Discovery of 1,4-disubstituted 3-cyano-2-pyridones: A new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2388-2405

  Cid, Jose María ^a   Duvey, Guillaume ^c   Tresadern, Gary ^a   Nhem, Vanthea ^c   Furnari, Rocco ^c   Cluzeau, Philippe ^c   Vega, Juan Antonio ^a   De Lucas, Ana Isabel ^a   Matesanz, Encarnación ^a   Alonso, José Manuel ^a   Linares, María Lourdes ^a   Andrés, José Ignacio ^a   Poli, Sonia M ^c   Lutjens, Robert ^c   Himogai, Hassan ^c   Rocher, Jean Philippe ^c   MacDonald, Gregor J ^b   Oehlrich, Daniel ^b   Lavreysen, Hilde ^b   Ahnaou, Abdelah ^b   Drinkenburg, Wilhelmus ^b   MacKie, Claire ^a   Trabanco, Andrés A ^a   more..

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 4 [3 FLUORO 4 (2 METHYLPYRIDIN 4 YLOXY)PHENYL] 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 4 AMINO 2 THIABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID 2,2 DIOXIDE; CYANIDE; GLUTAMATE RECEPTOR 2; POMAGLUMETAD METHIONIL; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG POTENCY; ELECTROENCEPHALOGRAM; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN FUNCTION; RAT; SLEEP WAKING CYCLE; SUBSTITUTION REACTION;

ALLOSTERIC REGULATION; ANIMALS; BRAIN; DRUG SYNERGISM; ELECTROENCEPHALOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; ISOMERISM; MICE; NITRILES; PATCH-CLAMP TECHNIQUES; PYRIDONES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SLEEP, REM; STRUCTURE-ACTIVITY RELATIONSHIP; WAKEFULNESS;

EID: 84858052780     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2016864     Document Type: Article

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