Marking renal injury: Can we move beyond serum creatinine?

Translational Research

Volumn 159, Issue 4, 2012, Pages 277-289

  Slocum, Jessica L ^a,b   Heung, Michael ^a,b   Pennathur, Subramaniam ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CREATININE; CYSTATIN C; FATTY ACID; I KAPPA B KINASE BETA; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NUCLEIC ACID; PLASMA PROTEIN;

ACUTE HEART INFARCTION; ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; CARDIOPULMONARY BYPASS; CELL PROLIFERATION; CREATININE BLOOD LEVEL; CYTOTOXICITY; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HUMAN; KIDNEY DISEASE; KIDNEY GRAFT; LIPID PEROXIDATION; MASS SPECTROMETRY; METABOLOMICS; NEPHROTIC SYNDROME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN URINE LEVEL; PROTEOMICS; REVIEW; URINARY TRACT INFECTION; URINE VOLUME;

EID: 84858432322     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2012.01.014     Document Type: Review

References (120)

1. P.G. Metnitz, C.G. Krenn, and H. Steltzer Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients Crit Care Med 30 2002 2051 2058
2. R. Bellomo, C. Ronco, J.A. Kellum, R.L. Mehta, and P. Palevsky Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group Crit Care 8 2004 R204 R212
3. R.L. Mehta, J.A. Kellum, and S.V. Shah Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 11 2007 R31
4. O.D.J. Folin On the creatinine and creatinine content of blood Biol Chem 17 1914 487 491
5. S.S. Waikar, and J.V. Bonventre Creatinine kinetics and the definition of acute kidney injury J Am Soc Nephrol 20 2009 672 679
6. D. Portilla, C. Dent, and T. Sugaya Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery Kidney Int 73 2008 465 472
7. K. Doi, P.S. Yuen, and C. Eisner Reduced production of creatinine limits its use as marker of kidney injury in sepsis J Am Soc Nephrol 20 2009 1217 1221
8. C.R. Parikh, and P. Devarajan New biomarkers of acute kidney injury Crit Care Med 36 4 Suppl 2008 S159 S165
9. P. Devarajan Proteomics for biomarker discovery in acute kidney injury Semin Nephrol 27 2007 637 651
10. J.H. Wang, J. Byun, and S. Pennathur Analytical approaches to metabolomics and applications to systems biology Semin Nephrol 30 2010 500 511
11. M.R. Bennett, and P. Devarajan Proteomic analysis of acute kidney injury: biomarkers to mechanisms Proteomics Clin Appl 5 2011 67 77
12. A. Vivekanandan-Giri, J.L. Slocum, and C.L. Buller Urine glycoprotein profile reveals novel markers for chronic kidney disease Int J Proteomics 2011 2011 214715 Epub 2011 Oct 10
13. S.Y. Xu, M. Carlson, A. Engstrom, R. Garcia, C.G. Peterson, and P. Venge Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils Scand J Clin Lab Invest 54 1994 365 376
14. D.H. Goetz, M.A. Holmes, N. Borregaard, M.E. Bluhm, K.N. Raymond, and R.K. Strong The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition Mol Cell 10 2002 1033 1043
15. T.H. Flo, K.D. Smith, and S. Sato Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron Nature 432 2004 917 921
16. J. Mishra, Q. Ma, and A. Prada Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury J Am Soc Nephrol 14 2003 2534 2543
17. K.M. Schmidt-Ott, K. Mori, and J.Y. Li Dual action of neutrophil gelatinase-associated lipocalin J Am Soc Nephrol 18 2007 407 413
18. S. Supavekin, W. Zhang, R. Kucherlapati, F.J. Kaskel, L.C. Moore, and P. Devarajan Differential gene expression following early renal ischemia/reperfusion Kidney Int 63 2003 1714 1724
19. J. Mishra, K. Mori, Q. Ma, C. Kelly, J. Barasch, and P. Devarajan Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity Am J Nephrol 24 2004 307 315
20. K. Mori, H.T. Lee, and D. Rapoport Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury J Clin Invest 115 2005 610 621
21. P.S. Yuen, S.K. Jo, M.K. Holly, X. Hu, and R.A. Star Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses Physiol Genomics 25 2006 375 386
22. P. Devarajan Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury Biomark Med 4 2010 265 280
23. S.S. Soni, D. Cruz, and I. Bobek NGAL: a biomarker of acute kidney injury and other systemic conditions Int Urol Nephrol 42 2010 141 150
24. D.N. Cruz, C. Ronco, and N. Katz Neutrophil gelatinase-associated lipocalin: a promising biomarker for detecting cardiac surgery-associated acute kidney injury J Thorac Cardiovasc Surg 139 2010 1101 1106
25. J. Mishra, C. Dent, and R. Tarabishi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery Lancet 365 2005 1231 1238
26. G. Wagener, M. Jan, and M. Kim Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery Anesthesiology 105 2006 485 491
27. J.L. Koyner, M.R. Bennett, and E.M. Worcester Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery Kidney Int 74 2008 1059 1069
28. C. Xin, X. Yulong, C. Yu, C. Changchun, Z. Feng, and M. Xinwei Urine neutrophil gelatinase-associated lipocalin and interleukin-18 predict acute kidney injury after cardiac surgery Ren Fail 30 2008 904 913
29. S.M. Tuladhar, V.O. Puntmann, M. Soni, P.P. Punjabi, and R.G. Bogle Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass J Cardiovasc Pharmacol 53 2009 261 266
30. G. Wagener, G. Gubitosa, S. Wang, N. Borregaard, M. Kim, and H.T. Lee Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery Am J Kidney Dis 52 2008 425 433
31. C.R. Parikh, P. Devarajan, and M. Zappitelli Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery J Am Soc Nephrol 22 2011 1737 1747
32. C.R. Parikh, S.G. Coca, and H. Thiessen-Philbrook Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery J Am Soc Nephrol 22 2011 1748 1757
33. M. Zappitelli, K.K. Washburn, and A.A. Arikan Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study Crit Care 11 2007 R84
34. D.S. Wheeler, P. Devarajan, and Q. Ma Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock Crit Care Med 36 2008 1297 1303
35. K. Makris, N. Markou, and E. Evodia Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients Clin Chem Lab Med 47 2009 79 82
36. E.D. Siew, L.B. Ware, and T. Gebretsadik Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults J Am Soc Nephrol 20 2009 1823 1832
37. D.N. Cruz, M. de Cal, and F. Garzotto Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population Intensive Care Med 36 2010 444 451
38. J.M. Constantin, E. Futier, and S. Perbet Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: a prospective study J Crit Care 25 2010 176.e1 176.e6
39. S.M. Bagshaw, M. Bennett, and M. Haase Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness Intensive Care Med 36 2010 452 461
40. J. Mishra, Q. Ma, and C. Kelly Kidney NGAL is a novel early marker of acute injury following transplantation Pediatr Nephrol 21 2006 856 863
41. C.R. Parikh, A. Jani, and J. Mishra Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation Am J Transplant 6 2006 1639 1645
42. I.E. Hall, S.G. Yarlagadda, and S.G. Coca IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation J Am Soc Nephrol 21 2010 189 197
43. R. Hirsch, C. Dent, and H. Pfriem NGAL is an early predictive biomarker of contrast-induced nephropathy in children Pediatr Nephrol 22 2007 2089 2095
44. H. Bachorzewska-Gajewska, J. Malyszko, E. Sitniewska, J.S. Malyszko, and S. Dobrzycki Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions Am J Nephrol 26 2006 287 292
45. H. Bachorzewska-Gajewska, J. Malyszko, E. Sitniewska, J.S. Malyszko, and S. Dobrzycki Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography Nephrol Dial Transplant 22 2007 295 296
46. W. Ling, N. Zhaohui, and H. Ben Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography Nephron Clin Pract 108 2008 c176 c181
