NGAL is an early predictive biomarker of contrast-induced nephropathy in children

Pediatric Nephrology

Volumn 22, Issue 12, 2007, Pages 2089-2095

  Hirsch, Russel ^a   Dent, Catherine ^a   Pfriem, Holly ^a   Allen, Janene ^a   Beekman III, Robert H ^a   Ma, Qing ^a   Dastrala, Sudha ^a   Bennett, Michael ^a   Mitsnefes, Mark ^a   Devarajan, Prasad ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Acute kidney injury; Acute renal failure; Biomarkers; Contrast agents; Lipocalin

Indexed keywords

BIOLOGICAL MARKER; CREATININE; IOVERSOL; LIPOCALIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD ANALYSIS; CHILD; CONGENITAL HEART DISEASE; CONTRAST ENHANCEMENT; CONTRAST INDUCED NEPHROPATHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEMOGRAPHY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART CATHETERIZATION; HUMAN; INFANT; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; URINALYSIS;

ACUTE-PHASE PROTEINS; ANGIOGRAPHY; BIOLOGICAL MARKERS; CHILD; CONTRAST MEDIA; CREATININE; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART CATHETERIZATION; HEART DEFECTS, CONGENITAL; HUMANS; KIDNEY DISEASES; LIPOCALINS; MALE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; ROC CURVE; TRIIODOBENZOIC ACIDS;

EID: 36048965159     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-007-0601-4     Document Type: Article

References (32)

1. Goldstein SL (2006) Pediatric acute kidney injury: It's time for real progress. Pediatr Nephrol 21:891-895
2. Nguyen MT, Devarajan P (2007) Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol DOI 10.1007/s00467-007-0470-x
3. Nash K, Hafeez A, Hou S (2002) Hospital-acquired renal insufficiency. Am J Kidney Dis 39:930-936
4. Pannu N, Wiebe N, Tonelli M (2006) Prophylaxis strategies for contrast-induced nephropathy. JAMA 295:2765-2779
5. McCullough PA, Adam A, Becker CR, Davidson C, Lameire N, Stacul F, Tumlin J, CIN Consensus Working Panel (2006) Epidemiology and prognostic implications of contrast-induced nephropathy. Am J Cardiol 98(Suppl):5K-13K
6. McCullough PA, Adam A, Becker CR, Davidson C, Lameire N, Stacul F, Tumlin J, CIN Consensus Working Panel (2006) Risk prediction of contrast-induced nephropathy. Am J Cardiol 98(Suppl):27K-36K
7. Hui-Stickle S, Brewer ED, Goldstein SL (2005) Pediatric ARF epidemiology at a tertiary care center from 1999-2001. Am J Kidney Dis 45:96-101
8. Solomon R (2007) Contrast media nephropathy - how to diagnose and how to prevent? Nephrol Dial Transplant 22:1812-1815
9. Murphy SW, Barrett BJ, Parfrey PS (2000) Contrast nephropathy. J Am Soc Nephrol 11:177-182
10. Devarajan P (2007) Emerging biomarkers of acute kidney injury. Contrib Nephrol 156:203-212
11. Stacul F, Adam A, Becker CR, Davidson C, Lameire N, McCullough PA, Tumlin J (2006) Strategies to reduce the risk of contrast-induced nephropathy. Am J Cardiol 98(Suppl):59K-77K
12. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P (2003) Differential gene expression following early renal ischemia-reperfusion. Kidney Int 63:1714-1724
13. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of NGAL as a novel urinary biomarker for ischemic injury. J Am Soc Nephrol 4:2534-2543
14. Devarajan P, Mishra J, Supavekin S, Patterson LT, Potter SS (2003) Gene expression in early ischemic renal injury: Clues towards pathogenesis, biomarker discovery and novel therapeutics. Mol Genet Metab 80:365-376
15. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2004) Neutrophil gelatinase-associated lipocalin (NGAL): A novel urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24:307-315
16. Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, Barasch J, Devarajan P (2004) Amelioration of ischemic acute renal injury by NGAL. J Am Soc Nephrol 15:3073-3082
17. Mori K, Lee HT, Rapoport D, Drexler I, Foster K, Yang J, Schmidt-Ott, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia. J Clin Invest 115:610-621
18. Mishra J, Ma Q, Kelly C, Mitsnefes M, Mori K, Barasch J, Devarajan P (2006) Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol 21:856-863
19. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury following cardiac surgery. Lancet 365:1231-1238
20. Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P (2006) Urine NGAL and IL-18 are predictive biomarkers for DGF following kidney transplantation. Am J Transplant 6:1639-1645
21. Trachtman H, Christen E, Cnaan A, Patrick J, Mai V, Mishra J, Jain A, Bullington N, Devarajan P (2006) Urinary NGAL in D+HUS: A novel marker of renal injury. Pediatr Nephrol 21:989-994
22. Brunner HI, Mueller M, Rutherford C, Passo MH, Witte D, Grom A, Mishra J, Devarajan P (2006) Urinary NGAL as a biomarker of nephritis in childhood-onset SLE. Arthritis Rheum 54:2577-2584
23. Mitsnefes M, Kathman T, Mishra J, Kartal J, Khoury P, Nickolas T, Barasch J, Devarajan P (2007) Serum NGAL as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 22:101-108
24. Xu S, Venge P (2000) Lipocalins as biomarkers of disease. Biochim Biophys Acta 1482:298-307
25. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, Devarajan P, Barasch J (2006) NGAL-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens 15:442-449
26. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (2007) Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18:407-413
27. Liu Q, Nilsen-Hamilton M (1995) Identification of a new acute phase protein. J Biol Chem 270:22565-22570
28. Bachorzewska-Gajewska H, Malyszko J, Sitniewska E, Malyszko JS, Dobrzycki S (2006) Neutrophil gelatinase-associated lipocalin and renal function after percutaneous coronary interventions. Am J Nephrol 26:287-292
29. Bachorzewska-Gajewska H, Malyszko J, Sitniewska E, Malyszko JS, Dobrzycki S (2007) Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography. Nephrol Dial Transplant 22:295-296
30. Herget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Janssen O, Philipp T, Kribben A (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66:1115-1122
31. Duan SB, Wu HW, Luo JA, Liu FY (1999) Assessment of renal function in the early stages of nephrotoxicity induced by iodinated contrast media. Nephron 83:122-125
32. Hampel DJ, Sansome C, Sha M, Brodsky S, Lawson WE, Goligorsky MS (2001) Toward proteomics in uroscopy: Urinary protein profiles after radiocontrast medium administration. J Am Soc Nephrol 12:1026-1035