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Volumn 2, Issue 9, 2007, Pages 1251-1261

Drug discovery for hyperuricemia

Author keywords

CFEX; Hyperuricemia; PDZK1; SMCT; URAT1; Urate

Indexed keywords

ALLOPURINOL; ANTILIPEMIC AGENT; BENZBROMARONE; CARRIER PROTEIN; CHLORIDE; DIURETIC AGENT; FEBUXOSTAT; FENOFIBRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTIC ACID; LOSARTAN; NICOTINIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; OXIPURINOL; PDZ PROTEIN; PHENYLBUTAZONE; PROBENECID; PYRAZINOIC ACID; RASBURICASE; SULFINPYRAZONE; UNCLASSIFIED DRUG; URATE; URATE TRANSPORTER 1; URIC ACID; URICOSURIC AGENT;

EID: 34848852618     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2.9.1251     Document Type: Review
Times cited : (28)

References (70)
  • 2
    • 10144245828 scopus 로고    scopus 로고
    • Hyperuricemia, gout, and the kidney
    • Schrier RW, Gottschalk CW Eds, Little, Brown and Company, Boston
    • EMMERSON BT: Hyperuricemia, gout, and the kidney. In: Diseases of the Kidney. Schrier RW, Gottschalk CW (Eds), Little, Brown and Company, Boston (1997):2175-2199.
    • (1997) Diseases of the Kidney , pp. 2175-2199
    • EMMERSON, B.T.1
  • 3
    • 0142123411 scopus 로고    scopus 로고
    • Clinical practice. Gout
    • TERKELTAUB RA: Clinical practice. Gout. N. Engl. J. Med. (2003) 349:1647-1655.
    • (2003) N. Engl. J. Med , vol.349 , pp. 1647-1655
    • TERKELTAUB, R.A.1
  • 4
    • 0030584230 scopus 로고    scopus 로고
    • The management of gout
    • EMMERSON BT: The management of gout. N. Engl. J. Med. (1996) 334:445-451.
    • (1996) N. Engl. J. Med , vol.334 , pp. 445-451
    • EMMERSON, B.T.1
  • 5
    • 4043075471 scopus 로고    scopus 로고
    • Gout: On the brink of novel therapeutic options for an ancient disease
    • BIEBER JD, TERKELTAUB RA: Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum. (2004) 50:2400-2414.
    • (2004) Arthritis Rheum , vol.50 , pp. 2400-2414
    • BIEBER, J.D.1    TERKELTAUB, R.A.2
  • 6
    • 33745274475 scopus 로고    scopus 로고
    • Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics
    • TERKELTAUB RA, BUSHINSKY DA, BECKER MA: Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. Arthiritis Res. Ther. (2006) 8(Suppl. 1):S4.
    • (2006) Arthiritis Res. Ther , vol.8 , Issue.SUPPL. 1
    • TERKELTAUB, R.A.1    BUSHINSKY, D.A.2    BECKER, M.A.3
  • 7
    • 33747626684 scopus 로고    scopus 로고
    • New developments in clinically relevant mechanisms and treatment of hyperuricemia
    • LEE SJ, TERKELTAUB RA: New developments in clinically relevant mechanisms and treatment of hyperuricemia. Curr. Rheumatol. Rep. (2006) 8:224-230.
    • (2006) Curr. Rheumatol. Rep , vol.8 , pp. 224-230
    • LEE, S.J.1    TERKELTAUB, R.A.2
  • 8
    • 33746830642 scopus 로고    scopus 로고
    • Advances in the management of gout and hyperuricaemia
    • HOSKISON TK, WORTMANN RL: Advances in the management of gout and hyperuricaemia. Scand. J. Rheumatol. (2006) 35:251-260.
    • (2006) Scand. J. Rheumatol , vol.35 , pp. 251-260
    • HOSKISON, T.K.1    WORTMANN, R.L.2
  • 10
    • 0003122021 scopus 로고    scopus 로고
    • Real handling of organic anions and cations: Excretion of uric acid
    • Brenner BM Ed, WB Saunders, Philadelphia
    • SICA DA, SCHOOLWERTH AC: Real handling of organic anions and cations: excretion of uric acid. In: The Kidney. Brenner BM (Ed.), WB Saunders, Philadelphia (2000):680-700.