47. T.L. Nickolas, M.J. O'Rourke, and J. Yang Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury Ann Intern Med 148 2008 810 819
48. M. Haase, R. Bellomo, P. Devarajan, P. Schlattmann, and A. Haase-Fielitz Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis Am J Kidney Dis 54 2009 1012 1024
49. J. Boldt, S. Suttner, C. Brosch, A. Lehmann, K. Rohm, and A. Mengistu Cardiopulmonary bypass priming using a high dose of a balanced hydroxyethyl starch versus an albumin-based priming strategy Anesth Analg 109 2009 1752 1762
50. G. Wagener, G. Gubitosa, S. Wang, N. Borregaard, M. Kim, and H.T. Lee Increased incidence of acute kidney injury with aprotinin use during cardiac surgery detected with urinary NGAL Am J Nephrol 28 2008 576 582
51. D.R. McIlroy, G. Wagener, and H.T. Lee Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance Clin J Am Soc Nephrol 5 2010 211 219
52. C.L. Edelstein, Y. Shi, and R.W. Schrier Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules J Am Soc Nephrol 10 1999 1940 1949
53. P. Li, H. Allen, and S. Banerjee Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock Cell 80 1995 401 411
54. V.Y. Melnikov, T. Ecder, and G. Fantuzzi Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure J Clin Invest 107 2001 1145 1152
55. Z. He, L. Lu, and C. Altmann Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury Am J Physiol Renal Physiol 295 2008 F1414 F1421
56. H. Wu, M.L. Craft, and P. Wang IL-18 contributes to renal damage after ischemia-reperfusion J Am Soc Nephrol 19 2008 2331 2341
57. G. Fantuzzi, D.A. Reed, and C.A. Dinarello IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor J Clin Invest 104 1999 761 767
58. C.R. Parikh, A. Jani, V.Y. Melnikov, S. Faubel, and C.L. Edelstein Urinary interleukin-18 is a marker of human acute tubular necrosis Am J Kidney Dis 43 2004 405 414
59. C.R. Parikh, E. Abraham, M. Ancukiewicz, and C.L. Edelstein Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit J Am Soc Nephrol 16 2005 3046 3052
60. C.R. Parikh, J. Mishra, and H. Thiessen-Philbrook Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery Kidney Int 70 2006 199 203
61. K.K. Washburn, M. Zappitelli, and A.A. Arikan Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children Nephrol Dial Transplant 23 2008 566 572
62. E.D. Siew, T.A. Ikizler, and T. Gebretsadik Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes Clin J Am Soc Nephrol 5 2010 1497 1505
63. J.A. Gracie, S.E. Robertson, and I.B. McInnes Interleukin-18 J Leukoc Biol 73 2003 213 224
64. T. Ichimura, J.V. Bonventre, and V. Bailly Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury J Biol Chem 273 1998 4135 4142
65. T. Ichimura, E.J. Asseldonk, B.D. Humphreys, L. Gunaratnam, J.S. Duffield, and J.V. Bonventre Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells J Clin Invest 118 2008 1657 1668
66. J.V. Bonventre Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more Nephrol Dial Transplant 24 2009 3265 3268
67. V. Bailly, Z. Zhang, W. Meier, R. Cate, M. Sanicola, and J.V. Bonventre Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration J Biol Chem 277 2002 39739 39748
68. T. Ichimura, C.C. Hung, S.A. Yang, J.L. Stevens, and J.V. Bonventre Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury Am J Physiol Renal Physiol 286 2004 F552 F563
69. V.S. Vaidya, V. Ramirez, T. Ichimura, N.A. Bobadilla, and J.V. Bonventre Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury Am J Physiol Renal Physiol 290 2006 F517 F529
70. W.C. Prozialeck, V.S. Vaidya, and J. Liu Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity Kidney Int 72 2007 985 993
71. Y. Zhou, V.S. Vaidya, and R.P. Brown Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium Toxicol Sci 101 2008 159 170
