Cancer gene discovery in the mouse

Current Opinion in Genetics and Development

Volumn 22, Issue 1, 2012, Pages 14-20

  McIntyre, Rebecca E ^a   van der Weyden, Louise ^a   Adams, David J ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BMI 1 GENE; CANCER GENETICS; CANCER RESEARCH; CSF1 GENE; DNA REPAIR; ENVIRONMENTAL FACTOR; FRAT 1 GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENE MUTATION; GENETIC SCREENING; GENOME ANALYSIS; GFI 1 GENE; LONG TERMINAL REPEAT; NONHUMAN; PIGGYBAC TRANSPOSON; PIM 1 GENE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SLEEPING BEAUTY TRANSPOSON; TRANSPOSON; TUMOR GENE;

EID: 84858441210     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2011.12.003     Document Type: Review

References (50)

1. Stratton M.R., Campbell P.J., Futreal P.A. The cancer genome. Nature 2009, 458:719-724.
2. Carter H., Samayoa J., Hruban R.H., Karchin R. Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). Cancer Biol Ther 2010, 10:582-587.
3. Integrated genomic analyses of ovarian carcinoma. Nature 2011, 474:609-615. Cancer Genome Atlas Research Network.
4. Powell S.M., Zilz N., Beazer-Barclay Y., Bryan T.M., Hamilton S.R., Thibodeau S.N., Vogelstein B., Kinzler K.W. Apc mutations occur early during colorectal tumorigenesis. Nature 1992, 359:235-237.
5. Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002, 420:520-562.
6. Frese K.K., Tuveson D.A. Maximizing mouse cancer models. Nat Rev Cancer 2007, 7:645-658.
7. Rangarajan A., Weinberg R.A. Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer 2003, 3:952-959.
8. Rangarajan A., Hong S.J., Gifford A., Weinberg R.A. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004, 6:171-183.
9. Hemann M.T., Greider C.W. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res 2000, 28:4474-4478.
10. Copeland N.G., Jenkins N.A. Harnessing transposons for cancer gene discovery. Nat Rev Cancer 2010, 10:696-706.
11. Dupuy A.J. Transposon-based screens for cancer gene discovery in mouse models. Semin Cancer Biol 2010, 20:261-268.
12. Kool J., Berns A. High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat Rev Cancer 2009, 9:389-399.
13. Dupuy A.J., Akagi K., Largaespada D.A., Copeland N.G., Jenkins N.A. Mammalian mutagenesis using a highly mobile somatic sleeping beauty transposon system. Nature 2005, 436:221-226.
14. Collier L.S., Adams D.J., Hackett C.S., Bendzick L.E., Akagi K., Davies M.N., Diers M.D., Rodriguez F.J., Bender A.M., Tieu C., et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res 2009, 69:8429-8437.
15. Rad R., Rad L., Wang W., Cadinanos J., Vassiliou G., Rice S., Campos L.S., Yusa K., Banerjee R., Li M.A., et al. Piggybac transposon mutagenesis: a tool for cancer gene discovery in mice. Science 2010, 330:1104-1107.
16. Keng V.W., Villanueva A., Chiang D.Y., Dupuy A.J., Ryan B.J., Matise I., Silverstein K.A., Sarver A., Starr T.K., Akagi K., et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol 2009, 27:264-274.
17. Starr T.K., Allaei R., Silverstein K.A., Staggs R.A., Sarver A.L., Bergemann T.L., Gupta M., O'Sullivan M.G., Matise I., Dupuy A.J., et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 2009, 323:1747-1750.
18. March H.N., Rust A.G., Wright N.A., Ten Hoeve J., de Ridder J., Eldridge M., van der Weyden L., Berns A., Gadiot J., Uren A., Kemp R., et al. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet 2011, 43(12):1202-1209.