    • (2000) The Kidney , pp. 680-700
    • SICA, D.A.1    SCHOOLWERTH, A.C.2
  • 11
    • 0026592267 scopus 로고
    • Two independent mutational events in the loss of urate oxidase during hominoid evolution
    • WU XW, MUZNY DM, LEE CC et al.: Two independent mutational events in the loss of urate oxidase during hominoid evolution. J. Mol. Evol. (1992) 34:78-84.
    • (1992) J. Mol. Evol , vol.34 , pp. 78-84
    • WU, X.W.1    MUZNY, D.M.2    LEE, C.C.3
  • 12
    • 27144524212 scopus 로고    scopus 로고
    • Disorders of purine and pyrimidine metabolism
    • Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL Eds, McGraw-Hill, New York
    • WORTMANN RL: Disorders of purine and pyrimidine metabolism. In: Harrison's Principles of Internal Medicine. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (Eds), McGraw-Hill, New York (2005):2308-2313.
    • (2005) Harrison's Principles of Internal Medicine , pp. 2308-2313
    • WORTMANN, R.L.1
  • 13
    • 34848885555 scopus 로고    scopus 로고
    • Guidelines for the management of hyperuricemia and gout (in Japanese)
    • COMMITTEE FOR THE PREPARATION OF THERAPEUTIC GUIDELINES
    • COMMITTEE FOR THE PREPARATION OF THERAPEUTIC GUIDELINES: Guidelines for the management of hyperuricemia and gout (in Japanese). Gout Nucleic Acid Metab. (2002) 26(Suppl. 1):1-79.
    • (2002) Gout Nucleic Acid Metab , vol.26 , Issue.SUPPL. 1 , pp. 1-79
  • 14
    • 0014222377 scopus 로고
    • Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis
    • SEEGMILLER JE, ROSENBLOOM FM, KELLEY WN: Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science (1967) 155:1682-1694.
    • (1967) Science , vol.155 , pp. 1682-1694
    • SEEGMILLER, J.E.1    ROSENBLOOM, F.M.2    KELLEY, W.N.3
  • 15
    • 0014096982 scopus 로고
    • A specific enzyme defect in gout associated with overproduction of uric acid
    • KELLEY WN, ROSENBLOOM FM, HENDERSON JF et al.: A specific enzyme defect in gout associated with overproduction of uric acid. Proc. Natl. Acad. Sci. USA (1967) 57:1735-1739.
    • (1967) Proc. Natl. Acad. Sci. USA , vol.57 , pp. 1735-1739
    • KELLEY, W.N.1    ROSENBLOOM, F.M.2    HENDERSON, J.F.3
  • 16
    • 0029070039 scopus 로고
    • Point mutations in PRPS1, the gene encoding the PPRP sythetase (PRS) 1 isoform, underlie X-liked PRS superactivity associated with purine nucleotide inhibitor-resistance
    • BECKER MA, NOSAL JM, SWITZER RL et al.: Point mutations in PRPS1, the gene encoding the PPRP sythetase (PRS) 1 isoform, underlie X-liked PRS superactivity associated with purine nucleotide inhibitor-resistance. Adv. Exp. Med. Biol. (1994) 370:707-710.
    • (1994) Adv. Exp. Med. Biol , vol.370 , pp. 707-710
    • BECKER, M.A.1    NOSAL, J.M.2    SWITZER, R.L.3
  • 17
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    • ENOMOTO A, KIMURA H, CHAIROUNGDUA A et al.: Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature (2002) 417:447-452.
    • (2002) Nature , vol.417 , pp. 447-452
    • ENOMOTO, A.1    KIMURA, H.2    CHAIROUNGDUA, A.3
  • 18
    • 0028134681 scopus 로고
    • Polynesian women are also at risk for hyperuricemia and gout because of a genetic defect in renal urate handling
    • SIMMONDS HA, MCBRIDE MB, HATFIELD PJ et al.: Polynesian women are also at risk for hyperuricemia and gout because of a genetic defect in renal urate handling. Br. J. Rheumatol. (1994) 33:932-937.
