Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole- N -methylimidazole polyamide conjugates

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2057-2066

  Kashiwazaki, Gengo ^a   Bando, Toshikazu ^a   Yoshidome, Tomofumi ^a   Masui, Seiji ^a   Takagaki, Toshiki ^a   Hashiya, Kaori ^a   Pandian, Ganesh N ^b   Yasuoka, Junichi ^c   Akiyoshi, Kazunari ^a,c   Sugiyama, Hiroshi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LIPOSOME; N METHYLPYRROLE N METHYLIMIDAZOLE POLYAMIDE CONJUGATE; POLYAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA ALKYLATION; DNA DAMAGE; DRUG ACTIVITY; DRUG CONJUGATION; GENE SEQUENCE; GENOME; HUMAN; HUMAN CELL; HUMAN GENOME; MALE; MOUSE; NONHUMAN; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, HUMAN; HUMANS; IMIDAZOLES; INDOLES; LIPOSOMES; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NYLONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 84858037284     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201225z     Document Type: Article

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