19. Berquam-Vrieze K.E., Nannanpaneni K., Brett B.T., Holmfeldt L., Ma J., Zagorodna O., Jenkins N.A., Copeland N.G., Meyerholz D.K., Knudson C.M., et al. Cell of origin strongly influences genetic selection in mouse models of t-all. Blood 2011, 118(17):4646-4656.
20. McGrail M., Hatler J.M., Kuang X., Liao H.K., Nannapaneni K., Watt K.E., Uhl J.D., Largaespada D.A., Vollbrecht E., Scheetz T.E., et al. Somatic mutagenesis with a sleeping beauty transposon system leads to solid tumor formation in zebrafish. PLoS One 2011, 6:e18826.
21. Uren A.G., Mikkers H., Kool J., van der Weyden L., Lund A.H., Wilson C.H., Rance R., Jonkers J., van Lohuizen M., Berns A., Adams D.J. A high-throughput splinkerette-pcr method for the isolation and sequencing of retroviral insertion sites. Nat Protoc 2009, 4:789-798.
22. de Jong J., de Ridder J., van der Weyden L., Sun N., van Uitert M., Berns A., van Lohuizen M., Jonkers J., Adams D.J., Wessels L.F. Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res 2011, 39:e105.
23. van der Weyden L., Giotopoulos G., Rust A.G., Matheson L.S., van Delft F.W., Kong J., Corcoran A.E., Greaves M.F., Mullighan C.G., Huntly B.J., Adams D.J. Modeling the evolution of etv6-runx1-induced b-cell precursor acute lymphoblastic leukemia in mice. Blood 2011, 118:1041-1051.
24. Starr T.K., Scott P.M., Marsh B.M., Zhao L., Than B.L., O'Sullivan M.G., Sarver A.L., Dupuy A.J., Largaespada D.A., Cormier R.T. A sleeping beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A 2011, 108:5765-5770.
25. Mattison J., van der Weyden L., Hubbard T., Adams D.J. Cancer gene discovery in mouse and man. Biochim Biophys Acta 2009, 1796:140-161.
26. Cuypers H.T., Selten G., Quint W., Zijlstra M., Maandag E.R., Boelens W., van Wezenbeek P., Melief C., Berns A. Murine leukemia virus-induced t-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region. Cell 1984, 37(1):141-150.
27. Dreyfus F., Sola B., Fichelson S., Varlet P., Charon M., Tambourin P., Wendling F., Gisselbrecht S. Rearrangements of the pim-1, c-myc, and p53 genes in friend helper virus-induced mouse erythroleukemias. Leukemia 1990, 4(8):590-594.
28. van Lohuizen M., Verbeek S., Scheijen B., Wientjens E., van der Gulden H., Berns A. Identification of cooperating oncogenes in e mu-myc transgenic mice by provirus tagging. Cell 1991, 65(5):737-752.
29. Haupt Y., Alexander W.S., Barri G., Klinken S.P., Adams J.M. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in e mu-myc transgenic mice. Cell 1991, 65(5):753-763.
30. Jonkers J., Korswagen H.C., Acton D., Breuer M., Berns A. Activation of a novel proto-oncogene, frat1, contributes to progression of mouse t-cell lymphomas. Embo J 1997, 16(3):441-450.
31. Gilks C.B., Bear S.E., Grimes H.L., Tsichlis P.N. Progression of interleukin-2 (il-2)-dependent rat t cell lymphoma lines to il-2-independent growth following activation of a gene (gfi-1) encoding a novel zinc finger protein. Mol Cell Biol 1993, 13(3):1759-1768.
32. Bender A.M., Collier L.S., Rodriguez F.J., Tieu C., Larson J.D., Halder C., Mahlum E., Kollmeyer T.M., Akagi K., Sarkar G., Largaespada D.A., et al. Sleeping beauty-mediated somatic mutagenesis implicates csf1 in the formation of high-grade astrocytomas. Cancer Res 2010, 70(9):3557-3565.
33. Keane T.M., Goodstadt L., Danecek P., White M.A., Wong K., Yalcin B., Heger A., Agam A., Slater G., Goodson M., et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 2011, 477:289-294.
