메뉴 건너뛰기




Volumn 26, Issue 2, 2012, Pages 231-236

Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine

Author keywords

Drug resistant tuberculosis; MDRTB; Multidrug resistant tuberculosis; Phenothiazines; Thioridazine; XDRTB

Indexed keywords

CHLORPROMAZINE; ISONIAZID; LINEZOLID; METHYLENE BLUE; MOXIFLOXACIN; OUABAIN; PHENOTHIAZINE DERIVATIVE; RIFAMPICIN; THIORIDAZINE;

EID: 84857879092     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey
Times cited : (20)

References (73)
  • 1
    • 0002205383 scopus 로고    scopus 로고
    • The diagnosis and management of multiple-drug-resistant tuberculosis at the beginning of the new millenium
    • Drobniewski FA and Balabanova YM: The diagnosis and management of multiple drug-resistant tuberculosis at the beginning of the new millenium. Int J Infect Dis 6(Suppl 1): S21-31, 2002. (Pubitemid 40090868)
    • (2002) International Journal of Infectious Diseases , vol.6 , Issue.SUPPL. 1
    • Drobniewski, F.A.1    Balabanova, Y.M.2
  • 3
    • 60549087911 scopus 로고    scopus 로고
    • Plan to combat extensively drug-resistant tuberculosis: Recommendations of the Federal Tuberculosis Task Force
    • Centers for Disease Control and Prevention [CDC]
    • Centers for Disease Control and Prevention [CDC]: Plan to combat extensively drug-resistant tuberculosis: recommendations of the Federal Tuberculosis Task Force. Morb Mortal Wkly Rep 58(RR-3): 1-43, 2009.
    • (2009) Morb Mortal Wkly Rep , vol.58 , Issue.RR-3 , pp. 1-43
  • 4
    • 0004054832 scopus 로고
    • Himmelweit F, Marquait M and Dale H (eds.). London: Pergamon Press
    • Ehrlich P: The Collected Papers of Paul Erhlich. Himmelweit F, Marquait M and Dale H (eds.). London: Pergamon Press, pp. 500-508, 1956.
    • (1956) The Collected Papers of Paul Erhlich , pp. 500-508
    • Ehrlich, P.1
  • 6
    • 11844292801 scopus 로고    scopus 로고
    • Antimicrobial activity of phenothiazines
    • Amaral L, Viveiros M and Molnar J: Antimicrobial activity of phenothiazines. In Vivo 18: 725-732, 2004. (Pubitemid 40089621)
    • (2004) In Vivo , vol.18 , Issue.6 , pp. 725-732
    • Amaral, L.1    Viveiros, M.2    Molnar, J.3
  • 7
    • 0030801767 scopus 로고    scopus 로고
    • The potential management of resistant infections with non-antibiotics
    • DOI 10.1093/jac/40.3.319
    • Kristiansen JE and Amaral L: The potential management of resistant infections with non-antibiotics. J Antimicrobial Chemother 40: 319-27, 1997. (Pubitemid 27437949)
    • (1997) Journal of Antimicrobial Chemotherapy , vol.40 , Issue.3 , pp. 319-327
    • Kristiansen, J.E.1    Amaral, L.2
  • 9
    • 0035657318 scopus 로고    scopus 로고
    • Phenothiazines: Potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries
    • DOI 10.1046/j.1365-3156.2001.00804.x
    • Amaral L, Viveiros M and Kristiansen J: Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries. Trop Med Int Health 6: 1016-1022, 2001. (Pubitemid 34008769)
    • (2001) Tropical Medicine and International Health , vol.6 , Issue.12 , pp. 1016-1022
    • Amaral, L.1    Viveiros, M.2    Kristiansen, J.E.3
  • 10
    • 0035010729 scopus 로고    scopus 로고
    • Activity of phenothiazines against antibiotic resistant Mycobacterium tuberculosis: A review supporting further studies that may elucidate the potential use of thioridazine as an anti-TB agent
    • Amaral L, Kristiansen JE, Viveiros M and Atouguia J: Activity of phenothiazines against antibiotic resistant Mycobacterium tuberculosis: A review supporting further studies that may elucidate the potential use of thioridazine as an anti-TB agent. J Antimicrob Chemother 47: 505-507, 2001.
