메뉴 건너뛰기




Volumn 427, Issue 1, 2012, Pages 134-142

Calcium condensed cell penetrating peptide complexes offer highly efficient, low toxicity gene silencing

Author keywords

A549 luc C8 cells; Biodistribution; dTAT; RNAi; siRNA; TAT; Toxicity

Indexed keywords

ARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGININE; ARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGINYLHISTIDYLARGINYLARGINYLLYSYLLYSYLARGININE; CALCIUM; CELL PENETRATING PEPTIDE; LIPID; NANOPARTICLE; PLASMID DNA; POLYMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84858746533     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.08.012     Document Type: Article
Times cited : (46)

References (86)
  • 1
    • 34248682403 scopus 로고    scopus 로고
    • RNAi therapeutics: Principles, prospects and challenges
    • DOI 10.1016/j.addr.2007.03.005, PII S0169409X07000166, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
    • L. Aagaard, and J.J. Rossi RNAi therapeutics: principles, prospects and challenges Adv. Drug Deliv. Rev. 59 2007 75 86 (Pubitemid 46770900)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.2-3 , pp. 75-86
    • Aagaard, L.1    Rossi, J.J.2
  • 2
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • S. Akhtar, and I.F. Benter Nonviral delivery of synthetic siRNAs in vivo J. Clin. Invest. 117 2007 3623
    • (2007) J. Clin. Invest. , vol.117 , pp. 3623
    • Akhtar, S.1    Benter, I.F.2
  • 4
    • 70449094651 scopus 로고    scopus 로고
    • Soft calcium crosslinks enable highly efficient gene transfection using TAT peptide
    • A. Baoum, S.X. Xie, A. Fakhari, and C. Berkland Soft calcium crosslinks enable highly efficient gene transfection using TAT peptide Pharm. Res. 26 2009 2619 2629
    • (2009) Pharm. Res. , vol.26 , pp. 2619-2629
    • Baoum, A.1    Xie, S.X.2    Fakhari, A.3    Berkland, C.4
  • 5
    • 79952221839 scopus 로고    scopus 로고
    • Calcium condensation of DNA complexed with cell penetrating peptides offers efficient, noncytotoxic gene delivery
    • Baoum, A.A.; Berkland, C.; 2011. Calcium condensation of DNA complexed with cell penetrating peptides offers efficient, noncytotoxic gene delivery. Journal of Pharmaceutical Sciences.
    • (2011) Journal of Pharmaceutical Sciences
    • Baoum, A.A.1    Berkland, C.2
  • 6
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • D.W. Bartlett, H. Su, I.J. Hildebrandt, W.A. Weber, and M.E. Davis Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. 104 2007 15549
    • (2007) Proc. Natl. Acad. Sci. , vol.104 , pp. 15549
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 7
    • 33645500266 scopus 로고    scopus 로고
    • Progress towards in vivo use of siRNAs
    • M.A. Behlke Progress towards in vivo use of siRNAs Mol. Ther. 13 2006 644 670
    • (2006) Mol. Ther. , vol.13 , pp. 644-670
    • Behlke, M.A.1
  • 8
    • 30344454402 scopus 로고    scopus 로고
    • Short interfering RNA (siRNA): Tool or therapeutic?
    • DOI 10.1042/CS20050162
    • D. Cejka, D. Losert, and V. Wacheck Short interfering RNA (siRNA): tool or therapeutic? Clin. Sci. 110 2006 47 58 (Pubitemid 43059044)
    • (2006) Clinical Science , vol.110 , Issue.1 , pp. 47-58
    • Cejka, D.1    Losert, D.2    Wacheck, V.3
  • 9
    • 33847767005 scopus 로고    scopus 로고
    • Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing
    • DOI 10.2174/138945007780058988
    • C. Chakraborty Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing Curr. Drug Targets 8 2007 469 482 (Pubitemid 46381297)
    • (2007) Current Drug Targets , vol.8 , Issue.3 , pp. 469-482
    • Chakraborty, C.1
  • 11
    • 4344651353 scopus 로고    scopus 로고
    • Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
    • DOI 10.1016/j.chembiol.2004.06.006, PII S1074552104001930
    • Y.L. Chiu, A. Ali, C. Chu, H. Cao, and T.M. Rana Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells Chem. Biol. 11 2004 1165 1175 (Pubitemid 39138769)
    • (2004) Chemistry and Biology , vol.11 , Issue.8 , pp. 1165-1175
    • Chiu, Y.-L.1    Ali, A.2    Chu, C.-Y.3    Cao, H.4    Rana, T.M.5
  • 12
    • 36849094017 scopus 로고    scopus 로고
    • Chemical modification: The key to clinical application of RNA interference?