    • (1994) Br. J. Rheumatol , vol.33 , pp. 932-937
    • SIMMONDS, H.A.1    MCBRIDE, M.B.2    HATFIELD, P.J.3
  • 19
    • 7344245989 scopus 로고    scopus 로고
    • Presymptomatic detection of familial juvenile hyperuricaemic ephropathy in children
    • MCBRIDE MB, RIGDEN S, HAYCOCK GB et al.: Presymptomatic detection of familial juvenile hyperuricaemic ephropathy in children. Pediatr. Nephrol. (1998) 12:357-364.
    • (1998) Pediatr. Nephrol , vol.12 , pp. 357-364
    • MCBRIDE, M.B.1    RIGDEN, S.2    HAYCOCK, G.B.3
  • 20
    • 0033850904 scopus 로고    scopus 로고
    • Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family
    • KAMATANI N, MORITANI M, YAMANAKA H et al.: Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family. Arthritis Rheum. (2000) 43:925-929.
    • (2000) Arthritis Rheum , vol.43 , pp. 925-929
    • KAMATANI, N.1    MORITANI, M.2    YAMANAKA, H.3
  • 21
    • 0036914069 scopus 로고    scopus 로고
    • Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    • HART TC, GORRY MC, HART PS et al.: Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J. Med. Genet. (2002) 39:882-892.
    • (2002) J. Med. Genet , vol.39 , pp. 882-892
    • HART, T.C.1    GORRY, M.C.2    HART, P.S.3
  • 22
    • 0037341801 scopus 로고    scopus 로고
    • Uromodulin mutations cause familial juvenile hyperuricemic nephropathy
    • TURNER JJ, STACEY JM, HARDING B et al.: Uromodulin mutations cause familial juvenile hyperuricemic nephropathy. J. Clin. Endocriol. Metab. (2003) 88:1398-1401.
    • (2003) J. Clin. Endocriol. Metab , vol.88 , pp. 1398-1401
    • TURNER, J.J.1    STACEY, J.M.2    HARDING, B.3
  • 23
    • 0031795642 scopus 로고    scopus 로고
    • Regulation of renal urate excretion: A critical review
    • MAESAKA JK, FISHBANE S: Regulation of renal urate excretion: a critical review. Am. J. Kidney Dis. (1998) 32:917-933.
    • (1998) Am. J. Kidney Dis , vol.32 , pp. 917-933
    • MAESAKA, J.K.1    FISHBANE, S.2
  • 24
    • 0000196910 scopus 로고
    • Evolution of the uric acid transport mechanisms in vertebrate kidney
    • Kinne RKH Ed, Karger, Basel
    • ABRAMSON RG, LIPKOWITZ MS: Evolution of the uric acid transport mechanisms in vertebrate kidney. In: Basic Principles in Transport, Comp. Physiol. (Volume 3). Kinne RKH (Ed.), Karger, Basel (1990):115-153.
    • (1990) Basic Principles in Transport, Comp. Physiol , vol.3 , pp. 115-153
    • ABRAMSON, R.G.1    LIPKOWITZ, M.S.2
  • 25
    • 23844514428 scopus 로고    scopus 로고
    • Renal urate handling-clinical relevance of recent advances
    • ANZAI N, ENOMOTO A, ENDOU H: Renal urate handling-clinical relevance of recent advances. Curr. Rheumatol. Rep. (2005) 7:227-234.
    • (2005) Curr. Rheumatol. Rep , vol.7 , pp. 227-234
    • ANZAI, N.1    ENOMOTO, A.2    ENDOU, H.3
  • 27
    • 33846837206 scopus 로고    scopus 로고
    • New insights into renal transport of urate
    • ANZAI N, KANAI Y, ENDOU H: New insights into renal transport of urate. Curr. Opin. Rheumatol. (2007) 19:151-157.
    • (2007) Curr. Opin. Rheumatol , vol.19 , pp. 151-157
    • ANZAI, N.1    KANAI, Y.2    ENDOU, H.3
  • 29
    • 0026527261 scopus 로고
    • Pilot study of the uricosuric effects of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects
    • NAKASHIMA M, UEMATSU T, KOSUGE K, KANAMARU M: Pilot study of the uricosuric effects of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects. Eur. J. Clin. Pharmacol. (1992) 42:333-335.