    • (2001) J Antimicrob Chemother , vol.47 , pp. 505-507
    • Amaral, L.1    Kristiansen, J.E.2    Viveiros, M.3    Atouguia, J.4
  • 12
    • 0024505848 scopus 로고
    • ANTIMYKOBAKTERIELLE EIGENSCHAFTEN VON VERBINDUNGEN DES PHENOTHIAZINTYPS
    • DOI 10.1002/ardp.19893220303
    • Meindl W and Laske R: Antimycobacterial properties of phenothiazine type compounds Arch Pharm [Weinheim] 322: 133-136, 1989. (Pubitemid 19078041)
    • (1989) Archiv der Pharmazie , vol.322 , Issue.3 , pp. 133-136
    • Meindl, W.1    Laske, R.2
  • 13
    • 0027177990 scopus 로고
    • Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine
    • Chakrabarty AN, Bhattacharya CP and Dastidar SG: Antimycobacterial activity of methdilazine [Md], an antimicrobic phenothiazine. APMIS 101: 449-454, 1993. (Pubitemid 23255824)
    • (1993) APMIS , vol.101 , Issue.6 , pp. 449-454
    • Chakrabarty, A.N.1    Bhattacharya, C.P.2    Dastidar, S.G.3
  • 14
    • 0017570247 scopus 로고
    • Studies on antituberculotic action of some phenothiazine derivatives in vitro
    • Orig A
    • Molnár J, Béládi I and Földes I: Studies on antituberculotic action of some phenothiazine derivatives in vitro. Zentralbl Bakteriol [Orig A] 239: 521-526, 1977.
    • (1977) Zentralbl Bakteriol , vol.239 , pp. 521-526
    • Molnár, J.1    Béládi, I.2    Földes, I.3
  • 15
    • 0030462751 scopus 로고    scopus 로고
    • Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: Potential use for initial therapy of freshly diagnosed tuberculosis
    • DOI 10.1093/jac/38.6.1049
    • Amaral L, Kristiansen JE, Abebe LS and Millett W: Inhibition of the respiration of multidrug-resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis. J Antimicrob Chemother 38: 1049-1053, 1996. (Pubitemid 27073284)
    • (1996) Journal of Antimicrobial Chemotherapy , vol.38 , Issue.6 , pp. 1049-1053
    • Amaral, L.1    Kristiansen, J.E.2    Abebe, L.S.3    Millett, W.4
  • 16
    • 0033839994 scopus 로고    scopus 로고
    • Comparative in vitro activity of phenothiazines against multidrug- resistant Mycobacterium tuberculosis
    • DOI 10.1016/S0924-8579(00)00199-0, PII S0924857900001990
    • Bettencourt MV, Bosne-David S and Amaral L: Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis. Int J Antimicrob Agents 16: 69-71, 2000. (Pubitemid 30665428)
    • (2000) International Journal of Antimicrobial Agents , vol.16 , Issue.1 , pp. 69-71
    • Bettencourt, M.V.1    Bosne-David, S.2    Amaral, L.3
  • 17
    • 0035098674 scopus 로고    scopus 로고
    • Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines
    • Viveiros M and Amaral L: Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines. Int J Antimicrob Agents 17: 225-258, 2001.
    • (2001) Int J Antimicrob Agents , vol.17 , pp. 225-258
    • Viveiros, M.1    Amaral, L.2
  • 18
    • 0027052626 scopus 로고
    • Chlorpromazine: A drug potentially useful for treating mycobacterial infections
    • Crowle AJ, Douvas GS and May MH: Chlorpromazine: a drug potentially useful for treating mycobacterial infections. Chemotherapy 35: 410-409, 1992.
