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Volumn 10, Issue 5, 2009, Pages 476-482

Enhanced α-synuclein expression in human neurodegenerative diseases: Pathogenetic and therapeutic implications

Author keywords

synuclein; Aggregation; Aging; Autophagy; Neurotoxins; Parkinson's disease; RNA interference; Substantia nigra

Indexed keywords

ALPHA SYNUCLEIN;

EID: 70349481750     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920309789351912     Document Type: Review
Times cited : (21)

References (73)
  • 2
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini, M.G.; Crowther, R.A.; Jakes, R.; Hasegawa, M.; Goerdert, M. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA, 1998, 95, 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goerdert, M.5
  • 4
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba, M.; Nakajo, S.; Tu, P.H.; Tomita, T.; Nakaya, K.; Lee, V.M.; Trojanowski, J.Q.; Iwatsubo, T. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol., 1998, 152, 879-884.
    • (1998) Am. J. Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Trojanowski, J.Q.7    Iwatsubo, T.8
  • 7
    • 0036679197 scopus 로고    scopus 로고
    • α-Synucleinopathy and selective dopaminergic loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco, C.; Ridet, J-L.; Schneider, B.L.; Déglon, N.; Aebischer, P. α-Synucleinopathy and selective dopaminergic loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl. Acad. Sci. USA, 2002, 99, 10813-10818.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.-L.2    Schneider, B.L.3    Déglon, N.4    Aebischer, P.5
  • 8
    • 0345269757 scopus 로고    scopus 로고
    • Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease
    • Kirik, D.; Annett, L.E., Burger, C.; Muzyczka, N.; Mandel, R.J.; Björklund, A. Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: a new primate model of Parkinson's disease. Proc. Natl. Acad. Sci. USA, 2003, 100, 2884-2889.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2884-2889
    • Kirik, D.1    Annett, L.E.2    Burger, C.3    Muzyczka, N.4    Mandel, R.J.5    Björklund, A.6
  • 13
    • 33751019425 scopus 로고    scopus 로고
    • Levels of α-synuclein mRNA in sporadic Parkinson's disease patients
    • Chiba-Falek, O.; Lopez, G.J.; Nussbaum, R.L. Levels of α-synuclein mRNA in sporadic Parkinson's disease patients. Mov. Disord., 2006, 21, 1703-1708.
    • (2006) Mov. Disord , vol.21 , pp. 1703-1708
    • Chiba-Falek, O.1    Lopez, G.J.2    Nussbaum, R.L.3
  • 18
    • 42549095759 scopus 로고    scopus 로고
    • Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
    • Gründemann, J.; Schlaudraff, F.; Haeckel, O.; Liss, B. Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res., 2008, 36, e38.
    • (2008) Nucleic Acids Res , vol.36
    • Gründemann, J.1    Schlaudraff, F.2    Haeckel, O.3    Liss, B.4
  • 19
    • 0029904487 scopus 로고    scopus 로고
    • Weinreb, P.H.; Zhen, W.; Poon, A.W.; Conway, K.A.; Lansbury, P.T. Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry, 1996, 35, 13709-13715.
    • Weinreb, P.H.; Zhen, W.; Poon, A.W.; Conway, K.A.; Lansbury, P.T. Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry, 1996, 35, 13709-13715.
  • 20
    • 0035815115 scopus 로고    scopus 로고
    • Conformational properties of α-synuclein in its free and lipid-associated states
    • Eliezer, D.; Kutluay, E.; Bussell, R.; Jr.; Browne, G. Conformational properties of α-synuclein in its free and lipid-associated states. J. Mol. Biol., 2001, 307, 1061-1073.
    • (2001) J. Mol. Biol , vol.307 , pp. 1061-1073
    • Eliezer, D.1    Kutluay, E.2    Bussell Jr., R.3    Browne, G.4
  • 21
    • 0033538541 scopus 로고    scopus 로고
    • α-Synuclein fibrillogenesis is nucleation-dependent: Implications for the pathogenesis of Parkinson's disease
    • Wood, S.J.; Wypych, J.; Steavenson, S.; Louis, J.C.; Citron, M.; Biere, A.L. α-Synuclein fibrillogenesis is nucleation-dependent: implications for the pathogenesis of Parkinson's disease. J. Biol. Chem., 1999, 274, 19509-19512.