    • (1992) Eur. J. Clin. Pharmacol , vol.42 , pp. 333-335
    • NAKASHIMA, M.1    UEMATSU, T.2    KOSUGE, K.3    KANAMARU, M.4
  • 30
    • 0028300464 scopus 로고
    • Urate transport in brush-border membrane of human kidney
    • ROCH-RAMEL F, WERNER D, GUISAN B: Urate transport in brush-border membrane of human kidney. Am. J. Physiol. (1994) 266:F797-F805.
    • (1994) Am. J. Physiol , vol.266
    • ROCH-RAMEL, F.1    WERNER, D.2    GUISAN, B.3
  • 31
    • 0015817330 scopus 로고
    • Urate secretion in man: The pyrazinamide suppression test
    • STEELE TH: Urate secretion in man: the pyrazinamide suppression test. Ann. Intern. Med. (1976) 79:734-737.
    • (1976) Ann. Intern. Med , vol.79 , pp. 734-737
    • STEELE, T.H.1
  • 32
    • 2142758435 scopus 로고
    • Studies of hyperuricemia produced by pyrazinamide
    • CULLEN JH, LEVINE M, FIORE JM: Studies of hyperuricemia produced by pyrazinamide. Am. J. Med. (1957) 23:587-595.
    • (1957) Am. J. Med , vol.23 , pp. 587-595
    • CULLEN, J.H.1    LEVINE, M.2    FIORE, J.M.3
  • 33
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    • ICHIDA K, HOSOYAMADA M, HISATOME I et al.: Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J. Am. Soc. Nephrol. (2004) 15:164-173.
    • (2004) J. Am. Soc. Nephrol , vol.15 , pp. 164-173
    • ICHIDA, K.1    HOSOYAMADA, M.2    HISATOME, I.3
  • 34
    • 3142674476 scopus 로고    scopus 로고
    • The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
    • KOMODA F, SEKINE T, INATOMI J et al.: The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia. Pediatr. Nephrol. (2004) 19:728-733.
    • (2004) Pediatr. Nephrol , vol.19 , pp. 728-733
    • KOMODA, F.1    SEKINE, T.2    INATOMI, J.3
  • 35
    • 0022335845 scopus 로고
    • Urate transport in the proximal tubule: In vivo and vesicle studies
    • KAHN AM, WEINMAN EJ: Urate transport in the proximal tubule: in vivo and vesicle studies. Am. J. Physiol. (1985) 249:F789-F798.
    • (1985) Am. J. Physiol , vol.249
    • KAHN, A.M.1    WEINMAN, E.J.2
  • 36
    • 7244236578 scopus 로고    scopus 로고
    • Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate
    • GOPAL E, FEI YJ, SUGAWARA M et al.: Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. J. Biol. Chem. (2004) 279:44522-44532.
    • (2004) J. Biol. Chem , vol.279 , pp. 44522-44532
    • GOPAL, E.1    FEI, Y.J.2    SUGAWARA, M.3
  • 37
    • 29644435407 scopus 로고    scopus 로고
    • Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)
    • SRINIVAS SR, GOPAL E, ZHUANG L et al.: Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Biochem. J. (2005) 392:655-664.
    • (2005) Biochem. J , vol.392 , pp. 655-664
    • SRINIVAS, S.R.1    GOPAL, E.2    ZHUANG, L.3
  • 38
    • 23844545249 scopus 로고    scopus 로고
    • Slc5a8 functions as a sodium-dependent pyrazionate and nicotinate cotransporter; Implications for renal urate transport
    • Abstract
    • ZANDI-NEJAD K, PLATA C, ENCK AH et al.: Slc5a8 functions as a sodium-dependent pyrazionate and nicotinate cotransporter; Implications for renal urate transport. J. Am. Soc. Nephrol. (2004) 15:A89 (Abstract).
