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Volumn 20, Issue 2, 2008, Pages 192-197

Control of renal uric acid excretion and gout

Author keywords

Gout; Hyperuricemia; Transporter; Urate; Uromodulin

Indexed keywords

ALLOPURINOL; BENZBROMARONE; BUTYRIC ACID; LACTIC ACID; LOSARTAN; PROBENECID; PYRAZINAMIDE; SULFINPYRAZONE; URATE;

EID: 40349096090     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e3282f33f87     Document Type: Review
Times cited : (54)

References (45)
  • 1
    • 40349093664 scopus 로고    scopus 로고
    • The biochemistry of gout
    • Wortmann RL, Schumacher R Jr, Becker MA, Ryan LM, editors, New York: Taylor & Francis;
    • Becker MA. The biochemistry of gout. In: Wortmann RL, Schumacher R Jr, Becker MA, Ryan LM, editors. Crystal-induced arthropathies: gout, pseudogout and apatite-associated syndromes. New York: Taylor & Francis; 2006. pp. 189-212.
    • (2006) Crystal-induced arthropathies: Gout, pseudogout and apatite-associated syndromes , pp. 189-212
    • Becker, M.A.1
  • 2
    • 0037114923 scopus 로고    scopus 로고
    • Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output
    • Perez-Ruiz F, Calabozo M, Erauskin GG, et al. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47:610-613.
    • (2002) Arthritis Rheum , vol.47 , pp. 610-613
    • Perez-Ruiz, F.1    Calabozo, M.2    Erauskin, G.G.3
  • 3
    • 33745274475 scopus 로고    scopus 로고
    • Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics
    • Current understanding of hyperuricemia with urate underexcretion is extensively reviewed
    • Terkeltaub R, Bushinsky DA, Becker MA. Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. Arthritis Res Ther 2006; 8 (Suppl 1):S4. Current understanding of hyperuricemia with urate underexcretion is extensively reviewed.
    • (2006) Arthritis Res Ther , vol.8 , Issue.SUPPL. 1
    • Terkeltaub, R.1    Bushinsky, D.A.2    Becker, M.A.3
  • 4
    • 0033422249 scopus 로고    scopus 로고
    • Renal transport of urate in humans
    • Roch-Ramel F, Guisan B. Renal transport of urate in humans. News Physiol Sci 1999; 14:80-84.
    • (1999) News Physiol Sci , vol.14 , pp. 80-84
    • Roch-Ramel, F.1    Guisan, B.2
  • 5
    • 23844450407 scopus 로고    scopus 로고
    • Molecular physiology and the four-component model of renal urate transport
    • Mount DB. Molecular physiology and the four-component model of renal urate transport. Curr Opin Nephrol Hypertens 2005; 14:460-463.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 460-463
    • Mount, D.B.1
  • 6
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    • Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417:447-452.
    • (2002) Nature , vol.417 , pp. 447-452
    • Enomoto, A.1    Kimura, H.2    Chairoungdua, A.3
  • 7
    • 33846837206 scopus 로고    scopus 로고
    • New insights into renal transport of urate
    • This is an extensive and excellent review of the urate transport in kidney
    • Anzai N, Kanai Y, Endou H. New insights into renal transport of urate. Curr Opin Rheumatol 2007; 19:151-157. This is an extensive and excellent review of the urate transport in kidney.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 151-157
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 8
    • 1842732504 scopus 로고    scopus 로고
    • Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules
    • Ekaratanawong S, Anzai N, Jutabha P, et al. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharmacol Sci 2004; 94:297-304.
    • (2004) J Pharmacol Sci , vol.94 , pp. 297-304
    • Ekaratanawong, S.1    Anzai, N.2    Jutabha, P.3
  • 10
    • 0041344601 scopus 로고    scopus 로고
    • Identification of a novel voltagedriven organic anion transporter present at apical membrane of renal proximal tubule
    • Jutabha P, Kanai Y, Hosoyamada M, et al. Identification of a novel voltagedriven organic anion transporter present at apical membrane of renal proximal tubule. J Biol Chem 2003; 278:27930-27938.
    • (2003) J Biol Chem , vol.278 , pp. 27930-27938
    • Jutabha, P.1    Kanai, Y.2    Hosoyamada, M.3
