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Volumn 16, Issue 16, 2010, Pages 1801-1812

Lesson learned from nature for the development of novel anti-cancer agents: Implication of isoflavone, curcumin, and their synthetic analogs

Author keywords

Cancer therapy; Chemoprevention; Curcumin; Isoflavone

Indexed keywords

1,5 DIARYLPENTADIENONE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 HYDROXY 3 METHOXYBENZOIC ACID METHYL ESTER; BENZYLOXIME; BIOCHANIN A; CDF; CURCUMIN; DAIDZEIN; EF 24; FLLL 11; FLLL 12; FLUORIDE; GENISTEIN; GLYCITEIN; GO Y030; HYDROXYFLUTAMIDE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLAVONE; ISOFLAVONE DERIVATIVE; ISOXAZOLE; NOVASOY; PHENOXODIOL; PROSTAGLANDIN SYNTHASE; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE B; SEMAXANIB; STAT3 PROTEIN; SU 1433; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77953497158     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210791208956     Document Type: Article
Times cited : (113)

References (129)
  • 1
    • 0034162497 scopus 로고    scopus 로고
    • Ongoing research to identify environmental risk factors in breast carcinoma
    • Johnson-Thompson MC, Guthrie J. Ongoing research to identify environmental risk factors in breast carcinoma. Cancer 2000; 88: 1224-9.
    • (2000) Cancer , vol.88 , pp. 1224-1229
    • Johnson-Thompson, M.C.1    Guthrie, J.2
  • 2
    • 0029603561 scopus 로고
    • Differences in cancer incidence, mortality, and survival between African Americans and whites
    • Walker B, Figgs LW, Zahm SH. Differences in cancer incidence, mortality, and survival between African Americans and whites. Environ Health Perspect 1995; 103 (Suppl 8): 275-81.
    • (1995) Environ Health Perspect , vol.103 , Issue.SUPPL. 8 , pp. 275-281
    • Walker, B.1    Figgs, L.W.2    Zahm, S.H.3
  • 3
    • 49549097364 scopus 로고    scopus 로고
    • The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: A global perspective
    • Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc 2008; 67: 253-6.
    • (2008) Proc Nutr Soc , vol.67 , pp. 253-256
    • Wiseman, M.1
  • 7
  • 8
    • 0037384508 scopus 로고    scopus 로고
    • Gene expression profiles of I3C- and DIM- treated PC3 human prostate cancer cells determined by cDNA microarray analysis
    • Li Y, Li X, Sarkar FH. Gene expression profiles of I3C- and DIM- treated PC3 human prostate cancer cells determined by cDNA microarray analysis. J Nutr 2003; 133: 1011-9.
    • (2003) J Nutr , vol.133 , pp. 1011-1019
    • Li, Y.1    Li, X.2    Sarkar, F.H.3
  • 9
    • 0043067996 scopus 로고    scopus 로고
    • Role of p53 and NF-kappaB in epigallocatechin-3- gallate-induced apoptosis of LNCaP cells
    • Hastak K, Gupta S, Ahmad N, Agarwal MK, Agarwal ML, Mukhtar H. Role of p53 and NF-kappaB in epigallocatechin-3- gallate-induced apoptosis of LNCaP cells. Oncogene 2003; 22: 4851-9.
    • (2003) Oncogene , vol.22 , pp. 4851-4859
    • Hastak, K.1    Gupta, S.2    Ahmad, N.3    Agarwal, M.K.4    Agarwal, M.L.5    Mukhtar, H.6
  • 10
    • 66849115652 scopus 로고    scopus 로고
    • Adolescent and adult soy food intake and breast cancer risk: Results from the Shanghai Women's Health Study
    • Lee SA, Shu XO, Li H, Yang G, Cai H, Wen W, et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study. Am J Clin Nutr 2009; 89: 1920-6.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1920-1926
    • Lee, S.A.1    Shu, X.O.2    Li, H.3    Yang, G.4    Cai, H.5    Wen, W.6
  • 11
    • 51849137447 scopus 로고    scopus 로고
    • Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study
    • Kim MK, Kim JH, Nam SJ, Ryu S, Kong G. Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutr Cancer 2008; 60: 568-76.
    • (2008) Nutr Cancer , vol.60 , pp. 568-576
    • Kim, M.K.1    Kim, J.H.2    Nam, S.J.3    Ryu, S.4    Kong, G.5
  • 12
    • 23044470000 scopus 로고    scopus 로고
    • Soybean products and reduction of breast cancer risk: A case- control study in Japan
    • Hirose K, Imaeda N, Tokudome Y, Goto C, Wakai K, Matsuo K, et al. Soybean products and reduction of breast cancer risk: a case- control study in Japan. Br J Cancer 2005; 93: 15-22.
    • (2005) Br J Cancer , vol.93 , pp. 15-22
    • Hirose, K.1    Imaeda, N.2    Tokudome, Y.3    Goto, C.4    Wakai, K.5    Matsuo, K.6
  • 13
    • 11144354162 scopus 로고    scopus 로고
    • A case-control study of diet and prostate cancer in Japan: Possible protective effect of traditional Japanese diet
    • Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, et al. A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet. Cancer Sci 2004; 95: 238-42.
    • (2004) Cancer Sci , vol.95 , pp. 238-242
    • Sonoda, T.1    Nagata, Y.2    Mori, M.3    Miyanaga, N.4    Takashima, N.5    Okumura, K.6
  • 14
    • 0033587157 scopus 로고    scopus 로고
    • Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein
    • Li Y, Upadhyay S, Bhuiyan M, Sarkar FH. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 1999; 18: 3166-72.