    • (2004) J. Am. Soc. Nephrol , vol.15
    • ZANDI-NEJAD, K.1    PLATA, C.2    ENCK, A.H.3
  • 39
    • 33748755827 scopus 로고    scopus 로고
    • c/ebpdelta null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney
    • THANGARAJU M, ANANTH S, MARTIN PM et al.: c/ebpdelta null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney. J. Biol. Chem. (2006) 281:26769-26773.
    • (2006) J. Biol. Chem , vol.281 , pp. 26769-26773
    • THANGARAJU, M.1    ANANTH, S.2    MARTIN, P.M.3
  • 40
    • 0030874878 scopus 로고    scopus 로고
    • Mechanisms of chloride transport in the proximal tubule
    • ARONSON PS, GIEBISCH G: Mechanisms of chloride transport in the proximal tubule. Am. J. Physiol. (1997) 273:F179-F192.
    • (1997) Am. J. Physiol , vol.273
    • ARONSON, P.S.1    GIEBISCH, G.2
  • 41
    • 0035979278 scopus 로고    scopus 로고
    • Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells
    • KNAUF F, YANG CL, THOMSON RB, MENTONE SA, GIEBISCH G, ARONSON PS: Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc. Natl. Acad. Sci. USA (2001) 98:9425-9430.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9425-9430
    • KNAUF, F.1    YANG, C.L.2    THOMSON, R.B.3    MENTONE, S.A.4    GIEBISCH, G.5    ARONSON, P.S.6
  • 44
    • 8544277306 scopus 로고    scopus 로고
    • The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C-terminal
    • ANZAI N, MIYAZAKI H, NOSHIRO R et al.: The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C-terminal. J. Biol. Chem. (2004) 279:45942-45950.
    • (2004) J. Biol. Chem , vol.279 , pp. 45942-45950
    • ANZAI, N.1    MIYAZAKI, H.2    NOSHIRO, R.3
  • 45
    • 34848826360 scopus 로고    scopus 로고
    • Identification of the multivalent PDZ domain protein PDZK1 as a binding partner of sodium-coupled monocarboxylate cotransporter 1 (SMCT1)
    • Abstract
    • ANZAI N, MIYAZAKI H, HE X et al.: Identification of the multivalent PDZ domain protein PDZK1 as a binding partner of sodium-coupled monocarboxylate cotransporter 1 (SMCT1). J. Am. Soc. Nephrol. (2006) 17:A753 (Abstract).
    • (2006) J. Am. Soc. Nephrol , vol.17
    • ANZAI, N.1    MIYAZAKI, H.2    HE, X.3
  • 46
    • 24944486255 scopus 로고    scopus 로고
    • Role of PDZK1 in membrane expression of renal brush border ion exchangers
    • THOMSON RB, WANG T, THOMSON BR et al.: Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc. Natl. Acad. Sci. USA (2005) 102:13331-13336.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13331-13336
    • THOMSON, R.B.1    WANG, T.2    THOMSON, B.R.3
  • 47
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • ANZAI N, KANAI Y, ENDOU H: Organic anion transporter family: current knowledge. J. Pharmacol. Sci. (2006) 100:411-426.
    • (2006) J. Pharmacol. Sci , vol.100 , pp. 411-426
    • ANZAI, N.1    KANAI, Y.2    ENDOU, H.3
  • 48
    • 0037103137 scopus 로고    scopus 로고
    • Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout
    • PEREZ-RUIZ F, CALABOZO M, PIJOAN JI et al.: Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout. Arthritis Rheum. (2002) 47:356-360.
    • (2002) Arthritis Rheum , vol.47 , pp. 356-360
    • PEREZ-RUIZ, F.1    CALABOZO, M.2    PIJOAN, J.I.3
  • 49
    • 2642527090 scopus 로고    scopus 로고
    • A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: Evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy
    • SHOJI A, YAMANAKA H, KAMATANI N: A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. Arthritis Rheum. (2004) 51:321-325.
    • (2004) Arthritis Rheum , vol.51 , pp. 321-325
    • SHOJI, A.1    YAMANAKA, H.2    KAMATANI, N.3
  • 50
    • 33748608331 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR standing committee for international clinical studies including therapeutics (ESCISIT)
    • ZHANG W, DOHERTY M, BARDIN T et al.: EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR standing committee for international clinical studies including therapeutics (ESCISIT). Ann. Rheum. Dis. (2006) 65:1312-1324.
