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Buscaglia C.A., Coppens I., Hol W.G., and Nussenzweig V. Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium. Mol Biol Cell 14 (2003) 4947-4957
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Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein
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Buscaglia C.A., Penesetti D., Tao M., and Nussenzweig V. Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein. J Biol Chem 281 (2006) 1324-1331
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Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite
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Bosch J., Buscaglia C.A., Krumm B., Ingason B.P., Lucas R., Roach C., Cardozo T., Nussenzweig V., and Hol W.G. Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc Natl Acad Sci U S A 104 (2007) 7015-7020
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Aldolase is essential for energy production and bridging adhesion-actin cytoskeletal interactions during parasite invasion of host cells
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Aldolase was reported to bridge host cell receptors to the parasite actin filaments via interaction with adhesins. In this study, the authors generated a conditional KO of TgALD and in a series of complementation experiments using aldolase mutants affected either in enzyme activity or in binding to MIC2, they established the dual essential role of aldolase in energy production and host cell invasion.
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Starnes G.L., Coincon M., Sygusch J., and Sibley L.D. Aldolase is essential for energy production and bridging adhesion-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host Microbe 5 (2009) 353-364. Aldolase was reported to bridge host cell receptors to the parasite actin filaments via interaction with adhesins. In this study, the authors generated a conditional KO of TgALD and in a series of complementation experiments using aldolase mutants affected either in enzyme activity or in binding to MIC2, they established the dual essential role of aldolase in energy production and host cell invasion.
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Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites
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This study highlights the importance of glycolysis in empowering the gliding motility in Toxoplasma gondii. Authors provide the first demonstration of a striking relocalization of glycolytic enzymes from parasites cytoplasm to the pellicle upon egress from host cells.
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Pomel S., Luk F.C., and Beckers C.J. Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites. PLoS Pathog 4 (2008) e1000188. This study highlights the importance of glycolysis in empowering the gliding motility in Toxoplasma gondii. Authors provide the first demonstration of a striking relocalization of glycolytic enzymes from parasites cytoplasm to the pellicle upon egress from host cells.
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Host-Derived Glucose and its Transporter in the Obligate Intracellular Pathogen Toxoplasma gondii are Dispensable by Glutaminolysis
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in press
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Blume M, Rodriguez-Contreras D, Landfear S, Fleige T, Soldati-Favre D, Lucius R, Gupta N: Host-Derived Glucose and its Transporter in the Obligate Intracellular Pathogen Toxoplasma gondii are Dispensable by Glutaminolysis, Proc Natl Acad Sci USA 2009, in press.
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Proc Natl Acad Sci USA
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Blume, M.1
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Gupta, N.7
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48
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Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei
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Promeneur D., Liu Y., Maciel J., Agre P., King L.S., and Kumar N. Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Proc Natl Acad Sci U S A 104 (2007) 2211-2216
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Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei
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Zeuthen T., Wu B., Pavlovic-Djuranovic S., Holm L.M., Uzcategui N.L., Duszenko M., Kun J.F., Schultz J.E., and Beitz E. Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol Microbiol 61 (2006) 1598-1608
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50
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Distinct physiological states of Plasmodium falciparum in malaria-infected patients
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This study provides important ground work for analyzing host-parasite interaction. The availability of this dataset provides biochemical evidence that the physiological states of the malaria parasite in different in vivo conditions.
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Daily J.P., Scanfeld D., Pochet N., Le Roch K., Plouffe D., Kamal M., Sarr O., Mboup S., Ndir O., Wypij D., et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 450 (2007) 1091-1095. This study provides important ground work for analyzing host-parasite interaction. The availability of this dataset provides biochemical evidence that the physiological states of the malaria parasite in different in vivo conditions.
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Nature
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Daily, J.P.1
Scanfeld, D.2
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Le Roch, K.4
Plouffe, D.5
Kamal, M.6
Sarr, O.7
Mboup, S.8
Ndir, O.9
Wypij, D.10
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