Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI

Diabetes Care

Volumn 31, Issue 8, 2008, Pages 1662-1667

  Brandstäter, Anita ^a   Kiechl, Stefan ^a   Kollerits, Barbara ^a   Hunt, Steven C ^b   Heid, Iris M ^c,d   Coassin, Stefan ^a   Willeit, Johann ^a   Adams, Ted D ^b   Illig, Thomas ^c   Hopkins, Paul N ^b   Kronenberg, Florian ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGOUT AGENT; ANTILIPEMIC AGENT; CARRIER PROTEIN; CREATININE; SLCSA9 PROTEIN; UNCLASSIFIED DRUG; URIC ACID; GLUCOSE TRANSPORTER; SLC2A9 PROTEIN, HUMAN;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENOTYPE; GOUT; HEXOSE TRANSPORT; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POPULATION RESEARCH; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; URIC ACID BLOOD LEVEL; AUSTRIA; BLOOD; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; REFERENCE VALUE; SEXUAL DEVELOPMENT; UNITED STATES;

ADULT; AGED; AUSTRIA; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GENOTYPE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; SEX CHARACTERISTICS; URIC ACID; UTAH; VARIATION (GENETICS);

EID: 49649125935     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-0349     Document Type: Article

References (24)

1. Ames BN, Cathcart R, Schwiers E, et al.: Uric acid provides an antioxidant defense in humans against oxidant- and radical- caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78:6858-6862, 1981
2. Kanellis J, Kang DH: Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol 25:39-42, 2005
3. Ford ES, Li C, Cook S, et al.: Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 115:2526-2532, 2007
4. Facchini F, Chen YD, Hollenbeck CB, et al.: Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266:3008-3011, 1991
5. Dehghan A, van Hoek M, Sijbrands EJ, et al.: High serum uric acid as a novel risk factor for type 2 diabetes mellitus. Diabetes Care 2007
6. Wilk JB, Djousse L, Borecki I, et al.: Segregation analysis of serum uric acid in the NHLBI Family Heart Study. Hum Genet 106:355-359, 2000
7. Yang Q, Guo CY, Cupples LA, et al.: Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study. Metabolism 54:1435-1441, 2005
8. Li S, Sanna S, Maschio A, et al.: The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3:e194, 2007
9. Wallace C, Newhouse SJ, Braund P, et al.: Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet 82:139-149, 2008
10. Doring A, Gieger C, Mehta D, et al.: SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet 40:430-436, 2008
11. Vitart V, Rudan I, Hayward C, et al.: SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40:437-442, 2008
12. Miller A, Adeli K: Dietary fructose and the metabolic syndrome. Curr Opin Gastroenterol 24:204-209, 2008
13. Kiechl S, Willeit J, Mayr M, et al.: Oxidized phospholipids, lipoprotein(a), li- poprotein-associated phospholipase A2 activity and 10-year cardiovascular outcomes: prospective results from the Bruneck Study. Arterioscler Thromb Vasc Biol 27:1788-1795, 2007
14. Schoenborn V, Heid IM, Vollmert C, et al.: The ATGL gene is associated with free fatty acids, triglycerides and type 2 diabetes. Diabetes 55:1270-1275, 2006
15. GrundySM, CleemanJI, Daniels SR, et al.: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 112:2735-2752, 2005
16. Horsley V, Pavlath GK: NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol 156:771-774, 2002
17. Joost HG, Thorens B: The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Mol Membr Biol 18:247-256, 2001
18. Stirpe F, Della CE, Bonetti E, et al.: Fructose-induced hyperuricaemia. Lancet 2: 1310-1311, 1970
19. Choi HK, Curhan G: Soft drinks, fructose consumption, and the risk ofgout in men: prospective cohort study. BMJ336:309 - 312, 2008
20. Hallfrisch J: Metabolic effects of dietary fructose. FASEBJ 4:2652-2660, 1990
21. Johnson RJ, Segal MS, Sautin Y, et al.: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86:899-906, 2007
22. BrayGA, NielsenSJ, PopkinBM: Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am JClin Nutr 79:537-543, 2004
23. Nakagawa T, Hu H, Zharikov S, et al.: A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 290:F625-F631, 2006
24. Patsopoulos NA, Tatsioni A, Ioannidis JP: Claims of sex differences: an empirical assessment in genetic associations. JAMA 298:880 -893, 2007