Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders

Annals of the Rheumatic Diseases

Volumn 69, Issue 5, 2010, Pages 887-890

  Tu, Hung Pin ^a   Chen, Chung Jen ^b   Tovosia, Silent ^c   Ko, Albert Min Shan ^d   Lee, Chien Hung ^d   Ou, Tsan Teng ^e   Lin, Gau Tyan ^e   Chang, Shun Jen ^a   Chiang, Shang Lun ^e   Chiang, Hung Che ^a,f   Chen, Ping Ho ^f   Wang, Shu Jung ^d   Lai, Han Ming ^b   Ko, Ying Chin ^a,d,f  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c National Referral Hospital   (Solomon Islands)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; SLC2A9 PROTEIN; UNCLASSIFIED DRUG; URIC ACID;

ADULT; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENE REPLICATION; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; GOUT; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOLOMON ISLANDS; TAIWAN; URIC ACID BLOOD LEVEL;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ARTHRITIS, GOUTY; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; MALE; MELANESIA; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TAIWAN; URIC ACID;

EID: 77951557511     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.113357     Document Type: Article

References (15)

1. Choi HK, Mount DB, Reginato AM; American College of Physicians; American Physiological Society. Pathogenesis of gout. Ann Intern Med 2005;143:499-516.
2. Hediger MA, Johnson RJ, Miyazaki H, et al. Molecular physiology of urate transport. Physiology (Bethesda) 2005;20:125-133
3. Gutman AB. The past four decades of progress in the knowledge of gout, with an assessment of the present status. Arthritis Rheum 1973;16:431-445
4. Chang HY, Pan WH, Yeh WT, et al. Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993-1996). J Rheumatol 2001;28:1640-1646
5. Klemp P, Stansfield SA, Castle B, et al. Gout is on the increase in New Zealand. Ann Rheum Dis 1997;56:22-26
6. Döring A, Gieger C, Mehta D, et al. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet 2008;40:430-436 (Pubitemid 351454014)
7. Vitart V, Rudan I, Hayward C, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 2008;40:437-442 (Pubitemid 351450879)
8. Stark K, Reinhard W, Neureuther K, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS ONE 2008;3:e1948. (Pubitemid 351984398)
9. Dehghan A, Köttgen A, Yang Q, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 2008;372:1953-1961
10. McArdle PF, Parsa A, Chang YP, et al. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. Arthritis Rheum 2008;58:2874-2881
11. Mobasheri A, Neama G, Bell S, et al. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int 2002;26:297-300.
12. Chang SJ, Tsai MH, Ko YC, et al. The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. Ann Rheum Dis 2009;68:1213-1219
13. Wallace SL, Robinson H, Masi AT, et al. Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 1977;20:895-900.
14. Terkeltaub RA. Clinical practice. Gout. N Engl J Med 2003;349:1647-1655
15. Doege H, Bocianski A, Joost HG, et al. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. Biochem J 2000;350:771-776