메뉴 건너뛰기




Volumn 16, Issue 1, 2012, Pages 89-95

Recent advances in renal urate transport: Characterization of candidate transporters indicated by genome-wide association studies

Author keywords

Genome wide association study; Gout; Hyperuricemia; Hypouricemia; Transporter; Urate

Indexed keywords

ALLANTOIN; ANTIPORTER; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; GLUCOSE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 9; PDZK PROTEIN; SODIUM PHOSPHATE COTRANSPORTER 1; SODIUM PHOSPHATE COTRANSPORTER HOMOLOG; UNCLASSIFIED DRUG; URATE; URATE ANION EXCHANGER; URATE OXIDASE; URATE TRANSPORT RELATED PROTEIN; URATE TRANSPORTOME; URATV1 PROTEIN; URIC ACID; VOLTAGE DEPENDENT URATE TRANSPORTER GLUT9;

EID: 84858276787     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-011-0532-z     Document Type: Review
Times cited : (89)

References (59)
  • 1
    • 0003122021 scopus 로고    scopus 로고
    • Renal handling of organic anions and cations: Excretion of uric acid
    • Brenner BM, editor. 6th ed. Philadelphia: WB Saunders
    • Sica DA, Schoolwerth AC. Renal handling of organic anions and cations: excretion of uric acid. In: Brenner BM, editor. The Kidney. 6th ed. Philadelphia: WB Saunders; 2000. p. 680-700.
    • (2000) The Kidney , pp. 680-700
    • Sica, D.A.1    Schoolwerth, A.C.2
  • 2
    • 33846837206 scopus 로고    scopus 로고
    • New insights into renal transport of urate
    • DOI 10.1097/BOR.0b013e328032781a, PII 0000228120070300000012
    • Anzai N, Kanai Y, Endou H. New insights into renal transport of urate. Curr Opin Rheumatol. 2007;19:151-7. (Pubitemid 46208773)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.2 , pp. 151-157
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 4
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • DOI 10.1254/jphs.CRJ06006X
    • Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci. 2006;100:411-26. (Pubitemid 44609532)
    • (2006) Journal of Pharmacological Sciences , vol.100 , Issue.5 , pp. 411-426
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 6
    • 12144257103 scopus 로고    scopus 로고
    • Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    • DOI 10.1152/ajprenal.00133.2004
    • van Aubel RA, Smeets PH, van den Heuvel JJ, Russel FG. Human organic anion transporterMRP4 (ABCC4) is an efflux pump for the purine endmetabolite urate withmultiple allosteric substrate binding sites. Am J Physiol Renal Physiol. 2005;288:F327-33. (Pubitemid 40109516)
    • (2005) American Journal of Physiology - Renal Physiology , vol.288 , Issue.2
    • Van Aubel, R.A.M.H.1    Smeets, P.H.E.2    Van Den, H.J.J.M.W.3    Russel, F.G.M.4
  • 8
    • 35848971238 scopus 로고    scopus 로고
    • Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney
    • Gopal E, Umapathy NS, Martin PM, Ananth S, Gnana-Prakasam JP, Becker H, et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochim Biophys Acta. 2007;1768:2690-7.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 2690-2697
    • Gopal, E.1    Umapathy, N.S.2    Martin, P.M.3    Ananth, S.4    Gnana-Prakasam, J.P.5    Becker, H.6
  • 9
    • 47749112096 scopus 로고    scopus 로고
    • Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
    • Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, et al. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem. 2008;283:16332-41.
    • (2008) J Biol Chem , vol.283 , pp. 16332-16341
    • Bahn, A.1    Hagos, Y.2    Reuter, S.3    Balen, D.4    Brzica, H.5    Krick, W.6
  • 11
    • 55249096942 scopus 로고    scopus 로고
    • Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    • Anzai N, Ichida K, Jutabha P, Kimura T, Babu E, Jin CJ, et al. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem. 2008;283:26834-8.