    • (1999) Oncogene , vol.18 , pp. 3166-3172
    • Li, Y.1    Upadhyay, S.2    Bhuiyan, M.3    Sarkar, F.H.4
  • 15
    • 0035992417 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway
    • Li Y, Sarkar FH. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 2002; 8: 2369-77.
    • (2002) Clin Cancer Res , vol.8 , pp. 2369-2377
    • Li, Y.1    Sarkar, F.H.2
  • 16
    • 0028815434 scopus 로고
    • Effect of genistein on in vitro and in vivo models of cancer
    • Barnes S. Effect of genistein on in vitro and in vivo models of cancer. J Nutr 1995; 125: 777S-83S.
    • (1995) J Nutr , vol.125
    • Barnes, S.1
  • 17
    • 0036898130 scopus 로고    scopus 로고
    • Gene expression profiles of genistein-treated PC3 prostate cancer cells
    • Li Y, Sarkar FH. Gene expression profiles of genistein-treated PC3 prostate cancer cells. J Nutr 2002; 132: 3623-31.
    • (2002) J Nutr , vol.132 , pp. 3623-3631
    • Li, Y.1    Sarkar, F.H.2
  • 18
    • 0037027752 scopus 로고    scopus 로고
    • Down-regulation of invasion and angiogenesis- related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein
    • Li Y, Sarkar FH. Down-regulation of invasion and angiogenesis- related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Lett 2002; 186: 157-64.
    • (2002) Cancer Lett , vol.186 , pp. 157-164
    • Li, Y.1    Sarkar, F.H.2
  • 19
    • 38349048822 scopus 로고
    • Turmeric (curcumin) in biliary diseases
    • Oppenheimer A. Turmeric (curcumin) in biliary diseases. Lancet 1937; 229: 619-21.
    • (1937) Lancet , vol.229 , pp. 619-621
    • Oppenheimer, A.1
  • 20
    • 51349137454 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    • Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 2008; 269: 199-225.
    • (2008) Cancer Lett , vol.269 , pp. 199-225
    • Kunnumakkara, A.B.1    Anand, P.2    Aggarwal, B.B.3
  • 21
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    • Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001; 480-481: 243-68.
    • (2001) Mutat Res , vol.480-481 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3    Han, S.S.4    Keum, Y.S.5    Park, K.K.6
  • 23
    • 70449637229 scopus 로고    scopus 로고
    • Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    • Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, et al. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol 2010; 79(3): 330-8.
    • (2010) Biochem Pharmacol , vol.79 , Issue.3 , pp. 330-338
    • Anand, P.1    Nair, H.B.2    Sung, B.3    Kunnumakkara, A.B.4    Yadav, V.R.5    Tekmal, R.R.6
  • 24
    • 58149165086 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway
    • Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res 2008; 14: 6228-36.
    • (2008) Clin Cancer Res , vol.14 , pp. 6228-6236
    • Wang, D.1    Veena, M.S.2    Stevenson, K.3    Tang, C.4    Ho, B.5    Suh, J.D.6
  • 25
    • 0018129082 scopus 로고
    • Phytoestrogen interaction with estrogen receptors in human breast cancer cells
    • Martin PM, Horwitz KB, Ryan DS, McGuire WL. Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 1978; 103: 1860-7.
    • (1978) Endocrinology , vol.103 , pp. 1860-1867
    • Martin, P.M.1    Horwitz, K.B.2    Ryan, D.S.3    McGuire, W.L.4
  • 26
    • 0032516722 scopus 로고    scopus 로고
    • Genistein in the control of breast cancer cell growth: Insights into the mechanism of action in vitro
    • Fioravanti L, Cappelletti V, Miodini P, Ronchi E, Brivio M, Di FG. Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett 1998; 130: 143-52.
    • (1998) Cancer Lett , vol.130 , pp. 143-152
    • Fioravanti, L.1    Cappelletti, V.2    Miodini, P.3    Ronchi, E.4    Brivio, M.5    Di, F.G.6
  • 28
    • 0032481676 scopus 로고    scopus 로고
    • Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy
    • Zhou Y, Lee AS. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J Natl Cancer Inst 1998; 90: 381-8.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 381-388
    • Zhou, Y.1    Lee, A.S.2
  • 29
    • 0035371244 scopus 로고    scopus 로고
    • Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes
    • Davis JN, Kucuk O, Djuric Z, Sarkar FH. Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. Free Radic Biol Med 2001; 30: 1293-302.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1293-1302
    • Davis, J.N.1    Kucuk, O.2    Djuric, Z.3    Sarkar, F.H.4
  • 30
    • 0036883592 scopus 로고    scopus 로고
    • Dietary genistein suppresses chemically induced prostate cancer in Lobund-Wistar rats
    • Wang J, Eltoum IE, Lamartiniere CA. Dietary genistein suppresses chemically induced prostate cancer in Lobund-Wistar rats. Cancer Lett 2002; 186: 11-8.
    • (2002) Cancer Lett , vol.186 , pp. 11-18
    • Wang, J.1    Eltoum, I.E.2    Lamartiniere, C.A.3
  • 31
    • 0031445284 scopus 로고    scopus 로고
    • The chemopreventive properties of soy isoflavonoids in animal models of breast cancer
    • Barnes S. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res Treat 1997; 46: 169-79.