    • D.R. Corey Chemical modification: the key to clinical application of RNA interference? J. Clin. Invest. 117 2007 3615
    • (2007) J. Clin. Invest. , vol.117 , pp. 3615
    • Corey, D.R.1
  • 14
    • 8544231403 scopus 로고    scopus 로고
    • Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation
    • T.J. Davidson, S. Harel, V.A. Arboleda, G.F. Prunell, M.L. Shelanski, L.A. Greene, and C.M. Troy Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation J. Neurosci. 24 2004 10040
    • (2004) J. Neurosci. , vol.24 , pp. 10040
    • Davidson, T.J.1    Harel, S.2    Arboleda, V.A.3    Prunell, G.F.4    Shelanski, M.L.5    Greene, L.A.6    Troy, C.M.7
  • 16
    • 0028239908 scopus 로고
    • The third helix of the Antennapedia homeodomain translocates through biological membranes
    • D. Derossi, A.H. Joliot, G. Chassaing, and A. Prochiantz The third helix of the Antennapedia homeodomain translocates through biological membranes J. Biol. Chem. 269 1994 10444
    • (1994) J. Biol. Chem. , vol.269 , pp. 10444
    • Derossi, D.1    Joliot, A.H.2    Chassaing, G.3    Prochiantz, A.4
  • 17
    • 67649408951 scopus 로고    scopus 로고
    • SiRNA delivery using peptide transduction domains
    • A. Eguchi, and S.F. Dowdy siRNA delivery using peptide transduction domains Trends Pharmacol. Sci. 30 2009 341 345
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 341-345
    • Eguchi, A.1    Dowdy, S.F.2
  • 18
    • 44349165666 scopus 로고    scopus 로고
    • Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference
    • DOI 10.1021/bc800020n
    • T. Endoh, M. Sisido, and T. Ohtsuki Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference Bioconjug. Chem. 19 2008 1017 1024 (Pubitemid 351748309)
    • (2008) Bioconjugate Chemistry , vol.19 , Issue.5 , pp. 1017-1024
    • Endoh, T.1    Sisido, M.2    Ohtsuki, T.3
  • 19
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • A. Fire, S.Q. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 20
    • 33845197894 scopus 로고    scopus 로고
    • The Application of siRNA Technology to Cancer Biology Discovery
    • DOI 10.1016/S0065-230X(06)96004-7, PII S0065230X06960047
    • U. Fuchs, and A. Borkhardt The application of siRNA technology to cancer biology discovery Adv. Cancer Res. 96 2006 75 102 (Pubitemid 44855847)
    • (2006) Advances in Cancer Research , vol.96 , pp. 75-102
    • Fuchs, U.1    Borkhardt, A.2
  • 22
    • 14044270161 scopus 로고    scopus 로고
    • Binding of oligoarginine to membrane lipids and heparan sulfate: Structural and thermodynamic characterization of a cell-penetrating peptide
    • DOI 10.1021/bi048046i
    • E. Gonalves, E. Kitas, and J. Seelig Binding of oligoarginine to membrane lipids and heparan sulfate: structural and thermodynamic characterization of a cell-penetrating peptide Biochemistry 44 2005 2692 2702 (Pubitemid 40279574)
    • (2005) Biochemistry , vol.44 , Issue.7 , pp. 2692-2702
    • Goncalves, E.1    Kitas, E.2    Seelig, J.3
  • 23
    • 33750405780 scopus 로고    scopus 로고
    • Kinetic and efficacy analysis of RNA interference in stably and transiently expressing cell lines
    • DOI 10.1021/mp060026i
    • A.C.R. Grayson, J. Ma, and D. Putnam Kinetic and efficacy analysis of RNA interference in stably and transiently expressing cell lines Mol. Pharm. 3 2006 601 613 (Pubitemid 44639137)
    • (2006) Molecular Pharmaceutics , vol.3 , Issue.5 , pp. 601-613
    • Grayson, A.C.R.1    Ma, J.2    Putnam, D.3
  • 24
    • 0035816168 scopus 로고    scopus 로고
    • PEG drugs: An overview
    • DOI 10.1016/S0168-3659(01)00331-5, PII S0168365901003315
