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Volumn 16, Issue 14, 1997, Pages 4317-4332

The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase

Author keywords

Chemotaxis; Dictyostelium discoideum; Guanylyl cyclase; MAP kinase; MEK; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; CHEMOATTRACTANT; CYCLIC AMP; GUANYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 0030753611     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.14.4317     Document Type: Article
Times cited : (72)

References (79)
  • 1
    • 0031054447 scopus 로고    scopus 로고
    • The Dictyostelium MAP kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function
    • Aubry, L., Maeda, M., Insall, R., Devreotes, P.N. and Firtel, R.A. (1997) The Dictyostelium MAP kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. J. Biol. Chem., 272, 3883-3886.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3883-3886
    • Aubry, L.1    Maeda, M.2    Insall, R.3    Devreotes, P.N.4    Firtel, R.A.5
  • 2
    • 0030272039 scopus 로고    scopus 로고
    • A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs
    • Bardwell, L. and Thorner, J. (1996) A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs. Trends Bleichem. Sci., 21, 373-374.
    • (1996) Trends Bleichem. Sci. , vol.21 , pp. 373-374
    • Bardwell, L.1    Thorner, J.2
  • 3
    • 0029992810 scopus 로고    scopus 로고
    • Signaling in the yeast pheromone response pathway: Specific and high-affinity interaction of the mitogen-activated protein (MAP) kinase Kss 1 and Fus3 with the upstream MAP kinase kinase Ste7
    • Bardwell, L., Cook, J., Chang, E., Cairns, B. and Thorner, J. (1996) Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinase Kss 1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol. Cell. Biol., 16, 3637-3650.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3637-3650
    • Bardwell, L.1    Cook, J.2    Chang, E.3    Cairns, B.4    Thorner, J.5
  • 4
    • 0029977106 scopus 로고    scopus 로고
    • Multiple intracellular MAP kinase signaling cascades
    • Bokemeyer, D., Sorokin, A. and Du, M. (1996) Multiple intracellular MAP kinase signaling cascades. Kidney Int., 49, 1187-1198.
    • (1996) Kidney Int. , vol.49 , pp. 1187-1198
    • Bokemeyer, D.1    Sorokin, A.2    Du, M.3
  • 5
    • 0027955437 scopus 로고
    • Phospholipase C in Dictyostelium discoideum - Cyclic AMP surface receptor and G-protein-regulated activity in vitro
    • Bominaar, A.A., Kesbeke, F. and Van Haastert, P.J.M. (1994) Phospholipase C in Dictyostelium discoideum - cyclic AMP surface receptor and G-protein-regulated activity in vitro. Biochem. J., 297, 181-187.
    • (1994) Biochem. J. , vol.297 , pp. 181-187
    • Bominaar, A.A.1    Kesbeke, F.2    Van Haastert, P.J.M.3
  • 7
    • 0024405410 scopus 로고
    • Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2+ protein structure and function
    • Carr, A.M., MacNeil, S.A., Hayles, J. and Nurse, P. (1989) Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: implications for cdc2+ protein structure and function. Mol. Gen. Genet., 218, 41-49.
    • (1989) Mol. Gen. Genet. , vol.218 , pp. 41-49
    • Carr, A.M.1    MacNeil, S.A.2    Hayles, J.3    Nurse, P.4
  • 8
    • 0030028743 scopus 로고    scopus 로고
    • Signaling through chemoattractant receptors in Dictyostelium
    • Chen, M., Insall, R. and Devreotes, P. (1996) Signaling through chemoattractant receptors in Dictyostelium. Trends Genet., 12, 52-57.
    • (1996) Trends Genet. , vol.12 , pp. 52-57
    • Chen, M.1    Insall, R.2    Devreotes, P.3
  • 9
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • Davis, R. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem., 268, 14553-14556.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14553-14556
    • Davis, R.1
  • 10
    • 0028293178 scopus 로고
    • G protein-linked signaling pathways control the developmental program of Dictyostelium
    • Devreotes, P.N. (1994) G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron, 12, 235-241.
