DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11497-11502

  Burnett, Ryan ^a   Melander, Christian ^a   Puckett, James W ^b   Son, Leslie S ^c   Wells, Robert D ^c   Dervan, Peter B ^b   Gottesfeld, Joel M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b California Institute of Technology   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Frataxin; Gene regulation; Triplet repeat expansion

Indexed keywords

ADENINE; BETA ALANINE; CYTOSINE; DNA; FLUORESCENT DYE; FRATAXIN; GUANINE; IMIDAZOLE DERIVATIVE; LIGAND; POLYAMIDE; PYRROLE DERIVATIVE; THYMINE;

ARTICLE; BINDING AFFINITY; CASE REPORT; CELL CULTURE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHROMATIN; CONJUGATE; CONTROLLED STUDY; DNA CONFORMATION; DNA MICROARRAY; DNA SEQUENCE; FLUORESCENCE; FRATAXIN GENE; FRIEDREICH ATAXIA; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRON; LYMPHOID CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION; TRINUCLEOTIDE REPEAT;

CELL LINE; FRIEDREICH ATAXIA; HUMANS; IRON-BINDING PROTEINS; LIGANDS; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NYLONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION, GENETIC; TRINUCLEOTIDE REPEATS;

ATAXIA;

EID: 33746795976     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604939103     Document Type: Article

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