Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2392-2404

  Moeker, Janina ^a   Teruya, Kanae ^a   Rossit, Sabine ^a   Wilkinson, Brendan L ^a   Lopez, Marie ^a   Bornaghi, Laurent F ^a   Innocenti, Alessio ^b   Supuran, Claudiu T ^b   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbohydrate; Carbonic anhydrase; Hypoxia; Inhibitor; Thiourea

Indexed keywords

CARBONATE DEHYDRATASE; GLYCOSYL ISOTHIOCYANIC ACID; ISOTHIOCYANIC ACID; N [4 (AMINOSULFONYL)BENZYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO LACTOSYL)THIOUREA; N [4 (AMINOSULFONYL)BENZYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO MALTOSYL)THIOUREA; N [4 (AMINOSULFONYL)BENZYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)BENZYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)BENZYL] N' (BETA DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)BENZYL] N' (BETA DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENETHYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO LACTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENETHYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENETHYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENETHYL] N' (BETA DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENETHYL] N' (BETA DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO LACTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO MALTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (2',3',4',6' TETRA O ACETYL DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (BETA DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (BETA DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYL] N' (BETA DEXTRO MALTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLETHYL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO MALTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDO] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO LACTOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDO] N' (2',3',4',6' TETRA O ACETYL DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDO] N' (2',3',4',6' TETRA O ACETYL DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDO] N' (BETA DEXTRO GALACTOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDO] N' (BETA DEXTRO GLUCOPYRANOSYL)THIOUREA; N [4 (AMINOSULFONYL)PHENYLHYDRAZIDOL] N' (2',2'',3',3'',4'',6',6'' HEPTA O ACETYL DEXTRO MALTOSYL)THIOUREA; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; PHYSICAL CHEMISTRY;

CARBOHYDRATES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DRUG DESIGN; GLYCOCONJUGATES; HUMANS; PROTEIN ISOFORMS; SOLUBILITY; SULFONAMIDES; THIOUREA;

EID: 84858286827     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.052     Document Type: Article

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