    • (1994) Neuron , vol.12 , pp. 235-241
    • Devreotes, P.N.1
  • 11
    • 0024147085 scopus 로고
    • Chemotaxis in eukaryotic cells: A focus on leukocytes and Dictyostelium
    • Devreotes, P.N. and Zigmond, S.H. (1988) Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu. Rev. Cell Biol., 4, 649-686.
    • (1988) Annu. Rev. Cell Biol. , vol.4 , pp. 649-686
    • Devreotes, P.N.1    Zigmond, S.H.2
  • 13
    • 0028231283 scopus 로고
    • LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium
    • Dynes, J.L., Clark, A.M., Shaulsky, G., Kuspa, A., Loomis, W.F. and Firtel, R.A. (1994) LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes Dev., 8, 948-958.
    • (1994) Genes Dev. , vol.8 , pp. 948-958
    • Dynes, J.L.1    Clark, A.M.2    Shaulsky, G.3    Kuspa, A.4    Loomis, W.F.5    Firtel, R.A.6
  • 14
    • 0030605380 scopus 로고    scopus 로고
    • Feedback regulation of map kinase signal pathways
    • Errede, B. and Ge, Q. (1996) Feedback regulation of map kinase signal pathways. Phil. Trans. R. Soc. Lond. B, 351, 143-149.
    • (1996) Phil. Trans. R. Soc. Lond. B , vol.351 , pp. 143-149
    • Errede, B.1    Ge, Q.2
  • 15
    • 0027586171 scopus 로고
    • A conserved kinase cascade for MAP kinase activation in yeast
    • Errede, B. and Levin, D. (1993) A conserved kinase cascade for MAP kinase activation in yeast. Curr. Opin. Cell Biol. 5, 254-260.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 254-260
    • Errede, B.1    Levin, D.2
  • 16
    • 0029042376 scopus 로고
    • Integration of signaling information in controlling cell-fate decisions in Dictyostelium
    • Firtel, R.A. (1995) Integration of signaling information in controlling cell-fate decisions in Dictyostelium. Genes Der., 9, 1427-1444.
    • (1995) Genes Der. , vol.9 , pp. 1427-1444
    • Firtel, R.A.1
  • 17
    • 0025057255 scopus 로고
    • Role for cAMP-dependent protein kinase-A in early Dictyostelium development
    • Firtel, R.A. and Chapman, A.L. (1990) Role for cAMP-dependent protein kinase-A in early Dictyostelium development. Genes Dev., 4, 18-28.
    • (1990) Genes Dev. , vol.4 , pp. 18-28
    • Firtel, R.A.1    Chapman, A.L.2
  • 18
    • 0027938452 scopus 로고
    • Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum
    • Gaskins, C., Maeda, M. and Firtel, R.A. (1994) Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum. Mol. Cell. Biol., 14, 6996-7012.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6996-7012
    • Gaskins, C.1    Maeda, M.2    Firtel, R.A.3
  • 19
    • 0030023902 scopus 로고    scopus 로고
    • The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways
    • Gaskins, C., Clark, A.M., Aubry, L., Segall, J.E. and Firtel, R.A. (1996) The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways. Genes Dev., 10, 118-128.
    • (1996) Genes Dev. , vol.10 , pp. 118-128
    • Gaskins, C.1    Clark, A.M.2    Aubry, L.3    Segall, J.E.4    Firtel, R.A.5
  • 20
    • 0342297254 scopus 로고
    • Membrane sites implicated in cell adhesion: Their developmental control in Dictyostelium discoideum
    • Brinkley, B.R. and Porter, K.R. (eds), 1976-1977. Rockefeller University Press, New York
    • Gerisch, G. (1977) Membrane sites implicated in cell adhesion: their developmental control in Dictyostelium discoideum. In Brinkley, B.R. and Porter, K.R. (eds), International Cell Biology, 1976-1977. Rockefeller University Press, New York, pp. 36-42.