    • (1992) Chemotherapy , vol.35 , pp. 410-1409
    • Crowle, A.J.1    Douvas, G.S.2    May, M.H.3
  • 19
    • 0036745629 scopus 로고    scopus 로고
    • Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrations
    • Ordway D, Viveiros M, Leandro C, Arroz MJ and Amaral L: Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrations. J Infect Chemother 8: 227-231, 2002.
    • (2002) J Infect Chemother , vol.8 , pp. 227-231
    • Ordway, D.1    Viveiros, M.2    Leandro, C.3    Arroz, M.J.4    Amaral, L.5
  • 20
    • 0035996896 scopus 로고    scopus 로고
    • Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    • DOI 10.1016/S0924-8579(02)00110-3, PII S0924857902001103
    • Ordway D, Viveiros M, Leandro C, Arroz MJ and Amaral L: Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus. Int J Antimicrob Agents 20: 34-43, 2002. (Pubitemid 34778465)
    • (2002) International Journal of Antimicrobial Agents , vol.20 , Issue.1 , pp. 34-43
    • Ordway, D.1    Viveiros, M.2    Leandro, C.3    Arroz, M.J.4    Amaral, L.5
  • 21
    • 19944427226 scopus 로고    scopus 로고
    • Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: An in vivo, ex vivo and electron microscopy study
    • Martins M, Bleiss W, Marko A et al: Ordway D, Viveiros M, Leandro C, Pacheco T, Molnar J, Kristiansen JE and Amaral L: Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study. In Vivo 18: 787-794, 2004. (Pubitemid 40089628)
    • (2004) In Vivo , vol.18 , Issue.6 , pp. 787-794
    • Martins, M.1    Bleiss, W.2    Marko, A.3    Ordway, D.4    Viveiros, M.5    Leandro, C.6    Pacheco, T.7    Molnar, J.8    Kristiansen, J.E.9    Amaral, L.10
  • 23
    • 62949134547 scopus 로고    scopus 로고
    • SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis [XDR-TB]
    • Martins M, Viveiros M, Ramos J, Couto I, Molnar J, Boeree M, Amaral L: SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis [XDR-TB]. Int J Antimicrob Agents 33: 479-482, 2009.
    • (2009) Int J Antimicrob Agents , vol.33 , pp. 479-482
    • Martins, M.1    Viveiros, M.2    Ramos, J.3    Couto, I.4    Molnar, J.5    Boeree, M.6    Amaral, L.7
  • 24
    • 35648948351 scopus 로고    scopus 로고
    • The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis
    • Martins M, Viveiros M, Kristiansen JE, Molnar J and Amaral L: The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. In Vivo 21: 771-775. 2007.
    • (2007) In Vivo , vol.21 , pp. 771-775
    • Martins, M.1    Viveiros, M.2    Kristiansen, J.E.3    Molnar, J.4    Amaral, L.5
  • 27
    • 35248895271 scopus 로고    scopus 로고
    • Thioridazine: Resurrection as an antimicrobial agent?
    • Thanacoody HK: Thioridazine: resurrection as an antimicrobial agent? Br J Clin Pharmacol 64: 566-574, 2007.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 566-574
    • Thanacoody, H.K.1
  • 28
    • 0025887116 scopus 로고
    • Phenothiazines and calmodulin
    • review
    • Motohashi N: Phenothiazines and calmodulin [review]. Anticancer Res 11: 1125-1164, 1991.
    • (1991) Anticancer Res , vol.11 , pp. 1125-1164
    • Motohashi, N.1
  • 29
    • 0032153028 scopus 로고    scopus 로고
    • Inhibitor of calmodulin and calmodulin dependent enzyme
    • Hidaka H and Naito Y: Inhibitor of calmodulin and calmodulin dependent enzyme. Tanpakushitsu Kakusan Koso. 43(12 Suppl): 1732-1738, 1998.