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 1312-1324
    • ZHANG, W.1    DOHERTY, M.2    BARDIN, T.3
  • 51
    • 1542313924 scopus 로고    scopus 로고
    • Quality of care indicators for gout management
    • MIKULS TR, MACLEAN CH, OLIVIERI J et al.: Quality of care indicators for gout management. Arthritis Rheum. (2004) 50:937-943.
    • (2004) Arthritis Rheum , vol.50 , pp. 937-943
    • MIKULS, T.R.1    MACLEAN, C.H.2    OLIVIERI, J.3
  • 52
    • 34848822621 scopus 로고
    • Comparative study concerning the effects of allopurinol and benzbromarone based on the uric acid metabolism (in Japanese)
    • YAMANAKA H, KAMATANI N, KASHIWAZAKI S: Comparative study concerning the effects of allopurinol and benzbromarone based on the uric acid metabolism (in Japanese). Hyperuricemia and Gout (1994) 2:103-111.
    • (1994) Hyperuricemia and Gout , vol.2 , pp. 103-111
    • YAMANAKA, H.1    KAMATANI, N.2    KASHIWAZAKI, S.3
  • 53
    • 0014187863 scopus 로고
    • Uric acid urolithiasis in gout: Predisposing factors
    • YU TF, GUTMAN AB: Uric acid urolithiasis in gout: predisposing factors. Ann. Intern. Med. (1967) 67:1133-1148.
    • (1967) Ann. Intern. Med , vol.67 , pp. 1133-1148
    • YU, T.F.1    GUTMAN, A.B.2
  • 54
    • 49749155541 scopus 로고
    • Protracted uricosuirc therapy in tophaceous gout
    • GUTMAN AB, YU TF: Protracted uricosuirc therapy in tophaceous gout. Lancet (1955) 2:1258-1260.
    • (1955) Lancet , vol.2 , pp. 1258-1260
    • GUTMAN, A.B.1    YU, T.F.2
  • 55
    • 33947365498 scopus 로고    scopus 로고
    • Emerging therapies in the long-term management of hyperuricaemia and gout
    • STAMP LK, O'DONNELL JL, CHAPMAN PT: Emerging therapies in the long-term management of hyperuricaemia and gout. Intern. Med. J. (2007) 37:258-266.
    • (2007) Intern. Med. J , vol.37 , pp. 258-266
    • STAMP, L.K.1    O'DONNELL, J.L.2    CHAPMAN, P.T.3
  • 56
    • 0034718556 scopus 로고    scopus 로고
    • Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
    • ENROTH C, EGER BT, OKAMOTO K et al.: Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc. Natl. Acad. Sci. USA (2000) 97:10723-10728.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10723-10728
    • ENROTH, C.1    EGER, B.T.2    OKAMOTO, K.3
  • 57
    • 0034525032 scopus 로고    scopus 로고
    • Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk
    • EGER BT, OKAMOTO K, ENROTH C et al.: Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk. Acta Cystallogr. D. Biol. Crystallogr. (2000) 56:1656-1658.
    • (2000) Acta Cystallogr. D. Biol. Crystallogr , vol.56 , pp. 1656-1658
    • EGER, B.T.1    OKAMOTO, K.2    ENROTH, C.3
  • 58
    • 0037816302 scopus 로고    scopus 로고
    • Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
    • KUWABARA Y, NISHINO T, OKAMOTO K et al.: Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase. Proc. Natl. Acad. Sci. USA (2003) 100:8170-8175.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8170-8175
    • KUWABARA, Y.1    NISHINO, T.2    OKAMOTO, K.3
  • 59
    • 0021366307 scopus 로고
    • Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency
    • HANDE KR, NOONE RM, STONE WJ: Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am. J. Med. (1984) 76:47-56.
