Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1021-1031

  Carter, Dawn S ^a   Haider, S Naqeeb ^a   Blair, Robert E ^b   Deshpande, Laxmikant S ^b   Sombati, Sompong ^b   DeLorenzo, Robert J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCIUM; CALMODULIN BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM HOMEOSTASIS; CELL LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; EPILEPTIC DISCHARGE; GENE REPRESSION; HIPPOCAMPUS; HISTOGRAM; IMMUNOCYTOCHEMISTRY; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECURRENT DISEASE;

ALGORITHMS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; DATA INTERPRETATION, STATISTICAL; ENZYME INHIBITORS; EPILEPSY; FLUORESCENT DYES; GLUTAMIC ACID; HIPPOCAMPUS; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; MAGNESIUM; MUTATION, MISSENSE; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33751168282     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.110403     Document Type: Article

References (39)

1. Berridge MJ (1998) Neuronal calcium signaling. Neuron 21:13-26.
2. 2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent seizures. Brain Res 851:54-65.
3. Bronstein JM, Farber DB, and Wasterlain CG (1993) Regulation of type-II calmodulin kinase: functional implications. Brain Res Brain Res Rev 18:135-147.
4. 2+/ calmodulin-dependent kinase II alpha-subunit mutation. Proc Natl Acad Sci USA 92:6852-6855.
5. Carafoli E, Nicotera P, and Santella L (1997) Calcium signalling in the cell nucleus. Cell Calcium 22:313-319.
6. 2+-independent inhibition of type-1 inositol trisphosphate receptors. Biochem J 334:447-455.
7. Churn SB (1995) Multifunctional calcium and calmodulin-dependent kinase II in neuronal function and disease. Adv Neuroimmunol 5:241-259.
8. 2+/calmodulin kinase II activity in the pilocarpine model of epilepsy. Brain Res 875:66-77.
9. Churn SB, Sombati S, Jakoi ER, Severt L, DeLorenzo RJ, and Sievert L (2000b) Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons. Proc Natl Acad Sci USA 97:5604-5609.
10. Colyer J (1998) Phosphorylation states of phospholamban. Ann NY Acad Sci 853:79-91.
11. 2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture. Proc Natl Acad Sci USA 95:14482-14487.
12. Delorenzo RJ, Sun DA, and Deshpande LS (2005) Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy. Pharmacol Ther 105:229-266.
13. Dou D and Joseph R (1996) Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel "proteolipid". Brain Res 723:8-22.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
15. Hauser W and Hesdorffer D (1990) Epilepsy: frequency, causes, and consequences. Demos Publications, New York.
16. Huang CS, Shi SH, Ule J, Ruggiu M, Barker LA, Darnell RB, Jan YN, and Jan LY (2005) Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell 123:105-118.
17. Hyrc K, Handran SD, Rothman SM, and Goldberg MP (1997) Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators. J Neurosci 17:6669-6677.
18. 2+/calmodulin- dependent protein kinase. Proc Natl Acad Sci USA 81:945-949.
19. Kunz WS, Goussakov IV, Beck H, and Elger CE (1999) Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res 826:236-242.
20. Llinas R, Sugimori M, and Silver RB (1992) Microdomains of high calcium concentration in a presynaptic terminal. Science (Wash DC) 256:677-679.
21. McNamara JO (1999) Emerging insights into the genesis of epilepsy. Nature (Lond) 399:A15-22.
22. 2+ release. Trends Pharmacol Sci 16:356-359.
23. 2+ influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy. J Neurosci 20:1831-1836.
24. Pal S, Limbrick DD Jr, Rafiq A, and DeLorenzo RJ (2000) Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium 28:181-193.
25. Pal S, Sombati S, Limbrick DD Jr, and DeLorenzo RJ (1999) In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Res 851:20-31.
26. Pal S, Sun D, Limbrick D, Rafiq A, and DeLorenzo RJ (2001) Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium 30:285-296.
27. 2+ uptake. J Neurochem 75:1209-1218.
28. Perlin JB, Churn SB, Lothman EW, and DeLorenzo RJ (1992) Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat. Epilepsy Res 11:111-118.
29. 2+-transport ATPase isozymes in pig cerebellar Purkinje neurons. J Neurosci 11:650-656.
30. Putney JW Jr (1999) TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry. Proc Natl Acad Sci USA 96:14669-14671.
31. Raza M, Blair RE, Sombati S, Carter DS, Deshpande LS, and DeLorenzo RJ (2004) Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy. Proc Natl Acad Sci USA 101:17522-17527.
32. Raza M, Pal S, Rafiq A, and DeLorenzo RJ (2001) Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy. Brain Res 903:1-12.
33. Ryan SG (1999) Ion channels and the genetic contribution to epilepsy. J Child Neurol 14:58-66.
34. Shin C and McNamara JO (1994) Mechanism of epilepsy. Annu Rev Med 45:379-389.
35. Sombati S and Delorenzo RJ (1995) Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture. J Neurophysiol 73:1706-1711.
36. Sun DA, Sombati S, Blair RE, and DeLorenzo RJ (2004) Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy. Cell Calcium 35:155-163.
37. Taft WC, Goldenring JR, and DeLorenzo RJ (1987) Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. Adv Exp Med Biol 221:409-425.
38. Wasterlain CG and Farber DB (1984) Kindling alters the calcium/calmodulin-dependent phosphorylation of synaptic plasma membrane proteins in rat hippocampus. Proc Natl Acad Sci USA 81:1253-1257.
39. 2+/calmodulin-dependent protein kinase. J Biol Chem 268:8394-8397.