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Excellent recent (2010) review of the mechanisms of epigenetic reprogramming that control gene expression, and how environmental exposures, working through epigenetic means, affect the expression of asthma and the Th2 phenotype. Specific sections are devoted to discussing the effects of individual exposures such as traffic, ozone, endotoxin, and diet
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Ho SM. Environmental epigenetics of asthma: an update. J Allergy Clin Immunol 2010; 126:453-465. Excellent recent (2010) review of the mechanisms of epigenetic reprogramming that control gene expression, and how environmental exposures, working through epigenetic means, affect the expression of asthma and the Th2 phenotype. Specific sections are devoted to discussing the effects of individual exposures such as traffic, ozone, endotoxin, and diet.
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Martino DJ, Prescott SL. Silent mysteries: Epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease. Allergy 2010; 65:7-15. Another thorough study presenting compelling evidence that immune development is under epigenetic regulation. The focus of this study includes in-utero and perinatal periods that are less relevant to the adult population that is the focus of this study.
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