  • 11
    • 12144257103 scopus 로고    scopus 로고
    • Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    • Van Aubel RA, Smeets PH, van den Heuvel JJ, Russel FG. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol 2005; 288:F327-F333.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Van Aubel, R.A.1    Smeets, P.H.2    van den Heuvel, J.J.3    Russel, F.G.4
  • 12
    • 33645909146 scopus 로고    scopus 로고
    • Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins
    • Miyazaki H, Anzai N, Ekaratanawong S, et al. Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J Am Soc Nephrol 2005; 16:3498-3506.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3498-3506
    • Miyazaki, H.1    Anzai, N.2    Ekaratanawong, S.3
  • 13
    • 34248148043 scopus 로고    scopus 로고
    • Sodium-hydrogen exchanger regulatory factor-1 interacts withmouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    • Cunningham R, Brazie M, Kanumuru S, et al. Sodium-hydrogen exchanger regulatory factor-1 interacts withmouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol 2007; 18:1419-1425.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1419-1425
    • Cunningham, R.1    Brazie, M.2    Kanumuru, S.3
  • 15
    • 0036198703 scopus 로고    scopus 로고
    • Gender-specific and developmental influences on the expression of rat organic anion transporters
    • Buist SC, Cherrington NJ, Choudhuri S, et al. Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther 2002; 301:145-151.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 145-151
    • Buist, S.C.1    Cherrington, N.J.2    Choudhuri, S.3
  • 16
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • This is an extensive review about the roles of the organic anion transporters in physiological and pathological conditions
    • Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007; 24:450-470. This is an extensive review about the roles of the organic anion transporters in physiological and pathological conditions.
    • (2007) Pharm Res , vol.24 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 17
    • 2942675119 scopus 로고    scopus 로고
    • Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
    • Ljubojevic M, Herak-Kramberger CM, Hagos Y, et al. Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 2004; 287:F124-F138.
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Ljubojevic, M.1    Herak-Kramberger, C.M.2    Hagos, Y.3
  • 18
    • 0942265459 scopus 로고    scopus 로고
    • Function and localization of urate transporter 1 in mouse kidney
    • Hosoyamada M, Ichida K, Enomoto A, et al. Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol 2004; 15:261-268.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 261-268
    • Hosoyamada, M.1    Ichida, K.2    Enomoto, A.3
  • 19
    • 9244264985 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter
    • Li T, Walsh JR, Ghishan FK, Bai L. Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter. Biochim Biophys Acta 2004; 1681:53-58.
    • (2004) Biochim Biophys Acta , vol.1681 , pp. 53-58
    • Li, T.1    Walsh, J.R.2    Ghishan, F.K.3    Bai, L.4
  • 21
    • 7244236578 scopus 로고    scopus 로고
    • Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate
    • Gopal E, Fei YJ, Sugawara M, et al. Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. J Biol Chem 2004; 279:44522-44532.
    • (2004) J Biol Chem , vol.279 , pp. 44522-44532
    • Gopal, E.1    Fei, Y.J.2    Sugawara, M.3
  • 22
    • 29644435407 scopus 로고    scopus 로고
    • Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)
    • Srinivas SR, Gopal E, Zhuang L, et al. Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Biochem J 2005; 392:655-664.
    • (2005) Biochem J , vol.392 , pp. 655-664
    • Srinivas, S.R.1    Gopal, E.2    Zhuang, L.3
  • 23
    • 35848971238 scopus 로고    scopus 로고
    • Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney
    • This paper shows the localization of SMCT1/2 and provides evidence of the transport of lactate via these molecules