    • (1997) Breast Cancer Res Treat , vol.46 , pp. 169-179
    • Barnes, S.1
  • 32
    • 69049087664 scopus 로고    scopus 로고
    • Cellular signaling perturbation by natural products
    • Sarkar FH, Li Y, Wang Z, Kong D. Cellular signaling perturbation by natural products. Cell Signal 2009; 21: 1541-7.
    • (2009) Cell Signal , vol.21 , pp. 1541-1547
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 33
    • 34548406410 scopus 로고    scopus 로고
    • Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy
    • Sarkar FH, Li YW. Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy. Acta Pharmacol Sin 2007; 28: 1305-15.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1305-1315
    • Sarkar, F.H.1    Li, Y.W.2
  • 34
    • 33646397565 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
    • Li Y, Kucuk O, Hussain M, Abrams J, Cher ML, Sarkar FH. Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer. Cancer Res 2006; 66: 4816-25.
    • (2006) Cancer Res , vol.66 , pp. 4816-4825
    • Li, Y.1    Kucuk, O.2    Hussain, M.3    Abrams, J.4    Cher, M.L.5    Sarkar, F.H.6
  • 35
    • 0033509354 scopus 로고    scopus 로고
    • Genistein inhibits NF-kappa B activation in prostate cancer cells
    • Davis JN, Kucuk O, Sarkar FH. Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer 1999; 35: 167-74.
    • (1999) Nutr Cancer , vol.35 , pp. 167-174
    • Davis, J.N.1    Kucuk, O.2    Sarkar, F.H.3
  • 36
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 2005; 65: 6934-42.
    • (2005) Cancer Res , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 37
    • 0041589149 scopus 로고    scopus 로고
    • Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells
    • Gong L, Li Y, Nedeljkovic-Kurepa A, Sarkar FH. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 2003; 22: 4702-9.
    • (2003) Oncogene , vol.22 , pp. 4702-4709
    • Gong, L.1    Li, Y.2    Nedeljkovic-Kurepa, A.3    Sarkar, F.H.4
  • 38
    • 0034283944 scopus 로고    scopus 로고
    • TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: Involvement of the phospholipase C-gamma 2, protein kinase C- alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway
    • Chen CC, Sun YT, Chen JJ, Chiu KT. TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C- alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. J Immunol 2000; 165: 2719-28.
    • (2000) J Immunol , vol.165 , pp. 2719-2728
    • Chen, C.C.1    Sun, Y.T.2    Chen, J.J.3    Chiu, K.T.4
  • 39
    • 0032053283 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression
    • Natarajan K, Manna SK, Chaturvedi MM, Aggarwal BB. Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression. Arch Biochem Biophys 1998; 352: 59-70.
    • (1998) Arch Biochem Biophys , vol.352 , pp. 59-70
    • Natarajan, K.1    Manna, S.K.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 40
    • 0035371244 scopus 로고    scopus 로고
    • Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes
    • Davis JN, Kucuk O, Djuric Z, Sarkar FH. Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. Free Radic Biol Med 2001; 30: 1293-302.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1293-1302
    • Davis, J.N.1    Kucuk, O.2    Djuric, Z.3    Sarkar, F.H.4
  • 41
    • 55549148757 scopus 로고    scopus 로고
    • Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
    • Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem 2008; 283: 27707-16.
    • (2008) J Biol Chem , vol.283 , pp. 27707-16
    • Li, Y.1    Wang, Z.2    Kong, D.3    Li, R.4    Sarkar, S.H.5    Sarkar, F.H.6
  • 42
    • 60149095682 scopus 로고    scopus 로고
    • Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta- catenin signaling in mammary epithelial cells
    • Su Y, Simmen RC. Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta- catenin signaling in mammary epithelial cells. Carcinogenesis 2009; 30: 331-9.
    • (2009) Carcinogenesis , vol.30 , pp. 331-339
    • Su, Y.1    Simmen, R.C.2
  • 43
    • 34447289163 scopus 로고    scopus 로고
    • Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
    • Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol Genomics 2007; 30: 8-16.
    • (2007) Physiol Genomics , vol.30 , pp. 8-16
    • Su, Y.1    Simmen, F.A.2    Xiao, R.3    Simmen, R.C.4
  • 44
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down- regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. Notch-1 down- regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006; 106: 2503-13.
    • (2006) Cancer , vol.106 , pp. 2503-2513
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 45
    • 33645473185 scopus 로고    scopus 로고
    • Down- regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down- regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5: 483-93.
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 46
    • 0034202014 scopus 로고    scopus 로고
    • Inhibition of prostate specific antigen expression by genistein in prostate cancer cells
    • Davis JN, Muqim N, Bhuiyan M, Kucuk O, Pienta KJ, Sarkar FH. Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol 2000; 16: 1091-7.
    • (2000) Int J Oncol , vol.16 , pp. 1091-1097
    • Davis, J.N.1    Muqim, N.2    Bhuiyan, M.3    Kucuk, O.4    Pienta, K.J.5    Sarkar, F.H.6
  • 47
    • 0036270108 scopus 로고    scopus 로고
    • Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells
    • Davis JN, Kucuk O, Sarkar FH. Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells. Mol Carcinog 2002; 34: 91-101.
    • (2002) Mol Carcinog , vol.34 , pp. 91-101
    • Davis, J.N.1    Kucuk, O.2    Sarkar, F.H.3
  • 48
    • 0037081891 scopus 로고    scopus 로고
    • Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate
    • Fritz WA, Wang J, Eltoum IE, Lamartiniere CA. Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol Cell Endocrinol 2002; 186: 89-99.
