Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools

Biochemistry

Volumn 44, Issue 17, 2005, Pages 6670-6674

  Ito, Riyoko ^a   Hayakawa, Hiroshi ^b   Sekiguchi, Mutsuo ^a,c   Ishibashi, Toru ^a,c  

^a FUKUOKA DENTAL COLLEGE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; ENZYMES; ESCHERICHIA COLI; NUCLEIC ACIDS; OXYGEN; PROTEINS; RNA;

CELLULAR METABOLIC PROCESSES; MULTIPLE ENZYME ACTIVITIES; NUCLEOTIDES; REACTIVE OXYGEN;

BIOCHEMISTRY;

8 HYDROXYGUANINE; 8 OXO 7,8 DIHDYRO 2' DEOXYGUANOSINE 5' DIPHOSPHATE; 8 OXO 7,8 DIHDYRO 2' DEOXYGUANOSINE 5' TRIPHOSPHATE; BACTERIAL PROTEIN; DNA; GUANOSINE DERIVATIVE; GUANOSINE DIPHOSPHATE; PHOSPHORUS DERIVATIVE; PROTEIN MUTT; RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DNA TRANSCRIPTION; ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RNA SYNTHESIS;

DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA REPLICATION; DNA, BACTERIAL; ESCHERICHIA COLI PROTEINS; GUANINE; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; KINETICS; MULTIENZYME COMPLEXES; PHOSPHORIC MONOESTER HYDROLASES; PYROPHOSPHATASES; RNA, BACTERIAL; THYMINE NUCLEOTIDES; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI;

EID: 17844405031     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047550k     Document Type: Article

References (24)

1. Sekiguchi, M. (1996) MutT-related error avoidance mechanism for DNA synthesis, Genes Cells 1, 139-145.
2. Treffers, H. P., Spinelli, V., and Belser, N. O. (1954) A factor (or mutator gene) influencing mutation rates in Eschenchia coli, Proc. Natl. Acad. Sci. U.S.A. 40, 1064-1071.
3. Yanofsky, C., Cox, E. C., and Horn, V. (1966) The unusual mutagenic specificity of an E. coli mutator gene, Proc. Natl. Acad. Sci. U.S.A. 55, 274-281.
4. Cox, E. C., and Yanofsky, C. (1967) Altered base ratios in the DNA of an Eschenchia coli mutator strain, Proc. Natl. Acad. Sci. U.S.A. 58, 1895-1902.
5. Akiyama, M., Horiuchi, T., and Sekiguchi, M. (1987) Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that cause A:T to C:G transversion, Mol. Gen. Genet. 206, 9-16.
6. Bhatnagar, S. K., and Bessman, M. J. (1988) Studies on the mutator gene, mutT of Eschenchia coli, J. Biol. Chem. 263, 8953-8957.
7. Akiyama, M., Maki, H., Sekiguchi, M., and Horiuchi, T. (1989) A specific role of MutT protein: To prevent dG·dA mispairing in DNA replication, Proc. Natl. Acad. Sci. U.S.A. 86, 3949-3952.
8. Maki, H., and Sekiguchi, M. (1992) MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis, Nature 355, 273-275.
9. Mo, J.-Y., Maki, H., and Sekiguchi, M. (1992) Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of nucleotide pool, Proc. Natl. Acad. Sci. U.S.A. 89, 11021-11025.
10. Cai, J.-P., Ishibashi, T., Takagi, Y., Hayakawa, H., and Sekiguchi, M. (2003) Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides, Biochem. Biophys. Res. Commun. 305, 1073-1077.
11. Ishibashi, T., Hayakawa, H., and Sekiguchi, M. (2003) A novel mechanism for preventing mutations caused by oxidation of guaine nucleotides, EMBO Rep. 4, 479-483.
12. Furuichi, M., Yoshida, M. C., Oda, H., Tajiri, T., Nakabeppu, Y., Tsuzuki, T., and Sekiguchi, M. (1994) Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion, Genomics 24, 485-490.
13. Tajiri, T., Maki, H., and Sekiguchi, M. (1995) Functional cooperation of MutT, MutM, and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli, Mutat. Res. 336, 257-267.
14. Taddei, F., Hayakawa, H., Bouton, M.-F., Cirinesi, A.-M., Matic, I., Sekiguchi, M., and Radman, M. (1997) Counteraction by MutT protein of transcriptional errors caused by oxidative damage, Science 278, 128-130.
15. Shimokawa, H., Fujii, Y., Furuichi, M., Sekiguchi, M., and Nakabeppu, Y. (2000) Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein, Nucleic Acid Res. 28, 3240-3249.
16. Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y., and Kasai, H. (1999) The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein, J. Biol. Chem. 274, 18201-18205.
17. Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., and Loeb, L. A. (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions, J. Biol. Chem. 267, 166-172.
18. Schaaper, R. M., Danforth, B. N., and Glickman, B. W. (1986) Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lac1 gene, J. Mol. Biol. 189, 273-284.
19. Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H., and Sekiguchi, M. (1993) Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis, J. Biol. Chem. 268, 23524-23530.
20. Yang, H., Slupska, M. M., Wei, Y. F., Tai, J. H., Luther, W. M., Xia, Y.-R., Shih, D. M., Chiang, J.-H., Baikalov, C., Fitz-Gibbon, S., Phan, I. T., Conrad, A., and Miller, J. H. (2000) Cloning and characterization of a new member of the Nudix hydrolases from human and mouse, J. Biol. Chem. 275, 8844-8853.
21. Mclennan, A. G. (1999) The mutT motif family of nucleotide phosphohydrolases in man and human pathogens, Int. J. Mol. Med. 4, 79-89.
22. Reichard, P. (1987) Regulation of deoxyribotide synthesis, Biochemistry 26, 3245-3248.
23. Hayakawa, H., Hofer, A., Thelander, L., Kitajima, S., Cai, Y., Oshiro, S., Yakushiji, H., Nakabeppu, Y., Kuwano, M., and Sekiguchi, M. (1999) Metabolic fate of oxidized guanine ribonucleotides in mammalian cells, Biochemistry 38, 3610-3614.
24. Hayakawa, H., Taketomi, A., Sakumi, K., Kuwano, M., and Sekiguchi, M. (1995) Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells, Biochemistry 34, 89-95.