    • Gopal E, Umapathy NS, Martin PM, et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochim Biophys Acta 2007; 1768:2690-2697. This paper shows the localization of SMCT1/2 and provides evidence of the transport of lactate via these molecules.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 2690-2697
    • Gopal, E.1    Umapathy, N.S.2    Martin, P.M.3
  • 24
    • 0026548215 scopus 로고
    • Genetic control of the renal clearance of urate: A study of twins
    • Emmerson BT, Nagel SL, Duffy DL, Martin NG. Genetic control of the renal clearance of urate: a study of twins. Ann Rheum Dis 1992; 51:375-377.
    • (1992) Ann Rheum Dis , vol.51 , pp. 375-377
    • Emmerson, B.T.1    Nagel, S.L.2    Duffy, D.L.3    Martin, N.G.4
  • 25
    • 23644434855 scopus 로고    scopus 로고
    • A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout
    • Taniguchi A, Urano W, Yamanaka M, et al. A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout. Arthritis Rheum 2005; 52:2576-2577.
    • (2005) Arthritis Rheum , vol.52 , pp. 2576-2577
    • Taniguchi, A.1    Urano, W.2    Yamanaka, M.3
  • 26
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and molecular analysis of patients with renal hypouricemia in Japan - influence of URAT1 gene on urinary urate excretion
    • Ichida K, Hosoyamada M, Hisatome I, et al. Clinical and molecular analysis of patients with renal hypouricemia in Japan - influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 2004; 15:164-173.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 164-173
    • Ichida, K.1    Hosoyamada, M.2    Hisatome, I.3
  • 27
    • 3142674476 scopus 로고    scopus 로고
    • The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
    • Komoda F, Sekine T, Inatomi J, et al. The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia. Pediatr Nephrol 2004; 19:728-733.
    • (2004) Pediatr Nephrol , vol.19 , pp. 728-733
    • Komoda, F.1    Sekine, T.2    Inatomi, J.3
  • 28
    • 31144433386 scopus 로고    scopus 로고
    • Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population
    • Graessler J, Graessler A, Unger S, et al. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthritis Rheum 2006; 54:292-300.
    • (2006) Arthritis Rheum , vol.54 , pp. 292-300
    • Graessler, J.1    Graessler, A.2    Unger, S.3
  • 30
    • 34547802776 scopus 로고    scopus 로고
    • Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid
    • Vazquez-Mellado J, Alvarado-Romano V, Burgos-Vargas R, et al. Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid. J Clin Pathol 2007; 60:947-948.
    • (2007) J Clin Pathol , vol.60 , pp. 947-948
    • Vazquez-Mellado, J.1    Alvarado-Romano, V.2    Burgos-Vargas, R.3
  • 31
    • 4344630808 scopus 로고    scopus 로고
    • A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese
    • Iwai N, Mino Y, Hosoyamada M, et al. A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int 2004; 66:935-944.
    • (2004) Kidney Int , vol.66 , pp. 935-944
    • Iwai, N.1    Mino, Y.2    Hosoyamada, M.3
  • 32
    • 33750478368 scopus 로고    scopus 로고
    • Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese
    • Shima Y, Teruya K, Ohta H. Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. Life Sci 2006; 79:2234-2237.
    • (2006) Life Sci , vol.79 , pp. 2234-2237
    • Shima, Y.1    Teruya, K.2    Ohta, H.3
  • 33
    • 0033850904 scopus 로고    scopus 로고
    • Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family
    • Kamatani N, Moritani M, Yamanaka H, et al. Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family. Arthritis Rheum 2000; 43:925-929.
    • (2000) Arthritis Rheum , vol.43 , pp. 925-929
    • Kamatani, N.1    Moritani, M.2    Yamanaka, H.3
  • 34
    • 0033928339 scopus 로고    scopus 로고
    • Familial juvenile hyperuricemic nephropathy: Localization of the gene on chromosome 16p11.2 and evidence for genetic heterogeneity
    • Stiburkova B, Majewski J, Sebesta I, et al. Familial juvenile hyperuricemic nephropathy: localization of the gene on chromosome 16p11.2 and evidence for genetic heterogeneity. Am J Hum Genet 2000; 66:1989-1994.