    • (2002) Mol Cell Endocrinol , vol.186 , pp. 89-99
    • Fritz, W.A.1    Wang, J.2    Eltoum, I.E.3    Lamartiniere, C.A.4
  • 49
    • 55549148757 scopus 로고    scopus 로고
    • Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
    • Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem 2008; 283: 27707-16.
    • (2008) J Biol Chem , vol.283 , pp. 27707-16
    • Li, Y.1    Wang, Z.2    Kong, D.3    Li, R.4    Sarkar, S.H.5    Sarkar, F.H.6
  • 50
    • 33646551734 scopus 로고    scopus 로고
    • The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy
    • Sarkar FH, Adsule S, Padhye S, Kulkarni S, Li Y. The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev Med Chem 2006; 6: 401-7.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 401-407
    • Sarkar, F.H.1    Adsule, S.2    Padhye, S.3    Kulkarni, S.4    Li, Y.5
  • 51
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996; 20: 933-56.
    • (1996) Free Radic Biol Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 52
    • 33645547602 scopus 로고    scopus 로고
    • Phenoxodiol: Isoflavone analog with antineoplastic activity
    • Choueiri TK, Wesolowski R, Mekhail TM. Phenoxodiol: isoflavone analog with antineoplastic activity. Curr Oncol Rep 2006; 8: 104-7.
    • (2006) Curr Oncol Rep , vol.8 , pp. 104-107
    • Choueiri, T.K.1    Wesolowski, R.2    Mekhail, T.M.3
  • 53
    • 0037854571 scopus 로고    scopus 로고
    • Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells
    • Kamsteeg M, Rutherford T, Sapi E, Hanczaruk B, Shahabi S, Flick M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 2003; 22: 2611-20.
    • (2003) Oncogene , vol.22 , pp. 2611-2620
    • Kamsteeg, M.1    Rutherford, T.2    Sapi, E.3    Hanczaruk, B.4    Shahabi, S.5    Flick, M.6
  • 54
    • 33745146190 scopus 로고    scopus 로고
    • Phenoxodiol, a novel approach for the treatment of ovarian cancer
    • Mor G, Fu HH, Alvero AB. Phenoxodiol, a novel approach for the treatment of ovarian cancer. Curr Opin Investig Drugs 2006; 7: 542-8.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 542-548
    • Mor, G.1    Fu, H.H.2    Alvero, A.B.3
  • 55
    • 0037403574 scopus 로고    scopus 로고
    • Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague- Dawley rats
    • Constantinou AI, Mehta R, Husband A. Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague- Dawley rats. Eur J Cancer 2003; 39: 1012-8.
    • (2003) Eur J Cancer , vol.39 , pp. 1012-1018
    • Constantinou, A.I.1    Mehta, R.2    Husband, A.3
  • 56
    • 31544466555 scopus 로고    scopus 로고
    • Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells
    • Alvero AB, O'Malley D, Brown D, Kelly G, Garg M, Chen W, et al. Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells. Cancer 2006; 106: 599-608.
    • (2006) Cancer , vol.106 , pp. 599-608
    • Alvero, A.B.1    O'Malley, D.2    Brown, D.3    Kelly, G.4    Garg, M.5    Chen, W.6
  • 57
    • 19944430097 scopus 로고    scopus 로고
    • Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol
    • Sapi E, Alvero AB, Chen W, O'Malley D, Hao XY, Dwipoyono B, et al. Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol. Oncol Res 2004; 14: 567-78.
    • (2004) Oncol Res , vol.14 , pp. 567-578
    • Sapi, E.1    Alvero, A.B.2    Chen, W.3    O'Malley, D.4    Hao, X.Y.5    Dwipoyono, B.6
  • 58
    • 77449098645 scopus 로고    scopus 로고
    • Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo
    • Georgaki S, Skopeliti M, Tsiatas M, Nicolaou KA, Ioannou K, Husband A, et al. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J Cell Mol Med 2009; 13(9B): 3929-38.
    • (2009) J Cell Mol Med , vol.13 , Issue.9 B , pp. 3929-3938
    • Georgaki, S.1    Skopeliti, M.2    Tsiatas, M.3    Nicolaou, K.A.4    Ioannou, K.5    Husband, A.6
  • 59
    • 33645547602 scopus 로고    scopus 로고
    • Phenoxodiol: Isoflavone analog with antineoplastic activity
    • Choueiri TK, Wesolowski R, Mekhail TM. Phenoxodiol: isoflavone analog with antineoplastic activity. Curr Oncol Rep 2006; 8: 104-7.
    • (2006) Curr Oncol Rep , vol.8 , pp. 104-107
    • Choueiri, T.K.1    Wesolowski, R.2    Mekhail, T.M.3
  • 60
    • 0031939310 scopus 로고    scopus 로고
    • Chemo- prevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A
    • Gotoh T, Yamada K, Yin H, Ito A, Kataoka T, Dohi K. Chemo- prevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Jpn J Cancer Res 1998; 89: 137-42.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 137-142
    • Gotoh, T.1    Yamada, K.2    Yin, H.3    Ito, A.4    Kataoka, T.5    Dohi, K.6
  • 61
    • 70449602363 scopus 로고    scopus 로고
    • Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A
    • Ullah MF, Shamim U, Hanif S, Azmi AS, Hadi SM. Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A. Mol Nutr Food Res 2009; 53(11): 1376-85.
