Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers

Biochemical and Biophysical Research Communications

Volumn 300, Issue 2, 2003, Pages 391-396

  Mascle, Xavier ^a   Albagli, Olivier ^b   Lemercier, Claudie ^a  

^a INSTITUT ALBERT BONNIOT   (France)

^b CNRS   (France)

Author keywords

BCL6; DNA binding; HDAC; Repression; Zinc finger

Indexed keywords

DNA; HISTONE DEACETYLASE; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN BCL 6; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; B CELL LYMPHOMA 6 GENE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; FEMALE; GENE; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

EID: 0037427528     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02873-5     Document Type: Article

References (19)

1. Dent A.L., Vasanwala F.H., Toney L.M. Regulation of gene expression by the proto-oncogene BCL-6. Crit. Rev. Oncol. Hematol. 41:2002;1-9.
2. Albagli O., Lindon C., Lantoine S., Quief S., Puvion E., Pinset C., Puvion-Dutilleul F. DNA replication progresses on the periphery of nuclear cores formed by the BCL6 transcription factor. Mol. Cell. Biol. 20:2000;8560-8570.
3. Shaffer A.L., Yu X., He Y., Boldrick J., Chan E.P., Staudt L.M. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity. 13:2000;199-212.
4. Toney L.M., Cattoretti G., Graf J.A., Merghoub T., Pandolfi P.P., Dalla-Favera R., Ye B.H., Dent A.L. BCL-6 regulates chemokine gene transcription in macrophages. Nat. Immunol. 1:2000;214-220.
5. Lemercier C., Brocard M.-P., Puvion-Dutilleul F., Kao H.Y., Albagli O., Khochbin S. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J. Biol. Chem. 277:2002;22045-22052.
6. Vasanwala F.H., Kusam S., Toney L.M., Dent A.L. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J. Immunol. 169:2002;1922-1929.
7. Dhordain P., Albagli O., Honore N., Guidez F., Lantoine D., Schmid M., The H.D., Zelent A., Koken M.H. Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF. Oncogene. 19:2000;6240-6250.
8. Lemercier C., To R.Q., Carrasco R.A., Konieczny S.F. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J. 17:1998;1412-1422.
9. Chang C.C., Ye B.H., Chaganti R.S., Dalla-Favera R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA. 93:1996;6947-6952.
10. Lemercier C., Verdel A., Galloo B., Curtet S., Brocard M.P., Khochbin S. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275:2000;15594-15599.
11. Turner J., Crossley M. Mammalian Krüppel-like transcription factors: more than just a pretty finger. Trends Biochem. Sci. 24:1999;236-240.
12. Obata T., Yanagidani A., Yokoro K., Numoto M., Yamamoto S. Analysis of the consensus binding sequence and the DNA-binding domain of ZF5. Biochem. Biophys. Res. Commun. 255:1999;528-534.
13. Daniel J.M., Spring C.M., Crawford H.C., Reynolds A.B., Baig A. The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res. 30:2002;2911-2919.
14. Wolfe S.A., Nekludova L., Pabo C.O. DNA recognition by Cys2His2 zinc finger proteins. Annu. Rev. Biophys. Biomol. Struct. 29:2000;183-212.
15. Pavletich N.P., Pabo C.O. Crystal structure of a five-finger GLI-DNA complex on zinc fingers. Science. 261:1993;1701-1707.
16. Nolte R.T., Conlin R.M., Harrison S.C., Brown R.S. Differing roles for zinc finger in DNA recognition: structure of a six-finger transcription factor IIIA complex. Proc. Natl. Acad. Sci. USA. 95:1998;2938-2943.
17. Arima M., Toyama H., Ichii H., Kojima S., Okada S., Hatano M., Cheng G., Kubo M., Fukuda T., Tokuhisa T. A putative silencer element in the IL-5 gene recognized by Bcl6. J. Immunol. 169:2002;829-836.
18. Filippova G.N., Fagerlie S., Klenova E.N., Myers C., Dehner Y., Goodwin G., Neiman P.E., Collins S.J., Lobanenkov V.V. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequence of avian and mammalian c-myc oncogenes. Mol. Cell. Biol. 16:1996;2802-2813.
19. Melnick A., Licht J.D. Deconstructing a disease: RAR. α, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia Blood. 93:1999;3167-3215.