Alterations in the expression of antioxidant genes and the levels of transcription factor NF-Kappa B in relation to diabetic embryopathy in the cohen diabetic rat model

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 76, Issue 2, 2006, Pages 107-114

  Zangen, Sarah W ^a   Ryu, Seonghun ^a   Ornoy, Asher ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

CAT; NF B; NTD; Oxidative stress; SOD; Type 2 diabetes

Indexed keywords

CATALASE; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; SUCROSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIETARY INTAKE; DISEASE MODEL; EMBRYO; EMBRYOPATHY; FEMALE; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC DIFFERENCE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TERATOGENICITY;

ANIMALS; ANTIOXIDANTS; CATALASE; COPPER; DIABETES MELLITUS, EXPERIMENTAL; DIET; ENZYMES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE PEROXIDASE; MALE; NF-KAPPA B; PREGNANCY; PREGNANCY OUTCOME; RATS; REACTIVE OXYGEN SPECIES; SUCROSE; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 33644872133     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20227     Document Type: Article

References (55)

1. Aban M, Cinel L, Arslan M, et al. 2004. Expression of nuclear factor-kappa B and placental apoptosis in pregnancies complicated with intrauterine growth restriction and preeclampsia: an immunohistochemical study. Tohoku J Exp Med 204:195-202.
2. Allen RG, Balin AK. 1989. Oxidative influence on development and differentiation: an overview of a free radical theory of development. Free Radic Biol Med 6:631-661.
3. Baeuerle PA, Henkel T. 1994. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141-179.
4. Baynes JW. 1991. Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-412.
5. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
6. Brown NA, Fabro S. 1981. Quantitation of rat embryos development in in vitro morphological scoring system. Teratology 24:65-78.
7. Cederberg J, Eriksson UJ. 1997. Decreased catalase activity in malformation-prone embryos of diabetic rats. Teratology 56:350-357.
8. Cederberg J, Galli J, Luthman H, Eriksson UJ. 2000. Increased mRNA levels of Mn-SOD and catalase in embryos of diabetic rats from a malformation- resistant strain. Diabetes 49:101-107.
9. Dixon G, Nolan J, McClenaghan NH, et al. 2004. Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. Clin Sci (Lond) 106:191-199.
10. Eriksson UJ. 1988. Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats. Teratology 37:365-374.
11. Eriksson UJ, Borg LA. 1991. Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro. Diabetologia 34:325-331.
12. Eriksson UJ, Borg LA. 1993. Diabetes and embryonic malformations. Role of substrate induced free-oxygen radical production for dysmorphogenesis in cultures rat embryos. Diabetes 42:411-419.
13. Fantel AG, Barber CV, Carda MB, et al. 1992. Studies of the role of ischemia/reperfusion and superoxide anion radical production in the teratogenicity of cocaine. Teratology 46:293-300.
14. Fine EL, Horal M, Chang TI, et al. 1999. Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. Diabetes 48:2454-2462.
15. Forsberg H, Borg LA, Cagliero E, Eriksson UJ. 1996. Altered levels of scavenging enzymes in embryos subjected to a diabetic environment. Free Radic Res 24:451-459.
16. Frank I. 1991. Developmental aspects of experimental pulmonary oxygen toxicity. Free Radic Biol Med 11:463-499.
17. Ghosh S, Karin M. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):S81-S96.
18. Ito CY, Kazantsev AG, Baldwin AS Jr. 1994. Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha. Nucleic Acids Res 22:3787-3792.
19. Jones PL, Ping D, Boss JM. 1997. Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Mol Cell Biol 17:6970-6981.
20. Karin M, Cao Y, Greten FR, Li ZW. 2002. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301-310.
21. Kucera J. 1971. Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7:73-82.
22. Le Bail O, Schmidt-Ullrich R, Israel A. 1993. Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family. EMBO J 12:5043-5049.
23. Lee AT, Plum A, DeSimone C, et al. 1995. A role for DNA mutations in diabetes associated teratogenesis in transgenic embryos. Diabetes 44: 20-24.
24. Li Q, Verma IM. 2002. NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725-734.
