Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: An electronic and structural analysis

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 861-868

  Kadam, Rameshwar U ^a   Chavan, Archana ^a   Roy, Nilanjan ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

HD; HUMO; LpxC; LUMO; MESP

Indexed keywords

DEACETYLASE INHIBITOR; NATURAL PRODUCT; OXAZOLINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE [3 O (3 HYDROXYMYRISTOYL)] N ACETYLGLUCOSAMINE;

ARTICLE; CALCULATION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ELECTROCHEMICAL ANALYSIS; ENZYME INHIBITION; HYDROGEN BOND; INHIBITION KINETICS; NONHUMAN; PHARMACOPHORE; PSEUDOMONAS AERUGINOSA; STRUCTURE ANALYSIS; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING;

AMIDOHYDROLASES; CHEMISTRY, PHYSICAL; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

PSEUDOMONAS AERUGINOSA;

EID: 33846601268     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.069     Document Type: Article

References (17)

1. Nicoll L. N. Eng. J. Med. 332 (1995) 616
2. Van Delden C., and Iglewski B.H. Emerg. Infect. Dis. 4 (1998) 551
3. Whittington D.A., Rusche K.M., Shin H., Fierke C.A., and Christianson D.W. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8146
4. Kline T., Andersen N.H., Harwood E.A., Bowman J., Malanda A., Endsley S., Erwin A.L., Doyle M., Fong S., Harris A.L., Mendelsohn B., Mdluli K., Raetz C.R., Stover C.K., Witte P.R., Yabannavar A., and Zhu S. J. Med. Chem. 45 (2002) 3112
5. Pirrung M.C., Tumey L.N., Raetz C.R., Jackman J.E., Snehalatha K., McClerren A.L., Fierke C.A., Gantt S.L., and Rusche K.M. J. Med. Chem. 45 (2002) 4359
6. SYBYL; version 6.9; Tripos Associates Inc.; 1699, S Hanley Rd., St. Louis, MO631444; USA.
7. Dewar M.J., Zoebisch E.G., Healy E.F., and Stewart J.P. J. Am. Chem. Soc. 107 (1985) 3902
8. Murray J.S., Zilles B.A., Jayaswuya K., and Politzer D. J. Am. Chem. Soc. 108 (1986) 915
9. Naray-Szabo G. J. Mol. Graphics 7 (1989) 76
10. Bhattacharrjee A.K., and Karle J.M. Bioorg. Med. Chem. 6 (1998) 1927
11. Bhattacharrjee A.K., and Karle J.M. Chem. Res. Toxicol. 12 (1999) 422
12. Whittington D.A., Rusche K.M., Shin H., Fierke C.A., and Christianson D.W. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8146
13. Clure C.P., Rusche K.M., Peariso K., Jackman J., Fierke C.A., and Penner-Hahn J.E. J. Inorg. Biochem. 94 (2003) 78
14. Robert G.P., and Ralph G.P. J. Am. Chem. Soc. 105 (1983) 7512
15. Cao H., Pan X.-L., Li C., Zhou C., Deng F.-Y., and Li T.-H. Bioorg. Med. Chem. Lett. 13 (2003) 1869
16. Kleinman E.F., Campbell E., Giordano L.A., Cohan V.L., Jenkinson T.H., Cheng B., Shirley J.T., Pettipher E.R., Salter E.D., Hibbs T.A., DiCapua F.M., and Bordner J. J. Med. Chem. 41 (1998) 266
17. Pirrung M.C., Tumey L.N., McClerren A.L., and Raetz C.R.H. J. Am. Chem. Soc. 125 (2003) 1575