    • (1977) International Cell Biology , pp. 36-42
    • Gerisch, G.1
  • 21
    • 0002971324 scopus 로고
    • Cyclic AMP signals and the control of cell aggregation in Dictyostelium discoideum
    • Cappuccinelli, P. and Ashworth, J.M. (eds), Elsevier/North-Holland, Amsterdam
    • Gerisch, G., Maeda, Y., Malchow, D., Roos, W., Wick, U. and Wurster, B. (1977) Cyclic AMP signals and the control of cell aggregation in Dictyostelium discoideum. In Cappuccinelli, P. and Ashworth, J.M. (eds), Development and Differentiation in the Cellular Slime Moulds. Elsevier/North-Holland, Amsterdam, pp. 105-124.
    • (1977) Development and Differentiation in the Cellular Slime Moulds , pp. 105-124
    • Gerisch, G.1    Maeda, Y.2    Malchow, D.3    Roos, W.4    Wick, U.5    Wurster, B.6
  • 22
    • 0025255873 scopus 로고
    • A spatial gradient of expresssion of a cAMP-regulated prespore cell type-specific gene in Dictyostelium
    • Haberstroh, L. and Firtel, R.A. (1990) A spatial gradient of expresssion of a cAMP-regulated prespore cell type-specific gene in Dictyostelium. Genes Dev., 4, 596-612.
    • (1990) Genes Dev. , vol.4 , pp. 596-612
    • Haberstroh, L.1    Firtel, R.A.2
  • 23
    • 0027212049 scopus 로고
    • The role of the cyclic nucleotide phosphodiesterase of Dictyostelium discoideum during growth, aggregation, and morphogenesis: Overexpression and localization studies with the separate promoters of the pde
    • Hall, A.L., Franke, J., Faure, M. and Kessin, R.H. (1993) The role of the cyclic nucleotide phosphodiesterase of Dictyostelium discoideum during growth, aggregation, and morphogenesis: overexpression and localization studies with the separate promoters of the pde. Dev. Biol., 157, 73-84.
    • (1993) Dev. Biol. , vol.157 , pp. 73-84
    • Hall, A.L.1    Franke, J.2    Faure, M.3    Kessin, R.H.4
  • 24
    • 0028985079 scopus 로고
    • MAP kinase pathways in yeast: For mating and more
    • Herskowitz, I. (1995) MAP kinase pathways in yeast: for mating and more. Cell, 80, 187-107.
    • (1995) Cell , vol.80 , pp. 187-1107
    • Herskowitz, I.1
  • 25
    • 0028146177 scopus 로고
    • Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development
    • Howard, P.K., Gamper, M., Hunter, T. and Firtel, R.A. (1994) Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development. Mol. Cell. Biol., 14, 5154-5164.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5154-5164
    • Howard, P.K.1    Gamper, M.2    Hunter, T.3    Firtel, R.A.4
  • 26
    • 0027992319 scopus 로고
    • A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases
    • Hsu, J. and Perrimon, N. (1994) A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev., 8, 2176-2187.
    • (1994) Genes Dev. , vol.8 , pp. 2176-2187
    • Hsu, J.1    Perrimon, N.2
  • 27
    • 0028916307 scopus 로고
    • Biochemical and biological analysis of Mek1 phosphorylation site mutants
    • Huang, W., Kessler, D.S. and Erikson, R.L. (1995) Biochemical and biological analysis of Mek1 phosphorylation site mutants. Mol. Biol. Cell., 6, 237-245.
    • (1995) Mol. Biol. Cell. , vol.6 , pp. 237-245
    • Huang, W.1    Kessler, D.S.2    Erikson, R.L.3
  • 28
    • 0026666934 scopus 로고
    • Selection of Dictyostelium discoideum transformants and analysis of vector maintenance using live bacteria resistant to G418
    • Hughes, J.E., Podgorski, G.J. and Welker, D.L. (1992) Selection of Dictyostelium discoideum transformants and analysis of vector maintenance using live bacteria resistant to G418. Plasmid, 28, 46-60.
    • (1992) Plasmid , vol.28 , pp. 46-60
    • Hughes, J.E.1    Podgorski, G.J.2    Welker, D.L.3
  • 29
    • 0028093610 scopus 로고
    • CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
    • Insall, R., Kuspa, A., Lilly, P.J., Shaulsky, G., Levin, L.R., Loomis, W.F. and Devreotes, P. (1994) CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol., 126, 1537-1545.
