MAP kinase cascades: Scaffolding signal specificity

Current Biology

Volumn 12, Issue 2, 2002, Pages

  Van Drogen, Frank ^a   Peter, Matthias ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME SPECIFICITY; FEEDBACK SYSTEM; REVIEW; SIGNAL TRANSDUCTION;

FEEDBACK; MAP KINASE SIGNALING SYSTEM; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 0037154295     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00672-8     Document Type: Review

References (20)

1. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
2. MAP kinase pathways in the yeast Saccharomyces cerevisiae
3. Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein
4. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo
5. Pheromone response, mating and cell biology
6. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK
7. Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins
8. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the G beta gamma complex underlies activation of the yeast pheromone response pathway
9. MAP kinase dynamics in response to pheromones in budding yeast
10. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
11. MAPK specificity in the yeast pheromone response independent of transcriptional activation
12. Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation
13. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
14. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
15. Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases
16. FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
17. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae
18. Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates
19. Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669
20. Docking domains and substrate-specificity determination for MAP kinases