MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 5, 2012, Pages 978-987

  Palma, Catalina A ^a   Tonna, Elise J ^a   Ma, David F ^a,b   Lutherborrow, Mark A ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Acute myeloid leukaemia; Haematopoiesis; MicroRNA

Indexed keywords

MICRORNA;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL; APOPTOSIS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; MACROPHAGE; METABOLISM; MOUSE; MYELOPOIESIS; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MACROPHAGES; MICE; MICRORNAS; MYELOPOIESIS;

EID: 84858445809     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01514.x     Document Type: Review

References (88)

1. Mrozek K, Heerema NA, Bloomfield CD. Cytogenetics in acute leukaemia. Blood Rev. 2004; 18: 115-36.
2. Mrozek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukaemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 2007; 109: 431-48.
3. Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukaemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005; 106: 3740-6.
4. Paschka P, Marcucci G, Ruppert AS, et al. Wilms' tumour 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukaemia: a cancer and leukaemia group B study. J Clin Oncol. 2008; 26: 4595-602.
5. Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukaemia. N Engl J Med. 2004; 350: 1617-28.
6. Marcucci G, Mrozek K, Radmacher MD, et al. The prognostic and functional role of microRNAs in acute myeloid leukaemia. Blood. 2010; 117: 1121-9.
7. Havelange V, Stauffer N, Heaphy CC, et al. Functional implications of microRNAs in acute myeloid leukaemia by integrating microRNA and messenger RNA expression profiling. Cancer. 2011; in press: doi: 10.1002/cncr.26096.
8. Swerdlow S, Campo S, Harris N, et al. WHO classification of tumours of haematopoietic and lymphoid tissue. 4th ed. Lyon, France: IARC; 2008.
9. Guo S, Lu J, Schlanger R, et al. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci USA. 2010; 107: 14229-34.
10. Georgantas RW 3rd, Hildreth R, Morisot S, et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci USA. 2007; 104: 2750-5.
11. Han YC, Park CY, Bhagat G, et al. microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukaemia. J Exp Med. 2010; 207: 475-89.
12. Petriv OI, Kuchenbauer F, Delaney AD, et al. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 2010; 107: 15443-8.
13. Dickstein J, Senyuk V, Premanand K, et al. Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc Natl Acad Sci USA. 2010; 107: 9783-8.
14. Melton C, Judson RL, Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature. 2010; 463: 621-6.
15. Starczynowski DT, Kuchenbauer F, Wegrzyn J, et al. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol. 2011; 39: 167-78 e4.
16. Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med. 2010; 16: 49-58.
17. Velu CS, Baktula AM, Grimes HL. Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood. 2009; 113: 4720-8.
18. White SL, Belov L, Barber N, et al. Immunophenotypic changes induced on human HL60 leukaemia cells by 1alpha, 25-dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate. Leuk Res. 2005; 29: 1141-51.
19. Tenedini E, Roncaglia E, Ferrari F, et al. Integrated analysis of microRNA and mRNA expression profiles in physiological myelopoiesis: role of hsa-mir-299-5p in CD34+ progenitor cells commitment. Cell Death Dis. 2010; 1: e28.
20. Fontana L, Pelosi E, Greco P, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol. 2007; 9: 775-87.
21. Lutherborrow M, Bryant A, Jayaswal V, et al. Expression profiling of cytogenetically normal acute myeloid leukaemia identifies microRNAs that target genes involved in monocytic differentiation. Am J Hematol. 2011; 86: 2-11.
22. Forrest AR, Kanamori-Katayama M, Tomaru Y, et al. Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia. 2010; 24: 460-6.
23. Mann M, Barad O, Agami R, et al. miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci USA. 2010; 107: 15804-9.
24. Li T, Morgan MJ, Choksi S, et al. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol. 2010; 11: 799-805.
25. Schmeier S, MacPherson CR, Essack M, et al. Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation. BMC Genomics. 2009; 10: 595.