    • R. Greenwald PEG drugs: an overview J. Control. Rel. 74 2001 159 171 (Pubitemid 32727618)
    • (2001) Journal of Controlled Release , vol.74 , Issue.1-3 , pp. 159-171
    • Greenwald, R.B.1
  • 27
    • 0029257245 scopus 로고
    • Structural characterization of viral fusion proteins
    • F.M. Hughson Structural characterization of viral fusion proteins Curr. Biol. 5 1995 265 274
    • (1995) Curr. Biol. , vol.5 , pp. 265-274
    • Hughson, F.M.1
  • 28
    • 0035079050 scopus 로고    scopus 로고
    • Effects of structure of β-cyclodextrin-containing polymers on gene delivery
    • DOI 10.1021/bc0001084
    • S.J. Hwang, N.C. Bellocq, and M.E. Davis Effects of structure of beta-cyclodextrin-containing polymers on gene delivery Bioconjug. Chem. 12 2001 280 290 (Pubitemid 32235481)
    • (2001) Bioconjugate Chemistry , vol.12 , Issue.2 , pp. 280-290
    • Hwang, S.J.1    Bellocq, N.C.2    Davis, M.E.3
  • 31
    • 37549064689 scopus 로고    scopus 로고
    • Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea
    • L.N. Johnson, S.M. Cashman, and R. Kumar-Singh Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea Mol. Ther. 16 2007 107 114
    • (2007) Mol. Ther. , vol.16 , pp. 107-114
    • Johnson, L.N.1    Cashman, S.M.2    Kumar-Singh, R.3
  • 33
    • 47249138782 scopus 로고    scopus 로고
    • Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
    • R. Juliano, and M. Alam Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides Nucleic Acids Res. 36 2008 4158
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4158
    • Juliano, R.1    Alam, M.2
  • 34
    • 33746863376 scopus 로고    scopus 로고
    • Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma
    • DOI 10.1016/j.ymthe.2006.03.022, PII S1525001606001420
    • W.J. Kim, L.V. Christensen, S. Jo, J.W. Yockman, J.H. Jeong, Y.H. Kim, and S.W. Kim Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma Mol. Ther. 14 2006 343 350 (Pubitemid 44184964)
    • (2006) Molecular Therapy , vol.14 , Issue.3 , pp. 343-350
    • Kim, W.J.1    Christensen, L.V.2    Jo, S.3    Yockman, J.W.4    Jeong, J.H.5    Kim, Y.-H.6    Kim, S.W.7
  • 38
    • 23044506285 scopus 로고    scopus 로고
    • Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
    • DOI 10.1158/0008-5472.CAN-05-0530
    • C.N. Landen Jr.; A. Chavez-Reyes, C. Bucana, R. Schmandt, M.T. Deavers, G. Lopez-Berestein, and A.K. Sood Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery Cancer Res. 65 2005 6910 6918 (Pubitemid 41060730)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6910-6918
    • Landen Jr., C.N.1    Chavez-Reyes, A.2    Bucana, C.3    Schmandt, R.4    Deavers, M.T.5    Lopez-Berestein, G.6    Sood, A.K.7
  • 39
    • 4444220551 scopus 로고    scopus 로고
    • Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
    • DOI 10.1016/j.bmcl.2004.07.018, PII S0960894X04009084
    • C. Lorenz, P. Hadwiger, M. John, H.P. Vornlocher, and C. Unverzagt Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells Bioorg. Med. Chem. Lett. 14 2004 4975 4977 (Pubitemid 39165605)
    • (2004) Bioorganic and Medicinal Chemistry Letters , vol.14 , Issue.19 , pp. 4975-4977
    • Lorenz, C.1    Hadwiger, P.2    John, M.3    Vornlocher, H.-P.4    Unverzagt, C.5
  • 40
    • 25144498128 scopus 로고    scopus 로고
    • In Vivo Application of RNA Interference: From Functional Genomics to Therapeutics
    • DOI 10.1016/S0065-2660(05)54006-9, PII S0065266005540069, Non-Viral Vectors for Gene Therapy, Second Edition: Part 2
    • P.Y. Lu, F. Xie, and M.C. Woodle In vivo application of RNA interference: from functional genomics to therapeutics Adv. Genet. 54 2005 115 142 (Pubitemid 43583920)