    • (2000) Am J Hum Genet , vol.66 , pp. 1989-1994
    • Stiburkova, B.1    Majewski, J.2    Sebesta, I.3
  • 35
    • 0036914069 scopus 로고    scopus 로고
    • Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    • Hart TC, Gorry MC, Hart PS, et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 2002; 39:882-892.
    • (2002) J Med Genet , vol.39 , pp. 882-892
    • Hart, T.C.1    Gorry, M.C.2    Hart, P.S.3
  • 36
    • 33749532096 scopus 로고    scopus 로고
    • Defective intracellular trafficking of uromodulin mutant isoforms
    • Bernascone I, Vavassori S, Di Pentima A, et al. Defective intracellular trafficking of uromodulin mutant isoforms. Traffic 2006; 7:1567-1579.
    • (2006) Traffic , vol.7 , pp. 1567-1579
    • Bernascone, I.1    Vavassori, S.2    Di Pentima, A.3
  • 37
    • 33846021647 scopus 로고    scopus 로고
    • Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy
    • Jennings P, Aydin S, Kotanko P, et al. Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy. J Am Soc Nephrol 2007; 18:264-273.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 264-273
    • Jennings, P.1    Aydin, S.2    Kotanko, P.3
  • 38
    • 33748413779 scopus 로고    scopus 로고
    • Alterations of uromodulin biology: A common denominator of the genetically heterogeneous FJHN/MCKD syndrome
    • A comprehensive study of the FJHN/MCKD phenotype using 19 families is described
    • Vylet'al P, Kublova M, Kalbacova M, et al. Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndrome. Kidney Int 2006; 70:1155-1169. A comprehensive study of the FJHN/MCKD phenotype using 19 families is described.
    • (2006) Kidney Int , vol.70 , pp. 1155-1169
    • Vylet'al, P.1    Kublova, M.2    Kalbacova, M.3
  • 39
    • 2342453842 scopus 로고    scopus 로고
    • Familial juvenile hyperuricemic nephropathy: Detection of mutations in the uromodulin gene in five Japanese families
    • Kudo E, Kamatani N, Tezuka O, et al. Familial juvenile hyperuricemic nephropathy: detection of mutations in the uromodulin gene in five Japanese families. Kidney Int 2004; 65:1589-1597.
    • (2004) Kidney Int , vol.65 , pp. 1589-1597
    • Kudo, E.1    Kamatani, N.2    Tezuka, O.3
  • 40
    • 20044368467 scopus 로고    scopus 로고
    • Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    • Bachmann S, Mutig K, Bates J, et al. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am J Physiol Renal Physiol 2005; 288:F559-F567.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Bachmann, S.1    Mutig, K.2    Bates, J.3
  • 41
    • 33745622386 scopus 로고    scopus 로고
    • Is salt-wasting the long awaited answer to the hyperuricaemia seen in uromodulin storage diseases?
    • Gersch M, Mutig K, Bachmann S, et al. Is salt-wasting the long awaited answer to the hyperuricaemia seen in uromodulin storage diseases? Nephrol Dial Transplant 2006; 21:2028-2029.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2028-2029
    • Gersch, M.1    Mutig, K.2    Bachmann, S.3
  • 43
    • 0037408284 scopus 로고    scopus 로고
    • Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation
    • Bingham C, Ellard S, van't Hoff WG, et al. Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation. Kidney Int 2003; 63:1645-1651.
    • (2003) Kidney Int , vol.63 , pp. 1645-1651
    • Bingham, C.1    Ellard, S.2    van't Hoff, W.G.3
  • 44
    • 2342508500 scopus 로고    scopus 로고
    • A transcriptional network in polycystic kidney disease
    • Gresh L, Fischer E, Reimann A, et al. A transcriptional network in polycystic kidney disease. EMBO J 2004; 23:1657-1668.
    • (2004) EMBO J , vol.23 , pp. 1657-1668
    • Gresh, L.1    Fischer, E.2    Reimann, A.3
  • 45
    • 31644431556 scopus 로고    scopus 로고
    • Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    • Hodanova K, Majewski J, Kublova M, et al. Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41. Kidney Int 2005; 68:1472-1482.
    • (2005) Kidney Int , vol.68 , pp. 1472-1482
    • Hodanova, K.1    Majewski, J.2    Kublova, M.3


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