    • (1994) J. Cell Biol. , vol.126 , pp. 1537-1545
    • Insall, R.1    Kuspa, A.2    Lilly, P.J.3    Shaulsky, G.4    Levin, L.R.5    Loomis, W.F.6    Devreotes, P.7
  • 30
    • 0030156329 scopus 로고    scopus 로고
    • The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
    • Insall, R.H., Borleis, J. and Devreotes, P.N. (1996) The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr. Biol., 6, 719-729.
    • (1996) Curr. Biol. , vol.6 , pp. 719-729
    • Insall, R.H.1    Borleis, J.2    Devreotes, P.N.3
  • 31
    • 0022815791 scopus 로고
    • Developmental regulation of Dictyostelium discoideum actin gene fusions carried on low-copy and high-copy transformation vectors
    • Knecht, D.A., Cohen, S.M., Loomis, W.F. and Lodish, H.F. (1986) Developmental regulation of Dictyostelium discoideum actin gene fusions carried on low-copy and high-copy transformation vectors. Mol. Cell. Biol., 6, 3973-3983.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3973-3983
    • Knecht, D.A.1    Cohen, S.M.2    Loomis, W.F.3    Lodish, H.F.4
  • 32
    • 0030055549 scopus 로고    scopus 로고
    • Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum
    • Knetsch, M.L.W., Epskamp, S.J.P, Schenk, P.W., Wang, Y.W., Segall, J.E. and Snaar-Jagalska, B.E. (1996) Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum. EMBO J., 15, 3361-3368.
    • (1996) EMBO J. , vol.15 , pp. 3361-3368
    • Knetsch, M.L.W.1    Epskamp, S.J.P.2    Schenk, P.W.3    Wang, Y.W.4    Segall, J.E.5    Snaar-Jagalska, B.E.6
  • 33
    • 0014947106 scopus 로고
    • Microbiological assay for cyclic 3′,57prime;-AMP
    • Konijn, T.M. (1970) Microbiological assay for cyclic 3′,57prime;-AMP. Experientia, 26, 367-369.
    • (1970) Experientia , vol.26 , pp. 367-369
    • Konijn, T.M.1
  • 35
    • 0026059565 scopus 로고
    • Molecular genetic analysis of two Gα protein subunits in Dictyostelium
    • Kumagai, A., Hadwiger, J.A., Pupillo, M. and Firtel, R.A. (1991) Molecular genetic analysis of two Gα protein subunits in Dictyostelium. J. Biol. Chem., 266, 1220-1228.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1220-1228
    • Kumagai, A.1    Hadwiger, J.A.2    Pupillo, M.3    Firtel, R.A.4
  • 36
    • 0027739744 scopus 로고
    • Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction
    • Kuwayama, H., Ishida, S. and Van Haastert, P.J.M. (1993) Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction. J. Cell Biol., 123, 1453-1462.
    • (1993) J. Cell Biol. , vol.123 , pp. 1453-1462
    • Kuwayama, H.1    Ishida, S.2    Van Haastert, P.J.M.3
  • 37
    • 0029131012 scopus 로고
    • Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants
    • Kuwayama, H., Viel, G.T., Ishida, S. and Van Haastert, P.J.M. (1995) Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants. Biochim. Biophys. Acta, 1268, 214-220.
    • (1995) Biochim. Biophys. Acta , vol.1268 , pp. 214-220
    • Kuwayama, H.1    Viel, G.T.2    Ishida, S.3    Van Haastert, P.J.M.4
  • 38
    • 0030024280 scopus 로고    scopus 로고
    • Protection against osmotic stress by cGMP-mediated myosin phosphorylation
    • Kuwayama, H., Ecke, M., Gerisch, G. and Van Haastert, P.J.M. (1996) Protection against osmotic stress by cGMP-mediated myosin phosphorylation. Science, 271, 207-209.
