Calcium ion transients in peri-infarct depolarizations may deteriorate ion homeostasis and expand infarction in focal cerebral ischemia in cats

Stroke

Volumn 32, Issue 2, 2001, Pages 535-543

  Ohta, Kouichi ^a   Graf, Rudolf ^a   Rosner, Gerd ^a   Heiss, Wolf Dieter ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Calcium; Cats; Cerebral infarction; Ischemia; MK 801; Nitric oxide; Spreading cortical depression

Indexed keywords

CALCIUM ION; DIZOCILPINE; HALOTHANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN ISCHEMIA; CALCIUM BALANCE; CALCIUM TRANSPORT; CAT; CONTROLLED STUDY; DEPOLARIZATION; DIRECT CURRENT; ELECTROCORTICOGRAPHY; FEMALE; ION SELECTIVE ELECTRODE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPREADING CORTICAL DEPRESSION; SUPRASYLVIAN GYRUS;

EID: 0035135596     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.2.535     Document Type: Article

References (39)

1. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats
2. Periinfarct depolarizations
3. 14C]2-deoxyglucose phosphorylation
4. Changes in extracellular calcium activity in cerebral ischaemia
5. Spreading depression of activity in the cerebral cortex
6. Pathophysiology and treatment of focal cerebral ischemia, part I: Pathophysiology
7. Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion
8. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: Effect on volume of ischemic injury
9. Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat
10. Reduction of infarct volume by halothane: Effect on cerebral blood flow or perifocal spreading depression-like depolarizations
11. Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia
12. Profiles of cortical tissue depolarization in cat focal cerebral ischemia in relation to calcium ion homeostasis and nitric oxide production
13. Miniature calomel electrode for recording DC potential changes accompanying spreading depression on the freely moving rat
14. Physiological properties of ATP-activated cation channels in rat brain microvascular endothelial cells
15. Early nitric oxide increase in depolarized tissue of cat focal cerebral ischaemia
16. B receptor in endothelial cells
17. Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle
18. An electrochemical microprobe for detecting nitric oxide release in brain tissue
19. Photo-thrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions
20. Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain
21. Recovery of apparent diffusion coefficient after ischemia-induced spreading depression relates to cerebral perfusion gradient
22. Influence of plasma glucose concentration on rat brain extracellular calcium transients during spreading depression
23. Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex
24. Calcium modulation in brain extracellular microenvironment demonstrated with ionselective micropipette
25. Three-dimensional image analysis of brain glucose metabolism: Blood flow uncoupling and its electrophysiological correlates in the acute ischemic penumbra following middle cerebral artery occlusion
26. The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat
27. The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression
28. Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression
29. Cortical blood flow changes during spreading depression in cats
30. Halothane, but not α-chloralose, blocks potassium-evoked cortical spreading depression in cats
31. Cerebral blood flow and oxygen consumption in cortical spreading depression
32. Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex
33. Cerebral glucose utilization: Local changes during and after recovery from spreading cortical depression
34. Spreading depression is not associated with neuronal injury in the normal brain
35. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: Effect on blood flow, tissue oxygenation, and electroencephalogram
36. Glutamate-mediated injury in focal cerebral ischemia: The excitotoxin hypothesis revised
37. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia