Mass Spectrometry-Based Proteomic Analysis of Urine in Acute Kidney Injury Following Cardiopulmonary Bypass: A Nested Case-Control Study

American Journal of Kidney Diseases

Volumn 53, Issue 4, 2009, Pages 584-595

  Ho, Julie ^a   Lucy, Malcolm ^a   Krokhin, Oleg ^b   Hayglass, Kent ^a   Pascoe, Edward ^a   Darroch, Gayle ^a   Rush, David ^a   Nickerson, Peter ^a   Rigatto, Claudio ^a   Reslerova, Martina ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

CXCR3 chemokine; hepcidin; IP 10; Ischemia reperfusion injury

Indexed keywords

ALPHA 1 MICROGLOBULIN; CHEMOKINE; CREATININE; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEPCIDIN; HEPCIDIN 25; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CASE CONTROL STUDY; CREATININE BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; IRON METABOLISM; KIDNEY INJURY; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PROTEIN URINE LEVEL; PROTEOMICS; QUANTITATIVE ANALYSIS; REPERFUSION INJURY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS;

ACUTE-PHASE PROTEINS; AGED; ALPHA-GLOBULINS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; CARDIOPULMONARY BYPASS; CASE-CONTROL STUDIES; CHEMOKINE CXCL10; CREATININE; DISEASE PROGRESSION; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; KIDNEY FAILURE, ACUTE; LIPOCALINS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEOMICS; PROTO-ONCOGENE PROTEINS; REPERFUSION INJURY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 62749180220     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.10.037     Document Type: Article

References (41)

1. Chertow G.M., Lazarus J.M., Christiansen C.L., et al. Preoperative renal risk stratification. Circulation 95 (1997) 878-884
2. Thakar C.V., Arrigain S., Worley S., et al. A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol 16 (2005) 162-168
3. Mangano C.M., Diamondstone L.S., Ramsay J.G., et al. Renal dysfunction after myocardial revascularization: Risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med 128 (1998) 194-203
4. Loef B.G., Epema A.H., Smilde T.D., et al. Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival. J Am Soc Nephrol 16 (2005) 195-200
5. Trof R.J., Di Maggio F., Leemreis J., et al. Biomarkers of acute renal injury and renal failure. Shock 26 (2006) 245-253
6. Bonaventre J.V., and Weinberg J.M. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14 (2003) 2199-2210
7. Devarajan P., Mishra J., Supavekin S., et al. Gene expression in early ischemic renal injury: Clues towards pathogenesis, biomarker discovery, and novel therapeutics. Mol Genet Metab 80 (2003) 365-376
8. Boldt J., Brenner T., Lehmann A., et al. Is kidney function altered by the duration of cardiopulmonary bypass?. Ann Thorac Surg 75 (2003) 906-912
9. Bucerius J., Gummert J.F., Walther T., et al. On-pump versus off-pump coronary artery bypass grafting: Impact on post-operative renal failure requiring renal replacement therapy. Ann Thorac Surg 77 (2004) 1250-1256
10. Stallwood M.I., Grayson A.D., Mills K., et al. Acute renal failure in coronary artery bypass surgery: Independent effect of cardiopulmonary bypass. Ann Thorac Surg 77 (2004) 968-972
11. Rosner M.H., and Okusa M.D. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 1 (2006) 19-32
12. Bonventre J.V., and Zuk A. Ischemic acute renal failure: An inflammatory disease?. Kidney Int 66 (2004) 480-485
13. Schaub S., Rush D., Wilkins J., et al. Proteomic-based detection of urine proteins associated with acute renal allograft rejection. J Am Soc Nephrol 15 (2004) 219-227
14. 2-microglobulin as a potential marker for acute tubular injury in renal allografts. Am J Transplant 5 (2005) 729-738
15. Tomogusi N., Kawabata H., Wakatabe R., et al. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system. Blood 108 (2006) 1381-1387
16. Kemna E.H.J.M., Tjalsma H., Podust V.N., and Swinkels D.W. Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications. Clin Chem 53 (2007) 620-628
17. Bozzini C., Campostrini N., Trombini P., et al. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis 40 (2008) 347-352
18. Campbell J.D., Gangur V., Simons F.E., et al. Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop. FASEB J 18 (2004) 329-331
19. Fiorina P., Ansari M.J., Jurewicz M., et al. Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol 17 (2006) 716-723
20. Frangogiannis N.G. Chemokines in ischemia and reperfusion. Thromb Haemost 97 (2007) 738-747
21. Sutton T.A., Fisher C.J., and Molitoris B.M. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int 62 (2002) 1539-1549
22. 1-microglobulin: An indicator protein for renal tubular function. J Clin Pathol 36 (1983) 253-259
23. Regeniter A., Siede W., Scholer A., et al. Interpreting complex urinary patterns with MDI lablink: A statistical evaluation. Clin Chim Acta 297 (2000) 261-273
24. 1-microglobulin in assessment of prognosis in renal transplant recipients. Transplantation 70 (2000) 1154-1159
25. Gormley S.M.C., McBride W.T., Armstrong M.A., et al. Plasma and urinary cytokine homeostasis and renal function during cardiac surgery without cardiopulmonary bypass. Cytokine 17 (2002) 61-65
26. Leheste J.R., Rolinski B., Vorum H., et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 155 (1999) 1361-1370
27. Christensen E.I., and Birn H. Megalin and cubilin: Synergistic endocytic receptors in renal proximal tubule. Am J Physiol Renal Physiol 280 (2001) F562-F573
28. Mishra J., Ma Q., Prada A., et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14 (2003) 2534-2543
29. Mishra J., Dent C., Tarabishi R., et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365 (2005) 1231-1238
30. Wagener G., Jan M., Kim M., et al. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology 105 (2006) 485-491
31. Hvidberg V., Jacobsen C., Strong R.K., et al. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579 (2005) 773-777
32. Jo S.K., Rosner M.H., and Okusa M.D. Pharmacological treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol 2 (2007) 356-365
33. Wright G. Hemolysis during cardiopulmonary bypass: Update. Perfusion 16 (2001) 345-351
34. Baliga R., Ueda N., Walker P., et al. Oxidant mechanisms in toxic acute renal failure. Drug Met Rev 31 (1999) 971-997
35. Davis C.L., Kausz A.T., Zager R.A., et al. Acute renal failure after cardiopulmonary bypass is related to decreased serum ferritin levels. J Am Soc Nephrol 10 (1999) 2396-2402
36. Ganz T. Molecular control of iron transport. J Am Soc Nephrol 18 (2007) 394-400
37. Kulaksiz H., Theilig F., Bachmann S., et al. The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney. J Endocrinol 184 (2005) 361-370
38. Mori K., Lee H.T., Rapoport D., et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia reperfusion injury. J Clin Invest 115 (2005) 610-621
39. Rosner M.H., and Okusa M.D. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 1 (2006) 19-32
40. Kielar M.L., John R., Bennett M., et al. Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol 16 (2005) 3315-3325
41. Patel N.S.A., Chatterjee P.K., Di Paola R., et al. Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharm Exp Ther 312 (2005) 1170-1178