Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 23, 2009, Pages 9138-9143

  Wang, Zhu ^a   Zhou, X Edward ^c   Motola, Daniel L ^a,g   Gao, Xin ^d   Suino Powell, Kelly ^c   Conneely, Aoife ^c   Ogata, Craig ^e   Sharma, Kamalesh K ^a   Auchus, Richard J ^a   Lok, James B ^f   Hawdon, John M ^d   Kliewer, Steven A ^a,b   Xu, H Eric ^c   Mangelsdorf, David J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g MOUNT SINAI HOSPITAL   (United States)

Author keywords

Dafachronic acid; Parasitology; Pharmacology; X ray crystal structure

Indexed keywords

CELL NUCLEUS RECEPTOR; DAFACHRONIC ACID; NUCLEAR RECEPTOR DAF 12; STEROID; UNCLASSIFIED DRUG;

ANCYLOSTOMA; ARTICLE; BINDING ASSAY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CRYSTALLIZATION; DEVELOPMENTAL STAGE; DIAPAUSE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; LARVAL DEVELOPMENT; LIGAND BINDING; NECATOR AMERICANUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRONGYLOIDES STERCORALIS; STRONGYLOIDIASIS; STRUCTURE ANALYSIS;

ANCYLOSTOMA; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; CHOLESTENES; CRYSTALLOGRAPHY, X-RAY; HUMANS; LARVA; MODELS, MOLECULAR; NECATOR AMERICANUS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROIDS; STRONGYLIDA INFECTIONS; STRONGYLOIDES STERCORALIS;

ANCYLOSTOMA; CAENORHABDITIS ELEGANS; NECATOR AMERICANUS; NEMATODA; STRONGYLOIDES STERCORALIS;

EID: 67249153259     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904064106     Document Type: Article

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