    • (2005) Advances in Genetics , vol.54 , pp. 115-142
    • Lu, P.Y.1    Xie, F.2    Woodle, M.C.3
  • 41
    • 34548484580 scopus 로고    scopus 로고
    • Delivery of short interfering RNA using endosomolytic cell-penetrating peptides
    • P. Lundberg, S. El-Andaloussi, T. Sütlü, H. Johansson, and Ü. Langel Delivery of short interfering RNA using endosomolytic cell-penetrating peptides FASEB J. 21 2007 2664
    • (2007) FASEB J. , vol.21 , pp. 2664
    • Lundberg, P.1    El-Andaloussi, S.2    Sütlü, T.3    Johansson, H.4    Langel, Ü.5
  • 43
    • 38749103118 scopus 로고    scopus 로고
    • Biodegradable polymers as non-viral carriers for plasmid DNA delivery
    • J. Luten, C.F. Van Nostrum, S.C. De Smedt, and W.E. Hennink Biodegradable polymers as non-viral carriers for plasmid DNA delivery J. Control. Rel. 126 2008 97 110
    • (2008) J. Control. Rel. , vol.126 , pp. 97-110
    • Luten, J.1    Van Nostrum, C.F.2    De Smedt, S.C.3    Hennink, W.E.4
  • 44
    • 75349114584 scopus 로고    scopus 로고
    • Chemically modified cell-penetrating peptides for the delivery of nucleic acids
    • M. Mäe, S.E. Andaloussi, T. Lehto, and Ü. Langel Chemically modified cell-penetrating peptides for the delivery of nucleic acids Expert Opin. Drug Deliv. 6 2009 1195 1205
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 1195-1205
    • Mäe, M.1    Andaloussi, S.E.2    Lehto, T.3    Langel, Ü.4
  • 45
    • 33748994569 scopus 로고    scopus 로고
    • Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes
    • DOI 10.1021/bc060129j
    • S. Mao, M. Neu, O. Germershaus, O. Merkel, J. Sitterberg, U. Bakowsky, and T. Kissel Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly (ethylene imine)-graft-poly (ethylene glycol) block copolymer/SiRNA polyplexes Bioconjug. Chem. 17 2006 1209 1218 (Pubitemid 44455329)
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.5 , pp. 1209-1218
    • Mao, S.1    Neu, M.2    Germershaus, O.3    Merkel, O.4    Sitterberg, J.5    Bakowsky, U.6    Kissel, T.7
  • 46
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • M.T. McManus, and P.A. Sharp Gene silencing in mammals by small interfering RNAs Nat. Rev. Genet. 3 2002 737 747
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 737-747
    • McManus, M.T.1    Sharp, P.A.2
  • 47
    • 34248680739 scopus 로고    scopus 로고
    • Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides
    • DOI 10.1016/j.addr.2007.03.004, PII S0169409X0700021X, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
    • B.R. Meade, and S.F. Dowdy Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides Adv. Drug Deliv. Rev. 59 2007 134 140 (Pubitemid 46770904)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.2-3 , pp. 134-140
    • Meade, B.R.1    Dowdy, S.F.2
  • 48
    • 39149093340 scopus 로고    scopus 로고
    • Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides
    • B.R. Meade, and S.F. Dowdy Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides Adv. Drug Deliv. Rev. 60 2008 530 536
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 530-536
    • Meade, B.R.1    Dowdy, S.F.2
  • 49
    • 28844460780 scopus 로고    scopus 로고
    • Intracellular trafficking of nonviral vectors
    • DOI 10.1038/sj.gt.3302592, PII 3302592
    • L. Medina-Kauwe, J. Xie, and S. Hamm-Alvarez Intracellular trafficking of nonviral vectors Gene Ther. 12 2005 1734 1751 (Pubitemid 41760286)
    • (2005) Gene Therapy , vol.12 , Issue.24 , pp. 1734-1751
    • Medina-Kauwe, L.K.1    Xie, J.2    Hamm-Alvarez, S.3
  • 50
    • 14844323999 scopus 로고    scopus 로고
    • The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction
    • H. Michiue, K. Tomizawa, F.Y. Wei, M. Matsushita, Y.F. Lu, T. Ichikawa, T. Tamiya, I. Date, and H. Matsui The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction J. Biol. Chem. 280 2005 8285
    • (2005) J. Biol. Chem. , vol.280 , pp. 8285
    • Michiue, H.1    Tomizawa, K.2    Wei, F.Y.3    Matsushita, M.4    Lu, Y.F.5    Ichikawa, T.6    Tamiya, T.7    Date, I.8    Matsui, H.9
  • 51
    • 0030804766 scopus 로고    scopus 로고
    • A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
    • M. Morris, P. Vidal, L. Chaloin, F. Heitz, and G. Divita A new peptide vector for efficient delivery of oligonucleotides into mammalian cells Nucleic Acids Res. 25 1997 2730
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2730
    • Morris, M.1    Vidal, P.2    Chaloin, L.3    Heitz, F.4    Divita, G.5
  • 53
    • 34648834877 scopus 로고    scopus 로고
    • Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
    • DOI 10.1021/bc070077d
    • S.A. Moschos, S.W. Jones, M.M. Perry, A.E. Williams, J.S. Erjefalt, J.J. Turner, P.J. Barnes, B.S. Sproat, M.J. Gait, and M.A. Lindsay Lung delivery studies using siRNA conjugated to TAT (48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity Bioconjug. Chem. 18 2007 1450 1459 (Pubitemid 47464052)
    • (2007) Bioconjugate Chemistry , vol.18 , Issue.5 , pp. 1450-1459
    • Moschos, S.A.1    Jones, S.W.2    Perry, M.M.3    Williams, A.E.4    Erjefalt, J.S.5    Turner, J.J.6    Barnes, P.J.7    Sproat, B.S.8    Gait, M.J.9    Lindsay, M.A.10
  • 54
    • 0842346326 scopus 로고    scopus 로고
    • Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
    • DOI 10.1016/S0014-5793(03)01505-9
    • A. Muratovska, and M.R. Eccles Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells FEBS Lett. 558 2004 63 68 (Pubitemid 38167411)
    • (2004) FEBS Letters , vol.558 , Issue.1-3 , pp. 63-68
    • Muratovska, A.1    Eccles, M.R.2
  • 55
    • 22644439250 scopus 로고    scopus 로고
    • Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer
    • A. Pal, A. Ahmad, S. Khan, I. Sakabe, C. Zhang, U.N. Kasid, and I. Ahmad Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer Int. J. Oncol. 26 2005 1087
    • (2005) Int. J. Oncol. , vol.26 , pp. 1087
    • Pal, A.1    Ahmad, A.2    Khan, S.3    Sakabe, I.4    Zhang, C.5    Kasid, U.N.6    Ahmad, I.7
  • 57
    • 15544385237 scopus 로고    scopus 로고
    • Biodegradable polymers for microencapsulation of drugs
    • J.H. Park, M. Ye, and K. Park Biodegradable polymers for microencapsulation of drugs Molecules 10 2005 146 161 (Pubitemid 40404892)
    • (2005) Molecules , vol.10 , Issue.1 , pp. 146-161
    • Park, J.H.1    Ye, M.2    Park, K.3
  • 60
    • 33645357434 scopus 로고
    • Polymer conjugates with anticancer activity
    • D. Putnam, and J. Kope ek Polymer conjugates with anticancer activity Biopolymers Ii 1995 55 123
    • (1995) Biopolymers , vol.2 , pp. 55-123
    • Putnam, D.1    Kope Ek, J.2
  • 61
    • 0033579873 scopus 로고    scopus 로고
    • Membrane translocation of charged residues at the tips of hydrophobic helices in the T domain of diphtheria toxin
    • J. Ren, J.C. Sharpe, R.J. Collier, and E. London Membrane translocation of charged residues at the tips of hydrophobic helices in the T domain of diphtheria toxin Biochemistry 38 1999 976 984
    • (1999) Biochemistry , vol.38 , pp. 976-984
    • Ren, J.1    Sharpe, J.C.2    Collier, R.J.3    London, E.4
  • 62
    • 33746871883 scopus 로고    scopus 로고
    • Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro
    • DOI 10.1007/s11095-006-9009-2