    • (2008) J Biol Chem , vol.283 , pp. 26834-26838
    • Anzai, N.1    Ichida, K.2    Jutabha, P.3    Kimura, T.4    Babu, E.5    Jin, C.J.6
  • 16
    • 37349008492 scopus 로고    scopus 로고
    • The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
    • Li S, Sanna S, Maschio A, Busonero F, Usala G, Mulas A, et al. The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet. 2007;3:e194.
    • (2007) PLoS Genet , vol.3
    • Li, S.1    Sanna, S.2    Maschio, A.3    Busonero, F.4    Usala, G.5    Mulas, A.6
  • 19
    • 44849133635 scopus 로고    scopus 로고
    • Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study
    • Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, Baessler A, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One. 2008;3:e1948.
    • (2008) PLoS One , vol.3
    • Stark, K.1    Reinhard, W.2    Neureuther, K.3    Wiedmann, S.4    Sedlacek, K.5    Baessler, A.6
  • 20
    • 49649125935 scopus 로고    scopus 로고
    • Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI
    • Brandstätter A, Kiechl S, Kollerits B, Hunt SC, Heid IM, Coassin S, et al. Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabetes Care. 2008;31:1662-7.
    • (2008) Diabetes Care , vol.31 , pp. 1662-1667
    • Brandstätter, A.1    Kiechl, S.2    Kollerits, B.3    Hunt, S.C.4    Heid, I.M.5    Coassin, S.6
  • 21
    • 57049083981 scopus 로고    scopus 로고
    • Association of three genetic loci with uric acid concentration and risk of gout: A genome-wide association study
    • Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372:1953-61.
    • (2008) Lancet , vol.372 , pp. 1953-1961
    • Dehghan, A.1    Köttgen, A.2    Yang, Q.3    Hwang, S.J.4    Kao, W.L.5    Rivadeneira, F.6
  • 22
    • 67651056502 scopus 로고    scopus 로고
    • Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    • Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. Plos Genet. 2009;5:1-10.
    • (2009) Plos Genet , vol.5 , pp. 1-10
    • Kolz, M.1    Johnson, T.2    Sanna, S.3    Teumer, A.4    Vitart, V.5    Perola, M.6
  • 23
    • 70350523960 scopus 로고    scopus 로고
    • Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets
    • Hollis-Moffatt JE, Xu X, Dalbeth N, Merriman ME, Topless R, Waddell C, et al. Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets. Arthritis Rheum. 2009;60: 3485-92.
    • (2009) Arthritis Rheum , vol.60 , pp. 3485-3492
    • Hollis-Moffatt, J.E.1    Xu, X.2    Dalbeth, N.3    Merriman, M.E.4    Topless, R.5    Waddell, C.6
  • 24
    • 77951557511 scopus 로고    scopus 로고
    • Associations of a nonsynonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese and Solomon Islanders
    • Tu HP, Chen CJ, Tovosia S, Ko AM, Lee CH, Ou TT, et al. Associations of a nonsynonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese and Solomon Islanders. Ann Rheum Dis. 2010;69:887-90.
    • (2010) Ann Rheum Dis , vol.69 , pp. 887-890
    • Tu, H.P.1    Chen, C.J.2    Tovosia, S.3    Ko, A.M.4    Lee, C.H.5    Ou, T.T.6
  • 25
    • 18244387733 scopus 로고    scopus 로고
    • Molecular physiology of urate transport
    • Hediger MA, Johnson RJ, Miyazaki H, Endou H. Molecular physiology of urate transport. Physiology (Bethesda). 2005;20:125-33. (Pubitemid 40627553)
    • (2005) Physiology , Issue.2 , pp. 125-133
    • Hediger, M.A.1    Johnson, R.J.2    Miyazaki, H.3    Endou, H.4
  • 26
    • 26244449838 scopus 로고    scopus 로고
    • Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
    • DOI 10.1007/s10157-005-0368-5
    • Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol. 2005;9:195-205. (Pubitemid 41414118)
    • (2005) Clinical and Experimental Nephrology , vol.9 , Issue.3 , pp. 195-205
    • Enomoto, A.1    Endou, H.2
  • 27
