Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 30, Issue 1, 2010, Pages 1-7

  Guo, Yanchun ^a   Wang, Jianfei ^a   Wang, Zhongqiang ^b   Yang, Yi ^a   Wang, Ximing ^a   Duan, Qiuhong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

Author keywords

3 MA; Autophagy; Beclin1; Ischemia reperfusion; LC3; Melatonin; N2a; PKB; Rapamycin

Indexed keywords

MELATONIN; NEUROPROTECTIVE AGENT;

ANIMAL; ARTICLE; AUTOPHAGY; CELL HYPOXIA; MOUSE; NEUROBLASTOMA; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; CELL HYPOXIA; CELL LINE, TUMOR; MELATONIN; MICE; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; REPERFUSION INJURY;

EID: 77149160042     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-010-0101-9     Document Type: Article

References (38)

1. G. Olivieri C. Brack Muller-Spahn, et al. 2000 Mercury induces cell cytotoxicity and oxidative stress and increases β-amyloid secretion and Tau phosphorylation in SHSY'5Y neuroblastoma cells J Neurochem 74 1 231 236 10.1046/j.1471-4159.2000.0740231.x 1:CAS:528:DC%2BD3cXlt12h 10617124 (Pubitemid 30012773)
2. R.T. Cheung 2001 Cerebrovascular disease-advances in management Hong Kong Med J 7 1 58 66 1:STN:280:DC%2BD3Mzktlajtg%3D%3D 11406677
3. P.H. Chan 1996 Role of oxidants in ischemic brain damage Stroke 27 6 1124 1129 1:CAS:528:DyaK28XktVegs7g%3D 8650725
4. I. Margaill M. Plotkine D. Lerouet 2005 Antioxidant strategies in the treatment of stroke Free Rad Biol Med 39 4 429 443 10.1016/j.freeradbiomed.2005. 05.003 1:CAS:528:DC%2BD2MXmvVKgur0%3D 16043015 (Pubitemid 41021642)
5. P. Lipton 1999 Ischemic cell death in brain neurons Physiol Rev 79 4 1431 1568 1:STN:280:DyaK1MvjvVagtw%3D%3D 10508238
6. D.S. Warner H. Sheng I. Batinie-Haberle 2004 Oxidants, antioxidants and the ischemic brain J Exp Biol 207 18 3221 3231 10.1242/jeb.01022 1:CAS:528:DC%2BD2cXovF2ku70%3D 15299043 (Pubitemid 39275296)
7. G. Letechipía-Vallejo E. López-Loeza V. Espinoza-González, et al. 2007 Long-term morphological and functional evaluation of the neuroprotective effects of post-ischemic treatment with melatonin in rats J Pineal Res 42 2 138 146 10.1111/j.1600-079X.2006.00395.x 17286745 (Pubitemid 46233059)
8. Z. Pei R.T. Cheung 2004 Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model J Pineal Res 37 2 85 91 10.1111/j.1600-079X.2004.00138.x 15298666 (Pubitemid 39120211)
9. K. Watanabe A. Wakatsuki K. Shinohara, et al. 2004 Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain J Pineal Res 37 4 276 280 10.1111/j.1600-079X.2004.00167.x 1:CAS:528:DC%2BD2cXpsFCgsr0%3D 15485554 (Pubitemid 39457049)
10. M. Lipartiti D. Franceschini R. Zanoni, et al. 1996 Neuroprotective effects of melatonin Adv Exp Med Biol 398 315 321 1:CAS:528:DyaK28XmvFSqsrw%3D 8906283
