Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 168-174

  Minoshima, Masafumi ^a   Chou, James C ^b   Lefebvre, Sophie ^c   Bando, Toshikazu ^a   Shinohara, Ken ichi ^a   Gottesfeld, Joel M ^c   Sugiyama, Hiroshi ^a,d  

^a KYOTO UNIVERSITY   (Japan)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Anticancer agent; DNA alkylating agent; Gene Silencing; Histone; Pyrrole imidazole polyamide

Indexed keywords

1 CBI; 2 CBI; 3 CBI; 4 CBI; 5 CBI; ANTINEOPLASTIC AGENT; CANNABINOID; HISTONE H4; IMIDAZOLE; POLYAMIDE; PYRROLE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DNA ALKYLATION; DNA MICROARRAY; DOWN REGULATION; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; DNA; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES; HISTONES; HUMANS; IMIDAZOLES; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; NYLONS; PYRROLES;

EID: 72149130297     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.005     Document Type: Article

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