Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- mice

Circulation Research

Volumn 108, Issue 6, 2011, Pages 686-694

  Cole, Laura K ^a   Dolinsky, Vernon W ^b   Dyck, Jason R B ^b   Vance, Dennis E ^a,b  

^a School of Molecular and Systems Medicine   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

apolipoprotein E; atherosclerosis; lipotoxic cardiomyopathy; phosphatidylcholine; phosphatidylethanolamine N methyltransferase

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER; INTERMEDIATE DENSITY LIPOPROTEIN; MALONYL COENZYME A; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME DEFICIENCY; HEART CONTRACTION; HEART DISEASE; HEART MUSCLE FIBROSIS; LIPID COMPOSITION; LIPID LIVER LEVEL; LIPOPROTEIN BLOOD LEVEL; LIPOTOXICITY; MALE; MOUSE; MUSCLE FIBRIL; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; TISSUE LEVEL; TRANSTHORACIC ECHOCARDIOGRAPHY; TRIACYLGLYCEROL BLOOD LEVEL;

AGING; ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; HEART; HEART DISEASES; LIPID METABOLISM; LIPOPROTEINS; LIVER; MICE; MICE, KNOCKOUT; MYOCARDIUM; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; TRIGLYCERIDES;

EID: 79953064630     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.238691     Document Type: Article

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