72. V.S. Vaidya, G.M. Ford, and S.S. Waikar A rapid urine test for early detection of kidney injury Kidney Int 76 2009 108 114
73. V.S. Vaidya, J.S. Ozer, and F. Dieterle Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies Nat Biotechnol 28 2010 478 485
74. W.K. Han, V. Bailly, R. Abichandani, R. Thadhani, and J.V. Bonventre Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury Kidney Int 62 2002 237 244
75. W.K. Han, S.S. Waikar, and A. Johnson Urinary biomarkers in the early diagnosis of acute kidney injury Kidney Int 73 2008 863 869
76. O. Liangos, H. Tighiouart, and M.C. Perianayagam Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass Biomarkers 14 2009 423 431
77. W.K. Han, G. Wagener, Y. Zhu, S. Wang, and H.T. Lee Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery Clin J Am Soc Nephrol 4 2009 873 882
78. O. Liangos, M.C. Perianayagam, and V.S. Vaidya Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure J Am Soc Nephrol 18 2007 904 912
79. Y. Huang, and A.C. Don-Wauchope The clinical utility of kidney injury molecule 1 in the prediction, diagnosis and prognosis of acute kidney injury: a systematic review Inflamm Allergy Drug Targets 10 2011 260 271
80. A. Chmurzynska The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism J Appl Genet 47 2006 39 48
81. B.A. Ek-Von Mentzer, F. Zhang, and J.A. Hamilton Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation J Biol Chem 276 2001 15575 15580
82. G. Wang, Y. Gong, and J. Anderson Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells Hepatology 42 2005 871 879
83. A. Kamijo, T. Sugaya, and A. Hikawa Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules Am J Pathol 165 2004 1243 1255
84. A. Kamijo-Ikemori, T. Sugaya, and A. Obama Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction Am J Pathol 169 2006 1107 1117
85. T. Yamamoto, E. Noiri, and Y. Ono Renal L-type fatty acid-binding protein in acute ischemic injury J Am Soc Nephrol 18 2007 2894 2902
86. K. Negishi, E. Noiri, and T. Sugaya A role of liver fatty acid-binding protein in cisplatin-induced acute renal failure Kidney Int 72 2007 348 358
87. K. Negishi, E. Noiri, R. Maeda, D. Portilla, T. Sugaya, and T. Fujita Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury Kidney Int 73 2008 1374 1384
88. K. Negishi, E. Noiri, and K. Doi Monitoring of urinary L-type fatty acid-binding protein predicts histological severity of acute kidney injury Am J Pathol 174 2009 1154 1159
89. T. Yokoyama, A. Kamijo-Ikemori, T. Sugaya, S. Hoshino, T. Yasuda, and K. Kimura Urinary excretion of liver type fatty acid binding protein accurately reflects the degree of tubulointerstitial damage Am J Pathol 174 2009 2096 2106
90. T. Nakamura, T. Sugaya, K. Node, Y. Ueda, and H. Koide Urinary excretion of liver-type fatty acid-binding protein in contrast medium-induced nephropathy Am J Kidney Dis 47 2006 439 444
91. Y. Fukuda, S. Miura, and B. Zhang Significance of urinary liver-fatty acid-binding protein in cardiac catheterization in patients with coronary artery disease Intern Med 48 2009 1731 1737
92. T. Nakamura, T. Sugaya, and H. Koide Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion Shock 31 2009 454 459
93. M.A. Ferguson, V.S. Vaidya, and S.S. Waikar Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury Kidney Int 77 2010 708 714
94. J. Brzin, T. Popovic, V. Turk, U. Borchart, and W. Machleidt Human cystatin, a new protein inhibitor of cysteine proteinases Biochem Biophys Res Commun 118 1984 103 109
95. A.O. Grubb Cystatin C - properties and use as diagnostic marker Adv Clin Chem 35 2000 63 99
96. E. Coll, A. Botey, and L. Alvarez Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment Am J Kidney Dis 36 2000 29 34