    • (1999) J. Biol. Chem , vol.274 , pp. 19509-19512
    • Wood, S.J.1    Wypych, J.2    Steavenson, S.3    Louis, J.C.4    Citron, M.5    Biere, A.L.6
  • 22
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway, K.A.; Harper, J.D.; Lansbury, P.T. Jr. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry, 2000, 39, 2552-2563.
    • (2000) Biochemistry , vol.39 , pp. 2552-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury Jr., P.T.3
  • 23
    • 0035941305 scopus 로고    scopus 로고
    • Stabilization of partially folded conformation during α-synuclein oligomerization in both purified and cytosolic preparations
    • Uversky, V.N.; Lee, H.J.; Li, J.; Fink, A.L.; Lee, S.J. Stabilization of partially folded conformation during α-synuclein oligomerization in both purified and cytosolic preparations. J. Biol. Chem., 2001, 276, 43495-43498.
    • (2001) J. Biol. Chem , vol.276 , pp. 43495-43498
    • Uversky, V.N.1    Lee, H.J.2    Li, J.3    Fink, A.L.4    Lee, S.J.5
  • 24
    • 0035815664 scopus 로고    scopus 로고
    • Evidence for a partially folded intermediate in α-synuclein fibril formation
    • Uversky, V.N.; Li, J.; Fink, A.L. Evidence for a partially folded intermediate in α-synuclein fibril formation. J. Biol. Chem., 2001, 276, 10737-10744.
    • (2001) J. Biol. Chem , vol.276 , pp. 10737-10744
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 25
    • 0037177250 scopus 로고    scopus 로고
    • Molecular crowding accelerates fibrillization of α-synuclein: Could an increase in the cytoplasmic protein concentration induce Parkinson's disease?
    • Shtilerman, M.D.; Ding, T.T.; Lansbury, P.T.; Jr. Molecular crowding accelerates fibrillization of α-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease? Biochemistry, 2002, 41, 3855-3860.
    • (2002) Biochemistry , vol.41 , pp. 3855-3860
    • Shtilerman, M.D.1    Ding, T.T.2    Lansbury Jr., P.T.3
  • 27
    • 0033966487 scopus 로고    scopus 로고
    • α-Synuclein up-regulation in the substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila, M.; Vukosavic, S.; Jackson-Lewis, V.; Neystat, M.; Jakowec, M.; Przedborski, S. α-Synuclein up-regulation in the substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem., 2004, 74, 721-729.
    • (2004) J. Neurochem , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 29
    • 20144389039 scopus 로고    scopus 로고
    • Occurrence of neuronal inclusions combined with increased nigral expression of α-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice
    • Fornai, F.; Lenzi, P.; Ferrucci, M.; Lazzeri, G.; di Poggio, A.B.; Natale, G.; Busceti, C.L.; Biagioni, F.; Giusiani, M.; Ruggieri, S.; Paparelli, A. Occurrence of neuronal inclusions combined with increased nigral expression of α-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice. Brain Res. Bull., 2005, 65, 405-413.
    • (2005) Brain Res. Bull , vol.65 , pp. 405-413
    • Fornai, F.1    Lenzi, P.2    Ferrucci, M.3    Lazzeri, G.4    di Poggio, A.B.5    Natale, G.6    Busceti, C.L.7    Biagioni, F.8    Giusiani, M.9    Ruggieri, S.10    Paparelli, A.11
  • 32
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton, D.F.; George, J.M. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci., 1998, 21, 249-254.
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 34
    • 52249119906 scopus 로고    scopus 로고
    • McCormack, A.L.; Mak, S.K.; Shenasa, M.; Langston, J.W.; Forno, L.S.; Di Monte, D.A. Pathological modifications of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. J. Neuropathol. Exp. Neurol., 2008, 67, 793-802.
