Ischemia-induced neuronal damage: A role for calcium/calmodulin-dependent protein kinase II

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 1, 1996, Pages 1-6

  Waxham, M Neal ^a   Grotta, James C ^a   Suva, Alcino J ^b   Strong, Roger ^a   Aronowski, Jaroslaw ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Watson School of Biological Sciences   (United States)

Author keywords

Excitotoxicity; Gene knock out; Ischemia; Kinase; Protein phosphorylation; Transgenic

Indexed keywords

PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BRAIN ISCHEMIA; BRAIN PROTECTION; DISEASE PREDISPOSITION; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME SUBUNIT; MOUSE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TISSUE DISTRIBUTION;

EID: 0030066622     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199601000-00001     Document Type: Article

References (27)

1. 2+/calmodulin-dependent protein kinase II: Potential role in neuronal damage. J Neurochem 58:1743-1753
2. Aronowski J, Ostrow P, Samways E, Strong R, Zivin JA, Grotta JC (1994) Graded bioassay for demonstration of brain rescue from experimental acute ischemia in rats. Stroke 25:2235-2240
3. 2+/calmodulin-dependent kinase II α-subunit mutation. Proc Natl Acad Sci USA 92:6852-6855
4. Chapman PF, Frenguelli BG, Smith A, Chen C-M, Suva AJ (1995) The alpha-calcium-calmodulin kinase II: A bidirectional modulator of pre-synaptic activity. Neuron 14:591-597
5. Chen C, Rainnie DG, Greene RW, Tonegawa S (1994) Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294
6. Choi DW (1990) Cerebral hypoxia: Some new approaches and unanswered questions. J Neurosci 11:465-469
7. Churn SB, Taft WC, Billingsley MS, Blair RE, DeLorenzo RJ (1990) Temperature modulation of ischemic neuronal death and inhibition of calcium/calmodulin-dependent protein kinase II in gerbils. Stroke 21:1715-1721
8. Churn SB, Limbrick D, Sombati S, DeLorenzo RJ (1995) Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. J Neurosci 15:3200-3214
9. Comery TA, Kleim JA, Suva A, Greenough WT (1994) Hippocampal anatomy and ultrastructural morphology of alpha- calcium-calmodulin kinase II deletion mice. [Abstract] Soc Neurosci Abs 20:1506
10. 2+/calmodulin-dependent protein kinases. Ann Rev Biochem 61:559-601
11. Hanson SK, Grotta JC, Waxham MN, Aronowski J, Ostrow P (1994) Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats. Stroke 25:466-473
12. Kara H, Onodera H, Yoshidomi M, Matsuda Y, Kogure K (1990) Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat. J Cereb Blood Flow Metab 10:646-653
13. Holmes GL (1991) The long-term effects of seizures on the developing brain: clinical and laboratory issues. Brain Devel 13:393-409
14. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885
15. 2+/calmodulin kinase II translocates in a hippocampal slice model of ischemia. J Neurochem 64:2147-2152
16. Lynch G, Seybert P (1989) Links between long-term potentiation and neuropathology. Ann NY Acad Sci 568:171-180
17. Madden KP, Clark WM, Kochhar A, Zivin JA (1990) Effects of protein kinase C modulation on outcome of experimental CNS ischemia. Brain Res 547:193-198
18. Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN (1989) An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340:554-557
19. Malinow R, Schulman H, Tsien RW (1989) Inhibition of postsyn- aptic PKC or CaMKII blocks induction but not expression of LTP. Science 245:862-866
20. 2+/ calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons. J Neurochem 64:2132-2139
21. Shackelford DA, Yeh RY, Hsu M, Buzsaki G, Zivin JA (1995) Effect of cerebral ischemia on calcium/calmodulin-dependent protein kinase II activity and phosphorylation. J Cereb Blood Flow Metab 15:450-461
22. Siesjo BK, Bengtsson F (1989) Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 9:127-140
23. Suva AJ, Paylor R, Wehner JM, Tonegawa S (1992a) Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-211
24. Suva AJ, Stevens CF, Tonegawa S, Wang Y (19926) Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice. Science 257:201-206
25. Taft WC, Tennes-Rees KA, Blair RE, Clifton GL, DeLorenzo RJ (1988) Cerebral ischemia decreases endogenous calcium-dependent protein phosphorylation in gerbil brain. Brain Res 447:159-163
26. 2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo. Neuron 11:221-235
27. 2+/calmodulin-dependent protein kinase II following ischemia: A comparison between CA1 and dentate gyrus in a hippocampal slice model. J Neurochem 63:2217-2224