    • (1984) Am. J. Med , vol.76 , pp. 47-56
    • HANDE, K.R.1    NOONE, R.M.2    STONE, W.J.3
  • 60
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • HUNG S, CHUNG W, LIOU L et al.: HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc. Natl. Acad. Sci. USA (2005) 102:4134-4139.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4134-4139
    • HUNG, S.1    CHUNG, W.2    LIOU, L.3
  • 61
    • 34848857142 scopus 로고
    • Analysis of allopurinol metabolism in urate translocation mechanism disorder (in Japanese)
    • YOSHIMURA R, FUJIMORI A, SAITO H et al.: Analysis of allopurinol metabolism in urate translocation mechanism disorder (in Japanese). Purine Pyrimidine Metab. (1994) 18:37.
    • (1994) Purine Pyrimidine Metab , vol.18 , pp. 37
    • YOSHIMURA, R.1    FUJIMORI, A.2    SAITO, H.3
  • 62
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • BECKER MA, SCHUMACHER HR Jr, WORTMANN RL et al.: Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N. Engl. J. Med. (2005) 353:2450-2461.
    • (2005) N. Engl. J. Med , vol.353 , pp. 2450-2461
    • BECKER, M.A.1    SCHUMACHER Jr, H.R.2    WORTMANN, R.L.3
  • 63
    • 0037449776 scopus 로고    scopus 로고
    • An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
    • OKAMOTO K, EGER BT, NISHINO T, KONDO S, PAI EF, NISHINO T: An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J. Biol. Chem. (2003) 278:1848-1855.
    • (2003) J. Biol. Chem , vol.278 , pp. 1848-1855
    • OKAMOTO, K.1    EGER, B.T.2    NISHINO, T.3    KONDO, S.4    PAI, E.F.5    NISHINO, T.6
  • 64
    • 0034646735 scopus 로고    scopus 로고
    • Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice
    • HORIUCHI H, OTA M, NISHIMURA S et al.: Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice. Life Sci. (2000) 66:2051-2070.
    • (2000) Life Sci , vol.66 , pp. 2051-2070
    • HORIUCHI, H.1    OTA, M.2    NISHIMURA, S.3
  • 65
    • 0034777451 scopus 로고    scopus 로고
    • Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: Results of a compassionate-use trial
    • PUI CH, JEHA S, IRWIN D, CAMITTA B: Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial. Leukemia (2001) 15:1505-1509.
    • (2001) Leukemia , vol.15 , pp. 1505-1509
    • PUI, C.H.1    JEHA, S.2    IRWIN, D.3    CAMITTA, B.4
  • 66
    • 4644275038 scopus 로고    scopus 로고
    • Serum uric acid-lowering therapies: Where are we heading in management of hyperuricemia and the potential role of uricase
    • BOMALASKI JS, CLARK MA: Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Curr. Rheumatol. Rep. (2004) 6:240-247.
    • (2004) Curr. Rheumatol. Rep , vol.6 , pp. 240-247
    • BOMALASKI, J.S.1    CLARK, M.A.2
  • 67
    • 0023905821 scopus 로고
    • Hypertriglyceridemia and hyperuricemia: Effects of two fibric acid derivatives (bezafibrate and fenofibrate) in a double-blind, placebo-controlled trial
    • BASTOW MD, DURRINGTON PN, ISHOLA M: Hypertriglyceridemia and hyperuricemia: effects of two fibric acid derivatives (bezafibrate and fenofibrate) in a double-blind, placebo-controlled trial. Metabolism (1988) 37:217-220.
    • (1988) Metabolism , vol.37 , pp. 217-220
    • BASTOW, M.D.1    DURRINGTON, P.N.2    ISHOLA, M.3
  • 69
    • 33845887252 scopus 로고    scopus 로고
    • Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter
    • IWANAGA T, SATO M, MAEDA T et al.: Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J. Pharmacol. Exp. Ther. (2007) 320:211-217.
    • (2007) J. Pharmacol. Exp. Ther , vol.320 , pp. 211-217
    • IWANAGA, T.1    SATO, M.2    MAEDA, T.3
  • 70
    • 10444276589 scopus 로고    scopus 로고
    • Making protein interactions druggable: Targeting PDZ domains
    • DEV KK: Making protein interactions druggable: targeting PDZ domains. Nat. Rev. Drug Discov. (2004) 3:1047-1056.
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 1047-1056
    • DEV, K.K.1


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