    • McCormack, A.L.; Mak, S.K.; Shenasa, M.; Langston, J.W.; Forno, L.S.; Di Monte, D.A. Pathological modifications of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. J. Neuropathol. Exp. Neurol., 2008, 67, 793-802.
  • 37
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of α-synuclein fibril formation: A possible risk factor in Parkinson's disease
    • Uversky V.N.; Li, J.; Fink, A.L. Pesticides directly accelerate the rate of α-synuclein fibril formation: a possible risk factor in Parkinson's disease. FEBS Lett., 2001, 500, 105-108.
    • (2001) FEBS Lett , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 38
    • 0042521076 scopus 로고    scopus 로고
    • The environment and Parkinson's disease: Is the nigrostriatal system preferentially targeted by neurotoxins?
    • Di Monte, D.A. The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet, 2003, 2, 531-538.
    • (2003) Lancet , vol.2 , pp. 531-538
    • Di Monte, D.A.1
  • 39
    • 0001496694 scopus 로고    scopus 로고
    • Burns, R.S.; Chiueh, C.C.; Markey, S.P.; Ebert, M.H.; Jacobowitz, D.M.; Kopin, I.J. A primate model of parkinsonism: selective destruction of the dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA, 1983, 80, 4546-4550.
    • Burns, R.S.; Chiueh, C.C.; Markey, S.P.; Ebert, M.H.; Jacobowitz, D.M.; Kopin, I.J. A primate model of parkinsonism: selective destruction of the dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA, 1983, 80, 4546-4550.
  • 40
    • 0034114557 scopus 로고    scopus 로고
    • Relationship between nigrostriatal denervation, parkinsonism and dyskinesias in the MPTP primate model
    • Di Monte, D.A.; McCormack, A.L.; Petzinger, G.M.; Janson, A.M.; Quik, M.; Langston, J.W. Relationship between nigrostriatal denervation, parkinsonism and dyskinesias in the MPTP primate model. Mov. Disord., 2000, 15, 459-466.
    • (2000) Mov. Disord , vol.15 , pp. 459-466
    • Di Monte, D.A.1    McCormack, A.L.2    Petzinger, G.M.3    Janson, A.M.4    Quik, M.5    Langston, J.W.6
  • 44
    • 0026569594 scopus 로고
    • Aging produces a specific pattern of striatal dopamine loss: Implications for the etiology of Parkinson's disease
    • Kish, S.J.; Shannak, K.; Rajput, A.; Deck, J.H.; Hornykiewicz, O. Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of Parkinson's disease. J. Neurochem., 1992, 58, 642-648.
    • (1992) J. Neurochem , vol.58 , pp. 642-648
    • Kish, S.J.1    Shannak, K.2    Rajput, A.3    Deck, J.H.4    Hornykiewicz, O.5
  • 46
    • 0036270056 scopus 로고    scopus 로고
    • Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys
    • Gerhardt, G.A.; Cass, W.A.; Yi, A.; Zhang, Z.; Gash, D.M. Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. J. Neurochem., 2002, 80, 168-177.
    • (2002) J. Neurochem , vol.80 , pp. 168-177
    • Gerhardt, G.A.1    Cass, W.A.2    Yi, A.3    Zhang, Z.4    Gash, D.M.5
  • 48
    • 33947211176 scopus 로고    scopus 로고
    • Age-related changes in the nigrostriatal dopamine system and the response to MPTP in non-human primates: Diminished compensatory mechanisms as a prelude to parkinsonism
    • Collier, T.J.; Lipton, J.; Daley, B.F.; Palfi, S.; Chu, Y.; Sortwell, C.; Bakay, R.A.; Sladek, J.R. Jr.; Kordower, J.H. Age-related changes in the nigrostriatal dopamine system and the response to MPTP in non-human primates: diminished compensatory mechanisms as a prelude to parkinsonism. Neurobiol. Dis., 2007, 26, 56-65.