    • (2009) Mol Nutr Food Res , vol.53 , Issue.11 , pp. 1376-1385
    • Ullah, M.F.1    Shamim, U.2    Hanif, S.3    Azmi, A.S.4    Hadi, S.M.5
  • 62
    • 33745642100 scopus 로고    scopus 로고
    • Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino- substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2- phenylbenzothiazoles
    • Vasselin DA, Westwell AD, Matthews CS, Bradshaw TD, Stevens MF. Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino- substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2- phenylbenzothiazoles. J Med Chem 2006; 49: 3973-81.
    • (2006) J Med Chem , vol.49 , pp. 3973-3981
    • Vasselin, D.A.1    Westwell, A.D.2    Matthews, C.S.3    Bradshaw, T.D.4    Stevens, M.F.5
  • 63
    • 25844486965 scopus 로고    scopus 로고
    • Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives
    • Wang TC, Chen IL, Lu PJ, Wong CH, Liao CH, Tsiao KC, et al. Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. Bioorg Med Chem 2005; 13: 6045-53.
    • (2005) Bioorg Med Chem , vol.13 , pp. 6045-6053
    • Wang, T.C.1    Chen, I.L.2    Lu, P.J.3    Wong, C.H.4    Liao, C.H.5    Tsiao, K.C.6
  • 64
    • 12244252763 scopus 로고    scopus 로고
    • Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents
    • Whatmore JL, Swann E, Barraja P, Newsome JJ, Bunderson M, Beall HD, et al. Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis 2002; 5: 45-51.
    • (2002) Angiogenesis , vol.5 , pp. 45-51
    • Whatmore, J.L.1    Swann, E.2    Barraja, P.3    Newsome, J.J.4    Bunderson, M.5    Beall, H.D.6
  • 67
    • 44349093070 scopus 로고    scopus 로고
    • Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy
    • Pendleton JM, Tan WW, Anai S, Chang M, Hou W, Shiverick KT, et al. Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy. BMC Cancer 2008; 8: 132.
    • (2008) BMC Cancer , vol.8 , pp. 132
    • Pendleton, J.M.1    Tan, W.W.2    Anai, S.3    Chang, M.4    Hou, W.5    Shiverick, K.T.6
  • 68
    • 34447132197 scopus 로고    scopus 로고
    • Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer
    • Hamilton-Reeves JM, Rebello SA, Thomas W, Slaton JW, Kurzer MS. Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer. J Nutr 2007; 137: 1769-75.
    • (2007) J Nutr , vol.137 , pp. 1769-1775
    • Hamilton-Reeves, J.M.1    Rebello, S.A.2    Thomas, W.3    Slaton, J.W.4    Kurzer, M.S.5
  • 70
    • 1242274347 scopus 로고    scopus 로고
    • Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer
    • Vere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology 2004; 63: 259-63.
    • (2004) Urology , vol.63 , pp. 259-263
    • Vere White, R.W.1    Hackman, R.M.2    Soares, S.E.3    Beckett, L.A.4    Li, Y.5    Sun, B.6
  • 71
    • 27144456477 scopus 로고    scopus 로고
    • Curcumin therapy in inflammatory bowel disease: A pilot study
    • Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005; 50: 2191-3.
    • (2005) Dig Dis Sci , vol.50 , pp. 2191-2193
    • Holt, P.R.1    Katz, S.2    Kirshoff, R.3
  • 72
    • 62049085133 scopus 로고    scopus 로고
    • The protective role of curcumin in cardiovascular diseases
    • Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009; 133: 145-51.
    • (2009) Int J Cardiol , vol.133 , pp. 145-151
    • Wongcharoen, W.1    Phrommintikul, A.2
  • 73
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009; 41: 40-59.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 74
    • 45949103317 scopus 로고    scopus 로고
    • Role of curcumin in health and disease
    • Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem 2008; 114: 127-49.
    • (2008) Arch Physiol Biochem , vol.114 , pp. 127-149
    • Pari, L.1    Tewas, D.2    Eckel, J.3
  • 75
    • 84934443974 scopus 로고    scopus 로고
    • Curcumin as chemosensitizer
    • Limtrakul P. Curcumin as chemosensitizer. Adv Exp Med Biol 2007; 595: 269-300.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 269-300
    • Limtrakul, P.1
  • 76
    • 0037305821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    • Bharti AC, Donato N, Singh S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003; 101: 1053-62.
    • (2003) Blood , vol.101 , pp. 1053-1062
    • Bharti, A.C.1    Donato, N.2    Singh, S.3    Aggarwal, B.B.4
  • 77
    • 55749098119 scopus 로고    scopus 로고
    • Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    • Hussain AR, Ahmed M, Al-Jomah NA, Khan AS, Manogaran P, Sultana M, et al. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther 2008; 7: 3318-29.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3318-3329
    • Hussain, A.R.1    Ahmed, M.2    Al-Jomah, N.A.3    Khan, A.S.4    Manogaran, P.5    Sultana, M.6
  • 78
    • 42249102138 scopus 로고    scopus 로고
    • Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products
    • Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, et al. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 2008; 14: 2128-36.
    • (2008) Clin Cancer Res , vol.14 , pp. 2128-2136
    • Kunnumakkara, A.B.1    Diagaradjane, P.2    Guha, S.3    Deorukhkar, A.4    Shentu, S.5    Aggarwal, B.B.6
  • 81
    • 54049128202 scopus 로고    scopus 로고
    • Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism
    • Yu S, Shen G, Khor TO, Kim JH, Kong AN. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther 2008; 7: 2609-20.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2609-2620
    • Yu, S.1    Shen, G.2    Khor, T.O.3    Kim, J.H.4    Kong, A.N.5
  • 82
    • 34247400267 scopus 로고    scopus 로고
    • Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK
    • Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, et al. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 2007; 6: 178-84.