11. E. Kilic Y.G. Ozdemir H. Bolay, et al. 1999 Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia J Cereb Blood Flow Metab 19 5 511 516 10.1097/00004647-199905000-00005 1:CAS:528: DC%2BD3cXksVCqtro%3D 10326718
12. A.S. Sarrafzadeh U.W. Thomale S.N. Kroppenstedt, et al. 2000 Neuroprotective effect of melatonin on cortical impact injury in the rat Acta Neurochir (Wien) 142 11 1293 1299 10.1007/s007010070028 1:STN:280: DC%2BD3M7pt1Wisg%3D%3D (Pubitemid 32010354)
13. Q.H. Duan Z.Q. Wang T. Lu, et al. 2006 Comparison of 6-hydroxylmelatonin or melatonin in protecting neurons against ischemia/reperfusion-mediated injury J Pineal Res 41 4 351 357 10.1111/j.1600-079X.2006.00374.x 1:CAS:528: DC%2BD28XhtFWqtr7M 17014692 (Pubitemid 44498221)
14. D.J. Klionsky S.D. Emr 2000 Autophagy as a regulated pathway of cellular degradation Science 290 5497 1717 1721 10.1126/science.290.5497.1717 1:CAS:528:DC%2BD3cXovVOitbw%3D 11099404 (Pubitemid 32004796)
15. T. Pan S. Kondo W. Zhu, et al. 2008 Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement Neurobiol Dis 32 1 16 25 10.1016/j.nbd.2008.06.003 1:CAS:528:DC%2BD1cXhtFantbjF 18640276
16. S. Carloni G. Buonocore W. Balduini 2008 Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury Neurobiol Dis 32 3 329 339 10.1016/j.nbd.2008.07.022 1:CAS:528:DC%2BD1cXhsVCms7vJ 18760364
17. K. Blomgren C.L. Zhu U. Hallin, et al. 2003 Mitochondria and ischemic reperfusion damage in the adult and in the developing brain Biochem Biophys Res Commun 304 3 551 559 10.1016/S0006-291X(03)00628-4 1:CAS:528: DC%2BD3sXjt1Kis7s%3D 12729590 (Pubitemid 36506528)
18. S. Love 2003 Apoptosis and brain ischaemia Prog Neuropsychopharmacol Biol Psychiatry 27 2 267 282 10.1016/S0278-5846(03)00022-8 1:CAS:528: DC%2BD3sXit12ntrg%3D 12657366 (Pubitemid 36351494)
19. I. Kim S. Rodriguez-Enriquez J.J. Lemasters 2007 Selective degradation of mitochondria by mitophagy Arch Biochem Biophys 462 2 245 253 10.1016/j.abb.2007.03.034 1:CAS:528:DC%2BD2sXmt1ygs70%3D 17475204 (Pubitemid 46876640)
20. K.J. Banasiak Y. Xia G.G. Haddad 2000 Mechanisms underlying hypoxia-induced neuronal apoptosis Prog Neurobil 62 3 215 249 10.1016/S0301-0082(00)00011-3 1:CAS:528:DC%2BD3cXlvFymt7g%3D (Pubitemid 30326775)
21. B. Poeggeler R.J. Reiter D.X. Tan, et al. 1993 Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis J Pineal Res 14 4 151 168 10.1111/j.1600-079X.1993.tb00498.x 1:CAS:528:DyaK3sXmt1aqsbc%3D 8102180
22. M. Cervantes G. Morali G. Letechipia-Vallejo 2008 Melatonin and ischemia-reperfusion injury of the brain J Pineal Res 45 1 1 7 10.1111/j.1600-079X.2007.00551.x 1:CAS:528:DC%2BD1cXpvVOnsL8%3D 18194199 (Pubitemid 351986258)
23. P.H. Chan 1996 Role of oxidants in ischemic brain damage Stroke 27 6 1124 1129 1:CAS:528:DyaK28XktVegs7g%3D 8650725
24. R.J. Reiter D.X. Tan M.A. Pappolla 2004 Melatonin relieves the neural oxidative burden that contributes to dementias Ann N Y Acad Sci 1035 179 196 10.1196/annals.1332.012 1:CAS:528:DC%2BD2MXivFymsbw%3D 15681808 (Pubitemid 40362334)