    • (2007) Neurobiol. Dis , vol.26 , pp. 56-65
    • Collier, T.J.1    Lipton, J.2    Daley, B.F.3    Palfi, S.4    Chu, Y.5    Sortwell, C.6    Bakay, R.A.7    Sladek Jr., J.R.8    Kordower, J.H.9
  • 49
  • 50
    • 0037116582 scopus 로고    scopus 로고
    • The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout life and is dramatically decreased in Parkinson's disease
    • Zecca, L.; Fariello, R.; Riederer, P.; Sulzer, D.; Gatti, A.; Tampellini, D. The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout life and is dramatically decreased in Parkinson's disease. FEBS Lett., 2002, 510, 216-220.
    • (2002) FEBS Lett , vol.510 , pp. 216-220
    • Zecca, L.1    Fariello, R.2    Riederer, P.3    Sulzer, D.4    Gatti, A.5    Tampellini, D.6
  • 51
    • 7244243876 scopus 로고    scopus 로고
    • Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation
    • Li, W.; Lesuisse, C.; Xu, Y.; Troncoso, J.C.; Price, D.L.; Lee, M.K. Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation. J. Neurosci., 2004, 24, 7400-7409.
    • (2004) J. Neurosci , vol.24 , pp. 7400-7409
    • Li, W.1    Lesuisse, C.2    Xu, Y.3    Troncoso, J.C.4    Price, D.L.5    Lee, M.K.6
  • 52
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Chu, Y.; Kordower, J.H. Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiol. Dis., 2007, 25, 134-149.
    • (2007) Neurobiol. Dis , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 53
    • 0032960760 scopus 로고    scopus 로고
    • Developmental expression of α-synuclein in rat hippocampus and cerebral cortex
    • Petersen, K.; Olesen, O.F.; Mikkelsen, J.D. Developmental expression of α-synuclein in rat hippocampus and cerebral cortex. Neuroscience, 1999, 91, 651-659.
    • (1999) Neuroscience , vol.91 , pp. 651-659
    • Petersen, K.1    Olesen, O.F.2    Mikkelsen, J.D.3
  • 54
    • 16444371982 scopus 로고    scopus 로고
    • Expression of α-synuclein in different brain parts of adult and aged rats
    • Adamczyk, A.; Solecka, J.; Strosznajder, J.B. Expression of α-synuclein in different brain parts of adult and aged rats. J. Physiol. Pharmacol., 2005, 56, 29-37.
    • (2005) J. Physiol. Pharmacol , vol.56 , pp. 29-37
    • Adamczyk, A.1    Solecka, J.2    Strosznajder, J.B.3
  • 57
    • 0037383760 scopus 로고    scopus 로고
    • Regional distribution of α-synuclein pathology in unimpaired aging and Alzheimer's disease
    • Parkkinen, L.; Soininen, H.; Alafuzoff, I. Regional distribution of α-synuclein pathology in unimpaired aging and Alzheimer's disease. J. Neuropathol. Exp. Neurol., 2003, 62, 363-367.
    • (2003) J. Neuropathol. Exp. Neurol , vol.62 , pp. 363-367
    • Parkkinen, L.1    Soininen, H.2    Alafuzoff, I.3
  • 58
    • 7944238570 scopus 로고    scopus 로고
    • Lewy body-related α-synucleinopathy in the aged human brain
    • Jellinger, K. Lewy body-related α-synucleinopathy in the aged human brain. J. Neural Transm., 2004, 111, 1219-1235.
    • (2004) J. Neural Transm , vol.111 , pp. 1219-1235
    • Jellinger, K.1
  • 59
    • 14844333173 scopus 로고    scopus 로고
    • Alpha-synuclein lesions in normal aging, Parkinson's disease, and Alzheimer's disease: Evidence from the Baltimore longitudinal study of aging (BLSA)
    • Mikolaenko, I.; Pletnikova, O.; Kazwas, C.H.; O'Brien, R.; Resnick, S.M.; Crain, B.; Troncoso, J.C. Alpha-synuclein lesions in normal aging, Parkinson's disease, and Alzheimer's disease: Evidence from the Baltimore longitudinal study of aging (BLSA). J. Neuropathol. Exp. Neurol., 2005, 64, 156-162.