    • (2007) Cancer Biol Ther , vol.6 , pp. 178-184
    • Weir, N.M.1    Selvendiran, K.2    Kutala, V.K.3    Tong, L.4    Vishwanath, S.5    Rajaram, M.6
  • 83
    • 0037902047 scopus 로고    scopus 로고
    • Slaga TJ. 4-Hydroxy-3-methoxybenzoic acid methyl ester: A curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: Potential for prostate cancer management
    • Kumar AP, Garcia GE, Ghosh R, Rajnarayanan RV, Alworth WL, Slaga TJ. 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. Neoplasia 2003; 5: 255-66.
    • (2003) Neoplasia , vol.5 , pp. 255-266
    • Kumar, A.P.1    Garcia, G.E.2    Ghosh, R.3    Rajnarayanan, R.V.4    Alworth, W.L.5
  • 84
    • 0037299799 scopus 로고    scopus 로고
    • Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells
    • Squires MS, Hudson EA, Howells L, Sale S, Houghton CE, Jones JL, et al. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochem Pharmacol 2003; 65: 361-76.
    • (2003) Biochem Pharmacol , vol.65 , pp. 361-376
    • Squires, M.S.1    Hudson, E.A.2    Howells, L.3    Sale, S.4    Houghton, C.E.5    Jones, J.L.6
  • 85
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3    Kim, D.G.4    Lee, K.S.5    Bae, J.H.6
  • 86
    • 56349116715 scopus 로고    scopus 로고
    • Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300
    • Ryu MJ, Cho M, Song JY, Yun YS, Choi IW, Kim DE, et al. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem Biophys Res Commun 2008; 377: 1304-8.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 1304-1308
    • Ryu, M.J.1    Cho, M.2    Song, J.Y.3    Yun, Y.S.4    Choi, I.W.5    Kim, D.E.6
  • 87
    • 0037028207 scopus 로고    scopus 로고
    • Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
    • Jaiswal AS, Marlow BP, Gupta N, Narayan S. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 2002; 21: 8414-27.
    • (2002) Oncogene , vol.21 , pp. 8414-8427
    • Jaiswal, A.S.1    Marlow, B.P.2    Gupta, N.3    Narayan, S.4
  • 88
    • 14844319300 scopus 로고    scopus 로고
    • Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin
    • Yan C, Jamaluddin MS, Aggarwal B, Myers J, Boyd DD. Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther 2005; 4: 233-41.
    • (2005) Mol Cancer Ther , vol.4 , pp. 233-241
    • Yan, C.1    Jamaluddin, M.S.2    Aggarwal, B.3    Myers, J.4    Boyd, D.D.5
  • 89
    • 0036781479 scopus 로고    scopus 로고
    • Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines
    • Nakamura K, Yasunaga Y, Segawa T, Ko D, Moul JW, Srivastava S, et al. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 2002; 21: 825-30.
    • (2002) Int J Oncol , vol.21 , pp. 825-830
    • Nakamura, K.1    Yasunaga, Y.2    Segawa, T.3    Ko, D.4    Moul, J.W.5    Srivastava, S.6
  • 90
    • 0037038324 scopus 로고    scopus 로고
    • Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents
    • Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, et al. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J Med Chem 2002; 45: 5037-42.
    • (2002) J Med Chem , vol.45 , pp. 5037-5042
    • Ohtsu, H.1    Xiao, Z.2    Ishida, J.3    Nagai, M.4    Wang, H.K.5    Itokawa, H.6
  • 91
    • 84934436223 scopus 로고    scopus 로고
    • Regulation of COX and LOX by curcumin
    • Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol 2007; 595: 213-26.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 213-226
    • Rao, C.V.1
  • 94
    • 12844277237 scopus 로고    scopus 로고
    • Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences
    • Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev 2005; 14: 120-5.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 120-125
    • Garcea, G.1    Berry, D.P.2    Jones, D.J.3    Singh, R.4    Dennison, A.R.5    Farmer, P.B.6
  • 95
    • 67650032601 scopus 로고    scopus 로고
    • New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells
    • Padhye S, Yang H, Jamadar A, Cui QC, Chavan D, Dominiak K, et al. New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells. Pharm Res 2009; 26: 1874-80.
    • (2009) Pharm Res , vol.26 , pp. 1874-1880
    • Padhye, S.1    Yang, H.2    Jamadar, A.3    Cui, Q.C.4    Chavan, D.5    Dominiak, K.6
  • 97
    • 70350217623 scopus 로고    scopus 로고
    • Fluorocurcumins as cyclooxygenase-2 inhibitor: Molecular docking, pharmacokinetics and tissue distribution in mice
    • Padhye S, Banerjee S, Chavan D, Pandye S, Swamy KV, Ali S, et al. Fluorocurcumins as cyclooxygenase-2 inhibitor: molecular docking, pharmacokinetics and tissue distribution in mice. Pharm Res 2009; 26: 2438-45.
    • (2009) Pharm Res , vol.26 , pp. 2438-2445
    • Padhye, S.1    Banerjee, S.2    Chavan, D.3    Pandye, S.4    Swamy, K.V.5    Ali, S.6
  • 98
    • 70449367087 scopus 로고    scopus 로고
    • Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
    • Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De AS, et al. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int J Oncol 2009; 35: 867-72.
