Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum

Journal of Molecular Biology

Volumn 366, Issue 2, 2007, Pages 602-610

  Murakami, M T ^a   Rios Steiner, J ^b   Weaver, S E ^b   Tulinsky, A ^b   Geiger, J H ^b   Arni, R K ^a,c  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c CAT CEPID   (Brazil)

Author keywords

factor VIIa tissue factor complex; factor Xa exosite; inhibition; nematode anticoagulant protein; selectide inhibitor

Indexed keywords

4 CARBOXYGLUTAMIC ACID; ANTICOAGULANT PROTEIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; DRUG RESIDUE; FACTOR XA EXOSITE; NAPC2 PROTEIN; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANCYLOSTOMA CANINUM; ANGIOPLASTY; ARTICLE; BETA SHEET; BLOOD CLOTTING; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; DEEP VEIN THROMBOSIS; ENZYME INHIBITION; HUMAN; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE;

ANCYLOSTOMA CANINUM;

EID: 33846377756     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.11.040     Document Type: Article

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