    • (1996) Science , vol.271 , pp. 207-209
    • Kuwayama, H.1    Ecke, M.2    Gerisch, G.3    Van Haastert, P.J.M.4
  • 39
    • 0028920365 scopus 로고
    • The proliferation of MAP kinase signaling pathways in yeast
    • Levin, D.E. and Errede, B. (1995) The proliferation of MAP kinase signaling pathways in yeast. Curr. Opin. Cell Biol., 7, 197-202.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 197-202
    • Levin, D.E.1    Errede, B.2
  • 40
    • 0028287376 scopus 로고
    • Identification of CRAC, a cytosolic regulator required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium
    • Lilly, P.J. and Devreotes, P.N. (1994) Identification of CRAC, a cytosolic regulator required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium. J. Biol. Chem., 269, 14123-14129.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14123-14129
    • Lilly, P.J.1    Devreotes, P.N.2
  • 41
    • 0028978605 scopus 로고
    • Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
    • Lilly, P.J. and Devreotes, P.N. (1995) Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol., 129, 1659-1665.
    • (1995) J. Cell Biol. , vol.129 , pp. 1659-1665
    • Lilly, P.J.1    Devreotes, P.N.2
  • 42
    • 0027374726 scopus 로고
    • The role of cyclic GMP in regulating myosin during chemotaxis of Dictyostelium: Evidence from a mutant lacking the normal cyclic GMP response to cyclic AMP
    • Liu, G., Kuwayama, H., Ishida, S. and Newell, P.C. (1993) The role of cyclic GMP in regulating myosin during chemotaxis of Dictyostelium: evidence from a mutant lacking the normal cyclic GMP response to cyclic AMP. J. Cell Sci., 106, 591-595.
    • (1993) J. Cell Sci. , vol.106 , pp. 591-595
    • Liu, G.1    Kuwayama, H.2    Ishida, S.3    Newell, P.C.4
  • 43
    • 0021013007 scopus 로고
    • Genetic analysis of cell adhesion
    • Loomis, W.F. (1983) Genetic analysis of cell adhesion. Dev. Genet., 4, 61-68.
    • (1983) Dev. Genet. , vol.4 , pp. 61-68
    • Loomis, W.F.1
  • 44
    • 0030023040 scopus 로고    scopus 로고
    • Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium: Role of heterotrimeric G proteins
    • Maeda, M., Aubry, L., Insall, R., Gaskins, C., Devreotes, P.N. and Firtel, R.A. (1996) Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium: role of heterotrimeric G proteins. J. Biol. Chem., 271, 3351-3354.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3351-3354
    • Maeda, M.1    Aubry, L.2    Insall, R.3    Gaskins, C.4    Devreotes, P.N.5    Firtel, R.A.6
  • 45
    • 0023084784 scopus 로고
    • Cyclic AMP regulation of early gene expression in Dictyostelium discoideum: Mediation via the cell surface cyclic AMP receptor
    • Mann, S.K.O. and Firtel, R.A. (1987) Cyclic AMP regulation of early gene expression in Dictyostelium discoideum: mediation via the cell surface cyclic AMP receptor. Mol. Cell. Biol., 7, 458-469.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 458-469
    • Mann, S.K.O.1    Firtel, R.A.2
  • 46
    • 0024637673 scopus 로고
    • Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium
    • Mann, S.K. and Firtel, R.A. (1989) Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium. Proc. Natl Acad. Sci. USA, 86, 1924-1928.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 1924-1928
    • Mann, S.K.1    Firtel, R.A.2
  • 47
    • 0025951960 scopus 로고
    • A developmentally regulated. putative serine/threonine protein kinase is essential for development in Dictyostelium
    • Mann, S.K.O. and Firtel, R.A. (1991) A developmentally regulated. putative serine/threonine protein kinase is essential for development in Dictyostelium. Mech. Dev., 35, 89-101.
    • (1991) Mech. Dev. , vol.35 , pp. 89-101
    • Mann, S.K.O.1    Firtel, R.A.2
  • 48
    • 0000519272 scopus 로고
    • Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium
    • Celis, J.E. (ed.), Academic Press, San Diego, CA
    • Mann, S.K.O. et al. (1994) Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium. In Celis, J.E. (ed.), Cell Biology - A Laboratory Handbook. Academic Press, San Diego, CA, pp. 412-451.
