Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2887-2893

  Kashiwazaki, Gengo ^a   Bando, Toshikazu ^a   Shinohara, Ken ichi ^a   Minoshima, Masafumi ^a   Kumamoto, Hana ^a   Nishijima, Shigeki ^a   Sugiyama, Hiroshi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Alkylating agent; Antitumor agent; Chlorambucil; PI polyamide; Telomere

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CHLORAMBUCIL N METHYLPYRROLE N METHYLIMIDAZOLE CONJUGATE; CHLORMETHINE DERIVATIVE; DISTAMYCIN A; DNA FRAGMENT; ETHYLENE; GUANINE; IMIDAZOLE DERIVATIVE; INDOLE; PROPYLENE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA ALKYLATION; DRUG CONJUGATION; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; NONHUMAN; NUCLEOTIDE REPEAT; POLYACRYLAMIDE GEL ELECTROPHORESIS; STRUCTURE ACTIVITY RELATION; TELOMERE;

ALKYLATION; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; CHLORAMBUCIL; HUMANS; MODELS, MOLECULAR; NYLONS; TELOMERE;

EID: 77950518998     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.011     Document Type: Article

References (26)

1. Trauger J.W., Baird E.E., and Dervan P.B. Nature 382 (1996) 559
2. Dervan P.B., and Edelson B.S. Curr. Opin. Struct. Biol. 13 (2003) 284
3. Bando T., and Sugiyama H. Acc. Chem. Res. 39 (2006) 935
4. Harki D.A., Satyamurthy N., Stout D.B., Phelps M.E., and Dervan P.B. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 13039
5. Chenoweth D.M., and Dervan P.B. Proc. Natl. Acad. Sci. U.S.A. 106 (2009) 13175
6. Westrate L., Mackay H., Brown T., Nguyen B., Kluza J., Wilson W.D., Lee M., and Hartley J.A. Biochemistry 48 (2009) 5679
7. Chen M., Matsuda H., Wang L., Watanabe T., Kimura M.T., Igarashi J., Wang X., Sakimoto T., Fukuda N., Sawa M., and Nagase H. Mol. Ther. 18 (2010) 519
8. Fukuda N., Tahira Y., Matsuda H., and Matsumoto K. J. Nephrol. 22 (2009) 708
9. Schmidt T.L., and Heckel A. Small 5 (2009) 1517
10. Cohen J.D., Sadowski J.P., and Dervan P.B. Angew. Chem., Int. Ed. 46 (2007) 7956
11. Minoshima M., Chou J.C., Lefebvre S., Bando T., Shinohara K., Gottesfeld J.M., and Sugiyama H. Bioorg. Med. Chem. 18 (2010) 168
12. Minoshima M., Bando T., Shinohara K., Kashiwazaki G., Nishijima S., and Sugiyama H. Bioorg. Med. Chem. 18 (2010) 1236
13. Sasaki S., Bando T., Minoshima M., Shinohara K., and Sugiyama H. Chem. Eur. J. 14 (2008) 864
14. Kashiwazaki G., Bando T., Shinohara K., Minoshima M., Nishijima S., and Sugiyama H. Bioorg. Med. Chem. 17 (2009) 1393
15. Takahashi R., Bando T., and Sugiyama H. Bioorg. Med. Chem. 11 (2003) 2503
16. Sasaki S., Bando T., Minoshima M., Shimizu T., Shinohara K., Takaoka T., and Sugiyama H. J. Am. Chem. Soc. 128 (2006) 12162
17. Blackburn E.H. Cell 106 (2001) 661
18. Aubert G., and Lansdorp P.M. Physiol. Rev. 88 (2008) 557
19. Lansdorp P.M. EMBO J. 28 (2009) 2532
20. Smogorzewska A., and Lange T.d. Annu. Rev. Biochem. 73 (2004) 177
21. Olaussen K.A., Dubrana K., Domont J., Spano J.-P., Sabatier L., and Soria J.-C. Crit. Rev. Oncol. Hematol. 57 (2005) 191
22. Shin-ya K., Wierzba K., Matsuo K., Ohtani T., Yamada Y., Furihata K., Hayakawa Y., and Seto H. J. Am. Chem. Soc. 123 (2001) 1262
23. Wheelhouse R.T., Sun D., Han H., Han F.X., and Hurley L.H. J. Am. Chem. Soc. 120 (1998) 3261
24. Wurtz N.R., and Dervan P.B. Chem. Biol. 7 (2000) 153
25. White S., Baird E.E., and Dervan P.B. J. Am. Chem. Soc. 119 (1997) 8756
26. Kopka M.L., Yoon C., Goodsell D., Pjura P., and Dickerson R.E. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 1376