Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy

Intensive Care Medicine

Volumn 37, Issue 3, 2011, Pages 493-501

  Royakkers, Annick A N M ^a   Korevaar, Johanna C ^b   Van Suijlen, Jeroen D E ^c   Hofstra, Lieuwe S ^d   Kuiper, Michael A ^e,f   Spronk, Peter E ^c,f   Schultz, Marcus J ^b,f   Bouman, Catherine S C ^b  

^a Tergooi Hospitals   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c GELRE HOSPITALS   (Netherlands)

^d Scheper Ziekenhuis   (Netherlands)

^e MEDICAL CENTER LEEUWARDEN   (Netherlands)

^f HERMES Critical Care Group   (Netherlands)

Author keywords

Acute kidney injury; Intensive care unit; Predictive biomarkers; Renal replacement therapy; Serum cystatin C; Urine cystatin C

Indexed keywords

BIOLOGICAL MARKER; CYSTATIN C;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; RENAL REPLACEMENT THERAPY; URINE LEVEL;

ACUTE KIDNEY INJURY; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COHORT STUDIES; CYSTATIN C; FEMALE; HUMANS; MALE; MIDDLE AGED; NEEDS ASSESSMENT; RENAL REPLACEMENT THERAPY;

EID: 79953824981     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-2087-y     Document Type: Article

References (42)

1. Joannidis M, Metnitz PG (2005) Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin 21:239-249 (Pubitemid 40386752)
2. Uchino S, Bellomo R, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Oudemans-van SH, Ronco C, Kellum JA (2007) Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med 33:1563-1570. doi: 10.1007/s00134-007-0754-4
3. Kolhe NV, Stevens PE, Crowe AV, Lipkin GW, Harrison DA (2008) Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme database. Crit Care 12(Suppl 1):S2. doi:10.1186/ccforum.com/ content/12/S1/S2
4. Jo SK, Rosner MH, Okusa MD (2007) Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol 2:356-365. doi: 10.2215/CJN.03280906
5. Bouman CS, Forni LG, Joannidis M (2010) Biomarkers and acute kidney injury: dining with the Fisher King? Intensive Care Med 36:381-384. doi: 10.1007/s00134-009-1733-8
6. Parikh CR, Devarajan P (2008) New biomarkers of acute kidney injury. Crit Care Med 36:S159-S165. doi: 10.1097/CCM.0b013e318168c652 (Pubitemid 351483046)
7. Herget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115-1122 (Pubitemid 39121017)
8. Conti M, Zater M, Lallali K, Durrbach A, Moutereau S, Manivet P, Eschwege P, Loric S (2005) Absence of circadian variations in urine cystatin C allows its use on urinary samples. Clin Chem 51:272-273. doi: 10.1373/clinchem.2004. 039123 (Pubitemid 40024060)
9. Conti M, Moutereau S, Zater M, Lallali K, Durrbach A, Manivet P, Eschwege P, Loric S (2006) Urinary cystatin C as a specific marker of tubular dysfunction. Clin Chem Lab Med 44:288-291. doi: 10.1515/CCLM.2006.050 (Pubitemid 43357687)
10. Herget-Rosenthal S, Feldkamp T, Volbracht L, Kribben A (2004) Measurement of urinary cystatin C by particle-enhanced nephelometric immunoassay: precision, interferences, stability and reference range. Ann Clin Biochem 41:111-118 (Pubitemid 38523595)
11. Herget-Rosenthal S, Poppen D, Husing J, Marggraf G, Pietruck F, Jakob HG, Philipp T, Kribben A (2004) Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin Chem 50:552-558. doi: 10.1373/clinchem.2003.027763 (Pubitemid 38297305)
12. Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT (2008) Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int 74:1059-1069. doi: 10.1038/ki.2008.341
13. Uchida K, Gotoh A (2002) Measurement of cystatin-C and creatinine in urine. Clin Chim Acta 323:121-128 (Pubitemid 34804801)
14. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204-R212. doi:10.1186/cc2872
15. Bouman CSC, Royakkers AA, Korevaar JC, van Suijlen JD, Hofstra LS, Kuiper MA, Spronk PE, Schultz MJ (2009) The utility of urinary cystatin C as early predictive biomarkers for acute kidney injury in critically il patients admitted to the ICU. Intensive Care Med 35:S221
16. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818-829 (Pubitemid 15250137)
17. Le Gall Jr, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963
18. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461-470 (Pubitemid 29135798)
19. Morgenstern BZ, Butani L, Wollan P, Wilson DM, Larson TS (2003) Validity of protein-osmolality versus protein-creatinine ratios in the estimation of quantitative proteinuria from random samples of urine in children. Am J Kidney Dis 41:760-766 (Pubitemid 36396743)
20. Nejat M, Pickering JW, Walker RJ, Endre ZH (2010) Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol Dial Transplant doi: 10.1093/ndt/gfq176
21. Ahlstrom A, Tallgren M, Peltonen S, Pettila V (2004) Evolution and predictive power of serum cystatin C in acute renal failure. Clin Nephrol 62:344-350 (Pubitemid 39480840)
22. Che M, Xie B, Xue S, Dai H, Qian J, Ni Z, Axelsson J, Yan Y (2010) Clinical usefulness of novel biomarkers for the detection of acute kidney injury following elective cardiac surgery. Nephron Clin Pract 115:c66-c72. doi: 10.1159/000286352
23. Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Dragun D, Haase M (2009) Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery - a prospective cohort study. Crit Care Med 37:553-560. doi: 10.1097/CCM.0b013e318195846e
24. Liangos O, Tighiouart H, Perianayagam MC, Kolyada A, Han WK, Wald R, Bonventre JV, Jaber BL (2009) Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 14:423-431. doi: 10.1080/13547500903067744
25. Endre ZH, Walker RJ, Pickering JW, Shaw GM, Frampton CM, Henderson SJ, Hutchison R, Mehrtens JE, Robinson JM, Schollum JB, Westhuyzen J, Celi LA, McGinley RJ, Campbell IJ, George PM (2010) Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int 77:1020-1030. doi:10:10.1038/ki.2010.25
26. Nejat M, Pickering JW, Walker RJ, Westhuyzen J, ShawGM, Frampton CM, Endre ZH (2010) Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit. Crit Care 14:R85
27. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31. doi: 10.1186/cc5713
28. Mazul-Sunko B, Zarkovic N, Vrkic N, Antoljak N, Bekavac BM, Nikolic HV, Siranovic M, Krizmanic-Dekanic A, Klinger R (2004) Proatrial natriuretic peptide (1-98), but not cystatin C, is predictive for occurrence of acute renal insufficiency in critically ill septic patients. Nephron Clin Pract 97:c103-c107 (Pubitemid 39077826)
29. Delanaye P, Lambermont B, Chapelle JP, Gielen J, Gerard P, Rorive G (2004) Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Intensive Care Med 30:980-983. doi: 10.1007/s00134-004- 2189-5 (Pubitemid 38639496)
30. Le Bricon T, Leblanc I, Benlakehal M, Gay-Bellile C, Erlich D, Boudaoud S (2005) Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rate estimates. Clin Chem Lab Med 43:953-957. doi: 10.1515/CCLM.2005.163 (Pubitemid 41461146)
31. Villa P, Jimenez M, Soriano MC, Manzanares J, Casasnovas P (2005) Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients. Crit Care 9:R139-R143. doi:10.1186/cc3044
32. Herrero-Morin JD, Malaga S, Fernandez N, Rey C, Dieguez MA, Solis G, Concha A, Medina A (2007) Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children. Crit Care 11:R59. doi:10.1186/cc5923
33. Wulkan R, den HJ, Berghout A (2005) Cystatin C: unsuited to use as a marker of kidney function in the intensive care unit. Crit Care 9:531-532. doi: 10.1186/cc3541 (Pubitemid 41498552)
34. Cruz DN, de CM, Garzotto F, Perazella MA, Lentini P, Corradi V, Piccinni P, Ronco C (2010) Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med 36:444-451. doi: 10.1007//00134-009-1711-1
35. Perianayagam MC, Seabra VF, Tighiouart H, Liangos O, Jaber BL (2009) Serum cystatin C for prediction of dialysis requirement or death in acute kidney injury: a comparative study. Am J Kidney Dis 54:1025-1033
36. Groesbeck D, Kottgen A, Parekh R, Selvin E, Schwartz GJ, Coresh J, Furth S (2008) Age, gender, and race effects on cystatin C levels in US adolescents. Clin J Am Soc Nephrol 3:1777-1785
37. Bokenkamp A, van Wijk JA, Lentze MJ, Stoffel-Wagner B (2002) Effect of corticosteroid therapy on serum cystatin C and beta2-microglobulin concentrations. Clin Chem 48:1123-1126 (Pubitemid 34680918)
38. Fricker M, Wiesli P, Brandle M, Schwegler B, Schmid C (2003) Impact of thyroid dysfunction on serum cystatin C. Kidney Int 63:1944-1947 (Pubitemid 36513345)
39. Yokoyama H, Inoue T, Node K (2009) Effect of insulin-unstimulated diabetic therapy with miglitol on serum cystatin C level and its clinical significance. Diabetes Res Clin Pract 83:77-82
40. Stevens LA, Schmid CH, Greene T, Li L, Beck GJ, Joffe MM, Froissart M, Kusek JW, Zhang YL, Coresh J, Levey AS (2009) Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int 75:652-660. doi:10.1038/ki.2008.638
41. Joannidis M, Metnitz B, Bauer P, Schusterschitz N, Moreno R, Druml W, Metnitz PG (2009) Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med 35:1692-1702. doi: 10.1007/s00134-009-1530-4
42. Siew ED, Matheny ME, Ikizler TA, Lewis JB, Miller RA, Waitman LR, Go AS, Parikh CR, Peterson JF (2010) Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Kidney Int 77:536-542. doi: 10.1038/ki.2009.479