    • (1994) Cell Biology - A Laboratory Handbook , pp. 412-451
    • Mann, S.K.O.1
  • 49
    • 0031569321 scopus 로고    scopus 로고
    • Role of cAMP-dependent protein kinase in controlling aggregation and post-aggregative development in Dictyostelium
    • Mann, S.K.O., Brown, J.M., Briscoe, C., Parent, C. Pitt, G., Devreotes, P.N. and Firtel, R.A. (1997) Role of cAMP-dependent protein kinase in controlling aggregation and post-aggregative development in Dictyostelium. Dev. Biol., 183, 208-211.
    • (1997) Dev. Biol. , vol.183 , pp. 208-211
    • Mann, S.K.O.1    Brown, J.M.2    Briscoe, C.3    Parent, C.4    Pitt, G.5    Devreotes, P.N.6    Firtel, R.A.7
  • 51
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C.J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 52
    • 0020730017 scopus 로고
    • Induction and modulation of cell-type specific gene expression in Dictyostelium
    • Mehdy, M.C., Ratner, D. and Firtel, R.A. (1983) Induction and modulation of cell-type specific gene expression in Dictyostelium. Cell, 32, 763-771.
    • (1983) Cell , vol.32 , pp. 763-771
    • Mehdy, M.C.1    Ratner, D.2    Firtel, R.A.3
  • 54
    • 0029550552 scopus 로고
    • Signal transduction and motility of Dictyostelium
    • Newell, P.C. (1995) Signal transduction and motility of Dictyostelium. Biosci. Rep., 15, 445-462.
    • (1995) Biosci. Rep. , vol.15 , pp. 445-462
    • Newell, P.C.1
  • 55
    • 0001373925 scopus 로고
    • Complete sequence and transcript regulation of a cell adhesion protein from aggregating Dictyostelium cells
    • Noegel, A., Gerisch, G., Stadler, J. and Westphal, M. (1986) Complete sequence and transcript regulation of a cell adhesion protein from aggregating Dictyostelium cells. EMBO J., 5, 1473-1476.
    • (1986) EMBO J. , vol.5 , pp. 1473-1476
    • Noegel, A.1    Gerisch, G.2    Stadler, J.3    Westphal, M.4
  • 56
    • 0027057211 scopus 로고
    • Amino acid substitutions in the Dictyostelium Gα subunit Gα2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase. guanylyl cyclase, and phospholipase-C
    • Okaichi, K., Cubitt, A.B., Pitt, G.S. and Firtel, R.A. (1992) Amino acid substitutions in the Dictyostelium Gα subunit Gα2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase. guanylyl cyclase, and phospholipase-C. Mol. Biol Cell. 3, 735-747.
    • (1992) Mol. Biol Cell. , vol.3 , pp. 735-747
    • Okaichi, K.1    Cubitt, A.B.2    Pitt, G.S.3    Firtel, R.A.4
  • 57
    • 13344276590 scopus 로고    scopus 로고
    • cGMP accumulation induced by hypertonic stress in Dictyostelium discoideum
    • Oyama, M. (1996) cGMP accumulation induced by hypertonic stress in Dictyostelium discoideum. J. Biol. Chem., 271, 5574-5579.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5574-5579
    • Oyama, M.1
  • 58
    • 0028359984 scopus 로고
    • Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)
    • Pages, G., Brunet, A., L'Allemain, G. and Pouyssegur, J. (1994) Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). EMBO J., 13, 3003-3010.
    • (1994) EMBO J. , vol.13 , pp. 3003-3010
    • Pages, G.1    Brunet, A.2    L'Allemain, G.3    Pouyssegur, J.4
  • 59
    • 0026504354 scopus 로고
    • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development
    • Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. (1992) Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell, 69, 305-315.
