Structural basis for ligand-mediated mouse GITR activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 2, 2008, Pages 641-645

  Zhou, Zhaocai ^a   Tone, Yukiko ^a   Song, Xiaomin ^a   Furuuchi, Keiji ^a   Lear, James D ^a   Waldmann, Herman ^b   Tone, Masahide ^a   Greene, Mark I ^a   Murali, Ramachandran ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Costimulation; Oligomerization; Regulatory; T cell; TNF

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADAPTIVE IMMUNITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; INNATE IMMUNITY; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; LIGANDS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NF-KAPPA B; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES; TUMOR NECROSIS FACTORS;

EID: 38649115316     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711206105     Document Type: Article

References (25)

1. Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 94:6216-6221.
2. Tone M, et al. (2003) Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci USA 100:15059-15064.
3. Stephens GL, et al. (2004) Engagement of glucocorticoid-induced TNFR family related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 173:5008-5020.
4. Gurney AL, et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol 9:215-218.
5. Nocentini G, et al. (2000) Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family. DNA Cell Biol 19:205-217.
6. Watts TH (2005) TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23:23-68.
7. Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem 274:6056-6061.
8. Riccardi C, Cifone MG, Migliorati G (1999) Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: Role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ 6:1182-1189.
9. Zhang G (2004) Tumor necrosis factor family ligand-receptor binding. Curr Opin Struct Biol 14:154-160.
10. Bossen C, et al. (2006) Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem 281:13964-13971.
11. Compaan DM, Hymowitz SG (2006) The crystal structure of the costimulatory OX40-OX40L complex. Structure (London) 14:1321-1330.
12. Eldredge J, et al. (2006) Stoichiometry of LTbetaR binding to LIGHT. Biochemistry 45:10117-10128.
13. Nocentini G, Ronchetti S, Cuzzocrea S, Riccardi C (2007) GITR/GITRL: More than an effector T cell costimulatory system. Eur J Immunol 37:1165-1169.
14. Ward CW, Lawrence MC, Streltsov VA, Adams TE, McKern NM (2007) The insulin and EGF receptor structures: New insights into ligand-induced receptor activation. Trends Biochem Sci 32:129-137.
15. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S (2002) Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3:135-142.
16. Cachero TG, et al. (2006) Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry 45:2006-2013.
17. Bazzoni F, Alejos E, Beutler B (1995) Chimeric tumor necrosis factor receptors with constitutive signaling activity. Proc Natl Acad Sci USA 92:5376-5380.
18. Otwinowski Z, Minor W (1997) Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol 276:307-326.
19. Terwilliger TC (2003) Automated main-chain model building by template matching and iterative fragment extension. Acta Crystallogr D 59:38-44.
20. Terwilliger TC, Berendzen J (1999) Automated MAD, MIR structure solution. Acta Crystallogr D 55:849-861.
21. Hymowitz SG, et al. (2003) The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity. Structure (London) 11:1513-1520.
22. Jones TA, Zou JY, Cowan SW, Kjeldgaard M (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47:110-119.
23. Brunger AT, et al. (1998) Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D 54:905-921.
24. Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283-291.
25. CCP4 (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D 50:760-763.