97. V.R. Dharnidharka, C. Kwon, and G. Stevens Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis Am J Kidney Dis 40 2002 221 226
98. J.F. Roos, J. Doust, S.E. Tett, and C.M. Kirkpatrick Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children - a meta-analysis Clin Biochem 40 2007 383 391
99. R. Kaseda, N. Iino, and M. Hosojima Megalin-mediated endocytosis of cystatin C in proximal tubule cells Biochem Biophys Res Commun 357 2007 1130 1134
100. S. Herget-Rosenthal, G. Marggraf, and J. Husing Early detection of acute renal failure by serum cystatin C Kidney Int 66 2004 1115 1122
101. A.A. Royakkers, J.C. Korevaar, and J.D. van Suijlen Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy Intensive Care Med 37 2011 493 501
102. H. Rickli, K. Benou, and P. Ammann Time course of serial cystatin C levels in comparison with serum creatinine after application of radiocontrast media Clin Nephrol 61 2004 98 102
103. A. Ahlstrom, M. Tallgren, S. Peltonen, and V. Pettila Evolution and predictive power of serum cystatin C in acute renal failure Clin Nephrol 62 2004 344 350
104. K. Soto, S. Coelho, and B. Rodrigues Cystatin C as a marker of acute kidney injury in the emergency department Clin J Am Soc Nephrol 5 2010 1745 1754
105. D.N. Cruz, H.R. de Geus, and S.M. Bagshaw Biomarker strategies to predict need for renal replacement therapy in acute kidney injury Semin Dial 24 2011 124 131
106. Z. Zhang, B. Lu, X. Sheng, and N. Jin Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis Am J Kidney Dis 58 2011 356 365
107. M.T. Nguyen, G.F. Ross, C.L. Dent, and P. Devarajan Early prediction of acute renal injury using urinary proteomics Am J Nephrol 25 2005 318 326
108. M.T. Nguyen, C.L. Dent, and G.F. Ross Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapy Pediatr Nephrol 23 2008 1317 1326
109. P. Devarajan, C.D. Krawczeski, M.T. Nguyen, T. Kathman, Z. Wang, and C.R. Parikh Proteomic identification of early biomarkers of acute kidney injury after cardiac surgery in children Am J Kidney Dis 56 2010 632 642
110. J. Ho, M. Lucy, and O. Krokhin Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass: a nested case-control study Am J Kidney Dis 53 2009 584 595
111. J. Ho, M. Reslerova, and B. Gali Urinary hepcidin-25 and risk of acute kidney injury following cardiopulmonary bypass Clin J Am Soc Nephrol 6 2011 2340 2346
112. F. Aregger, C. Pilop, and D.E. Uehlinger Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury J Thorac Cardiovasc Surg 139 2010 692 700
113. F. Heller, S. Frischmann, M. Grunbaum, W. Zidek, and T.H. Westhoff Urinary calprotectin and the distinction between prerenal and intrinsic acute kidney injury Clin J Am Soc Nephrol 6 2011 2347 2355
114. R.D. Beger, R.D. Holland, and J. Sun Metabonomics of acute kidney injury in children after cardiac surgery Pediatr Nephrol 23 2008 977 984
115. P.J. Foxall, G.J. Mellotte, M.R. Bending, J.C. Lindon, and J.K. Nicholson NMR spectroscopy as a novel approach to the monitoring of renal transplant function Kidney Int 43 1993 234 245
116. D.S. Wishart Metabolomics: the principles and potential applications to transplantation Am J Transplant 5 2005 2814 2820
117. K.J. Boudonck, D.J. Rose, E.D. Karoly, D.P. Lee, K.A. Lawton, and P.J. Lapinskas Metabolomics for early detection of drug-induced kidney injury: review of the current status Bioanalysis 1 2009 1645 1663
118. V.S. Vaidya, S.S. Waikar, and M.A. Ferguson Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans Clin Transl Sci 1 2008 200 208
119. J. Metzger, T. Kirsch, and E. Schiffer Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury Kidney Int 78 2010 1252 1262
120. I.E. Hall, S.G. Coca, and M.A. Perazella Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis Clin J Am Soc Nephrol 6 2011 2740 2749