    • (1992) Cell , vol.69 , pp. 305-315
    • Pitt, G.S.1    Milona, N.2    Borleis, J.3    Lin, K.C.4    Reed, R.R.5    Devreotes, P.N.6
  • 60
    • 0027997674 scopus 로고
    • Progression of an inductive signal activates sporulation in Dictyostelium discoideum
    • Richardson, D.L., Loomis, W.F. and Kimmel, A.R. (1994) Progression of an inductive signal activates sporulation in Dictyostelium discoideum. Development, 120, 2891-2900.
    • (1994) Development , vol.120 , pp. 2891-2900
    • Richardson, D.L.1    Loomis, W.F.2    Kimmel, A.R.3
  • 61
    • 0019803308 scopus 로고
    • Streamers: Chemotactic mutants of Dictyostelium discoideum with altered cyclic GMP metabolism
    • Ross, F.M. and Newell, P.C. (1981) Streamers: chemotactic mutants of Dictyostelium discoideum with altered cyclic GMP metabolism. J. Gen. Microbiol., 127, 339-350.
    • (1981) J. Gen. Microbiol. , vol.127 , pp. 339-350
    • Ross, F.M.1    Newell, P.C.2
  • 63
    • 84990576519 scopus 로고
    • Regulation of size and pattern in the cellular slime molds
    • Schaap, P. (1986) Regulation of size and pattern in the cellular slime molds. Differentiation, 33, 1-16.
    • (1986) Differentiation , vol.33 , pp. 1-16
    • Schaap, P.1
  • 64
    • 0021987976 scopus 로고
    • cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium
    • Schaap, P. and Wang, M. (1985) cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium. Cell Differ., 16, 29-33.
    • (1985) Cell Differ. , vol.16 , pp. 29-33
    • Schaap, P.1    Wang, M.2
  • 65
    • 0028263179 scopus 로고
    • Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium
    • Schnitzler, G.R., Fischer, W.H. and Firtel, R.A. (1994) Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium. Genes Dev., 8, 502-514.
    • (1994) Genes Dev. , vol.8 , pp. 502-514
    • Schnitzler, G.R.1    Fischer, W.H.2    Firtel, R.A.3
  • 66
    • 0029019452 scopus 로고
    • cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium
    • Schulkes, C. and Schaap, P. (1995) cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium. FEBS Lett., 368, 381-384.
    • (1995) FEBS Lett. , vol.368 , pp. 381-384
    • Schulkes, C.1    Schaap, P.2
  • 67
    • 0028930549 scopus 로고
    • A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
    • Segall, J.E., Kuspa, A., Shaulsky, G., Ecke, M., Maeda, M. Gaskins, C. and Firtel, R.A. (1995) A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol., 128, 405-413.
    • (1995) J. Cell Biol. , vol.128 , pp. 405-413
    • Segall, J.E.1    Kuspa, A.2    Shaulsky, G.3    Ecke, M.4    Maeda, M.5    Gaskins, C.6    Firtel, R.A.7
  • 68
    • 0001205076 scopus 로고
    • Analysis of optical density wave propagation and cell movement in the cellular slime mold Dictyostelium discoideum
    • Siegert, F. and Weijer, C.J. (1991) Analysis of optical density wave propagation and cell movement in the cellular slime mold Dictyostelium discoideum. Physica D, 49, 224-232.
    • (1991) Physica D , vol.49 , pp. 224-232
    • Siegert, F.1    Weijer, C.J.2
  • 69
    • 0024454883 scopus 로고
    • Overproduction of the regulatory subunit of the cAMP-dependent protein kinase blocks the differentiation of Dictyostelium discoideum
    • Simon, M.N., Driscoll, D., Mutzel, R., Part, D., Williams, J. and Veron, M. (1989) Overproduction of the regulatory subunit of the cAMP-dependent protein kinase blocks the differentiation of Dictyostelium discoideum. EMBO J., 8, 2039-2044.
    • (1989) EMBO J. , vol.8 , pp. 2039-2044
    • Simon, M.N.1    Driscoll, D.2    Mutzel, R.3    Part, D.4    Williams, J.5    Veron, M.6
  • 70
    • 0024273555 scopus 로고
    • G-proteins in the signal-transduction pathways of Dictyostelium discoideum
    • Snaar-Jagalska, B.E., Kesbeke, F. and Van Haastert, P.J.M. (1988) G-proteins in the signal-transduction pathways of Dictyostelium discoideum. Dev. Genet., 9, 215-226.
