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Volumn 2, Issue 2, 2011, Pages 132-139

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

(21) Trabanco, Andrés A a Duvey, Guillaume b Cid, José María a MacDonald, Gregor J a Cluzeau, Philippe b Nhem, Vanthea b Furnari, Rocco b Behaj, Nadia b Poulain, Géraldine b Finn, Terry b Poli, Sonia b Lavreysen, Hilde a Raux, Alexandre b Thollon, Yves b Poirier, Nicolas b D'Addona, David b Andrés, José Ignacio a Lutjens, Robert b Le Poul, Emmanuel b Imogai, Hassan b Rocher, Jean Philippe b more..

a JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

b ADDEX PHARMACEUTICALS (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPYL 5 (3 TRIFLUOROMETHOXYBENZYLAMINO)ISOQUINOLIN 1(2H) ONE; 5 (2 CHLOROBENZYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (2 METHOXYPHENETHYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (3 METHOXYBENZYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (3 METHOXYPHENETHYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (3 PHENOXYBENZYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (3 PHENYLPROPYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (4 METHOXYBENZYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (4 METHOXYPHENETHYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (4 METHOXYPHENETOXY) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (4 METHYLPHENETHYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 (BENZYLAMINO) 8 CHLORO 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 [N (4 METHOXYPHENETHYL) N METHYLAMINO] 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 BENZYLAMINO 2 PROPYLISOQUINOLIN 1(2H) ONE; 5 PHENETHYLAMINO 2 PROPYLISOQUINOLIN 1(2H) ONE; 8 CHLORO 5 (3 METHOXYBENZYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; 8 CHLORO 5 (PHENETHYLAMINO) 2 PROPYLISOQUINOLIN 1(2H) ONE; METABOTROPIC RECEPTOR 2; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CHEMICAL MODIFICATION; CHO CELL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER MICROSOME; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 79952493408 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c0md00200c Document Type: Article

Times cited : (11)

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