    • (1998) Tanpakushitsu Kakusan Koso , vol.43 , Issue.12 SUPPL. , pp. 1732-1738
    • Hidaka, H.1    Naito, Y.2
  • 30
    • 0021875941 scopus 로고
    • Calmodulin regulation of adenylate cyclase activity
    • MacNeil S, Lakey T and Tomlinson S: Calmodulin regulation of adenylate cyclase activity. Cell Calcium 6: 213-216, 1985.
    • (1985) Cell Calcium , vol.6 , pp. 213-216
    • MacNeil, S.1    Lakey, T.2    Tomlinson, S.3
  • 31
    • 0025827114 scopus 로고
    • The role of calcium in the energetics of contracting skeletal muscle
    • Tate CA, Hyek MF and Taffet GE: The role of calcium in the energetics of contracting skeletal muscle. Sports Med 12: 208-217, 1991.
    • (1991) Sports Med , vol.12 , pp. 208-217
    • Tate, C.A.1    Hyek, M.F.2    Taffet, G.E.3
  • 32
    • 0030067124 scopus 로고    scopus 로고
    • Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM: Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241, 1996.
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 34
    • 0032007693 scopus 로고    scopus 로고
    • Isolation, purification and characterization of intracellular calmodulin like protein (CALF) from Mycobacterium phlei
    • DOI 10.1016/S0378-1097(97)00538-7, PII S0378109797005387
    • Sarma PV, Sarma PU and Murthy PS: Isolation, purification and characterization of intracellular calmodulin like protein [CALP] from Mycobacterium phlei. FEMS Microbiol Lett 159: 27-34, 1998. (Pubitemid 28051341)
    • (1998) FEMS Microbiology Letters , vol.159 , Issue.1 , pp. 27-34
    • Sarma, P.V.G.K.1    Usha, S.P.2    Murthy, P.S.3
  • 35
    • 34547127139 scopus 로고    scopus 로고
    • Type II NADH:menaquinone oxidoreductase of Mycobacterium tuberculosis
    • Teh JS, Yano T and Rubin H: Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis. Infect Disord Drug Targets 7: 169-181, 2007. (Pubitemid 47099126)
    • (2007) Infectious Disorders - Drug Targets , vol.7 , Issue.2 , pp. 169-181
    • Teh, J.S.1    Yano, T.2    Rubin, H.3
  • 37
    • 33744957049 scopus 로고    scopus 로고
    • Steady-state kinetics and inhibitory action of antitubercular phenothiazines on Mycobacterium tuberculosis Type-II NADH-menaquinone oxidoreductase (NDH-2)
    • DOI 10.1074/jbc.M508844200
    • Yano T, Li LS, Weinstein E, Teh JS and Rubin H: Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase [NDH-2]. J Biol Chem 281: 11456-63, 2006. (Pubitemid 43855400)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.17 , pp. 11456-11463
    • Yano, T.1    Lin-Sheng, L.2    Weinstein, E.3    Teh, J.-S.4    Rubin, H.5
  • 38
    • 22744459778 scopus 로고    scopus 로고
    • Mtb from Mycobacterium tuberculosis
    • DOI 10.1021/bi0505316
    • Avarbock A, Avarbock D, Teh JS, Buckstein M, Wang ZM, Rubin H: Functional regulation of the opposing [p]ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis. Biochemistry 44: 9913-9923, 2005. (Pubitemid 41033458)
    • (2005) Biochemistry , vol.44 , Issue.29 , pp. 9913-9923
    • Avarbock, A.1    Avarbock, D.2    Teh, J.-S.3    Buckstein, M.4    Wang, Z.-M.5    Rubin, H.6
  • 39
    • 0036968060 scopus 로고    scopus 로고
    • Thioridazine-fluoxetine interaction at the level of the distribution process in vivo
    • Wojcikowski J and Daniel WA: Thioridazine-fluoxetine interaction at the level of the distribution process in vivo. Pol J Pharmacol 54: 647-654, 2002. (Pubitemid 36124515)
    • (2002) Polish Journal of Pharmacology , vol.54 , Issue.6 , pp. 647-654
    • Wojcikowski, J.1    Daniel, W.A.2
  • 40
    • 0034748454 scopus 로고    scopus 로고
    • Distribution of psychotropic drugs in the grey and white matter of the brain: The role of lysosomal trapping
    • distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping. Br J Pharmacol 134: 807-814, 2001.