25. C. Harms M. Lauternschlager A. Bergk 2000 Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures FASEB J 14 12 1814 1824 10.1096/fj.99-0899com 1:CAS:528:DC%2BD3cXms1CmtLs%3D 10973931
26. Y. Kabeya N. Mizushima T. Ueno, et al. 2000 LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 21 5720 5728 10.1093/emboj/19.21.5720 1:CAS:528:DC%2BD3cXovFaiurk%3D 11060023
27. N. Mizushima 2004 Methods for monitoring autophagy Int J Biochem Cell Biol 36 12 2491 2502 10.1016/j.biocel.2004.02.005 1:CAS:528:DC%2BD2cXmvFemu7k%3D 15325587 (Pubitemid 39119761)
28. 12 myotubes Biochem J 376 Pt3 577 586 10.1042/BJ20030826 1:CAS:528:DC%2BD3sXps1yqt7k%3D 12967324 (Pubitemid 38058057)
29. J. Li M. Ni B. Lee, et al. 2008 The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells Cell Death Differ 15 9 1460 1471 10.1038/cdd.2008.81 1:CAS:528:DC%2BD1cXpvFKnsLw%3D 18551133
30. X.H. Liang S. Jackson M. Seaman, et al. 1999 Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 402 6762 672 676 10.1038/45257 1:CAS:528:DC%2BD3cXjslek 10604474
31. C.J. Potter L.G. Padraza T. Xu 2002 Akt regulates growth by directly phosphorylating Tsc2 Nat Cell Biol 4 9 658 665 10.1038/ncb840 1:CAS:528:DC%2BD38Xms1ahtLw%3D 12172554 (Pubitemid 34993701)
32. B.D. Manning A.R. Tee M.N. Logsdon, et al. 2002 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway Mol Cell 10 1 151 162 10.1016/S1097-2765(02)00568-3 1:CAS:528:DC%2BD38XmtFaktbg%3D 12150915 (Pubitemid 34876569)
33. K. Inoki Y. Li T. Zhu, et al. 2002 TSC is phosphorylated and inhibited by Akt and suppresses mTOR signaling Nat Cell Biol 4 9 648 657 10.1038/ncb839 1:CAS:528:DC%2BD38Xms1ahtL4%3D 12172553 (Pubitemid 34993700)
34. R.C. Scott O. Schuldiner T.P. Neufeld 2004 Role and regulation of starvation-induced autophagy in the Drosophila fat body Dev Cell 7 2 167 178 10.1016/j.devcel.2004.07.009 1:CAS:528:DC%2BD2cXnsVKntr0%3D 15296714 (Pubitemid 39145023)
35. S. Wullschleger R. Loewith M.N. Hall 2006 TOR signaling in growth and metabolism Cell 124 3 471 484 10.1016/j.cell.2006.01.016 1:CAS:528: DC%2BD28Xhslaqs74%3D 16469695 (Pubitemid 43199434)
36. J.J. Lum R.J. DeBerardinis C.B. Thompson 2005 Autophagy in metazoans: cell survival in the land of plenty Nat Rev Mol Cell Biol 6 6 439 448 10.1038/nrm1660 1:CAS:528:DC%2BD2MXks1Gmtb0%3D 15928708 (Pubitemid 40780556)
37. T. Noda Y.J. Ohsumi 1998 Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast J Biol Chem 273 7 3963 3966 10.1074/jbc.273.7.3963 1:CAS:528:DyaK1cXht1ahsr8%3D 9461583 (Pubitemid 28103257)
38. Y. Kabeya N. Mizushima T. Ueno, et al. 2000 LC3, a mammalian homologue of yeast Atg8p, is localized in autophagosome membranes after processing EMBO J 19 21 5720 5728 10.1093/emboj/19.21.5720 1:CAS:528:DC%2BD3cXovFaiurk%3D 11060023