25. Liptay S, Schmid RM, Nabel EG, Nabel GJ. 2000. Transcriptional regulation of NF-kB, evidence for NF kappa B-mediated positive and negative autoregulation. Mol Cell Biol 14:7695-7703.
26. Miki A, Fujimoto E, Ohsaki T, Mizoguti H. 1988. Effects of oxygen concentration on embryonic development in rats: a light and electron microscopic study using whole-embryo culture techniques. Anat Embryol (Berl) 178:337-343.
27. Moley KH. 2001. Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women. Trends Endocrinol Metab 12:78-82.
28. Mulcahy RT, Gipp JJ. 1995. Identification of a putative antioxidant response element in the 5′-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Biophys Res Commun 209:227-233.
29. Nishikawa T, Edelstein D, Du XL, et al. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790.
30. Oberley LW. 1988. Free radicals and diabetes. Free Radic Biol Med 5:113-124.
31. Ornoy A, Zaken V, Kohen R. 1999. Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies. Teratology 60:376-386.
32. Pani L, Horal M, Loeken MR. 2002. Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy. Diabetes 51:2871-2874.
33. Raha S, Robinson B. 1999. Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet 106:62-70.
34. Ray JG, O'Brien TE, Chan WS. 2001. Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a met-analysis. QJM 94:435-444.
35. Sakurai T, Tsuchiya S. 1988. Superoxide production from nonenzymatically glycated protein. FEBS Lett 236:406-410.
36. Schaefer-Graf UM, Buchanan TA, Xiang A, et al. 2000. Patterns of congenital anomalies and relationship to initial maternal fasting: glucose levels in pregnancies complicated by type 2 and gestational diabetes. Am J Obstet Gynecol 182:313-320.
37. Schmidt-Ullrich R, Memet S, Lilienbaum A, et al. 1996. NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity. Development 122:2117-2128.
38. Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Embo J 10:2247-2258.
39. Siman CM, Eriksson UJ. 1997. Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats. Diabetologia 40:1416-1424.
40. Sivan E, Lee YC, Wu YK, Reece EA. 1997. Free radical scavenging enzymes in fetal dysmorphogenesis among offspring of diabetic rats. Teratology, 56:343-349.
41. St. Johnston D, Nusslein-Volhard C. 1992. The origin of pattern and polarity in the Drosophila embryo. Cell 68:209-219.
42. Ten RM, Paya CV, Israel N, et al. 1992. The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation. EMBO J 11:195-203.
43. Van Dam PS, Van Asbeck BS, Erkelens DW, et al. 1995. The role of oxidative stress in neuropathy and other diabetic complications. Diabetes Metab Rev 11:181-192.
44. Viana M, Herrera E, Bonet B. 1996. Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E. Diabetologia 39:1041-1046.
45. Weksler-Zangen S, Yagil C, Zangen DH, et al. 2001. The newly inbred Cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. Diabetes 50:2521-2529.
46. Weksler-Zangen S, Yaffe P, Ornoy A. 2003. Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions. Birth Defects Res Part A Clin Mol Teratol 67:429-437.
47. Wentzel P, Welsh N, Eriksson UJ. 1999. Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. Diabetes 48:813-820.
48. Wentzel P, Wentzel CR, Gareskog MB, Eriksson UJ. 2001. Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity. Teratology 63:193-201.
49. Williams MD, Van Remmen H, Conrad CC, et al. 1998. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J Biol Chem 273: 28510-28515.
50. Wiznitzer A, Ayalon N, Hershkovitz R, et al. 1999. Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes. Am J Obstet Gynecol 180(1 Pt 1):188-193.
51. Xu Y, Porntadavity S, St Clair DK. 2002. Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2). Biochem J 362(Pt 2): 401-412.
52. Yang X, Borg LA, Eriksson UJ. 1997. Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose. Am J Physiol 272(1 Pt 1):E173-E180.
53. Zaken V, Kohen R, Ornoy A. 2000. The development of antioxidant defense mechanism in young rat embryos in vivo and in vitro. Early Pregnancy 4:110-123.
54. Zaken V, Kohen R, Ornoy A. 2001. Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium. Teratology 54:33-44.
55. Zangen SW, Yaffe P, Shechtman S, et al. 2002. The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats. Int J Exp Diabetes Res 3:247-255.