    • A.C. Richards Grayson, A.M. Doody, and D. Putnam Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro Pharm. Res. 23 2006 1868 1876 (Pubitemid 44200551)
    • (2006) Pharmaceutical Research , vol.23 , Issue.8 , pp. 1868-1876
    • Richards Grayson, A.C.1    Doody, A.M.2    Putnam, D.3
  • 63
    • 0024398880 scopus 로고
    • Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro
    • DOI 10.1016/0142-9612(89)90075-6
    • B. Rihova, M. Bilej, V. Vetvicka, K. Ulbrich, J. Strohalm, J. Kopecek, and R. Duncan Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin: immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro Biomaterials 10 1989 335 342 (Pubitemid 19174801)
    • (1989) Biomaterials , vol.10 , Issue.5 , pp. 335-342
    • Rihova, B.1    Bilej, M.2    Vetvicka, V.3    Ulbrich, K.4    Strohalm, J.5    Kopecek, J.6    Duncan, R.7
  • 64
    • 9144226019 scopus 로고    scopus 로고
    • Oncology studies using siRNA libraries: The dawn of RNAi-based geomics
    • DOI 10.1038/sj.onc.1208072
    • C. Sachse, and C.J. Echeverri Oncology studies using siRNA libraries: the dawn of RNAi-based genomics Oncogene 23 2004 8384 8391 (Pubitemid 39540720)
    • (2004) Oncogene , vol.23 , Issue.51 REV. ISS. 8 , pp. 8384-8391
    • Sachse, C.1    Echeverri, C.J.2
  • 66
    • 48949098577 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Synthetic polymer-based systems
    • D. Schaffert, and E. Wagner Gene therapy progress and prospects: synthetic polymer-based systems Gene Ther. 15 2008 1131 1138
    • (2008) Gene Ther. , vol.15 , pp. 1131-1138
    • Schaffert, D.1    Wagner, E.2
  • 67
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • S.R. Schwarze, A. Ho, A. Vocero-Akbani, and S.F. Dowdy In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285 1999 1569
    • (1999) Science , vol.285 , pp. 1569
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 68
    • 54249139512 scopus 로고    scopus 로고
    • Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides
    • L. Sepp-Lorenzino, and M. Ruddy Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides Clin. Pharmacol. Ther. 84 2008 628 632
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 628-632
    • Sepp-Lorenzino, L.1    Ruddy, M.2
  • 69
    • 0033783032 scopus 로고    scopus 로고
    • Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin
    • J.J. Skehel, and D.C. Wiley Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin Annu. Rev. Biochem. 69 2000 531 569
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 531-569
    • Skehel, J.J.1    Wiley, D.C.2
  • 70
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • DOI 10.1016/S0022-2836(03)00181-5
    • D.R. Sørensen, M. Leirdal, and M. Sioud Gene silencing by systemic delivery of synthetic siRNAs in adult mice J. Mol. Biol. 327 2003 761 766 (Pubitemid 36315917)
    • (2003) Journal of Molecular Biology , vol.327 , Issue.4 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 72
    • 34249825777 scopus 로고    scopus 로고
    • Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery
    • DOI 10.1016/j.biomaterials.2007.04.037, PII S0142961207003626
    • P.J. Tarcha, J. Pelisek, T. Merdan, J. Waters, K. Cheung, K. von Gersdorff, C. Culmsee, and E. Wagner Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery Biomaterials 28 2007 3731 3740 (Pubitemid 46855884)
    • (2007) Biomaterials , vol.28 , Issue.25 , pp. 3731-3740
    • Tarcha, P.J.1    Pelisek, J.2    Merdan, T.3    Waters, J.4    Cheung, K.5    Von Gersdorff, K.6    Culmsee, C.7    Wagner, E.8
  • 73
    • 0035902477 scopus 로고    scopus 로고
    • TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