    • (2001) Br J Pharmacol , vol.134 , pp. 807-814
  • 41
    • 0034509338 scopus 로고    scopus 로고
    • Distribution interactions between perazine and antidepressant drugs. In vivo studies
    • Wójcikowski J and Daniel WA: Distribution interactions between perazine and antidepressant drugs. In vivo studies. Pol J Pharmacol 52: 449-457, 2000. (Pubitemid 32045908)
    • (2000) Polish Journal of Pharmacology , vol.52 , Issue.6 , pp. 449-457
    • Wojcikowski, J.1    Daniel, W.A.2
  • 42
    • 0342614869 scopus 로고    scopus 로고
    • Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants
    • DOI 10.1016/S0924-977X(99)00034-6, PII S0924977X99000346
    • Daniel WA and Wójcikowski J: Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antide-pressants. Eur Neuropsychopharmacol 9: 483-491, 1999. (Pubitemid 30089061)
    • (1999) European Neuropsychopharmacology , vol.9 , Issue.6 , pp. 483-491
    • Daniel, W.A.1    Wojcikowski, J.2
  • 43
    • 35148834736 scopus 로고    scopus 로고
    • Drug-drug interactions affected by the transporter protein, P-glycoprotein [ABCB1, MDR1] II. Clinical aspects
    • Aszalos A: Drug-drug interactions affected by the transporter protein, P-glycoprotein [ABCB1, MDR1] II. Clinical aspects. Drug Discov Today 12: 838-843, 2007.
    • (2007) Drug Discov Today , vol.12 , pp. 838-843
    • Aszalos, A.1
  • 44
    • 35148867503 scopus 로고    scopus 로고
    • Drug-drug interactions affected by the transporter protein, P-glycoprotein [ABCB1, MDR1] I. Preclinical aspects
    • Aszalos A: Drug-drug interactions affected by the transporter protein, P-glycoprotein [ABCB1, MDR1] I. Preclinical aspects. Drug Discov Today 12: 833-837, 2007.
    • (2007) Drug Discov Today , vol.12 , pp. 833-837
    • Aszalos, A.1
  • 45
    • 33747202180 scopus 로고    scopus 로고
    • Multidrug transporters as drug targets
    • Liang XJ and Aszalos A: Multidrug transporters as drug targets. Curr Drug Targets 7: 911-921, 2006.
    • (2006) Curr Drug Targets , vol.7 , pp. 911-921
    • Liang, X.J.1    Aszalos, A.2
  • 46
    • 18044374124 scopus 로고    scopus 로고
    • + channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine
    • + channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. J Pharmacol Exp Ther 313: 888-895, 2005.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 888-895
    • Choi, S.Y.1    Koh, Y.S.2    Jo, S.H.3
  • 47
    • 0037172794 scopus 로고    scopus 로고
    • Real-time monitoring of P-glycoprotein activation in living cells
    • DOI 10.1021/bi025720s
    • Landwojtowicz E, Nervi P and Seelig A: Real-time monitoring of P-glycoprotein activation in living cells. Biochemistry 41: 8050-8057, 2002. (Pubitemid 34655172)
    • (2002) Biochemistry , vol.41 , Issue.25 , pp. 8050-8057
    • Landwojtowicz, E.1    Nervi, P.2    Seelig, A.3
  • 49
    • 0026316247 scopus 로고
    • The in vivo inhibition of transport enzyme activities in different organs of rat by chlorpromazine is reversible
    • Adhikary G, Nandy P, Chandra S, Sikdar R and Sen PC: The in vivo inhibition of transport enzyme activities in different organs of rat by chlorpromazine is reversible. Biochem Int 25: 951-961, 1991.
