KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

British Journal of Pharmacology

Volumn 162, Issue 1, 2011, Pages 255-270

  Brustovetsky, Tatiana ^a   Brittain, Matthew K ^a   Sheets, Patrick L ^a   Cummins, Theodore R ^a   Pinelis, Vsevolod ^b   Brustovetsky, Nickolay ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

calcium deregulation; cultured hippocampal neurons; excitotoxicity; glutamate; mitochondria; mitochondrial complex I; Na + Ca 2+ exchanger; NMDA receptor

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ROTENONE;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM TRANSPORT; CELL ISOLATION; CELL MEMBRANE DEPOLARIZATION; CELL ORGANELLE; CONTROLLED STUDY; HIPPOCAMPUS; IC 50; ION CURRENT; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NONHUMAN; OXIDATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; ELECTRON TRANSPORT COMPLEX I; HIPPOCAMPUS; MICROSCOPY, FLUORESCENCE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 78650086750     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01054.x     Document Type: Article

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