    • V.P. Torchilin, R. Rammohan, V. Weissig, and T.S. Levchenko TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors Proc. Natl. Acad. Sci. U.S.A. 98 2001 8786
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 8786
    • Torchilin, V.P.1    Rammohan, R.2    Weissig, V.3    Levchenko, T.S.4
  • 74
    • 29344436510 scopus 로고    scopus 로고
    • Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
    • J.J. Turner, G.D. Ivanova, B. Verbeure, D. Williams, A.A. Arzumanov, S. Abes, B. Lebleu, and M.J. Gait Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells Nucleic Acids Res. 33 2005 6837
    • (2005) Nucleic Acids Res. , vol.33 , pp. 6837
    • Turner, J.J.1    Ivanova, G.D.2    Verbeure, B.3    Williams, D.4    Arzumanov, A.A.5    Abes, S.6    Lebleu, B.7    Gait, M.J.8
  • 76
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • DOI 10.1038/sj.gt.3302425
    • B. Urban-Klein, S. Werth, S. Abuharbeid, F. Czubayko, and A. Aigner RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo Gene Ther. 12 2004 461 466 (Pubitemid 40394299)
    • (2005) Gene Therapy , vol.12 , Issue.5 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 77
    • 29544448116 scopus 로고    scopus 로고
    • Polymer conjugates: Nanosized medicines for treating cancer
    • DOI 10.1016/j.tibtech.2005.11.006, PII S0167779905003021
    • M.J. Vicent, and R. Duncan Polymer conjugates: nanosized medicines for treating cancer Trends Biotechnol. 24 2006 39 47 (Pubitemid 43017749)
    • (2006) Trends in Biotechnology , vol.24 , Issue.1 , pp. 39-47
    • Vicent, M.J.1    Duncan, R.2
  • 78
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • E. Vivs, P. Brodin, and B. Lebleu A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus J. Biol. Chem. 272 1997 16010
    • (1997) J. Biol. Chem. , vol.272 , pp. 16010
    • Vivs, E.1    Brodin, P.2    Lebleu, B.3
  • 79
    • 2342595835 scopus 로고    scopus 로고
    • Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
    • DOI 10.1038/nm996
    • J.S. Wadia, R.V. Stan, and S.F. Dowdy Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis Nat. Med. 10 2004 310 315 (Pubitemid 38667624)
    • (2004) Nature Medicine , vol.10 , Issue.3 , pp. 310-315
    • Wadia, J.S.1    Stan, R.V.2    Dowdy, S.F.3
  • 80
    • 67249148163 scopus 로고    scopus 로고
    • Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice
    • X.L. Wang, R. Xu, X. Wu, D. Gillespie, R. Jensen, and Z.R. Lu Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice Mol. Pharm. 6 2009 738 746
    • (2009) Mol. Pharm. , vol.6 , pp. 738-746
    • Wang, X.L.1    Xu, R.2    Wu, X.3    Gillespie, D.4    Jensen, R.5    Lu, Z.R.6
  • 81
    • 33646152761 scopus 로고    scopus 로고
    • A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes
    • S. Werth, B. Urban-Klein, L. Dai, S. Hobel, M. Grzelinski, U. Bakowsky, F. Czubayko, and A. Aigner A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes J. Control. Rel. 112 2006 257 270
    • (2006) J. Control. Rel. , vol.112 , pp. 257-270
    • Werth, S.1    Urban-Klein, B.2    Dai, L.3    Hobel, S.4    Grzelinski, M.5    Bakowsky, U.6    Czubayko, F.7    Aigner, A.8
  • 83
    • 33744501018 scopus 로고    scopus 로고
    • Future promise of siRNA and other nucleic acid based therapeutics for the treatment of chronic HCV
    • J. Wilson, and C. Richardson Future promise of siRNA and other nucleic acid based therapeutics for the treatment of chronic HCV Infect. Disord. Drug Targets (Formerly Current Drug Targets-Infectious) 6 2006 43 56 (Pubitemid 43796635)
    • (2006) Infectious Disorders - Drug Targets , vol.6 , Issue.1 , pp. 43-56
    • Wilson, J.A.1    Richardson, C.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.