    • 23844514428 scopus 로고    scopus 로고
    • Renal urate handling: Clinical relevance of recent advances
    • Anzai N, Enomoto A, Endou H. Renal urate handling: clinical relevance of recent advances. Curr Rheumatol Rep. 2005;7: 227-34.
    • (2005) Curr Rheumatol Rep , vol.7 , pp. 227-234
    • Anzai, N.1    Enomoto, A.2    Endou, H.3
  • 29
    • 40349096090 scopus 로고    scopus 로고
    • Control of renal uric acid excretion and gout
    • DOI 10.1097/BOR.0b013e3282f33f87, PII 0000228120080300000013
    • Taniguchi A, Kamatani N. Control of renal uric acid excretion and gout. Curr Opin Rheumatol. 2008;20:192-7. (Pubitemid 351339892)
    • (2008) Current Opinion in Rheumatology , vol.20 , Issue.2 , pp. 192-197
    • Taniguchi, A.1    Kamatani, N.2
  • 30
    • 1942437498 scopus 로고    scopus 로고
    • Identification and characterization of human glucose transporter-like protein-9 (GLUT9): Alternative splicing alters trafficking
    • DOI 10.1074/jbc.M312226200
    • Augustin R, Carayannopoulos MO, Dowd LO, Phay JE, Moley JF, Moley KH. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. J Biol Chem. 2004;279:16229-36. (Pubitemid 38509316)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.16 , pp. 16229-16236
    • Augustin, R.1    Carayannopoulos, M.O.2    Dowd, L.O.3    Phay, J.E.4    Moley, J.F.5    Moley, K.H.6
  • 35
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
    • Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, et al. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci USA. 2009;106:15501-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverrière, A.3    Rotman, S.4    Firsov, D.5    Da Costa, A.6
  • 37
    • 70349088929 scopus 로고    scopus 로고
    • Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics
    • Ishikawa T, Nakagawa H. Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics. J Exp Ther Oncol. 2009;8:5-24.
    • (2009) J Exp Ther Oncol , vol.8 , pp. 5-24
    • Ishikawa, T.1    Nakagawa, H.2
  • 38
    • 37549068911 scopus 로고    scopus 로고
    • The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane
    • Huls M, Brown CD, Windass AS, Sayer R, van den Heuvel JJ, Heemskerk S, et al. The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int. 2008;73:220-5.
    • (2008) Kidney Int , vol.73 , pp. 220-225
    • Huls, M.1    Brown, C.D.2    Windass, A.S.3    Sayer, R.4    Van Den Heuvel, J.J.5    Heemskerk, S.6
  • 39
    • 0345688604 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    • DOI 10.1038/sj.onc.1206938, Drug Resistance
    • Doyle LA, Ross DD. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene. 2003;22: 7340-58. (Pubitemid 37487163)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISS. 6 , pp. 7340-7358
    • Doyle, L.A.1    Ross, D.D.2
  • 40
    • 1242295189 scopus 로고    scopus 로고
    • Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
    • DOI 10.1007/s00424-003-1087-y, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Reimer RJ, Edwards RH. Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch. 2004;447:629-35. (Pubitemid 38241447)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 629-635
    • Reimer, R.J.1    Edwards, R.H.2
  • 42
    • 77951537880 scopus 로고    scopus 로고
    • Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout
    • Urano W, Taniguchi A, Anzai N, Inoue E, Kanai Y, Yamanaka M, et al. Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout. Ann Rheum Dis. 2010;69:932-3.
    • (2010) Ann Rheum Dis , vol.69 , pp. 932-933
    • Urano, W.1    Taniguchi, A.2    Anzai, N.3    Inoue, E.4    Kanai, Y.5    Yamanaka, M.6
  • 44
    • 78049387680 scopus 로고    scopus 로고
    • Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate
    • Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, et al. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010;285:35123-32.
    • (2010) J Biol Chem , vol.285 , pp. 35123-35132
    • Jutabha, P.1    Anzai, N.2    Kitamura, K.3    Taniguchi, A.4    Kaneko, S.5    Yan, K.6
  • 46
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family - From monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • DOI 10.1007/s00424-003-1067-2, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Halestrap AP, Meredith D. The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 2004;447:619-28. (Pubitemid 38241446)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 47
    • 77949483365 scopus 로고    scopus 로고
    • Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    • van der Harst P, Bakker SJ, de Boer RA, Wolffenbuttel BH, Johnson T, et al. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Hum Mol Genet. 2010;19:387-95.
    • (2010) Hum Mol Genet , vol.19 , pp. 387-395
    • Van Der Harst, P.1    Bakker, S.J.2    De Boer, R.A.3    Wolffenbuttel, B.H.4    Johnson, T.5
  • 48
    • 0031883886 scopus 로고    scopus 로고
    • Identification and partial characterization of PDZK1: A novel protein containing PDZ interaction domains
    • Kocher O, Comella N, Tognazzi K, Brown LF. Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest. 1998;78:117-25. (Pubitemid 28074315)
    • (1998) Laboratory Investigation , vol.78 , Issue.1 , pp. 117-125
    • Kocher, O.1    Comella, N.2    Tognazzi, K.3    Brown, L.F.4
  • 52
    • 33846786137 scopus 로고    scopus 로고
    • Interaction of the multivalent PDZ domain protein PDZK1 with type I sodium-phosphate cotransporter (NPT1)
    • Jutabha P, Anzai N, Endou H, Kanai Y. Interaction of the multivalent PDZ domain protein PDZK1 with type I sodium-phosphate cotransporter (NPT1). J Am Soc Nephrol. 2005;16:350A.
    • (2005) J Am Soc Nephrol , vol.16
    • Jutabha, P.1    Anzai, N.2    Endou, H.3    Kanai, Y.4
  • 53
    • 84858298123 scopus 로고    scopus 로고
    • Interaction of the multivalent PDZ proteins with sodium-phosphate transporter 4 (NPT4)
    • Fukutomi T, Anzai N, Jutabha P, Kanai Y, Sakurai H. Interaction of the multivalent PDZ proteins with sodium-phosphate transporter 4 (NPT4). J Pharmacol Sci. 2011;115:68P.
    • (2011) J Pharmacol Sci , vol.115
    • Fukutomi, T.1    Anzai, N.2    Jutabha, P.3    Kanai, Y.4    Sakurai, H.5
  • 55
    • 34848852618 scopus 로고    scopus 로고
    • Drug discovery for hyperuricemia
    • DOI 10.1517/17460441.2.9.1251
    • Anzai N, Endou H. Drug discovery for hyperuricemia. Expert Opin Drug Discov. 2007;2:1251-61. (Pubitemid 47496482)
    • (2007) Expert Opinion on Drug Discovery , vol.2 , Issue.9 , pp. 1251-1261
    • Anzait, N.1    Endou, H.2
  • 56
    • 84858283698 scopus 로고    scopus 로고
    • Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate cotransporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12) by yeast two-hybrid assay
    • Srivastava S, Anzai N, Miyauchi S, Miura D, Fukutomi T, et al. Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate cotransporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12) by yeast two-hybrid assay. J Pharmacol Sci. 2009;109:68.
    • (2009) J Pharmacol Sci , vol.109 , pp. 68
    • Srivastava, S.1    Anzai, N.2    Miyauchi, S.3    Miura, D.4    Fukutomi, T.5
  • 57
    • 0026592267 scopus 로고
    • Two independent mutational events in the loss of urate oxidase during hominoid evolution
    • Wu XW, Muzny DM, Lee CC, Caskey CT. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol. 1992;34:78-84.
    • (1992) J Mol Evol , vol.34 , pp. 78-84
    • Wu, X.W.1    Muzny, D.M.2    Lee, C.C.3    Caskey, C.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.