    • (1988) Dev. Genet. , vol.9 , pp. 215-226
    • Snaar-Jagalska, B.E.1    Kesbeke, F.2    Van Haastert, P.J.M.3
  • 71
    • 0027217068 scopus 로고
    • A transformation vector for Dictyostelium discoideum with a new selectable marker Bsr
    • Sutoh, K. (1993) A transformation vector for Dictyostelium discoideum with a new selectable marker Bsr. Plosmid, 30, 150-154.
    • (1993) Plosmid , vol.30 , pp. 150-154
    • Sutoh, K.1
  • 72
    • 0028332640 scopus 로고
    • A model for cAMP-mediated cGMP response in Dictyostelium discoideum
    • Valkema, R. and Van Haastert, P.J.M. (1994) A model for cAMP-mediated cGMP response in Dictyostelium discoideum. Mol. Biol. Cell, 5, 575-585.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 575-585
    • Valkema, R.1    Van Haastert, P.J.M.2
  • 73
    • 0029559029 scopus 로고
    • Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells
    • Van Haastert, P.J. (1995) Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells. Experientia, 51, 1144-1154.
    • (1995) Experientia , vol.51 , pp. 1144-1154
    • Van Haastert, P.J.1
  • 74
    • 0342286981 scopus 로고
    • Biochemistry and genetics of sensory transduction in Dictyostelium
    • Kurjan, J. and Taylor, B.L. (eds), Academic Press, San Diego, CA
    • Van Haastert, P.J.M. and Devreotes, P.N. (1993) Biochemistry and genetics of sensory transduction in Dictyostelium. In Kurjan, J. and Taylor, B.L. (eds), Signal Transduction: Prokaryotic and Simple Eukaryotic Systems. Academic Press, San Diego, CA, pp. 329-352.
    • (1993) Signal Transduction: Prokaryotic and Simple Eukaryotic Systems , pp. 329-352
    • Van Haastert, P.J.M.1    Devreotes, P.N.2
  • 75
    • 0023608869 scopus 로고
    • Direct induction of Dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen
    • Williams, J.G., Ceccarelli, A., McRobbie, S., Mahbubani, H., Kay, R.R., Farly, A., Berks, M. and Jermyn, K.A. (1987) Direct induction of Dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen. Cell, 49, 185-192.
    • (1987) Cell , vol.49 , pp. 185-192
    • Williams, J.G.1    Ceccarelli, A.2    McRobbie, S.3    Mahbubani, H.4    Kay, R.R.5    Farly, A.6    Berks, M.7    Jermyn, K.A.8
  • 76
    • 0028844095 scopus 로고
    • Regulation of Dictyostelium early development genes in signal transduction mutants
    • Wu, L., Hansen, D., Franke, J., Kessin, R.H. and Podgorski, G.J. (1995a) Regulation of Dictyostelium early development genes in signal transduction mutants. Dev. Biol., 171, 149-158.
    • (1995) Dev. Biol. , vol.171 , pp. 149-158
    • Wu, L.1    Hansen, D.2    Franke, J.3    Kessin, R.H.4    Podgorski, G.J.5
  • 77
    • 0029020634 scopus 로고
    • The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium
    • Wu, L.J., Valkema, R., Van Haastert, P.J.M. and Devreotes, P.N. (1995b) The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. J. Cell Biol., 129, 1667-1675.
    • (1995) J. Cell Biol. , vol.129 , pp. 1667-1675
    • Wu, L.J.1    Valkema, R.2    Van Haastert, P.J.M.3    Devreotes, P.N.4
  • 79
    • 0028329630 scopus 로고
    • Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
    • Zheng, C.-F. and Guan, K.-L. (1994) Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J., 13, 1123-1131.
    • (1994) EMBO J. , vol.13 , pp. 1123-1131
    • Zheng, C.-F.1    Guan, K.-L.2


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