26. Rosa A, Ballarino M, Sorrentino A, et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci USA. 2007; 104: 19849-54.
27. Ghani S, Riemke P, Schonheit J, et al. Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood. 2011; 118: 2275-84.
28. Fazi F, Rosa A, Fatica A, et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell. 2005; 123: 819-31.
29. Garzon R, Pichiorri F, Palumbo T, et al. MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukaemia. Oncogene. 2007; 26: 4148-57.
30. Jian P, Li ZW, Fang TY, et al. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. J Hematol Oncol. 2011; 4: 20.
31. Yuan JY, Wang F, Yu J, et al. MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. J Cell Mol Med. 2009; 13: 4551-9.
32. Johnnidis JB, Harris MH, Wheeler RT, et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature. 2008; 451: 1125-9.
33. Pulikkan JA, Peramangalam PS, Dengler V, et al. C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood. 2010; 116: 5638-49.
34. Zaidi SK, Dowdy CR, van Wijnen AJ, et al. Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res. 2009; 69: 8249-55.
35. Feng J, Iwama A, Satake M, et al. MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1. Br J Haematol. 2009; 145: 412-23.
36. De Marchis ML, Ballarino M, Salvatori B, et al. A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukaemia cells. Leukemia. 2009; 23: 856-62.
37. Surdziel E, Cabanski M, Dallmann I, et al. Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways. Blood. 2011; 117: 4338-48.
38. Li X, Zhang J, Gao L, et al. MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ. 2011; in press: doi: 10.1038/cdd.2011.127.
39. Bruchova-Votavova H, Yoon D, Prchal JT. miR-451 enhances erythroid differentiation in K562 cells. Leuk Lymphoma. 2010; 51: 686-93.
40. Ichimura A, Ruike Y, Terasawa K, et al. MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells. Mol Pharmacol. 2010; 77: 1016-24.
41. Navarro F, Gutman D, Meire E, et al. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood. 2009; 114: 2181-92.
42. Huang X, Gschweng E, Van Handel B, et al. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood. 2011; 117: 2157-65.
43. Grabher C, Payne EM, Johnston AB, et al. Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Leukemia. 2011; 25: 506-14.
44. Patrick DM, Zhang CC, Tao Y, et al. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 2010; 24: 1614-9.
45. Rasmussen KD, Simmini S, Abreu-Goodger C, et al. The miR-144/451 locus is required for erythroid homeostasis. J Exp Med. 2010; 207: 1351-8.
46. Svasti S, Masaki S, Penglong T, et al. Expression of microRNA-451 in normal and thalassemic erythropoiesis. Ann Hematol. 2010; 89: 953-8.
47. Romania P, Lulli V, Pelosi E, et al. MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors. Br J Haematol. 2008; 143: 570-80.
48. Ben-Ami O, Pencovich N, Lotem J, et al. A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis. Proc Natl Acad Sci USA. 2009; 106: 238-43.
49. Labbaye C, Spinello I, Quaranta MT, et al. A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nat Cell Biol. 2008; 10: 788-801.
50. Garzon R, Garofalo M, Martelli MP, et al. Distinctive microRNA signature of acute myeloid leukaemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA. 2008; 105: 3945-50.
51. Garzon R, Volinia S, Liu CG, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukaemia. Blood. 2008; 111: 3183-9.
52. Jongen-Lavrencic M, Sun SM, Dijkstra MK, et al. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukaemia. Blood. 2008; 111: 5078-85.
53. O'Connell RM, Rao DS, Chaudhuri AA, et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med. 2008; 205: 585-94.
54. Costinean S, Sandhu SK, Pedersen IM, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009; 114: 1374-82.
55. O'Connell RM, Chaudhuri AA, Rao DS, et al. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci USA. 2009; 106: 7113-8.
56. Pedersen IM, Otero D, Kao E, et al. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009; 1: 288-95.
57. Garzon R, Heaphy CE, Havelange V, et al. MicroRNA 29b functions in acute myeloid leukaemia. Blood. 2009; 114: 5331-41.
