Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 8495-8506

  Ashpole, Nicole M ^a   Song, Weihua ^a   Brustovetsky, Tatiana ^b   Engleman, Eric A ^b   Brustovetsky, Nickolay ^a,b   Cummins, Theodore R ^a,b   Hudmon, Andy ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; APOPTOTIC MECHANISMS; BRAIN TRAUMA; CALCIUM DYSREGULATION; CALCIUM SIGNALING; CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II; CASPASE-3; CENTRAL NERVOUS SYSTEMS; CULTURED CORTICAL NEURONS; CYCLOHEXIMIDES; EXTRACELLULAR; GLUTAMATE RECEPTOR; INHIBITORY PEPTIDES; NEURONAL ACTIVITIES; NEURONAL DEATH; NEURONAL POPULATIONS; NEURONAL STRUCTURE; NEUROTOXICITY; PEPTIDE INHIBITORS; PROGRAMMED CELL DEATHS; PROTEIN KINASE; SMALL MOLECULES; SYNAPTIC PLASTICITY;

AMINO ACIDS; CELL DEATH; ELECTROPHYSIOLOGY; PEPTIDES;

ENZYMES;

CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASPASE 3; CYCLOHEXIMIDE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ACTION POTENTIAL; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL SURVIVAL; CONTROLLED STUDY; DEPOLARIZATION; EMBRYO; ENZYME INHIBITION; EXCITOTOXICITY; EXTRACELLULAR SPACE; NERVE CELL EXCITABILITY; NERVE CELL NECROSIS; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT;

ACTION POTENTIALS; ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; CALCIUM; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASPASE 3; CELL DEATH; CELLS, CULTURED; CYCLOHEXIMIDE; EPILEPSY; GLUTAMIC ACID; NERVE TISSUE PROTEINS; NEURONS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84858013809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323915     Document Type: Article

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