    • (1991) Biochem Int , vol.25 , pp. 951-961
    • Adhikary, G.1    Nandy, P.2    Chandra, S.3    Sikdar, R.4    Sen, P.C.5
  • 50
    • 0025371018 scopus 로고
    • The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo
    • Mazumder B, Mukherjee S and Sen PC: The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo. Mol Cell Biochem 95: 13-20, 1990. (Pubitemid 20171468)
    • (1990) Molecular and Cellular Biochemistry , vol.95 , Issue.1 , pp. 13-20
    • Mazumder, B.1    Mukherjee, S.2    Sen, P.C.3
  • 51
    • 0023471349 scopus 로고
    • +-ATPase pumping and solute transport in rat hepatocytes
    • +-ATPase pumping and solute transport in rat hepatocytes. Am J Physiol 253(5 Pt 1): G613-621, 1987.
    • (1987) Am J Physiol , vol.253 , Issue.5 PART 1
    • Van Dyke, R.W.1    Scharschmidt, B.F.2
  • 52
    • 34047222991 scopus 로고    scopus 로고
    • Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents
    • Amaral L, Engi H, Viveiros M and Molnar J: Review. Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents. In Vivo 27: 237-244, 2007. (Pubitemid 46534275)
    • (2007) In Vivo , vol.21 , Issue.2 , pp. 237-244
    • Amaral, L.1    Engi, H.2    Viveiros, M.3    Molnar, J.4
  • 53
    • 17644377258 scopus 로고    scopus 로고
    • How neutrophils kill microbes
    • Segal AW: How neutrophils kill microbes. Annu Rev Immunol 23: 197-223, 2005.
    • (2005) Annu Rev Immunol , vol.23 , pp. 197-223
    • Segal, A.W.1
  • 56
    • 33846011388 scopus 로고    scopus 로고
    • New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target
    • Aperia A: New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target. J Intern Med 261: 44-52, 2007.
    • (2007) J Intern Med , vol.261 , pp. 44-52
    • Aperia, A.1
  • 57
    • 34447542162 scopus 로고    scopus 로고
    • Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps
    • Amaral L, Martins M and Viveiros M: Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps. J Antimicrob Chemother 59: 123712-123746, 2007.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 123712-123746
    • Amaral, L.1    Martins, M.2    Viveiros, M.3
  • 58
    • 40749110626 scopus 로고    scopus 로고
    • + transport enhance intracellular killing of M. tuberculosis by non-killing macrophages
    • + transport enhance intracellular killing of M. tuberculosis by non-killing macrophages. In Vivo 22: 69-75, 2008
    • (2008) In Vivo , vol.22 , pp. 69-75
    • Martins, M.1    Viveiros, M.2    Amaral, L.3
  • 59
    • 67649513152 scopus 로고    scopus 로고
    • Targeting the human macrophages for enhanced killing of intracellular XDT-TB and MDR-TB
    • Martins M, Viveiros M, Couto I and Amaral L: Targeting the human macrophages for enhanced killing of intracellular XDT-TB and MDR-TB. Int J Tuberc Lung Dis 13: 1-5, 2009.
    • (2009) Int J Tuberc Lung Dis , vol.13 , pp. 1-5
    • Martins, M.1    Viveiros, M.2    Couto, I.3    Amaral, L.4
  • 61
    • 38649084124 scopus 로고    scopus 로고
    • Cardiac side-effects of psychiatric drugs
    • Mackin P: Cardiac side-effects of psychiatric drugs. Hum Psychopharmacol 23(Suppl 1): 3-14, 2008.