    • (2009) Int J Oncol , vol.35 , pp. 867-872
    • Hutzen, B.1    Friedman, L.2    Sobo, M.3    Lin, L.4    Cen, L.5    De, A.S.6
  • 99
    • 70149085608 scopus 로고    scopus 로고
    • New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells
    • Lin L, Hutzen B, Ball S, Foust E, Sobo M, Deangelis S, et al. New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells. Cancer Sci 2009; 100: 1719-27.
    • (2009) Cancer Sci , vol.100 , pp. 1719-1727
    • Lin, L.1    Hutzen, B.2    Ball, S.3    Foust, E.4    Sobo, M.5    Deangelis, S.6
  • 100
    • 67249125471 scopus 로고    scopus 로고
    • Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells
    • Friedman L, Lin L, Ball S, Bekaii-Saab T, Fuchs J, Li PK, et al. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anticancer Drugs 2009; 20: 444-9.
    • (2009) Anticancer Drugs , vol.20 , pp. 444-449
    • Friedman, L.1    Lin, L.2    Ball, S.3    Bekaii-Saab, T.4    Fuchs, J.5    Li, P.K.6
  • 101
    • 65149101403 scopus 로고    scopus 로고
    • New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells
    • Cen L, Hutzen B, Ball S, Deangelis S, Chen CL, Fuchs JR, et al. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC Cancer 2009; 9: 99.
    • (2009) BMC Cancer , vol.9 , pp. 99
    • Cen, L.1    Hutzen, B.2    Ball, S.3    Deangelis, S.4    Chen, C.L.5    Fuchs, J.R.6
  • 102
    • 61649094969 scopus 로고    scopus 로고
    • Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer
    • Labbozzetta M, Notarbartolo M, Poma P, Maurici A, Inguglia L, Marchetti P, et al. Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer. Ann NY Acad Sci 2009; 1155: 278-83.
    • (2009) Ann NY Acad Sci , vol.1155 , pp. 278-283
    • Labbozzetta, M.1    Notarbartolo, M.2    Poma, P.3    Maurici, A.4    Inguglia, L.5    Marchetti, P.6
  • 103
    • 57649240265 scopus 로고    scopus 로고
    • Synthesis and evaluation of electron-rich curcumin analogues
    • Amolins MW, Peterson LB, Blagg BS. Synthesis and evaluation of electron-rich curcumin analogues. Bioorg Med Chem 2009; 17: 360-7.
    • (2009) Bioorg Med Chem , vol.17 , pp. 360-367
    • Amolins, M.W.1    Peterson, L.B.2    Blagg, B.S.3
  • 105
    • 50349098410 scopus 로고    scopus 로고
    • Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
    • Qiu X, Liu Z, Shao WY, Liu X, Jing DP, Yu YJ, et al. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors. Bioorg Med Chem 2008; 16: 8035-41.
    • (2008) Bioorg Med Chem , vol.16 , pp. 8035-8041
    • Qiu, X.1    Liu, Z.2    Shao, W.Y.3    Liu, X.4    Jing, D.P.5    Yu, Y.J.6
  • 106
    • 50449099855 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin
    • Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol 2008; 74: 654-61.
    • (2008) Mol Pharmacol , vol.74 , pp. 654-661
    • Kasinski, A.L.1    Du, Y.2    Thomas, S.L.3    Zhao, J.4    Sun, S.Y.5    Khuri, F.R.6
  • 107
    • 20044389847 scopus 로고    scopus 로고
    • EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism
    • Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, et al. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs 2005; 16: 263-75.
    • (2005) Anticancer Drugs , vol.16 , pp. 263-275
    • Adams, B.K.1    Cai, J.2    Armstrong, J.3    Herold, M.4    Lu, Y.J.5    Sun, A.6
  • 109
    • 35348900908 scopus 로고    scopus 로고
    • In vivo growth inhibitory and anti-angiogenic effects of synthetic novel dienone cyclopropoxy curcumin analogs on mouse Ehrlich ascites tumor
    • Chandru H, Sharada AC, Bettadaiah BK, Kumar CS, Rangappa KS, Sunila, et al. In vivo growth inhibitory and anti-angiogenic effects of synthetic novel dienone cyclopropoxy curcumin analogs on mouse Ehrlich ascites tumor. Bioorg Med Chem 2007; 15: 7696-703.
    • (2007) Bioorg Med Chem , vol.15 , pp. 7696-7703
    • Chandru, H.1    Sharada, A.C.2    Bettadaiah, B.K.3    Kumar, C.S.4    Rangappa, K.S.5    Sunila6
  • 110
    • 33750489699 scopus 로고    scopus 로고
    • Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer
    • Ohori H, Yamakoshi H, Tomizawa M, Shibuya M, Kakudo Y, Takahashi A, et al. Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther 2006; 5: 2563-71.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2563-2571
    • Ohori, H.1    Yamakoshi, H.2    Tomizawa, M.3    Shibuya, M.4    Kakudo, Y.5    Takahashi, A.6
  • 111
    • 33745087445 scopus 로고    scopus 로고
    • Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells
    • Jankun J, Aleem AM, Malgorzewicz S, Szkudlarek M, Zavodszky MI, Dewitt DL, et al. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Mol Cancer Ther 2006; 5: 1371-82.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1371-1382
    • Jankun, J.1    Aleem, A.M.2    Malgorzewicz, S.3    Szkudlarek, M.4    Zavodszky, M.I.5    Dewitt, D.L.6
  • 112
    • 73449113640 scopus 로고    scopus 로고
    • Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity
    • Shi Q, Shih CC, Lee KH. Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity. Anticancer Agents Med Chem 2009; 9(8): 904-12.
