Exploiting structural biology in the fight against parasitic diseases

Trends in Parasitology

Volumn 28, Issue 4, 2012, Pages 124-130

  Modis, Yorgo ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Disability Adjusted Life Year (DALY); Helminthic parasites; NMR; Protein Data Bank; Structure function studies; X ray crystallography

Indexed keywords

BACTERIAL PROTEIN; FUNGAL PROTEIN; MICROORGANISM PROTEIN; PROTOZOAL PROTEIN; VIRUS PROTEIN;

BACTERIUM; CRYSTALLIZATION; FUNGUS; HELMINTH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INFECTION PREVENTION; INFECTIOUS DIARRHEA; KINETOPLASTIDA; MACROMOLECULE; MALARIA; METAZOON; NONHUMAN; PARASITOSIS; PROTEIN DATA BANK; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; ROTAVIRUS; TUBERCULOSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; PARASITIC DISEASES; PARASITOLOGY; PROTEINS;

EUKARYOTA;

EID: 84859002085     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2012.01.003     Document Type: Review

References (47)

1. Newman J., et al. Phoenito experiments: combining the strengths of commercial crystallization automation. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 2008, 64:991-996.
2. Berry I.M., et al. SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects. Acta Crystallogr. D: Biol. Crystallogr. 2006, 62:1137-1149.
3. Pape T., Schneider T.R. HKL2MAP: a graphical user interface for macromolecular phasing with SHELX programs. J. Appl. Crystallogr. 2004, 37:843-844.
4. Adams P.D., et al. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D: Biol. Crystallogr. 2002, 58:1948-1954.
5. Langer G., et al. Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7. Nat. Protoc. 2008, 3:1171-1179.
6. Winn M.D., et al. Overview of the CCP4 suite and current developments. Acta Crystallogr. D: Biol. Crystallogr. 2011, 67:235-242.
7. Mathers C., et al. The Global Burden of Disease: 2004 Update 2008, World Health Organization.
8. Murray C.J. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull. World Health Organ. 1994, 72:429-445.
9. Murray C.J., Lopez A.D. Evidence-based health policy - lessons from the Global Burden of Disease Study. Science 1996, 274:740-743.
10. Myler P., et al. Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei. Nature 1984, 309:282-284.
11. Berriman M., et al. The genome of the African trypanosome Trypanosoma brucei. Science 2005, 309:416-422.
12. Scherf A., et al. Antigenic variation in Plasmodium falciparum. Annu. Rev. Microbiol. 2008, 62:445-470.
13. Stacy R., et al. Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 2011, 67:979-984.
14. Weiss M.S., Einspahr H. Publishing structural genomics results continued: the SSGCID special issue. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 2011, 67:1159.
15. Myler P.J., et al. The Seattle Structural Genomics Center for Infectious Disease (SSGCID). Infect. Disord. Drug Targets 2009, 9:493-506.
16. Anderson W.F. Structural genomics and drug discovery for infectious diseases. Infect. Disord. Drug Targets 2009, 9:507-517.
17. Gordon D.M., et al. Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine. J. Infect. Dis. 1995, 171:1576-1585.
18. Agnandji S.T., et al. First results of phase 3 trial of RTS, S/AS01 malaria vaccine in African children. N. Engl. J. Med. 2011, 365:1863-1875.
19. Hertz-Fowler C., Pain A. Sequence data swell for nematodes. Nat. Rev. Microbiol. 2008, 6:800-801.
20. Hotez P.J., et al. Hookworm: " the great infection of mankind" . PLoS Med. 2005, 2:e67.
21. Ghedin E., et al. Draft genome of the filarial nematode parasite Brugia malayi. Science 2007, 317:1756-1760.
22. Abubucker S., et al. The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences. Mol. Biochem. Parasitol. 2008, 157:187-192.
23. Bungiro R., Cappello M. Twenty-first century progress toward the global control of human hookworm infection. Curr. Infect. Dis. Rep. 2011, 13:210-217.
24. Hotez P.J., et al. Helminth infections: the great neglected tropical diseases. J. Clin. Invest. 2008, 118:1311-1321.
25. Hotez P.J., et al. Control of neglected tropical diseases. N. Engl. J. Med. 2007, 357:1018-1027.
26. McClain B., et al. X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J. Mol. Biol. 2010, 397:587-599.
27. Settembre E.C., et al. Atomic model of an infectious rotavirus particle. EMBO J. 2011, 30:408-416.
28. Daher W., Soldati-Favre D. Mechanisms controlling glideosome function in apicomplexans. Curr. Opin. Microbiol. 2009, 12:408-414.
29. Sibley L.D. Intracellular parasite invasion strategies. Science 2004, 304:248-253.
30. Dobrowolski J.M., Sibley L.D. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 1996, 84:933-939.
31. Gordon J.L., Sibley L.D. Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites. BMC Genomics 2005, 6:179.
32. Dobrowolski J.M., et al. Actin in the parasite Toxoplasma gondii is encoded by a single copy gene, ACT1 and exists primarily in a globular form. Cell Motil. Cytoskeleton 1997, 37:253-262.
33. Kucera K., et al. Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. J. Mol. Biol. 2010, 403:616-629.
34. De La Cruz E.M. Cofilin binding to muscle and non-muscle actin filaments: isoform-dependent cooperative interactions. J. Mol. Biol. 2005, 346:557-564.
35. Crepin T., et al. A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase. J. Mol. Biol. 2011, 405:1056-1069.
36. Perbandt M., et al. Structure of the major cytosolic glutathione S-transferase from the parasitic nematode Onchocerca volvulus. J. Biol. Chem. 2005, 280:12630-12636.
37. Perbandt M., et al. Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus. J. Mol. Biol. 2008, 377:501-511.
38. Wang Z., et al. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:9138-9143.
39. Asojo O.A., et al. X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanus. BMC Struct. Biol. 2007, 7:42.
40. Asojo O.A., et al. X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection. J. Mol. Biol. 2005, 346:801-814.
41. Murakami M.T., et al. Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematophagous nematode Ancylostoma caninum. J. Mol. Biol. 2007, 366:602-610.
42. Asojo O.A. Structure of a two-CAP-domain protein from the human hookworm parasite Necator americanus. Acta Crystallogr. D: Biol. Crystallogr. 2011, 67:455-462.
43. Cho Y.S., et al. Structural and functional characterization of a secreted hookworm macrophage migration inhibitory factor (MIF) that interacts with the human MIF receptor CD74. J. Biol. Chem. 2007, 282:23447-23456.
44. Rios-Steiner J.L., et al. Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum. J. Mol. Biol. 2007, 371:774-786.
45. Kucera K., et al. Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins. J. Mol. Biol. 2011, 408:9-17.
46. DeLano W.L. The PyMOL Molecular Graphics System 2010, Schrödinger, LLC, Version 1.3.
47. Lanata C.F., Mendoza W. Improving Diarrhoea Estimates 2002, World Health Organization.