 , pp. 38-42
    • Szymura-Oleksiak, J.1    Wyska, E.2    Wasieczko, A.3
  • 48
    • 0141783736 scopus 로고    scopus 로고
    • Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
    • Uhr M, Grauer MT, Holsboer F. Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry 2003; 54: 840-846
    • (2003) Biol Psychiatry , vol.54 , pp. 840-846
    • Uhr, M.1    Grauer, M.T.2    Holsboer, F.3
  • 49
    • 0033952456 scopus 로고    scopus 로고
    • Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption
    • Uhr M, Sleekler T, Yassouridis A, Holsboer F. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuropsychopharmacology 2000; 22: 380-387
    • (2000) Neuropsychopharmacology , vol.22 , pp. 380-387
    • Uhr, M.1    Sleekler, T.2    Yassouridis, A.3    Holsboer, F.4
  • 55
    • 0022353483 scopus 로고
    • Inhibition of serotonin uptake by optical isomers of fluoxetine
    • Wong DT, Bymaster FP, Reid LR. Inhibition of serotonin uptake by optical isomers of fluoxetine. Drug Dev Res 1985; 6: 397-403
    • (1985) Drug Dev Res , vol.6 , pp. 397-403
    • Wong, D.T.1    Bymaster, F.P.2    Reid, L.R.3
  • 58
    • 0035199681 scopus 로고    scopus 로고
    • The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients
    • Yokono A, Morita S, Someya T, Hirokane G, Okawa M, Shimoda K. The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients. J Clin Psychopharmacol 2001; 21: 549-555
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 549-555
    • Yokono, A.1    Morita, S.2    Someya, T.3    Hirokane, G.4    Okawa, M.5    Shimoda, K.6
  • 59
    • 0026763431 scopus 로고
    • Dextromethorphan: Enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6
    • Zhang Y, Britto MR, Valderhaug KL, Wedlund PJ, Smith RA. Dextromethorphan: enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6. Clin Pharmacol Ther 1992; 51: 647-655
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 647-655
    • Zhang, Y.1    Britto, M.R.2    Valderhaug, K.L.3    Wedlund, P.J.4    Smith, R.A.5


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