Mutations in the Dictyostelium heterotrimeric G protein α subunit Gα5 alter the kinetics of tip morphogenesis

Development

Volumn 122, Issue 4, 1996, Pages 1215-1224

  Hadwiger, Jeffrey A ^a,b   Natarajan, Kanchana ^b   Firtel, Richard A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Dictyostelium; G protein; G 5; Mound formation; Temporal regulation; Tip morphogenesis

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ARTICLE; CELL TYPE; DEVELOPMENTAL GENETICS; GENE NUMBER; KINETICS; MORPHOGENESIS; NONHUMAN; NULL CELL; PRIORITY JOURNAL; SARCODINA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DICTYOSTELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; HETEROTRIMERIC GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; MUTAGENESIS; MUTATION; PROTOZOAN PROTEINS; RNA, FUNGAL; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA;

DICTYOSTELIUM; SARCODINA;

EID: 0029917072     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Abe, K. and Yanagisawa, K. (1983). A new class of rapidly developing mutants in Dictyostelium discoideum: implications for cyclic AMP metabolism and cell differentiation. Dev. Biol. 95, 200-210.
2. Abe, T., Early, A., Siegert, F., Weijer, C. and Williams, J. (1994). Patterns of cell movement within the Dictyostelium slug revealed by cell type-specific, surtace labeling of living cells. Cell 77, 687-689.
3. Anjard, C., Pinaud, S., Kay, R. R. and Reymond, C. D. (1992). Overexpression of DdPK2 protein kinase causes rapid development and affectv the intracellular cAMP pathway of Dictyostelium discoideum. Development 115, 785-790.
4. Berks, M. and Kay, R. R. (1990). Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum. Development 110, 977-984.
5. Bourne, H. R., Sanders, D. A. and McCormick, F. (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127.
6. Carrel, F., Dharmawardhane, S., Clark, A. M., Powell-Coffman, J. A. and Firtel, R. A. (1994). Spatial and temporal expression of the Dictyostelium discoideum Ga protein subunit Gα2 - expression of a dominant negative protein inhibits proper prestalk to stalk differentiation. Mol. Biol. Cell 5, 7-16.
7. Cubitt, A. B., Carrel, F., Dharmawardhane, S., Gaskins, C., Hadwiger, J., Howard, P., Mann, S. K. O., Okaichi, K., Zhou, K. and Firtel, R. A. (1992). Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium. Cold Spring Harbor Symp. Quant Biol. 57, 177-192.
8. Devreotes, P. N. (1994). G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron 12, 235-241.
9. Dingermann, T., Reindl, N., Werner, H., Hildebrandt, M., Nellen, W., Harwood, A., Williams, J. and Nerke, K. (1989). Optimization and in situ detection of Escherichia coli β-galactosidase gene expression in Dictyostelium discoideum. Gene 85, 353,362.
10. Dynes, J. L. and Firtel, R. A. (1989). Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library. Proc. Natl. Acad. Sci. U S A 86, 7966-7970.
11. Early, A. E., Gaskell, M. J., Traynor, D. and Williams, J. G. (1993). Two distinct populations of prestalk cells within the tip of the migratory Dictyostelium slug with differing fates at culmination. Development 118, 353-362.
12. Esch, R. K. and Firtel, R. A. (1991). cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium. Genes Dev. 5, 9-21.
13. Haberstroh, L. and Firtel, R. A. (1990). A spatial gradient of expression of a cAMP-resulated prespore cell-type-specific gene in Dictyostelium. Genes Dev. 4, 596-612.
14. Hadwiger, J. A. and Firtel, R. A. (1992). Analysis of Gα4. a G-protein subunit required for multicellular development in Dictyostelium. Genes Dev. 6, 38-49.
15. Hadwiger, J. A., Lee, S. and Firtel, R. A. (1994). The Gα subunit Gα4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium. Proc. Natl. Acad. Sci. USA 91, 10566-10570.
16. Hadwiger, J. A., Wilkie, T. M., Strathmann, M. and Firtel, R. A. (1991). Identification of Dictyostelium Ga genes expressed during multicellular development. Proc. Natl. Acad. Sci. USA 88, 8213-8217.
17. Jermyn, K. A. and Williams, J. G. (1991). An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers. Development 111, 779-787.
18. Kalinec, G., Nazarali, A. J., Hermouet, S., Xu, N. and Gutkind, J. S. (1992). Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol. Cell Biol. 12, 4687-4693.
19. Kessin, R. H. (1977). Mutations causing rapid development of Dictyostelium discoideum. Cell 10, 703-708.
20. Kunkel, T. A. (1985). Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82, 488-492.
21. Landis, C. A., Masters, S. B., Spada, A., Pace, A. M., Bourne, H. R. and Vallar, L. (1989). GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340,692-696.