    • (2009) Anticancer Agents Med Chem , vol.9 , Issue.8 , pp. 904-912
    • Shi, Q.1    Shih, C.C.2    Lee, K.H.3
  • 113
    • 33846034078 scopus 로고    scopus 로고
    • Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors
    • Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem Pharm Bull (Tokyo) 2007; 55: 64-71.
    • (2007) Chem Pharm Bull (Tokyo) , vol.55 , pp. 64-71
    • Handler, N.1    Jaeger, W.2    Puschacher, H.3    Leisser, K.4    Erker, T.5
  • 115
    • 0037349016 scopus 로고    scopus 로고
    • Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis
    • Leyon PV, Kuttan G. Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis. J Exp Clin Cancer Res 2003; 22: 77-83.
    • (2003) J Exp Clin Cancer Res , vol.22 , pp. 77-83
    • Leyon, P.V.1    Kuttan, G.2
  • 116
    • 3242773727 scopus 로고    scopus 로고
    • Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis
    • Hahm ER, Gho YS, Park S, Park C, Kim KW, Yang CH. Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Biochem Biophys Res Commun 2004; 321: 337-44.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 337-344
    • Hahm, E.R.1    Gho, Y.S.2    Park, S.3    Park, C.4    Kim, K.W.5    Yang, C.H.6
  • 117
    • 0035991505 scopus 로고    scopus 로고
    • Anti-tumour studies of metal chelates of synthetic curcuminoids
    • John VD, Kuttan G, Krishnankutty K. Anti-tumour studies of metal chelates of synthetic curcuminoids. J Exp Clin Cancer Res 2002; 21: 219-24.
    • (2002) J Exp Clin Cancer Res , vol.21 , pp. 219-224
    • John, V.D.1    Kuttan, G.2    Krishnankutty, K.3
  • 118
    • 70349902499 scopus 로고    scopus 로고
    • Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin
    • Takahashi M, Uechi S, Takara K, Asikin Y, Wada K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem 2009; 57: 9141-6.
    • (2009) J Agric Food Chem , vol.57 , pp. 9141-9146
    • Takahashi, M.1    Uechi, S.2    Takara, K.3    Asikin, Y.4    Wada, K.5
  • 119
    • 67650882757 scopus 로고    scopus 로고
    • Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model
    • Mach CM, Mathew L, Mosley SA, Kurzrock R, Smith JA. Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. Anticancer Res 2009; 29: 1895-9.
    • (2009) Anticancer Res , vol.29 , pp. 1895-1899
    • Mach, C.M.1    Mathew, L.2    Mosley, S.A.3    Kurzrock, R.4    Smith, J.A.5
  • 120
    • 24644508916 scopus 로고    scopus 로고
    • Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis
    • Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005; 104: 1322-31.
    • (2005) Cancer , vol.104 , pp. 1322-1331
    • Li, L.1    Braiteh, F.S.2    Kurzrock, R.3
  • 121
    • 66149107051 scopus 로고    scopus 로고
    • Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice
    • Narayanan NK, Nargi D, Randolph C, Narayanan BA. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer 2009; 125: 1-8.
    • (2009) Int J Cancer , vol.125 , pp. 1-8
    • Narayanan, N.K.1    Nargi, D.2    Randolph, C.3    Narayanan, B.A.4
  • 122
    • 67349107075 scopus 로고    scopus 로고
    • Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
    • Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MN. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 2009; 37: 223-30.
    • (2009) Eur J Pharm Sci , vol.37 , pp. 223-230
    • Shaikh, J.1    Ankola, D.D.2    Beniwal, V.3    Singh, D.4    Kumar, M.N.5
  • 123
    • 39549102649 scopus 로고    scopus 로고
    • Loading of curcumin into macrophages using lipid-based nanoparticles
    • Sou K, Inenaga S, Takeoka S, Tsuchida E. Loading of curcumin into macrophages using lipid-based nanoparticles. Int J Pharm 2008; 352: 287-93.
    • (2008) Int J Pharm , vol.352 , pp. 287-293
    • Sou, K.1    Inenaga, S.2    Takeoka, S.3    Tsuchida, E.4
  • 124
    • 34248205135 scopus 로고    scopus 로고
    • Polymeric nanoparticle-encapsulated curcumin (nanocurcumin): A novel strategy for human cancer therapy
    • Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, et al. Polymeric nanoparticle-encapsulated curcumin (nanocurcumin): a novel strategy for human cancer therapy. J Nanobiotechnol 2007; 5: 3.
    • (2007) J Nanobiotechnol , vol.5 , pp. 3
    • Bisht, S.1    Feldmann, G.2    Soni, S.3    Ravi, R.4    Karikar, C.5    Maitra, A.6
  • 125
    • 34248549039 scopus 로고    scopus 로고
    • Formulation and characterization of curcuminoids loaded solid lipid nanoparticles
    • Tiyaboonchai W, Tungpradit W, Plianbangchang P. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. Int J Pharm 2007; 337: 299-306.
    • (2007) Int J Pharm , vol.337 , pp. 299-306
    • Tiyaboonchai, W.1    Tungpradit, W.2    Plianbangchang, P.3
  • 128
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    • Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001; 21: 2895-900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3    Hsu, M.M.4    Ho, Y.F.5    Shen, T.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.