Thioridazine-fluoxetine interaction at the level of the distribution process in vivo

Polish Journal of Pharmacology

Volumn 54, Issue 6, 2002, Pages 647-654

  Wójcikowski, Jacek ^a   Daniel, Władysława A ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Distribution interaction; Fluoxetine; Lysosomal trapping; Thioridazine

Indexed keywords

ANTIDEPRESSANT AGENT; DRUG METABOLITE; FLUOXETINE; MESORIDAZINE; SULFORIDAZINE; THIORIDAZINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; LIVER LYSOSOME; LIVER METABOLISM; LUNG PARENCHYMA; MALE; MUSCLE TISSUE; NONHUMAN; RAT;

ANIMALS; DRUG INTERACTIONS; FLUOXETINE; MALE; RATS; RATS, WISTAR; THIORIDAZINE; TISSUE DISTRIBUTION;

EID: 0036968060     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Axelsson R.: On the serum concentrations and antipsychotic effects of thioridazine, thioridazine side-chain sulfoxide and thioridazine side-chain sulfone, in chronic psychotic patients. Curr. Ther. Res, 1977, 21, 587-605.
2. Bickel M.H., Steele J.W.: Binding of basic and acidic drugs to rat tissue subcellular fractions. Chem.-Biol. Inter., 1974, 25, 55-86.
3. Brøsen K., Skjelbo E., Rasmussen B.B., Poulsen H.E., Loft S.: Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem. Pharmacol., 1993, 45, 1211-1214.
4. Crewe H.K., Lennard M.S., Tucker G.T., Woods F.R., Haddock R.E.: The effect of selective re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Brit. J. Clin. Pharmacol., 1992, 34, 262-265.
5. Daniel W.A., Bickel M.H., Honegger U.E.: The contribution of lysosomal trapping to the uptake of desipramine and chloroquine by different tissues. Pharmacol. Toxicol., 1995, 77, 402-406.
6. Daniel W.A., Syrek M., Haduch A., Wójcikowski J.: The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: in vivo and in vitro studies. Exp. Toxicol. Pathol., 1999, 91, 309-314.
7. Daniel W.A., Syrek M., Haduch A., Wójcikowski J.: The effects of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics and metabolism of perazine in the rat. J. Pharm. Pharmacol., 2001, 53, 449-461.
8. Daniel W.A., Syrek M., Mach A., Wójcikowski J., Boksa J.: Pharmacokinetics of thioridazine and its metabolites in blood plasma and the brain of rats after acute and chronic treatment. Pol. J. Pharmacol., 1997, 49, 439-452.
9. Daniel W.A., Syrek M., Wójcikowski J.: The influence of selective serotonin reuptake inhibitors on the plasma and brain pharmacokinetics of the simplest phenothiazine neuroleptic promazine in the rat. Eur. Neuropsychopharmacol., 1999, 9, 337-344.
10. Daniel W.A., Wójcikowski J.: Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs. Pharmacol. Toxicol., 1997, 80, 62-68.
11. Daniel W.A., Wójcikowski J.: Interactions between promazine and antidepressants at the level of cellular distribution. Pharmacol. Toxicol., 1997, 81, 259-264.
12. Daniel W.A., Wójcikowski J.: Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants. Eur. Neuropsychopharmacol., 1999, 9, 483-491.
13. Daniel W.A., Wójcikowski J.: The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions. Toxicol. Appl. Pharmacol., 1999, 158, 115-124.
14. Daniel W.A., Wójcikowski J., Palucha A.: Intracellular distribution of psychotropic drugs in the gray and white matter of the brain: the role of lysosomal trapping. Brit. J. Pharmacol., 2001, 134, 807-814.
15. De Duve C., Barsy T., Poole B., Touret A., Tulkens P., van Hoof F.: Lysosomotropic agents. Biochem. Pharmacol., 1974, 23, 2495-2531.
16. Di Francesco C., Bickel M.H.: Membrane lipids as intracellular binders of chlorpromazine and related drugs. Chem.-Biol. Inter., 1977, 16, 335-346.
17. Gottschalk L.A., Dinovo E., Biener R., Nandi B.R.: Plasma concentrations of thioridazine metabolites and ECG abnormalities. J. Pharm. Sci., 1978, 67, 155-157.
18. Jeppesen U., Gram L.F., Vistisen K., Loft S., Poulsen H.E., Brøsen K.: Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur. J. Clin. Pharmacol., 1996, 51, 73-78.
19. Lüllmann H., Wehling M.: The binding of drugs to different polar lipids in vitro. Biochem. Pharmacol., 1979, 28, 3409-3415.
20. MacIntyre A., Cutler D.J.: Role of lysosomes in hepatic accumulation of chloroquine. J. Pharm. Sci., 1988, 77, 196-199.
21. MacIntyre A., Cutler D.J.: The potential role of lysosomes in tissue distribution of weak bases. Biopharm. Drug Dispos., 1988, 9, 513-526.
22. Ohkuma S., Poole B.: Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Nat. Acad. Sci. USA, 1978, 75, 3327-3331.
23. Römer J., Bickel M.H.: Interactions of chlorpromazine and imipramine with artificial membranes investigated by equilibrium dialysis, dual-wavelength photometry, and fluorimetry. Biochem. Pharmacol., 1979, 28, 799-805.
24. Samet J.M., Surawicz B.: Cardiac function in patients treated with phenothiazines. Comparison with quinidine. J. Clin. Pharmacol., 1974, 14, 588-596.
25. Sproule B.A., Naranjo C.A., Brenmer K.E., Hassan P.C.: Selective serotonin reuptake inhibitors and CNS drug interaction. A critical review of the evidence. Clin. Pharmacokinet., 1997, 33, 454-471.
26. Tsuneizumi T., Babb S.M., Cohen B.M.: Drug distribution between blood and brain as a determinant of antipsychotic drug effects. Biol. Psychiat., 1992, 32, 817-824.
27. Vandel B., Bertschy G., Baumann P., Bouquet S., Bonin B., Francois T., Sechter D., Bizouard P.: Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients. Pharmacol. Res., 1995, 31, 347-353.
28. Wójcikowski J., Daniel W.A.: Distribution interaction between perazine and antidepressant drugs. In vivo studies. Pol. J. Pharmacol., 2000, 52, 449-457.