58. Garzon R, Liu S, Fabbri M, et al. MicroRNA-29b induces global DNA hypomethylation and tumour suppressor gene reexpression in acute myeloid leukaemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. 2009; 113: 6411-8.
59. Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA. 2010; 107: 7473-8.
60. Liu S, Wu LC, Pang J, et al. Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukaemia. Cancer Cell. 2010; 17: 333-47.
61. Teichler S, Illmer T, Roemhild J, et al. MicroRNA29a regulates the expression of the nuclear oncogene Ski. Blood. 2011; 118: 1899-902.
62. Cammarata G, Augugliaro L, Salemi D, et al. Differential expression of specific microRNA and their targets in acute myeloid leukaemia. Am J Hematol. 2010; 85: 331-9.
63. Isken F, Steffen B, Merk S, et al. Identification of acute myeloid leukaemia associated microRNA expression patterns. Br J Haematol. 2008; 140: 153-61.
64. Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA. 2005; 102: 18081-6.
65. Hackanson B, Bennett KL, Brena RM, et al. Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukaemia. Cancer Res. 2008; 68: 3142-51.
66. Pulikkan JA, Dengler V, Peramangalam PS, et al. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukaemia. Blood. 2010; 115: 1768-78.
67. Eyholzer M, Schmid S, Wilkens L, et al. The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML. Br J Cancer. 2010; 103: 275-84.
68. Tse W, Meshinchi S, Alonzo TA, et al. Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukaemia. Blood. 2004; 104: 3058-63.
69. Xiong Y, Li Z, Ji M, et al. MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML. Br J Haematol. 2011; 153: 753-7.
70. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010; 17: 193-9.
71. Pigazzi M, Manara E, Baron E, et al. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukaemia. Cancer Res. 2009; 69: 2471-8.
72. He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature. 2005; 435: 828-33.
73. Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 2005; 65: 9628-32.
74. Venturini L, Battmer K, Castoldi M, et al. Expression of the miR-17-92 polycistron in chronic myeloid leukaemia (CML) CD34+ cells. Blood. 2007; 109: 4399-405.
75. Li Z, Lu J, Sun M, et al. Distinct microRNA expression profiles in acute myeloid leukaemia with common translocations. Proc Natl Acad Sci USA. 2008; 105: 15535-40.
76. Mi S, Li Z, Chen P, et al. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukaemia. Proc Natl Acad Sci USA. 2010; 107: 3710-5.
77. Garzon R, Pichiorri F, Palumbo T, et al. MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci USA. 2006; 103: 5078-83.
78. Wong P, Iwasaki M, Somervaille TC, et al. The miR-17-92 microRNA polycistron regulates MLL leukaemia stem cell potential by modulating p21 expression. Cancer Res. 2010; 70: 3833-42.
79. Popovic R, Riesbeck LE, Velu CS, et al. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood. 2009; 113: 3314-22.
80. Brackman D, Lund-Johansen F, Aarskog D. Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1, 25-dihydroxyvitamin D3, retinoic acid and DMSO. Leuk Res. 1995; 19: 57-64.
81. Wang X, Gocek E, Liu CG, et al. MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukaemia cells induced to differentiate by 1, 25-dihydroxyvitamin D3. Cell Cycle. 2009; 8: 736-41.
82. Bousquet M, Quelen C, Rosati R, et al. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukaemia with the t(2;11)(p21;q23) translocation. J Exp Med. 2008; 205: 2499-506.
83. O'Connell RM, Chaudhuri AA, Rao DS, et al. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci USA. 2010; 107: 14235-40.
84. Klusmann JH, Li Z, Bohmer K, et al. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukaemia. Genes Dev. 2010; 24: 478-90.
85. Bousquet M, Harris MH, Zhou B, et al. MicroRNA miR-125b causes leukaemia. Proc Natl Acad Sci USA. 2010; 107: 21558-63.
86. Saumet A, Vetter G, Bouttier M, et al. Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukaemia. Blood. 2009; 113: 412-21.
87. Careccia S, Mainardi S, Pelosi A, et al. A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. Oncogene. 2009; 28: 4034-40.
88. Fazi F, Racanicchi S, Zardo G, et al. Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell. 2007; 12: 457-66.