34. Yalcin B., Wong K., Agam A., Goodson M., Keane T.M., Gan X., Nellaker C., Goodstadt L., Nicod J., Bhomra A., et al. Sequence-based characterization of structural variation in the mouse genome. Nature 2011, 477:326-329.
35. Wong K.M., Hudson T.J., McPherson J.D. Unraveling the genetics of cancer: genome sequencing and beyond. Annu Rev Genomics Hum Genet 2011, 12:407-430.
36. Vassiliou G.S., Cooper J.L., Rad R., Li J., Rice S., Uren A., Rad L., Ellis P., Andrews R., Banerjee R., et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 2011, 43:470-475.
37. Uren A.G., Kool J., Matentzoglu K., de Ridder J., Mattison J., van Uitert M., Lagcher W., Sie D., Tanger E., Cox T., et al. Large-scale mutagenesis in p19(arf)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell 2008, 133:727-741.
38. Lauchle J.O., Kim D., Le D.T., Akagi K., Crone M., Krisman K., Warner K., Bonifas J.M., Li Q., Coakley K.M., et al. Response and resistance to mek inhibition in leukaemias initiated by hyperactive ras. Nature 2009, 461:411-414.
39. Sauvageau M., Miller M., Lemieux S., Lessard J., Hebert J., Sauvageau G. Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia. Blood 2008, 111:790-799.
40. Su Q., Prosser H.M., Campos L.S., Ortiz M., Nakamura T., Warren M., Dupuy A.J., Jenkins N.A., Copeland N.G., Bradley A., Liu P. A DNA transposon-based approach to validate oncogenic mutations in the mouse. Proc Natl Acad Sci U S A 2008, 105:19904-19909.
41. Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008, 321:1801-1806.
42. Wood L.D., Parsons D.W., Jones S., Lin J., Sjoblom T., Leary R.J., Shen D., Boca S.M., Barber T., Ptak J., et al. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113.
43. Mattison J., Kool J., Uren A.G., de Ridder J., Wessels L., Jonkers J., Bignell G.R., Butler A., Rust A.G., Brosch M., et al. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res 2010, 70:883-895.
44. Metzker M.L. Sequencing technologies-the next generation. Nat Rev Genet 2010, 11:31-46.
45. Varela I., Klijn C., Stephens P.J., Mudie L.J., Stebbings L., Galappaththige D., van der Gulden H., Schut E., Klarenbeek S., Campbell P.J., et al. Somatic structural rearrangements in genetically engineered mouse mammary tumors. Genome Biol 2010, 11:R100.
46. Wartman L.D., Larson D.E., Xiang Z., Ding L., Chen K., Lin L., Cahan P., Klco J.M., Welch J.S., Li C., et al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest 2011, 121:1445-1455.
47. Flex E., Petrangeli V., Stella L., Chiaretti S., Hornakova T., Knoops L., Ariola C., Fodale V., Clappier E., Paoloni F., et al. Somatically acquired jak1 mutations in adult acute lymphoblastic leukemia. J Exp Med 2008, 205:751-758.
48. Mullighan C.G., Zhang J., Harvey R.C., Collins-Underwood J.R., Schulman B.A., Phillips L.A., Tasian S.K., Loh M.L., Su X., Liu W., et al. Jak mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 2009, 106:9414-9418.
49. van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., Edkins S., Hardy C., O'Meara S., Teague J., et al. Somatic mutations of the histone h3k27 demethylase gene utx in human cancer. Nat Genet 2009, 41:521-523.
50. Stephens P.J., McBride D.J., Lin M.L., Varela I., Pleasance E.D., Simpson J.T., Stebbings L.A., Leroy C., Edkins S., Mudie L.J., et al. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 2009, 462:1005-1010.