    • (2008) Hum Psychopharmacol , vol.23 , Issue.SUPPL. 1 , pp. 3-14
    • Mackin, P.1
  • 62
    • 44449178386 scopus 로고    scopus 로고
    • Association of antipsychotic and antidepressant drugs with Q-T interval prolongation
    • DOI 10.2146/ajhp070279
    • Zemrak WR and Kenna GA: Association of antipsychotic and antidepressant drugs with Q-T interval prolongation. Am J Health Syst Pharm 65: 1029-1038, 2008. (Pubitemid 351768736)
    • (2008) American Journal of Health-System Pharmacy , vol.65 , Issue.11 , pp. 1029-1038
    • Zemrak, W.R.1    Kenna, G.A.2
  • 63
    • 33750341527 scopus 로고    scopus 로고
    • Formation of immature neutrophil leucocytes in schizophrenic patients treated with various antipsychotic drugs: Comparisons and predictions
    • DOI 10.1177/0269881106061112
    • Delieu JM, Horobin RW and Duguid JK: Formation of immature neutrophil leucocytes in schizophrenic patients treated with various antipsychotic drugs: comparisons and predictions. J Psychopharmacol 20: 824-828, 2006. (Pubitemid 44622747)
    • (2006) Journal of Psychopharmacology , vol.20 , Issue.6 , pp. 824-828
    • Delieu, J.M.1    Horobin, R.W.2    Duguid, J.K.3
  • 64
    • 46049088584 scopus 로고    scopus 로고
    • Prolong QT interval and "torsades de pointes" associated with different group of drugs
    • Gongadze N, Kezeli T and Antelava N: Prolong QT interval and "torsades de pointes" associated with different group of drugs. Georgian Med News 153: 45-49, 2007.
    • (2007) Georgian Med News , vol.153 , pp. 45-49
    • Gongadze, N.1    Kezeli, T.2    Antelava, N.3
  • 67
    • 36048947771 scopus 로고    scopus 로고
    • Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosis
    • Kim HR, Hwang SS, Kim HJ et al: Lee SM, Yoo CG, Kim YW, Han SK, Shim YS and Yim JJ: Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosis. Clin Infect Dis 45: 1290-1295, 2007.
    • (2007) Clin Infect Dis , vol.45 , pp. 1290-1295
    • Kim, H.R.1    Hwang, S.S.2    Kim, H.J.3    Lee, S.M.4    Yoo, C.G.5    Kim, Y.W.6    Han, S.K.7    Shim, Y.S.8    Yim, J.J.9
  • 68
    • 84857874918 scopus 로고    scopus 로고
    • TBTC Study 24: Center for Disease Control and Prevention; Clinical Trials. Gov Identifier:NCT00023374
    • TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance. Center for Disease Control and Prevention; Clinical Trials. Gov Identifier:NCT00023374, 2007.
    • (2007) Intermittent Treatment of TB with Isoniazid Resistance or Intolerance
  • 71
    • 77950849122 scopus 로고    scopus 로고
    • Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!
    • Amaral L, Boeree MJ, Gillespie SH, Udwadia ZF and van Soolingen D: Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! Int J Antimicrob Agents 35: 524-526, 2010.
    • (2010) Int J Antimicrob Agents , vol.35 , pp. 524-526
    • Amaral, L.1    Boeree, M.J.2    Gillespie, S.H.3    Udwadia, Z.F.4    Van Soolingen, D.5
  • 72
  • 73
    • 79959935423 scopus 로고    scopus 로고
    • Safety and efficacy of thioridazine as salvage therapy in Indian patients with XDR-TB
    • Udwadia ZF, Sen T and Pinto LM: Safety and efficacy of thioridazine as salvage therapy in Indian patients with XDR-TB. Recent Pat Antiinfect Drug Discov 6: 88-91, 2011.
    • (2011) Recent Pat Antiinfect Drug Discov , vol.6 , pp. 88-91
    • Udwadia, Z.F.1    Sen, T.2    Pinto, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.