    • (2005) J. Neuropathol. Exp. Neurol , vol.64 , pp. 156-162
    • Mikolaenko, I.1    Pletnikova, O.2    Kazwas, C.H.3    O'Brien, R.4    Resnick, S.M.5    Crain, B.6    Troncoso, J.C.7
  • 63
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 2001, 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 64
    • 33645159024 scopus 로고    scopus 로고
    • RNA knockdown as a potential therapeutic strategy in Parkinson's disease
    • Manfredsson, F.P.; Lewin, A.S.; Mandel, R.J. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Ther., 2006, 13, 517-524.
    • (2006) Gene Ther , vol.13 , pp. 517-524
    • Manfredsson, F.P.1    Lewin, A.S.2    Mandel, R.J.3
  • 66
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
    • Cuervo, A.M.; Stefanis, L.; Fredenburg, R.; Lansbury, P.T.; Sulzer, D. Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy. Science, 2004, 305, 1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 67
    • 53049098471 scopus 로고    scopus 로고
    • Wild-type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi, T.; Xilouri, M.; Vekrellis, K.; Stefanis, L. Wild-type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem., 2008, 283, 23542-23556.
    • (2008) J. Biol. Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 69
    • 33847652900 scopus 로고    scopus 로고
    • Autophagy and neurodegeneration: When the cleaning crew goes on strike
    • Martinez-Vicente, M.; Cuervo, A.M. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol., 2007, 6, 352-361.
    • (2007) Lancet Neurol , vol.6 , pp. 352-361
    • Martinez-Vicente, M.1    Cuervo, A.M.2
  • 70
    • 4344650564 scopus 로고    scopus 로고
    • Dopamine and L-Dopa disaggregate amyloid fibrils: Implications for Parkinson's and Alzheimer's disease
    • Li, J.; Zhu, M.; Manning-Bog, A.B.; Di Monte, D.A.; Fink, A.L. Dopamine and L-Dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease. FASEB J., 2004, 18, 962-964.
    • (2004) FASEB J , vol.18 , pp. 962-964
    • Li, J.1    Zhu, M.2    Manning-Bog, A.B.3    Di Monte, D.A.4    Fink, A.L.5
  • 71
    • 3042547187 scopus 로고    scopus 로고
    • The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils
    • Zhu, M.; Rajamani, S.; Kaylor, J.; Han, S.; Zhou, F.; Fink, A.L. The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils. J. Biol. Chem., 2004, 279, 26846-26857.
    • (2004) J. Biol. Chem , vol.279 , pp. 26846-26857
    • Zhu, M.1    Rajamani, S.2    Kaylor, J.3    Han, S.4    Zhou, F.5    Fink, A.L.6
  • 72
    • 20444401187 scopus 로고    scopus 로고
    • Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations
    • Norris, E.H.; Giasson, B.I.; Hodara, R.; Xu, S.; Trojanowski, J.Q.; Ischiropoulos, H.; Lee, V.M. Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J. Biol. Chem., 2005, 280, 21212-21219.
    • (2005) J. Biol. Chem , vol.280 , pp. 21212-21219
    • Norris, E.H.1    Giasson, B.I.2    Hodara, R.3    Xu, S.4    Trojanowski, J.Q.5    Ischiropoulos, H.6    Lee, V.M.7
  • 73
    • 61649127598 scopus 로고    scopus 로고
    • The therapeutic potential of α-synuclein antiaggregatory agents for dementia with Lewy bodies
    • Beyer, K.; Ariza, A. The therapeutic potential of α-synuclein antiaggregatory agents for dementia with Lewy bodies. Curr. Med. Chem., 2008, 15, 2748-2759.
    • (2008) Curr. Med. Chem , vol.15 , pp. 2748-2759
    • Beyer, K.1    Ariza, A.2


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