22. Loomis, W. F. (ed.) (1982). The Development of Dictyostelium discoideum. New York: Academic Press.
23. Lyons, J., Landis, C. A., Harsh, G., Vallar, L., Grunewald, K., Feichtinger, H., Duh, Q.-Y., Clark, O. H., Kawasaki, E., Bourne, H. R. and McCormick, F. (1990). Two G protein oncogenes in human endocrine tumors. Science 249, 655-659.
24. Mann, S. K. and Firtel, R. A. (1993). cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development. Development 119, 135-146.
25. Mann, S. K. O. and Firtel, R. A. (1987). Cyclic AMP regulation of early gene expression in Dictyostelium discoideum: Mediation via the cell surface cyclic AMP receptor Mol. Cell. Biol 7, 458-469.
26. Mann, S. K. O., Richardson, D. L., Lee, S., Kimmel, A. R. and Firtel, R. A. (1994). Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium Proc. Natl. Acad. Sci. USA 91, 10561-10565.
27. Mann, S. K. O., Yonemoto, W. M., Taylor, S. S. and Firtel, R. A. (1992). DdPK3, which plays essential roles during Dictyostelium development. encodes the catalytic subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 89, 10701-10705.
28. Matsukuma, S. and Durston, A. J. (1979). Chemotactic cell sorting in Dictyostelium discoideum. J. Embryol. Exp. Morph. 50, 243-251.
29. Okaichi, K., Cubitt, A. B., Pitt, G. S. and Firtel, R. A. (1992). Amino acid substitutions in the Dictyostelium Get subunit Gα2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase and phospholipase C. Mol. Biol. Cell 3, 735-747.
30. Osawa, S. and Johnson, G. L. (1991). A dominant negative Gαs mutant is rescued by secondary mutation of die alpha chain amino terminus. J. Biol. Chem. 266, 4673-4676.
31. Pupillo, M., Kumagai, A., Pitt, G. S., Firtel, R. A. and Devreotes, P. N. (1989). Multiple α subunits of guanine nucleotide-binding proteins in Dictyostelium. Proc. Natl. Acad. Sci. USA 86, 4892-4896.
32. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press.
33. Saxe, C. L., Ginsburg, G. T., Louis, J. M., Johnson, R., Devreotes, P. N. and Kimmel, A. R. (1993). CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes Dev. 7, 262-272.
34. Schnitzler, G. R., Briscoe, C., Brown, J. M. and Firtel, R. A. (1995). Serpentine cAMP receptors may act through a G-protein-independent pathway to induce post-aggregative development in Dictyostelium. Cell 81, 737-745..
35. Schnitzler, G., Fischer, W. and Firtel, R. (1994). Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development m Dictyostelium. Genes Dev. 8, 502-514.
36. Simon, M. I., Strathmann, M. P. and Gautam, N. (1991). Diversity of G proteins in signal transduction. Science 252, 802-808.
37. Simon, M. N., Pelegrini, O., Veron, M. and Kay, R. R. (1992). Mutation of protein kinase A causes heterochronic development of Dictyostelium. Nature 356, 171-172.
38. Sonneborn, D. R., White, G. J. and Sussman, M. (1963). Mutation affecting both rate and pattern of morphogenesis in Dictyostelium discoideum. Dev. Bioi. 7, 79-93.
39. Sternfeld, J. (1992) A study of pstB cells during Dictyosrelium migration and culmination reveals a unidirectional cell type conversion process. W.R. Arch. Der. Biol. 201, 354-363.
40. Sternfeld, J. and David, C. N. (1981). Cell sorting during pattern formation in Dictyostelium. Differentiation 20, 10-21.
41. Sternfeld, J. and David, C. N. (1982). Fate and regulation of anterior-like cells in Dictyostelium slugs. Dev: Biol. 93, 111-118.
42. Traynor, D., Kessin, R. H. and Williams, J. G. (1992). Chemotactic sorting to cAMP in the multicellular stages of Dictyostelium development. Proc. Natl. Acad. Sci. USA 89, 8303-8307.
43. Williams, J. G., Duffy, K. T., Lane, D. P., McRobbie, S. J., Harwood, A. J., Traynor, D., Kay, R. R. and Jermyn, K. A. (1989). Origins of the prestalk-prespore pattern in Dictyostelium development. Cell 59, 1157-1163.
44. Williams, J., Hopper, N., Early, A., Traynor, D., Harwood, A., Abe, T., Simon, M. and Veron, M. (1993). Interacting signalling pathways regulating prestalk cell differentiation and movement during the morphogenesis of Dictyostelium Development 1993 Supplement, 1-7.
45. Wu, L. J. and Devreotes, P. N. (1991). Dictyostelium transiently expresses eight distinct G-protein α-subunits during its developmental program. Biochem. Biophys. Res. Comm. 179, 1141-1147.
46. Wu, L., Gaskins, C., Zhou, K., Firtel, R. A. and Devreotes, P. N. (1994). Cloning and targeted mutations of Gα7 and Gα8, two developmentally regulated G protein α-subunit genes in Dictyostelium. Mol. Biol. Cell 5, 691-702.